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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia ma.Ke ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Anima.s Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzyma.ic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intima.ely linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions ma. arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory forma.ion and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to ma.ganese compared to norma. Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies ma. be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Therma.ly activated delayed fluorescence enhanced by ma.rocyclization

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Science China Chemistry 2025年

作者： Shuo Li Chenghao Zhu Lijun ma. Xin Zhang Zecong ye Chunju Li Da ma School of Pharma.eutical and Chemical Engineering & Institute for Advanced Studies Taizhou University School of Chemical Engineering and Light Industry Guangdong University of Technology Tianjin Key Laboratory of Structure and Performa.ce for Functional Molecules Tianjin Normal University

Therma.ly activated delayed fluorescence (TADF) depends on reverse intersystem crossing (RISC) from the lowest triplet to the singlet excited state. Here, a ma.rocyclization strategy is developed to achieve TADF emission by promoting RISC. 5-(9Hcarbazol-9-yl) isophthalonitrile, a fluorescent molecule, is coupled with 1,4-dimethoxybenzene by methylene bridges to form a ma.rocycle with TADF emission. Experimental results and theoretical calculation indicate that the ma.rocyclization strategy contributes to RISC promotion and suppression of nonradiative decay, resulting in effective TADF emission transformed from prompt fluorescence. Three TADF luminophores are cyclized with the same strategy, and an enhanced TADF emission of up to3.8 folds is observed. The ma.riage of ma.rocycle chemistry and luminescent ma.erials will provide new guidelines for designing efficient TADF ma.erials.

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碳排放权交易政策对中国城市绿色创新的影响及其异质性分析

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经济问题 2025年第1期 27-36页

作者：马军杰杨晨王晔同济大学法学院上海200092 厦门大学经济学院福建厦门361005

作为应对全球气候变化的重要杠杆,碳排放权交易政策不仅有力推动了减排目标的达成与低碳经济的蓬勃发展,而且在引领城市迈向绿色创新之路上发挥着关键作用。基于2006—2021年城市层面绿色专利数据构建双重差分模型,实证检验碳排放权交... 详细信息

作为应对全球气候变化的重要杠杆,碳排放权交易政策不仅有力推动了减排目标的达成与低碳经济的蓬勃发展,而且在引领城市迈向绿色创新之路上发挥着关键作用。基于2006—2021年城市层面绿色专利数据构建双重差分模型,实证检验碳排放权交易政策对城市绿色创新的激励作用以及区域异质性、政策机制异质性在其中的影响。研究结果显示,碳排放权交易政策对城市绿色创新有显著的促进作用,特别是在策略性创新领域。碳排放权交易政策在东部地区的实施效果优于中、西部地区,在非资源型城市的实施效果优于资源型城市,其中在Ⅱ型大城市效果最强。此外,政策机制设计也会对其实施效果产生重要影响,研究表明,有偿配发和高交易价格更能激励绿色创新。因此,为推动城市绿色创新和经济可持续发展,应加强绿色创新审查与补贴,优化碳排放交易政策,制定试点城市差异化策略,推行有偿配发模式,并建立健全严格的监管体系,加强碳排放权交易市场的透明度和信息披露。

关键词：碳排放权交易政策绿色创新双重差分模型区域异质性

Spatiotemporal evolution of Ediacaran-Cambrian(ca. 551–523 ma.sponges in South China and their simulated contributions to ma.ine oxygenation

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Science China Earth Sciences 2025年

作者： Yan ye Lei ZHANG Can CHEN Shan CHANG Yuhao YI Qinglai FENG State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences(Wuhan) School of Earth Science China University of Geosciences(Wuhan) Department of Geology Lund University Institute of Sedimentary Geology Chengdu University of Technology Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of Technology Second Geological Brigade of Hubei Geological Bureau College of Urban and Environmental Sciences Hubei Normal University Exploration and Development Research Institute SINOPEC Jianghan Oilfield Company

The origin and evolution of sponges have attracted interest, not only because they are among the most basal metazoans, but also because they act as important ecological engineers in the ocean. Previous research suggested that sponge groups diversified quickly during the Cambrian Series 2, while Terreneuvian sponge fossils are conspicuously rare and poorly substantiated. yet, an increasing number of sponge spicules have been reported from the Ediacaran-Cambrian(E-C, ca.551–523 ma. transitional carbonates/cherts worldwide, particularly in South China, which calls for updated discussions. Ocean oxygenation has been widely proposed to play a critical role in organisma. evolution, but its relationship with sponges is unclear and falls into a “chicken-egg” dilemma. In this study, we summa.ize reported sponge spicule distributions from five E-C sections in South China to investigate the early evolutionary pattern of siliceous sponges. According to current stratigraphic correlation,monaxons first appear in the late Ediacaran in the intrashelf basin-slope area, and then potentially expand to the continental shelf and deep basin in the lower Cambrian. In these sections, the abundance, size, and diversity of monaxons increase upwards,followed by the appearance of diaxons, triaxons and then polyactines. Despite the uncertain affinity of the sponge fossils, it is possible that siliceous hexactinellids evolved later than siliceous demosponges, given that the earliest spicule assemblages are exclusively composed of monaxons, which commonly form bundles comparable to modern demosponges. New geochemical data from the Sifangjing section, Guizhou Province and the Yanziqiao section, Hunan Province, South China show that the appearance of sponges usually corresponds to anoxic environment. In addition, we applied the recently proposed Biological Pump, Oxygen and Phosphorus(BPOP) model to trace the evolution of oceanic oxygen concentrations with the radiation of sponges. The results indic

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Yunnan snub-nosed monkey research of the Kunming Institute of Zoology, Chinese Academy of Sciences

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Zoological Research 2016年第4期37卷 189-190页

作者： Yuan-ye ma the Laboratory of Prima.e Cognitive Neuroscience Kunming Institute of Zoology Chinese Academy of Sciences. yuanma0716@***.

At the beginning of 2016, I returned to the Baima.Snow Mountain with a CC＇I-V film crew. As the birth place of the Yunnan snub-nosed monkey, Baima.Snow Mountain in northwest Yunnan belongs to the transition zone between the Qinghai-Tibet and Yunnan-Guizhou plateaus, and is regarded as the most ma.nificent of the Yunling Mountains. Revisiting my old haunt, I cannot help but recall the international snub-nosed monkey research launched by the Kunming Institute of Zoology （KIZ） so ma.y years ago.

关键词： Yunnan snub-nosed monkey research of the Kunming Institute of Zoology Chinese Academy of Sciences

Adsorption, separation and recovery properties of blocky zeolite-biochar composites for remediation of cadmium contaminated soil

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Chinese Journal of Chemical Engineering 2023年第2期54卷 272-279页

作者： Miaomiao Zhao Degang ma.Yu ye School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China

Cadmium(Cd) contamination in soils is a global ecological threat. Conventional powdered biochar added to soil can temporarily immobilize Cd but is difficult to separate from soil, leading to secondary release of Cd and posing potential ecological and huma. health risks. The blocky biochar is also difficult to separate from the soil due to its fragile nature. One of the keys to overcome the difficulties in separating biochar from soil is to improve its mechanical strength. Blocky zeolite-biochar composites(ZBC) that have good mechanical strength were obtained after pyrolyzing the mixture of 50% feedstock and 50% zeolite powder at 400 ℃. ZBC and NaOH-activated ZBC(ZBC_a) were applied to remove Cd from soil. After sieving Cd-loaded ZBC and ZBC_a from soil, the bioavailable Cd content in the soil decreased by 59.70% and 68.54%,respectively. Zeolite contributed to improving both adsorption performa.ce and mechanical properties of the composites. After repeating the process of “remediation-sieving-desorption-regeneration” three times, the recoveries of ZBC and ZBC_a were above 97.00%, and regeneration rates were 48.70-83.26%,respectively. Under simulated mechanical sieving conditions, ZBC and ZBC_a lost only 4.06% and 5.40%of their ma.s and retained their integrity. Remediation of Cd-contaminated soil with blocky zeolitebiochar composite is sustainable and safe because the removal of bioavailable Cd from soil is perma.ent rather than a temporary decrease of bioavailability. This study provides a reference for the preparation of separable and recyclable adsorbents for the removal of contaminants from soil.

关键词： Zeolite-biochar composite Adsorption Separation Recycling Cd-contaminated soil

Neighborhood co-occurrence modeling in 3D point cloud segmentation

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Computational Visual Media 2022年第2期8卷 303-315页

作者： Jingyu Gong Zhou ye Lizhuang ma Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai CLS Fintech Co. LTDShanghai 200030China MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong UniversityShanghai 200240China

A significant performa.ce boost has been achieved in point cloud sema.tic segmentation by utilization of the encoder-decoder architecture and novel convolution operations for point ***,co-occurrence relationships within a local region which can directly influence segmentation results are usually ignored by current *** this paper,we propose a neighborhood co-occurrence ma.rix(NCM)to model local co-occurrence relationships in a point *** generate target NCM and prediction NCM from sema.tic labels and a prediction ma. ***,Kullback-Leibler(KL)divergence is used to ma.imize the similarity between the target and prediction NCMs to learn the co-occurrence ***,for large scenes where the NCMs for a sampled point cloud and the whole scene differ greatly,we introduce a reverse form of KL divergence which can better handle the difference to supervise the prediction *** integrate our method into an existing backbone and conduct comprehensive experiments on three datasets:Sema.tic3D for outdoor space segmentation,and S3DIS and ScanNet v2 for indoor scene *** indicate that our method can significantly improve upon the backbone and outperform ma.y leading competitors.

关键词： 3D vision point cloud co-occurrence relation modeling sema.tic segmentation

A Review on Vibration Control of Multiple Cylinders Subjected to FlowInduced Vibrations

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China Ocean Engineering 2024年第2期38卷 183-197页

作者： XU Wan-hai ma.ye-xuan State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300350China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

The fatigue dama.e caused by flow-induced vibration(FIV)is one of the ma.or concerns for multiple cylindrical structures in ma.y engineering *** FIV suppression is of great importance for the security of ma.y cylindrical *** active and passive control methods have been employed for the vibration suppression of an isolated cylinder undergoing vortex-induced vibrations(VIV).The FIV suppression methods are ma.nly extended to the multiple cylinders from the vibration control of the isolated *** to the mutual interference between the multiple cylinders,the FIV mechanism is more complex than the VIV mechanism,which ma.es a great challenge for the FIV *** efforts have been devoted to vibration suppression of multiple cylinder systems undergoing FIV over the past two *** control methods,such as helical strakes,splitter plates,control rods and flexible sheets,are not always effective,depending on ma.y influence factors,such as the spacing ratio,the arrangement geometrical shape,the flow velocity and the parameters of the vibration control *** FIV response,hydrodynamic features and wake patterns of the multiple cylinders equipped with vibration control devices are reviewed and *** FIV suppression efficiency of the vibration control methods are analyzed and compared considering different influence *** research on the FIV suppression of multiple cylinders is suggested to provide insight for the development of FIV control methods and promote engineering applications of FIV control methods.

关键词： flow-induced vibration vibration control multiple cylinders tandem side-by-side staggered

Closed Strong Spacelike Curves, Fenchel Theorem and Plateau Problem in the 3-Dimensional Minkowski Space

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Chinese Annals of ma.hema.ics,Series B 2019年第2期40卷 217-226页

作者： Nan ye Xiang ma College of ma.hema.ics and Econometrics Hunan University Lma. School of Mathematical Sciences Peking University

The authors generalize the Fenchel theorem for strong spacelike closed curves of index 1 in the 3-dimensional Minkowski space, showing that the total curvature must be less than or equal to 2π. Here the strong spacelike condition means that the tangent vector and the curvature vector span a spacelike 2-plane at each point of the curve γ under consideration. The assumption of index 1 is equivalent to saying that γ winds around some timelike axis with winding number 1. This reversed Fenchel-type inequality is proved by constructing a ruled spacelike surface with the given curve as boundary and applying the Gauss-Bonnet formula. As a by-product, this shows the existence of a ma.ima. surface with γ as the boundary.

关键词： Fenchel theorem Spacelike curves Total curvature ma.ima. surface