检索结果-南通市图书馆

Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

引用

World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre ma.va.Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carva.ho Denis Pezet ma.hilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstra.ed with colibactin-producing Escherichia coli(CoPEC).AIM To eva.uate the association between CoPEC preva.ence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the preva.ence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Eleva.ed Plus ma.e test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenoma.ous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflamma.ion Anxiety Depression Behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of ozonation on disinfection byproducts forma.ion from phenylalanine during chlorination

引用

Journal of Environmental Sciences 2024年第10期144卷 199-211页

作者： Sinong Huang Hongwei Liu Kunming Wei Liang Zhang Xiaoyan ma.Qingsong Li Xueyan Li Andrea M.Dietrich College of Civil Engineering Zhejiang Key Laboratory of Civil Engineering Structures&Disaster Prevention and Mitigation TechnologyZhejiang University of TechnologyHangzhou 310023China Water Resources and Environmental Institute Xiamen University of TechnologyXiamen 361005China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlackburgVA 24061USA

As a strong oxidizing agent,ozone is used in some water treatment facilities for disinfection,taste and odor control,and remova. of organic ***(Phe)was used as the target amino acid to comprehensively investigate va.iability of disinfection byproducts(DBPs)forma.ion during chlorine disinfection and residual chlorine conditions subsequent to *** results showed that subsequent to ozonation,the typical regulated and unregulated DBPs forma.ion potential(DBPsFP),including trichloromethane(TCM),dichloroacetonitrile(DCAN),chloral hydrate(CH),dichloroacetic acid(DCAA),trichloroacetic acid(TCAA),and trichloroacetamide(TCAcAm)increased substantially,by 2.4,3.3,5.6,1.2,2.5,and 6.0 times,respectively,compared with only *** also significantly increased the DBPs yield under a 2 day simulated residual chlorine condition that mimicked the water distribution *** forma.ions followed pseudo first order *** forma.ion rates of DBPs in the first 6 hr were higher for TCM(0.214 hr^(−1)),DCAN(0.244 hr^(−1)),CH(0.105 hr^(−1)),TCAcAm(0.234 hr^(−1)),DCAA(0.375 hr^(−1))and TCAA(0.190 hr^(−1))than *** peak DBPsFP of TCM,DCAN,CH,TCAcAm,DCAA,and TCAA were obtained when that ozonation time was set at 5–15 *** times>30 min increased the mineralization of Phe and decreased the forma.ion of DBPs upon *** bromine ion(Br^(−1))concentra.ion increased production of bromine-DBPs and decreased chlorine-DBPs forma.ion by 59.3%–92.2%.Higher ozone dosages and slight alkaline favored to reduce DBP forma.ion and *** ozonation conditions should be optimized for all application purposes including DBPs reduction.

关键词： Ozone Amino acids Chlorination Disinfection by-products

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Using adjacency ma.rix to explore rema.kable associations in big and sma.l mineral data

引用

Geoscience Frontiers 2024年第5期15卷 61-74页

作者： Xiang Que Jingyi Huang Jolyon Ralph Jiyin Zhang Anirudh Prabhu Shaunna Morrison Robert Hazen Xiaogang ma Department of Computer Science University of IdahoMoscowID 83844USA College of Computer and Informa.ion Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Earth and Planets Laboratory Carnegie Institution for ScienceWashingtonDC 20015USA Hudson Institute of Mineralogy KeswickVA 22947USA

Data exploration,usually the first step in data analysis,is a useful method to tackle challenges caused by big geoscience *** conducts quick analysis of data,investigates the patterns,and generates/refines research questions to guide adva.ced statistics and ma.hine learning *** background of this work is the open mineral data provided by several sources,and the focus is different types of associations in mineral properties and *** in mineralogy have been applying different techniques for exploring such *** the explored associations can lead to new scientific insights that contribute to crystallography,mineralogy,and geochemistry,the exploration process is often daunting due to the wide range and complexity of factors *** this study,our purpose is implementing a visualization tool based on the adjacency ma.rix for a va.iety of datasets and testing its utility for quick exploration of association patterns in mineral ***,software packages,and use cases have been developed to process a va.iety of mineral *** results demonstra.e the efficiency of adjacency ma.rix in real-world *** the developed works of this study are open source and open access.

关键词： Adjacency ma.rix Association analysis Data exploration Mineral informa.ics Open data

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical study of enhanced recovery after surgery in laparoscopic appendectomy for acute appendici

引用

World Journal of Gastrointestinal Surgery 2024年第3期16卷 816-822页

作者： Zhu-Lin Li Hua-Chong ma.Yong Yang Jian-Jun Chen Zhen-Jun Wang Department of General Surgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Enhanced recovery after surgery(ERAS)protocol is a comprehensive ma.age-ment modality that promotes patient recovery,especially in the patients undergo-ing digestive tumor ***,it is less commonly used in the *** To study the application va.ue of ERAS in laparoscopic surgery for acute *** A total of 120 patients who underwent laparoscopic appendectomy due to acute appendicitis were divided into experimental group and control group by random number table method,including 63 patients in the experimental group and 57 patients in the control *** in the experimental group were ma.aged with the ERAS protocol,and those in the control group were received the tra.ditional *** exhaust time,the hospitalization duration,the hospita-lization expense and the pain score between the two groups were *** There was no significant difference in age,gender,body ma.s index and Sunshine Appendicitis Grading System score between the experimental group and the con-trol group(P>0.05).Compared to the control group,the patients in the expe-rimental group had earlier exhaust time,shorter hospitalization time,less hospi-talization cost and lower degree of pain *** differences were statis-tically significant(P<0.01).CONCLUSION ERAS could significantly accelerate the recovery of patients who underwent la-paroscopic appendectomy for acute appendicitis,shorten the hospitalization time and reduce hospitalization *** is a safe and effective approach.

关键词： Enhanced recovery after surgery Appendicectomy Laparoscopy Acute appendicitis Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of plasma.vitamin A level with type 2 diabetes mellitus:a community aging population-based cross-sectional study

引用

Food Science and Huma. Wellness 2024年第4期13卷 2079-2089页

作者： Pengfei Li Jingjing Xu Yujie Guo Xiaojun ma.Shaobo Zhou Chi Zhang Huiyan Yu Ying Wang Xixiang Wang Linhong Yuan School of Public Health Beijing Key Laboratory of Environmental ToxicologyChina-British Joint Laboratory of Nutrition Prevention and Control of Chronic DiseasesCapital Medical UniversityBeijing 100069China School of Science Faculty of Engineering and ScienceUniversity of GreenwichChatham ME44TBUK School of Biological Sciences University of Nebraska-LincolnNE 68588-0660USA Suzhou Hospital Affiliated Hospital of Medical SchoolNanjing UniversitySuzhou 215153China

Recent studies indicated that vitamin A(va.might be involved in the pathology of type 2 diabetes mellitus(T2DM).This cross-sectional study was conducted to explore the association between circulating va.level and T2DM.A total of 1818 subjects aged 50 years old and above were recruited from the *** logistic regression and restricted cubic spline(RCS)were applied to analyze the association of plasma.va.level with the risk of *** va.and lipid-adjusted va.levels of T2DM patients were significantly higher than that of non-T2DM subjects(Pma.va.total cholesterol(TC),va.high-density lipoprotein cholesterol(HDL-c)and va.low-density lipoprotein cholesterol(LDL-c)were positively associated with the risk of T2DM in the aging population(Pma.va.triglyceride(TG)have decreased risk of T2DM(odds ratio(OR)Q2=0.68,P_(Q2)=0.021;ORQ3=0.59,P_(Q3)va.might affect the relationship between va.and *** middle and aging subjects with higher ratios of plasma.va.TC,va.HDL-c,and va.LDL-c displayed increased risk for T2DM,but the moderate ratio of va.TG might protect against risk of T2DM.

关键词： Type 2 diabetes mellitus Vitamin A Lipid Nutrition Disease prevention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-photon live ima.ing of direct glia-to-neuron conversion in the mouse cortex

引用

Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin Xiang Shu He Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long ma.Ying Sun Yongpeng Qin Yi Chen Wen Li Xiangyu Wang Gong Chen Wenliang Lei Guangdong-Hong Kong-ma.ao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory for Neuroimmunology in Health and Diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIB-KU Leuven Center for Brain&Disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported tra.scription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult ma.ma.ian centra. ne rvous *** r,ma.y questions rema.n regarding how a terminally differentiated glial cell can tra.sform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra.cing *** this study,we employed repetitive two-photon ima.ing to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural tra.scription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra.ced astrocytes in the mouse ***-lapse ima.ing over several wee ks revealed the ste p-by-step tra.sition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local *** addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable ***,two-photon Ca2+ima.ing and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had ma.e functional synaptic connections within local neural *** conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstra.ed that adult ma.ma.ian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocyte-to-neuron conversion Ca2+ima.ing direct lineage conversion glia astrocyte in vivo reprogramming lineage-tra.ing mice NeuroD1 neuron two-photon ima.ing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cholecystitis-an uncommon complication following thoracic duct embolization for chylothorax: A case report

引用

World Journal of Clinical Cases 2022年第24期10卷 8775-8781页

作者： Le Viet Dung ma.ma. Hien Thieu-Thi tra.My Doan Tien Luu Le Tuan Linh Nguyen Minh Duc Diagnostic Ima.ing and Interventional Radiology Center Hanoi Medical University HospitalHanoi 100000Vietnam Department of Radiology Hanoi Medical UniversityHanoi 100000Vietnam Department of Radiology Pham Ngoc Thach University of MedicineHo Chi Minh 700000Vietnam

BACKGROUND Chylothorax is an uncommon condition in which chyle leaks into the pleural cavity,and biliary peritonitis is a rare complication of thoracic duct embolization in clinical *** SUMma.Y We describe the case of a 50-year-old woma. who presented with chylothorax and underwent thoracic duct embolization using a coil and a mixture of histoacryl glue and *** patient developed upper abdominal pain and fever after the *** was diagnosed with biliary peritonitis and treated with cholecystectomy at Hanoi Medical University *** Although thoracic duct embolization is considered a safe and minima.ly inva.ive procedure,it is not without *** thoracic duct embolization,severe or persistent abdominal pain should be explored utilizing ima.ing data and laboratory results to determine problems as soon as possible.

关键词： Lymphangiography Thoracic duct embolization Cholecystitis Chyle leakage Biliary peritonitis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beyond ribosoma. function:RPS6 deficiency suppresses cholangiocarcinoma.cell growth by disrupting alternative splicing

引用

Acta Pharma.eutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin Mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong ma.Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma.CCA)is a bile duct ma.ignancy with a disma. *** study systema.ically investigated the role of the ribosoma. protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by ma.s spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome ma.ntenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstra.e that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising stra.egy for treating CCA.

关键词： Cholangiocarcinoma Ribosoma. protein S6 Alternative splicing p53 Minichromosome ma.ntenance complex component 7 Vivo morpholino Patient-derived organoids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analyzing Changes in ma.ze Leaves Orientation due to GxExM Using an Automa.ic Method from RGB Ima.es

引用

Plant Phenomics 2023年第2期5卷 239-252页

作者： ma.io Serouart Raul Lopez-Lozano Gaëtan Daubige ma.va.Baumont Brigitte Escale Benoit De Solan Frédéric Baret Arva.is Institut du végétal228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France Arva.is Ecophysiology21 Chemin de Pau64121 MontardonFrance

The sowing pattern has an important impact on light interception efficiency in ma.ze by determining the spatial distribution of leaves within the *** orientation is an important architectural tra.t determining ma.ze canopies light *** studies have indicated how ma.ze genotypes ma. adapt leaves orientation to avoid mutual shading with neighboring plants as a plastic response to intra.pecific *** goal of the present study is 2-fold:firstly,to propose and va.idate an automa.ic algorithm(Automa.ic Leaf Azimuth Estima.ion from Midrib detection[ALAEM])based on leaves midrib detection in vertical red green blue(RGB)ima.es to describe leaves orientation at the canopy level;and secondly,to describe genotypic and environmental differences in leaves orientation in a panel of 5 ma.ze hybrids sowing at 2 densities(6 and 12 plants.m^(−2))and 2 row spacing(0.4 and 0.8 m)over 2 different sites in southern *** ALAEM algorithm was va.idated against in situ annotations of leaves orientation,showing a satisfactory agreement(root mean square[RMSE]error=0.1,R^(2)=0.35)in the proportion of leaves oriented perpendicular to rows direction across sowing patterns,genotypes,and *** results from ALAEM permitted to identify significant differences in leaves orientation associated to leaves intra.pecific *** both experiments,a progressive increase in the proportion of leaves oriented perpendicular to the row is observed when the rectangularity of the sowing pattern increases from 1(6 plants.m^(−2),0.4 m row spacing)towards 8(12 plants.m^(−2),0.8 m row spacing).Significant differences among the 5 cultiva.s were found,with 2 hybrids exhibiting,systema.ically,a more plastic behavior with a significantly higher proportion of leaves oriented perpendicularly to avoid overlapping with neighbor plants at high *** in leaves orientation were also found between experiments in a squared sowing pattern(6 plants.m^(−2),0.4 m

关键词： cultiva. spacing pattern

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于改进支持向量机的皮革划痕检测方法

引用

中国皮革 2024年第11期53卷 22-28页

作者：马静陕西国防工业职业技术学院

针对传统皮革划痕检测方法存在检测准确率低、检测效率不高的问题，提出一种基于K-means聚类算法改进支持向量机SVM的皮革划痕检测方法。首先，对支持向量机基本原理进行分析；然后采用K-means聚类算法解决支持向量机SVM的二分类问题；... 详细信息

针对传统皮革划痕检测方法存在检测准确率低、检测效率不高的问题，提出一种基于K-means聚类算法改进支持向量机SVM的皮革划痕检测方法。首先，对支持向量机基本原理进行分析；然后采用K-means聚类算法解决支持向量机SVM的二分类问题；最后搭建一个K-means-SVM皮革划痕检测模型，通过此模型实现皮革划痕快速准确检测。试验结果表明，本模型的检测精度为96.74%，相较于传统的YOLOv5模型、CRNN模型和SVM-DS模型分别高出了18.85%、20.17%、13.06%，且本模型进行皮革划痕检测的所用时长仅为11.52 s，均低于另外3种模型。由此说明，本模型的检测精度更高，检测速度更快，满足真皮表面划痕检测的实时性和准确性需求。

关键词：皮革划痕检测 K-means聚类支持向量机二分类问题

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：