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Genes & Diseases 2024年第1期11卷 76-79页

作者： bo Jin Yutong ma Qian Wu Qiuxiang ou Yang Shao Shun Xu Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Geneseeq Research Institute Nanjing Geneseeq Technology Inc.NanjingJiangsu 210000China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Department of Thoracic Surgery The First Hospital of China Medical UniversityShenyangLiaoning110001China

MET gene alterations in lung cancer patients mainly include exon 14 skipping and gene amplification,which are the key therapeutic targets and drive resistance to tyrosine kinase inhibitors(TKls).1 However,the structural variants of MET,such as MET fusions,are much rarer(0.26%),as reported in a Chinese non-small cell lung cancer(NSCLC)cohort.2 Several recurrent MET fusions,such as KIF5b-MET and HLADRb1-MET,were reported as oncogenic drivers and showed favorable responses to crizotinib.

关键词： lung patients alterations

Spatial Distribution Pattern and Influencing Factors of bed-and-breakfasts(b&bs)from the Perspective of Urban-rural Differences:A Case Study of Jiaodong Peninsula,China

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Chinese Geographical Science 2024年第4期34卷 752-763页

作者： WANG Xinyue ma Qian management College Ocean University of ChinaQingdao 266100China

There are significant differences between urban and rural bed-and-breakfasts(b&bs)in terms of customer positioning,economic strength and spatial *** identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural b&b agglomeration *** study used density-based spatial clustering of applications with noise(DbSCAN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural b&bs on the Jiaodong Peninsula of China from 2010 to *** results showed that:1)both urban and rural b&bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to ***,urban b&bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural b&bs continued to expand in terms of quantity and *** b&b clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level *** the number of rural b&b clusters steadily increased over time,their clustering scale was comparatively lower than that of urban b&bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban b&b clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban ***,rural b&bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural b&bs,with the density of road network having the strongest explanatory power for their spatial *** terms of differences,populati

关键词： urban-rural bed-and-breakfasts(b&bs) spatiotemporal evolution density-based spatial clustering of applications with noise(DbSCAN)model multi-scale geographically weighted regression(MGWR) Jiaodong Peninsula China

Two-stage aging treatment to accelerate aging kinetics without impairing strength in b_4C/7A04Al composite

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Science China(Technological Sciences) 2024年第8期67卷 2485-2492页

作者： CHEN YunTao ma GuoNan ZHU ShiZe WANG Dong XIAO boLv ma ZongYi Shi-Changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Centre of Excellence for Advanced materials Dongguan 523808China

Aging treatments are the key process to obtain satisfactory strength for 7xxxAl alloys and their composites. However, traditional single-stage(SS) aging is time-consuming to reach a peak strength condition. In this study, an efficient 120℃ + 160℃ two-stage(TS) aging treatment was proposed on a b_4C/7A04Al composite fabricated via powder metallurgy(PM) technology, which could acquire similar peak-aging strength but only took about 15% of the time compared to traditional 120℃ SS aging. The evolution of precipitation during the TS aging was investigated, as well as those of the 7A04Al alloys for comparison. In the second stage aging process, the higher aging temperature accelerated the nucleation of η′ phases inside the grains and thus increased the density of precipitates. Moreover, the short aging time limited the coarsening of precipitates and the broadening of precipitatefree zones. The above factors were beneficial for quickly obtaining satisfactory precipitation strengthening effects. The b_4C/7A04Al composite exhibited slower aging kinetics than the 7A04Al alloy in the TS aging. Mg elements consumption by the chemical reaction between b impurities introduced by b_4C particles and the Al matrix was considered to potentially retard the aging kinetics of the b_4C/7A04Al composite. Nevertheless, the precipitation sequence was not affected.

关键词： aluminum matrix composites aging treatment powder metallurgy mechanical properties precipitation

Effect of Al_(2)O_(3)on the Mechanical Properties of(b_(4)C+Al_(2)O_(3))/Al Neutron Absorbing materials

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： J.X.Cai b.M.Shi N.Li Y.Liu Z.G.Zhang Y.N.Zan Q.Z.Wang b.L.Xiao Z.Y.ma Shi‑Changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Department of materials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

b_(4)C/Al composites are widely utilized as neutron absorbing materials for the storage and transportation of spent nuclear *** order to improve the high-temperature mechanical properties of b_(4)C/Al composites,in-situ nano-Al_(2)O_(3)was introduced utilizing oxide on Al powder *** this study,the Al_(2)O_(3)content was adjusted by utilizing spheroid Al powder with varying diameters,thereby investigating the impact of Al_(2)O_(3)content on the tensile properties of(b_(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain boundaries could hinder the recovery of dislocations and lead to dislocation accumulation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain size,the high-temperature strength of the composites increased *** finest Al powder used in this investigation had a diameter of 1.4μm,whereas the resultant composite exhibited a maximum strength of 251 MPa at room temperature and 133 MPa at 350℃,surpassing that of traditional b_(4)C/Al composites.

关键词： Al matrix composites Neutron absorbing materials (b_(4)C+Al_(2)O_(3))/Al composites High-temperature strength

Flag Varieties of Type b/C and Twisted Yangian

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Algebra Colloquium 2024年第1期31卷 129-148页

作者： Zhijie Dong Haitao ma Institute for Advanced Study in mathematics of HIT Harbin Institute of Technology Harbin 150001China College of mathematical Science Harbin Engineering University Harbin 150001China

We study the convolution algebra H_(*)^(G×C^(*))(Z)of G×C^(*)-equivariant homology group on the Steinberg variety of type b/C and define an algebra Y that maps to H_(*)^(G×C^(*))(Z).We also study the G-equivariant ... 详细信息

关键词： Yangian fag variety convolution algebra

Overview of the immunological mechanisms in hepatitis b virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui ma Qing-Zhu Yan Jing-Ru ma Dong-Fu Li Jun-Ling Yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis b virus(HbV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HbV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HbV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis b virus reactivation Immunological mechanisms Disease progression management strategies Immune response

DeepSecE:A Deep-Learning-based Framework for Multiclass Prediction of Secreted Proteins in Gram-Negative bacteria

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Research 2024年第3期2023卷 243-257页

作者： Yumeng Zhang Jiahao Guan Chen Li Zhikang Wang Zixin Deng Robin bGasser Jiangning Song Hong-Yu ou state Key Laboratory of Microbial Metabolism Joint International Laboratory on Metabolic&Developmental SciencesSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Veterinary biotechnology Shanghai Jiao Tong UniversityShanghai 200240China biomedicine Discovery Institute and Department of biochemistry and Molecular biology Monash UniversityMelbourneViC 3800Australia Monash Data Futures Institute Monash UniversityMelbourneViC 3800Australia Melbourne Veterinary School Faculty of ScienceThe University of MelbourneParkvilleVIC 3010Australia.

Proteins secreted by Gram-negative bacteria are tightly linked to the virulence and adaptability of these microbes to environmental *** identification of such secreted proteins can facilitate the investigations of infections and diseases caused by these bacterial ***,current bioinformatic methods for predicting bacterial secreted substrate proteins have limited computational efficiency and application scope on a genome-wide ***,we propose a novel deep-learning-based framework—DeepSecE—for the simultaneous inference of multiple distinct groups of secreted proteins produced by Gram-negative *** remarkably improves their classification from nonsecreted proteins using a pretrained protein language model and transformer,achieving a macro-average accuracy of 0.883 on 5-fold *** benchmarking suggests that DeepSecE achieves competitive performance with the state-of-the-art binary predictors specialized for individual types of secreted *** attention mechanism corroborates salient patterns and motifs at the N or C termini of the protein *** this pipeline,we further investigate the genome-wide prediction of novel secreted proteins and their taxonomic distribution across~1,000 Gram-negative bacterial *** present analysis demonstrates that DeepSecE has major potential for the discovery of disease-associated secreted proteins in a diverse range of Gram-negative *** online web server of DeepSecE is also publicly available to predict and explore va.ious secreted substrate proteins via the input of bacterial genome sequences.

关键词： Deep server competitive

Re-examination of statistical relationships between dietary fats and other risk factors,and cardiovascular disease,based on two crucial datasets

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Quantitative biology 2024年第1期12卷 117-127页

作者： Jiarui ou Le Zhang Xiaoli Ru College of Computer Science Sichuan UniversityChengduChina Department of Gynecology and Obstetrics Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

Cardiovascular disease(CVD)is the major cause of death in many regions around the world,and several of its risk factors might be linked to *** improve public health and the understanding of this topic,we look at the recent Minnesota Coronary Experiment(MCE)analysis that used t-test and Cox model to evaluate CVD ***,these parametric methods might suffer from three problems:small sample size,right-censored bias,and lack of long-term *** overcome the first of these challenges,we utilize a nonparametric permutation test to examine the relationship between dietary fats and serum total *** address the second problem,we use a resampling-based rank test to examine whether the serum total cholesterol level affects CVD *** the third issue,we use some extra-Framingham Heart Study(FHS)data with an A/b test to look for meta-relationship between diets,risk factors,and CVD *** show that,firstly,the link between low saturated fat diets and reduction in serum total cholesterol is ***,reducing serum total cholesterol does not robustly have an impact on CVD hazards in the diet ***,the A/b test result suggests a more complicated relationship regarding abnormal diastolic blood pressure ranges caused by diets and how these might affect the associative link between the cholesterol level and heart disease *** study not only helps us to deeply analyze the MCE data but also,in combination with the long-term FHS data,reveals possible complex relationships behind diets,risk factors,and heart disease.

关键词： A/b test bioinformatics cardiovascular disease nonparametric statistics

A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis b

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Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu Guanghui ma Hua Yue State Key Laboratory of biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis b(CHb)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis b virus(HbV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHb *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis b vaccines based on exosome formulations.

关键词： chronic hepatitis b antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

Hepatitis b virus infection, infertility, and assisted reproduction

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2024年第8期25卷 672-685页

作者： Lingjian ZHANG Fangfang ZHANG Zhiyuan ma Jie JIN Department of Infectious Diseases Affiliated Hangzhou First People’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China

background:Hepatitis b virus(HbV)is one of the most widespread viruses worldwide and a major cause of hepatitis,cirrhosis,and hepatocellular *** studies have revealed the impacts of HbV infection on *** increasing number of infertile couples with chronic hepatitis b(CHb)virus infection choose assisted reproductive technology(ART)to meet their fertility *** the high prevalence of HbV,the effects of HbV infection on assisted reproduction treatment remain limited and ***:The aim of this study was to provide a comprehensive overview of the effect of HbV infection on fertility and discuss its effects on pregnancy outcomes,vertical transmission,pregnancy complications,and viral activity during ART ***:We conducted a literature search in PubMed for studies on HbV infection and ART published from 1996 to ***:HbV infection negatively affected fertility in both males and *** research shows that HbV infection may increase the risk of pregnancy complications in couples undergoing assisted reproduction *** impact of HbV infection on the pregnancy outcomes of ART is still *** evidence does not support that ART increases the risk of vertical transmission of HbV,while relevant studies are *** the development of ART,the risk of HbV reactivation(HbVr)is increasing,especially due to the wide application of immunosuppressive ***:Regular HbV infection screening and HbVr risk stratification and management are essential to prevent HbVr during *** determination of optimal strategy and timing of prophylactic anti-HbV therapy during ART still needs further investigation.

关键词： Assisted reproductive technology(ART) Hepatitis b virus(HbV) Immunosuppressive agent Pregnancy