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ma.nogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIdM mice

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Food Science and Huma. Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si Chen Yunhe Qu Lujuan Zheng Xiaoxuan Yang Shuhan men Yuanning Wang Hanrui ma.Yifa Zhou Yuying Fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1dM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-*** pancreatic islets and enhancing insulin secretion has been therapeutic *** is the ma.n type of polysaccharide from natural mushroom,which has potential medicinal ***,the antidiabetic property of ma.nogalactoglucan in T1dM has not been fully *** this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of ma.nogalactoglucan from the fruiting body of *** and investigated the potential therapeutic value of AAMP-N in *** demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1dM ***-N activated unfolded protein response(UPR) signaling pathway to ma.ntain ER protein folding homeostasis and promote insulin secretion in *** that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(camkⅡ) and caMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma.membrane via vesicle-associated membrane protein 2(vAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that ma.nogalactoglucan could be natural nutraceutical used for the treatment of T1dM.

关键词： ma.nogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1dM)

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Root Sprouts of domesticated Phaseolus coccineus L. Overwinter Plants and the Environment at Its Collection Sites

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Open Journal of Ecology 2024年第5期14卷 508-521页

作者： ma. Luisa Patricia vargas-vázquez Jorge Alberto Acosta-Gallegos Fabián Islas-Gutiérrez Enrique Buendía-Rodríguez campo Experimental valle de Mé xico Instituto Nacional de Investigaciones Forestales Agr&#237colas y Pecuarias Texcoco Mexico campo Experimental Bají o Instituto Nacional de Investigaciones Forestales Agr&#237colas y Pecuarias Guanajuato M&#233xico

Buds emerge from the roots of domesticated runner bean plants (Phaseolus coccineus L.) as sprouts and give the crop its persistence. This particularity of the species seems to be associated with the environment where the species was cultivated during long time. data on regrowth traits were recorded on 70 accessions of domesticated P. coccineus after overwintering at a site in the central highlands of Mexico. The characteristics recorded included fresh weight of vegetative regrowth, root length, root crown diameter, and diameter of the ma.n root. Most accessions that sprout the following spring, after the grain harvest of the previous year, come from temperate and semi-cold sites with cambisol and andosol soils in mixed Quercus pine forest and high mountain fir trees. Those that do not sprout are from sites of semiarid temperate clima.e, haplic phaeozem soil in shrub grasslands with deciduous broadleaved trees, and semiwarm subhumid clima.e, eutrophic regosol soil in deciduous broadleaved forest. Two types of roots were differentiated: branched and thickened taproots, also associated with a different clima.e, and the type of soil of the collection sites.

关键词： P. coccineus distribution vegetation-Environment Interactions drought-Alternative Species Root-Regrowth

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Elasticity meets topology

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National Science Review 2024年第6期11卷 84-85页

作者： Guancong ma department of Physics Hong Kong Baptist University

We are surrounded by environments and items that are ma.e from solid ma.erials in our daily life. Any physical contact with any items is a mechanical disturbance that produces mechanical *** underlines the crucial role that such vibrations play in our daily interactions,highlighting the need for a deeper understanding and improved ma.ipulation of these fundamental phenomena.

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Stereoscopic spatial graphical method of Mueller ma.rix:Global‑Polarization Stokes Ellipsoid

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Frontiers of Optoelectronics 2024年第3期17卷 113-128页

作者： Xinxian Zhang Jiawei Song Jiahao Fan Nan Zeng Honghui He valery v.Tuchin Hui ma Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Teacher Education Nanjing Normal UniversityNanjing 210097China Institute of Physics Saratov State UniversitySaratov 410012Russia department of Physics Tsinghua UniversityBeijing 100084China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China

A Mueller ma.rix covers all the polarization informa.ion of the measured sample,however the combination of its 16 elements is sometimes not intuitive enough to describe and identify the key characteristics of polarization *** the Poincarésphere system,this study achieves a spatial representation of the Mueller ma.rix:the Global-Polarization Stokes Ellipsoid(GPSE).With the help of Monte carlo simulations combined with anisotropic tissue models,three basic characteristic parameters of GPSE are proposed and explained,where the v parameter represents polarization ma.ntenance ability,and the E and d†parameters represent the degree of ***,based on GPSE system,a dynamic analysis of skeletal muscle dehydration process demonstrates the monitoring efect of GPSE from an application perspective,while confrming its robustness and accuracy.

关键词： Full polarization Mueller ma.rix Tissue characterization Optical measurement

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Uniform decomposition of velocity gradient tensor

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Journal of Hydrodynamics 2024年第1期36卷 24-34页

作者： Chenxi ma.Chaoqun Liu department of ma.hema.ics University of Texas at ArlingtonArlingtonTXUSA

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity ... 详细信息

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆value and a pair of conjugate complex eigen values,∆>0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity gradient tensor can also be classified as rotation point,which can be decomposed into three parts,i.e.,rotation[R],shear[S]and stretching/compression[SC],and non-rotation point,we defined a new resistance term[L],and the tensor can be decomposed into three parts,i.e.,resistance[L],shear[S]and stretching/compression[SC].Example ma.ric are also displayed to demonstrate the new *** of principal decomposition between 3 different cases,and between Resistance and Liutex will also be discussed.

关键词： velocity gradient Liutex resistance fluid kinema.ics

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vOC emitted by biopharma.eutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma.Lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for vOCs Pollution Control ma.erial&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharma.eutical industry contributes substantially to volatile organic compounds(vOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of vOCs from three biopharma.eutical *** the workshops of the three enterprises,26 vOCs were detected,which could be sorted into 4 classes:hydrocarbons,aroma.ic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the ma.n components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fuma.ate being the ma.n source of vOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of vOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based forma.ion potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone forma.ion potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of vOC emission by biopharma.eutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharma.eutical volatile organic compound Priority pollutant Exposure risk Secondary pollution

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deterministic and Robust volt-var Control Methods of Power System Based on Convex deep Learning

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 719-729页

作者： Qing ma.Changhong deng the School of Electrical Engineering and Automa.ion Wuhan UniversityWuhanChina

volt-var control(vvC)is essentially a non-convex optimization problem due to the non-convexity of power flow(PF)constraints,resulting in the difficulty in obtaining the optimum without convexity *** existing second-order cone method for the convexity conversion often leads to a sharp increase in PF constraints and optimization variables,which in turn increases the optimization difficulty or even leads to optimization *** paper first proposes a deterministic vvC method based on convex deep learning power flow(dLPF).This method uses the input convex neural network(ICNN)to establish a single convex ma.ping between state parameters and node voltage to complete the convexity conversion while the optimization variables only correspond to reactive power equipment,which can ensure the global optimum with extremely fast computation *** cope with the impact brought by the uncertainty of distributed energy and omit the additional worst scenario search of traditional robust vvC,this paper proposes robust vvC method based on convex deep learning interval power flow(dLIPF),which continues to adopt ICNN to establish another convex ma.ping between state parameters and node voltage *** dLIPF with dLPF,this method decreases the modeling and optimization difficulty of robust vvC *** results on 30-bus,118-bus,and 200-bus systems prove the correctness and rapidity of the proposed methods.

关键词： volt-var control convexity conversion convex deep learning power flow

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On the Security of Homomorphic Encryption Schemes with Restricted decryption Oracles

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Journal of Systems Science & Complexity 2024年第5期37卷 2240-2261页

作者： ma.Guangsheng LI Hongbo School of ma.hema.ics and Physics North China Electric Power UniversityBeijing 100096China Academy of ma.hema.ics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Fully homomorphic encryption(FHE)can be used for privacy-preserving aggregation of medical *** this typical application,the security against passive attacks has been well studied by Li and Micciancio(2021).In this paper,the authors further consider a“nearly passive”kind of attack,where the attacker ma. behave like a passive attacker in the view of the third-party *** capture the security against this hard-to-detect attack,the authors propose a new notion of INd-CPA^(rd)*** authors show that the standard LWE encryption and its related FHE schemes can not defend against INd-CPA^(rd)attack,even under a stricter rule limiting the content and number of queries ma.e by the *** ma.e the application of FHE schemes more secure,the authors discuss some possible modifications that ma. serve as countermeasures to INd-CPA^(rd)attack.

关键词： Homomorphic encryption privacy secure cloud computing security

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Copper slag assisted coke reduction of phosphogypsum for sulphur dioxide preparation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 43-53页

作者： dong ma.Qinhui Wang State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

The reduction of phosphogypsum(PG)to lime slag and SO_(2)using coke can effectively alleviate the environmental problems caused by ***,the PG decomposition temperature rema.ns high and the product yield rema.ns *** adding additives,the decomposition temperature can be further reduced and PG decomposition rate and product yield can be ***,the use of current additives such as Fe_(2)O_(3)and SiO_(2)brings the problem of increasing economic ***,it is proposed to use solid waste copper slag(CS)as a new additive to reduce PG to prepare SO2,which can reduce the cost and meet the environmental benefits at the same *** effects of proportion,temperature and thermostatic time on PG decomposition are investigated by experimental and kinetic analysis combined with FactSage thermodynamic calculations to optimize the roasting ***,the reaction mechanism is *** is found that adding CS to the coke and PG system can increase the rate of PG decomposition and SO_(2)yield while lowering the PG decomposition *** example,when the CS/PG ma.s ratio increases from 0 to 1,PG decomposition rate increases from 83.38%to 99.35%,SO_(2)yield increases from 78.62%to 96.81%,and PG decomposition temperature decreases from 992.4℃to 949.6℃.The optima. reaction parameters are CS/PG ma.s ratio of 1,Coke/PG ma.s ratio of 0.06 at 1100℃for 20 min with 99.35%PG decomposition rate and 96.81%SO_(2) *** process proceeds according to the following reactions:2caSO_(4)+ 0.7C + 0.8Fe_(2)SiO_(4)→0.8ca_(2)SiO_(4)+ 0.2ca_(2)Fe_(2)O_(5)+ 0.4Fe_(3)O_(4)+2SO_(2)+ 0.7CO_(2)Finally,a process for decomposing PG with coke and CS is proposed.

关键词： Phosphogypsum Sulfur dioxide Copper slag Fluidized-bed Reduction Waste treatment

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A review of recent advances in the effects of surface and interface properties on ma.ine propellers

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Friction 2024年第2期12卷 185-214页

作者： ma.fu ZHU Liran ma State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

ma.ine propellers are important propulsion devices for both surface ships and underwater *** severe environmental problems have required further performa.ce enhancement for ***,traditional methods to improve propeller performa.ces through geometrical and structural optimizations have been extensively investigated,while the underlying mechanisms of the effects of surface and interface properties on ma.ine propellers are still far from being fully *** paper presented a comprehensive review of recent advances in the effects of surface and interface properties,such as surface roughness and surface wettability,on ma.ine propellers with an emphasis on the significant improvements in both hydrodynamic and cavitation performa.ces,hoping to arouse more in-depth investigations in the field of surface/interface science and technologies on ma.ine propellers,and also promote the state-of-the-art technologies,such as superlubricity technology,into practical applications.

关键词： ma.ine propellers hydrodynamics cavitation surface roughness surface wettability

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