检索结果-南通市图书馆

High-mobility group box-1 and receptor for advanced glycation end products in preterm infants with brain injury

World Journal of Pediatrics 2017年第3期13卷 228-235页

作者： Hong-yan Lu Jiang-Lin ma Ji-yan Shan Jie Zhang Qiu-xia Wang Qiang Zhang Department of Pediatrics the Affiliated Hospital of Jiangsu University438 Jiefang RoadZhenjiangChina

Background:High-mobility group box-1 (HMGB1) protein acts as an important pro-inflammatory mediator,which is capable of activating inflammation and tissue ***1 can bind to its receptor such as advanced glycation end products (RAGE).RAGE,in turn,can promote the production of pro-inflammatory *** RAGE (sRAGE) is a truncated form of the receptor comprising the extracellular domain of RAGE and can inhibit *** objective of this study was to investigate whether HMGB1 and RAGE are involved in the development of brain injury in preterm ***:In total,108 infants ≤34 weeks gestation at birth were divided into 3 groups according to cranial altrasound scan:mild brain damage (n=33),severe brain damage (n=8) and no brain damage (n=67).All the placentas were submitted for pathologic *** chorioamnionitis (HCA) was defined as neutrophil infiltration of amniotic membranes,umbilical cord or chorionic *** of HMGB1 and RAGE proteins were assessed by immunohistochemical *** concentration of HMGB1 and sRAGE in umbilical cord blood were measured by enzyme-linked immunosorbent ***:The frequency of HCA was 30.12%.HCA was associated with elevated concentrations of HMGB1 and decreased sRAGE in umbilical cord *** severe brain injury group demonstrated higher cord blood HMGB1 concentrations (Pmature infants was linked to intense staining for HMGB1/RAGE,particularly in inflammatory ***:Changes of cord blood HMGB1 and sRAGE of premature infants had direct relationship with the degree of inflammation and severity of brain *** sRAGE and HMGB1 levels may be helpful to predict intrauterine infection and brain injury in premature infants.

关键词： brain injury HMGB1 preterm infants RAGE sRAGE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran yang Ziming yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Immune checkpoint inhibitor-associated ophthalmic adverse events: current understanding of its mechanisms,diagnosis, and management

引用

International Journal of Ophthalmology(English edition) 2022年第4期15卷 646-656页

作者： Yu-Wen Zhou Qian Xu yan Wang Ruo-Lan xia Ji-yan Liu Xue-Lei ma Department of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Medical Publishers West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospitalthe First People’s Hospital of Long Quan Yi DistrictChengdu 610041Sichuan ProvinceChina

Immune checkpoint inhibitors(ICIs) targeting cytotoxic T-lymphocyte antigen 4 and programmed cell death protein 1 receptor/ligand have revolutionized cancer treatment, achieving unprecedented efficacy in numerous malignancies. Despite the excellent therapeutic effects of ICIs, medications, such as pembrolizumab, ipilimumab, nivolumab, atezolizumab, avelumab, and durvalumab, typically cause a broad spectrum of toxicity events termed as immune-related adverse events(ir AEs). Out of all ir AEs, ophthalmic adverse events occur infrequently and are not comprehensively recognized. The current understanding of ophthalmic ir AEs is mainly derived from case reports and case series. In this review, based on relevant articles in the literature and current evidence, we summarize the incidences, manifestations, diagnoses, underlying mechanisms, treatments, and outcomes of ophthalmic ir AEs and discuss possible management strategies. A better understanding of these features is critical for managing patients with ICI-associated ophthalmic adverse events.

关键词： immune checkpoint inhibitor ophthalmological adverse events uveitis neuro-ophthalmic toxicity retinopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of MODIS and Deep Blue aerosol optical depth retrievals in an arid/semi-arid region of northwest China

引用

Particuology 2012年第1期10卷 132-139页

作者： xia Li xiangao xia Shengli Wang Jietai mao yan Liu LAGEO Institute of Atmospheric Physics ChineseAcademy of Sciences Beijing 100029 China Institute of Desert Meteorology China Meteorology Administration Urumqi 830002 China Xinjiang Climate Center Urumqi 830002 China School of Physics Peking University Beil＇ing 100871 China

The global aerosol optical depth （AOD or r） has been retrieved using the Dark Target algorithm （the C004 and C005 products） and the Deep Blue algorithm （DB product）. Few validations have thus far been performed in arid/semi-arid regions, especially in northwest China. The ground-based remote sensing of AOD from sun photometers at four sites in Xinjiang during the years 2002-2003 is used to validate aerosol products, including C004, C005 and DB of the Moderate Resolution Imaging Spectroradiometer （MODIS）. The results show substantial improvement in the C005 aerosol product over the C004 product. The average correlation coefficient of regression with ground measurements increased from 0.59 to 0.69, and the average offset decreased from 0.28 to 0.13. The slopes of the linear regressions tended to be close to unity. The percentage of AODs falling within the retrieval errors of 30% （or Δτ = ±0.1 ± 0.2τ） increased from 16.1% to 45.6%. The best retrievals are obtained over an oasis region, whereas the worst are obtained over urban areas. Both the MODIS C004 and C005 products overestimate AOD, which is likely related to improper assumptions of the aerosol model and of the estimation of surface reflectance. An encouraging result has been derived with regard to validation of the DB AOD. Overall, the average offset, slope and correlation coefficient of regression with sun-photometer measurements are -0.04, 0.88 and 0.85, respectively. Approximately 73% of the DB AOD retrievals fall within the expected error of 30%. Underestimation of the AOD by the DB products is observed. The aerosol model and estimations of surface reflectance in this region require further improvements.

关键词： MODISSun-photometerAerosol optical depthDeep blue algorithm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于弹丸膛内运动参数和压力测试的火炮膛内燃气温度估算方法

引用

火工品 2025年第1期 51-54页

作者：赵煜华闫光虎肖霞严文荣梁磊西安近代化学研究所陕西西安710065

为了解决火炮膛内测试环境恶劣而导致发射药燃气温度测试难度大的问题,基于微波干涉仪、压力测试系统,结合发射药配方性能计算理论、装药内弹道性能计算模型等理论,建立了一种基于实测参数的火炮膛内燃气温度估算方法,并开展了试验研究... 详细信息

为了解决火炮膛内测试环境恶劣而导致发射药燃气温度测试难度大的问题,基于微波干涉仪、压力测试系统,结合发射药配方性能计算理论、装药内弹道性能计算模型等理论,建立了一种基于实测参数的火炮膛内燃气温度估算方法,并开展了试验研究。结果表明:火炮膛内燃气温度的最高值约为2631.8 K,随着弹丸运动迅速降低,弹丸出炮口时膛内燃气温度降低到约1858.4 K;建立的火炮膛内发射药燃气温度估算方法可以有效地获得火炮整个内弹道过程中火药燃气温度随时间的变化规律,为低烧蚀发射药及装药的研制提供了一种新的研究手段。

关键词：发射药膛内燃气温度估算方法微波干涉仪

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

maximum Likelihood Estimation via Duality for Cell Probabilities Subject to Convex and Log-convex Constraints

引用

Acta mathematicae Applicatae Sinica 2014年第1期30卷 157-170页

作者： yan-ping ma School of Science Beijing Jiaotong University

This article proposes a method for fitting models subject to a convex and log-convex constraint on the probability vector of a product multinomial （binomial） distribution. We present an iterative algorithm for finding the restricted maximum likelihood estimates （MLEs） of the probability vector and show that the algorithm converges to the true solution. Some examples are discussed to illustrate the method.

关键词： convex cone duality cone I-projection log-convex constraint maximum likelihood estimation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

引用

Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong yang Haochen Shen xiaoming xiao Zhichao Li Qi Zhou Wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 ma cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 ma cm-2and exhibited high structural robustness,maintaining stability at 1000 ma cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microstructural regulation and properties enhancement of MgO-CaO ceramics by doping Y_(2)O_(3)

引用

Journal of Rare Earths 2023年第11期41卷 1771-1779,I0005页

作者： Nian Yi yan ma Zhoufu Wang Hao Liu Xitang Wang Yunjie Dong Zhongfeng xia Yuxuan Zhu Chengji Deng The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China

MgO-CaO ceramics with enhanced microhardness and hydration resistance were successfully prepared by doping Y_(2)O_(3) in this *** effects of introducing Y_(2)O_(3) on the microstructure and properties of MgO-CaO ceramics were *** microstructural regulation effects of Y_(2)O_(3) additive on MgO,CaO,and MgO-CaO ceramics were analyzed *** results show that Y_(2)O_(3) dissolves into the CaO lattice to form solid solution in CaO ceramics,and no obvious intergranular phase *** the Y_(2)O_(3) additive leads to the micro structural reconstruction in MgO and MgO-CaO *** adding Y_(2)O_(3),SiO_(2) impurity from magnesium source reacts with CaO to form the silicate phases containing Y^(3+)ions in MgO-CaO *** increase in the MgO/CaO interface and the microstructural reconstruction synergistically improves the microhardness and hydration resistance of MgO-CaO ceramics markedly.

关键词： Y_(2)O_(3) MgO-CaO ceramics Microstructural regulation Reconstruction Properties Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Rapamycin on the Differentiation and Function of macrophages In Vitro

引用

Agricultural Sciences in China 2009年第5期8卷 620-627页

作者： SHEN Hong WU Guo-juan LIU Guang-wei ma Hai-xia LIAO An-yan ZHAO Yong Department of Animal Science and Technology Beijing University of Agriculture Beijing 102206 P.R.China State Key Laboratory of Biomembrane and Membrane Biotechnology/Institute of Zoology Chinese Academy of Sciences Beijing 100101 P.R. China The Third Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100029 P.R.China

macrophages have been generated from bone marrow progenitor cells （BMPCs） with macrophage colony-stimulating factor （M-CSF）. Rapamycin （rapa） is an immunosuppressive drug, which could prevent renal graft rejection and inhibit tumor growth to yield antiproliferative activity in a variety of malignancies. However, the direct effect of rapa on the development of macrophages is unknown. In this study, we explored the direct effect of rapa on the differentiation and function of macrophages differentiated from mouse BMPCs in vitro in the presence of M-CSF. The experimental data showed that rapa prevented the differentiation of macrophagcs by down-regulating CD80 and CD86 expression but upregulating F4/80 expression, as well as by reducing the capacity of differentiated macrophages to stimulate lymphocyte proliferation in the allogeneic mixed lymphocyte reaction. Furthermore, the phagocytic capacity of differentiated macrophages was significantly reduced by rapa. Therefore, rapa may directly inhibit macrophage differentiation and function, which may have been one of the major targets for rapa to mediate its immunosuppressive properties.

关键词： function macrophages rapamycin differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hybrid scheme for three-cell multi-user MIMO cellular networks

引用

The Journal of China Universities of Posts and Telecommunications 2014年第5期21卷 37-42页

作者： ma yan-jun School of Communication Engineering Xi'an University of Science and Technology

Orthogonal schemes are usually adopted for cell-edge users in a cellular network, where the spectrum is poorly utilized. A new interference alignment （IA） based space-division hybrid （IA-SDH） scheme is proposed by joint design transmit precoding matrices and beamforming matrices for a three-cell constant cellular network, where users at cell-center work with a conventional scheme while users at cell-edge utilize an IA scheme. Therefore, the cell-edge users suffer no interference and cell-center users are only affected by negligible inter-cell interference. Analysis simulation shows that more users can be served simultaneously than that of a conventional scheme in certain user distributions.

关键词： iterference alignment degree of freedom interference channel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：