检索结果-南通市图书馆

Montelukast improves air trapping, not airway remodeling, in patients with moderate-to-severe asthma： a pilot study

Chinese Medical Journal 2013年第12期126卷 2229-2234页

作者： GAO Jin-ming CAI Feng peng Min ma Yi WANG bin Department of Respiratory Diseases Department of Radiology Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China

Background Evidence has demonstrated that the distal lung,which includes airways of 〈2 mm in diameter and lung parenchyma,constitutes an important component of asthma *** leukotrienes （CysLTs） are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic *** recommend the leukotriene-modifying agents for asthma *** hypothesized that a leukotriene receptor antagonist with an inhaled corticosteroid （ICS） and long-acting β2 agonist （LABA） combination would improve small airways function in moderate-tosevere asthmatics evaluated by physiological tests and high-resolution computed tomography （HRCT） *** study was performed at a tertiary university hospital in *** This was a randomized,double-blind,parallel study performed in 38 patients with moderate-to-severe asthma treated with salmeterol/fluticasone （SFC） plus montelukast （SFC＋M） or SFC plus placebo over 24 *** airway function was assessed by physiological studies and HRCT image *** Montelukast significantly improved air trapping as expressed by the residual volume （RV）/total lung capacity （TLC）.Over 24 weeks of treatment,RV/TLC was improved by （15.41±6.67）% in patients receiving SFC＋M while RV/TLC was decreased by （8.57±10.26）% in patients receiving SFC alone,the difference between the two groups was significant （P=0.02）.There was a trend towards a significant difference in forced expiratory volume in the first second （FEV1）/forced vital capacity （FVC） in the SFC＋M group compared to that in the SFC group （（17.87±8.17）% vs.（12.28±9.20）%,P=0.056）.There was no significant change in percentage wall area （WA%） after 24 weeks of add-on treatment with *** receiving SFC＋M showed significant improvement in the ratio of CT-determined values at full expiration to those at full inspiration （E/I ratio）（0.894±0.005 vs.0.871±0.003,P=0.002）.Conclusion We have shown,using lung function tests and HRCT image tech

关键词： asthma air trapping lung function airway remodeling high-resolution computed tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression profiles of sex-related genes in gonads of genetic male Takifugu rubripes after 17β-estradiol immersion

引用

Journal of Oceanology and Limnology 2019年第3期37卷 1113-1124页

作者： HU peng LIU bin ma Qian LIU Shufang LIU Xinfu ZHUANG Zhimeng Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Function Laboratory for marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology & Function Laboratory for Marine Biology and BiotechnologyQingdao 266000China

Estradiol treatment during early life stages of tiger puffer Takifugu rubripes induces feminization in genetic ***,the ovaries in genetic males may revert to testes once estradiol treatment is *** studies should investigate molecular mechanisms underlying ovary-to-testis recovery in genetic males after *** the present study,tiger puffer were exposed to 10,and 100μg/L 17β-estradiol(E 2)from 15 to 100 days post-hatching(dph),then gonad phenotypes and expression profi les of six sex-related genes(cyp19a,foxl2,dmrt1,amh,sox9a,and sox9b)were characterized after the *** showed that both 10 and 100μg/L E2 induced ovarian development in genetic males at 100 ***,all ovaries induced by 10μg/L E2 first developed into intersexual gonads and subsequently reverted to testes after the *** for treatment of 100μg/L E2,while the rest of the ovaries maintained morphological stability,percentages of intersexual gonads reached 38%-57%,and none were reverted to *** mRNA levels of cyp19a,foxl2 and sox9b and decreased mRNA levels of dmrt1,amh,and sox9a were observed during the ovarian development in genetic *** contrary gene expression profiles were detected during ovary-to-testis *** mRNA levels of all the six genes were increased during the development of intersexual *** results indicated that up-regulation of dmrt1,amh and sox9a is associated with initial ovary-to-intersexual transformation,and suppression of foxl2,cyp19a and sox9b is essential for complete ovary-to-testis recovery in genetic *** research will help to trace the molecular processes underlying gonadal transformation in teleosts.

关键词： Takifugu rubripes ovary-to-testis recovery sex-related genes mRNA expression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三项指标与老年急性STEMI患者介入术后无复流的相关性研究

引用

心脏杂志 2024年第1期36卷 40-44,49页

作者：马学平吴鹏马娟严宁王默函贾绍斌宁夏医科大学总医院心血管内科宁夏银川750000 宁夏医科大学研究生院宁夏银川750000

目的探讨入院休克指数(shock index, SI)、入院血糖(admission plasma glucose, APG)和同型半胱氨酸(homocysteine, HCY)与老年急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction, STEMI)患者行急诊经皮冠状动脉介入(percutaneous coronary intervention, PCI)术后无复流的相关性。方法分析行急诊PCI术379例老年急性STEMI患者的临床资料,根据PCI术后TIMI血流分为无复流组(n=71)和正常血流组(n=308)。比较两组患者的临床资料、造影及介入情况。采用单因素及多因素Logistic回归模型分析老年急性STEMI患者行急诊PCI术后出现无复流的独立危险因素,利用受试者工作特征(receiver operator characteristic,ROC)曲线评估老年急性STEMI患者行急诊PCI术后发生无复流的预测效能。结果与正常血流组比较,无复流组患者入院心率、SI高于正常血流组,收缩压、舒张压低于正常血流组,均Pbin, HGB)降低(P<0.05),C反应蛋白(C-reactive protein, CRP)升高(P<0.05),APG升高(P<0.05),尿素(serum urea nitrogen, UREA)升高(P<0.05),HCY升高(P<0.01),D-二聚体(D-Dimer,D-D)升高(P<0.01)多因素Logistic回归分析表示SI、APG、HCY是老年急性STEMI患者急诊PCI术后发生无复流的独立危险因素。ROC曲线分析显示SI+APG+HCY对老年STEMI患者行PCI术后发生无复流的预测价值优于SI、APG、HCY、SI+APG、SI+HCY、APG+HCY,差异有统计学意义(P<0.01)。结论 SI、APG和HCY是老年急性STEMI患者行急诊PCI术后发生无复流的独立危险因素,且SI+APG+HCY对其有较好的预测价值。

关键词：休克指数入院血糖同型半胱氨酸 STEMI PCI 无复流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

小视野扩散加权成像ADC值评估肝外胆管癌淋巴血管侵犯的应用价值

引用

影像诊断与介入放射学 2024年第2期33卷 83-88页

作者：彭彬马培旗袁玉山张宗夕阜阳市人民医院影像中心安徽阜阳236000

目的探索基于小视野扩散加权成像(DWI)表观扩散系数(ADC)值对肝外胆管癌淋巴血管侵犯(LVI)的应用价值。方法回顾性分析经手术病理证实的54例肝外胆管癌的临床及影像学资料,术前均行常规DWI及小视野DWI(r-FOV DWI),两名高年资放射影像诊... 详细信息

目的探索基于小视野扩散加权成像(DWI)表观扩散系数(ADC)值对肝外胆管癌淋巴血管侵犯(LVI)的应用价值。方法回顾性分析经手术病理证实的54例肝外胆管癌的临床及影像学资料,术前均行常规DWI及小视野DWI(r-FOV DWI),两名高年资放射影像诊断医师对常规DWI和小视野DWI图像质量进行5级李克特量表评分,并比较两组图像病灶区信噪比(SNR)、对比信噪比(CNR)和ADC值。根据病理资料分为LVI阳性组和LVI阴性组,分别比较两组间常规和小视野ADC值的差异,以受试者工作特征(ROC)曲线评估常规ADC值和小视野ADC值对LVI的诊断效能。结果小视野DWI图像质量在主观评分、SNR、CNR比较中均好于常规组,且小视野ADC值小于常规ADC值,差异均有统计学意义(P<0.05)。LVI阳性组中常规组ADC值和小视野ADC值均小于LVI阴性组,差异具有统计学意义(P<0.05)。常规组ADC值(<1.217×10^(-3)mm^(2)/s)诊断LVI阳性的曲线下面积(AUC)为0.746[95%CI(0.609,0.882),P<0.05],其敏感度及特异度分别为75.0%、73.5%;小视野组ADC值(<1.092×10^(-3)mm^(2)/s)诊断LVI阳性的AUC为0.932[95%CI(0.866,0.999),P<0.05],其敏感度及特异度分别为95.0%、85.3%。两组AUC值差异有统计学意义(P<0.05)。结论小视野DWI成像ADC值较常规ADC值对于预测肝外胆管癌LVI具有更好的诊断价值。

关键词：表观扩散系数肝外胆管癌淋巴血管侵犯扩散加权成像

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

涡喷压气机叶片精密铸造工艺探究

引用

热加工工艺 2024年第1期53卷 126-129页

作者：邢小颖汤彬彭世广马运姚启明王龙兵徐江波清华大学基础工业训练中心北京100084

叶片精密铸造是熔模精密铸造技术在叶片制造中的应用。本文对涡喷压气机叶片精密铸造工艺进行研究,利用SolidWorks软件建立三维模型,对压气机叶片进行充型凝固数值模拟,并总结出一套合适的铸造工艺。

关键词：精密铸造数值模拟压气机叶片

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

职业人群不健康生活方式与糖脂代谢异常的关联及网络分析

引用

中华流行病学杂志 2024年第3期45卷 425-431页

作者：马春兰余彬范云喆叶婷婷蔡长伟杨波曾红莲贾鹏杨淑娟四川大学华西公共卫生学院/华西第四医院成都610041 四川大学-香港理工大学灾后重建与管理学院成都610207 成都大学附属医院成都610081 武汉大学资源与环境科学学院武汉430072 武汉大学公共卫生学院武汉430071 武汉大学空间全生命周期健康国际研究中心武汉430072

目的分析职业人群不健康生活方式对糖脂代谢异常的影响及关键影响因素,为糖脂代谢异常的预防提供科学依据。方法基于2021年中国铁路成都局集团有限公司西南职业人群队列的基线数据和随访数据。糖脂代谢异常以糖尿病伴1项或多项血脂异常... 详细信息

目的分析职业人群不健康生活方式对糖脂代谢异常的影响及关键影响因素,为糖脂代谢异常的预防提供科学依据。方法基于2021年中国铁路成都局集团有限公司西南职业人群队列的基线数据和随访数据。糖脂代谢异常以糖尿病伴1项或多项血脂异常判断,不健康生活方式根据吸烟、饮酒、不健康膳食模式、低体力活动和BMI异常进行评分。通过多因素logistic回归模型分析不健康生活方式得分与糖脂代谢异常之间的关系,采用网络分析探索影响糖脂代谢的主要生活方式。结果共纳入25631名研究对象。不健康生活方式得分为2、3分人群患糖尿病伴≥1项血脂异常的风险分别为0分的1.93(95%CI:1.31~2.86)倍和2.37(95%CI:1.60~3.50)倍;不健康生活方式得分为1、2、3分人群患糖尿病伴≥2项血脂异常的风险分别为0分的1.98(95%CI:1.08~3.61)倍、2.87(95%CI:1.60~5.14)倍和3.95(95%CI:2.22~7.06)倍。网络分析发现BMI异常和HDL-C是连接不健康生活方式与糖脂代谢异常的“桥接节点”。结论不健康生活方式得分越高,患糖脂代谢异常的风险越大,BMI异常和HDL-C是关联不健康生活方式和糖脂代谢异常的关键因素。

关键词：糖脂代谢异常职业人群网络分析不健康生活方式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Smart Interfacing between Co-Fe Layered Double Hydroxide and Graphitic Carbon Nitride for High-efficiency Electrocatalytic Nitrogen Reduction

引用

Energy & Environmental materials 2023年第2期6卷 62-69页

作者： Xiaohui Wu Lu Tang Yang Si Chunlan ma peng Zhang Jianyong Yu Yitao Liu bin Ding Key Laboratory of High Performance Fibers&Products(Ministry of Education) College of TextilesDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 200051China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China State Center for International Cooperation on Designer Low-carbon&Environmental materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

Bimetallic compounds such as hydrotalcite-type layered double hydroxides(LDHs)are promising electrocatalysts owing to their unique electronic ***,their abilities toward nitrogen adsorption and reduction are undermined since the surface-mantled,electronegative-OH groups hinder the charge transfer between transition metal atoms and nitrogen ***,a smart interfacing strategy is proposed to construct a coupled heterointerface between LDH and 2D g-C_(3)N_(4),which is proven by density functional theory(DFT)investigations to be favorable for nitrogen adsorption and ammonia desorption compared with neat LDH *** interfaced LDH and g-C_(3)N_(4) is further hybridized with a self-standing TiO_(2) nanofibrous membrane(NM)to maximize the interfacial effect owing to its high porosity and large surface *** from the synergistic superiorities of the three components,the LDH@C_(3)N_(4)@TiO_(2) NM delivers superior ammonia yield(2.07×10^(−9) mol s^(−1) cm^(−2))and Faradaic efficiency(25.3%),making it a high-efficiency,noble-metal-free catalyst system toward electrocatalytic nitrogen reduction.

关键词： density functional theory electrocatalytic nitrogen reduction graphitic carbon nitride interface engineering layered double hydroxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

加减归脾汤治疗甲基丙二酸尿症认知障碍心脾两虚患儿的临床疗效观察

引用

中华中医药杂志 2024年第8期39卷 4478-4482页

作者：陆相朋彭琰琰郑宏党伟利张弛冯斌冯刚马丙祥河北中医药大学石家庄050091 郑州市中心医院郑州450007 河南中医药大学第一附属医院郑州450000

目的:观察加减归脾汤治疗甲基丙二酸尿症(Mma)心脾两虚证认知障碍患儿的临床疗效。方法:采用随机、双盲、安慰剂对照的观察试验设计,将65例Mma心脾两虚证认知障碍患儿随机分为试验组(32例)和对照组(33例)。两组患儿均给予西医基础治疗... 详细信息

目的:观察加减归脾汤治疗甲基丙二酸尿症(Mma)心脾两虚证认知障碍患儿的临床疗效。方法:采用随机、双盲、安慰剂对照的观察试验设计,将65例Mma心脾两虚证认知障碍患儿随机分为试验组(32例)和对照组(33例)。两组患儿均给予西医基础治疗及认知功能训练,在此基础上试验组给予加减归脾汤颗粒治疗,对照组给予模拟剂颗粒治疗,疗程共12周。在治疗前后采用Griffiths神经认知发育量表(GDS-C)及婴儿-初中生社会生活能力量表(S-M)对患儿认知功能进行评估比较。结果:治疗后两组患儿GDS-C量表总发育商及S-M量表标准分评分均有提升,其中试验组患儿GDS-C量表各分领域包括个人社会、听力与言语、手眼协调、操作表现评分及总发育商高于对照组(Pma心脾两虚证患儿的认知功能,提高患儿生活质量。

关键词：甲基丙二酸尿症儿童认知障碍归脾汤临床研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analyses of microRNAs and transcriptomes in the midgut of Spodoptera litura feeding on Brassica juncea

引用

Insect Science 2021年第2期28卷 533-547页

作者： Xiao-peng Zou Yi-Guang Lin Yong-Jie Cen Kang ma bin-bin Qiu Qi-Li Feng Si-Chun Zheng School of Life Sciences South China Normal UniversityGuangzhouChina

Spodoptera litura is a destructive agricultural pest in tropical and subtropical *** the molecular mechanisms of *** adaptation to its preferred host plants may help identify target genes useful for pest *** used high-throughput sequencing to characterize the expression patterns of messenger RNAs(mRNAs)and microRNAs(miRNAs)in the midgut of *** fed on Brassica juncea for 6 h and 48 h.A total of 108 known and 134 novel miRNAs were identified,29 miRNAs and 237 mRNAs were differentially expressed at 6 h of *** feeding,26 miRNAs and 433 mRNAs were differentially expressed at 48 *** the mRNAs,the up-regulated genes were mostly enriched in detoxification enzymes(cytochrome P450,esterase,glutathione^-transferase,uridine diphosphate-glucuronosyl transferase),while the down-regulated genes were mostly enriched in proteinases and immune-related ***,most detoxification enzymes begin to up-regulate at 6 h,while most digestion and immunerelated genes begin to up-or down-regulate at 48 *** and 37 differently expressed transcription factors were identified at 6 h and 48 h,which may regulate the functional *** acquired 136 and 41 miRNA versus mRNA pairs at 6 h and 48 h,*** down-regulated and up-regulated miRNAs were predicted to target detoxification enzymes and proteinases,***-time quantitative polymerase chain reaction of nine randomly selected miRNAs and 28 genes confirmed the results of *** analyses of miRNA and mRNA transcriptomes provides useful information about the molecular mechanisms of *** response to ***.

关键词： Brassica juncea midgut miRNAs RNA-Seq Spodoptera litura

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sources of Heterogeneity in Trials Reporting Hydroxyethyl Starch 130/0.4 or 0.42 Associated Excess Mortality in Septic Patients： A Systematic Review and Meta-regression

引用

Chinese Medical Journal 2015年第17期128卷 2374-2382页

作者： peng-Lin ma Xiao-Xia peng bin Du Xiao-Lan Hu Yi-Chun Gong Yu Wang Xiu-Ming Xi 1Department of Critical Care Medicine 309^th Hospital of Chinese People's Liberation Army Beijing 100091 China Centre of Clinical Epidemiology and Evidence-based Medicine Beijing Children Hospital Capital Medical University School of Public Health Capital Medical University Beijing 100069 China Medical ICU Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Department of Critical Care Medicine Beijing Fuxing Hospital Capital Medical University Beijing 100038 China

Background： This meta-analysis was to determine the association of the cumulative dose of 130/0.4 or 0.42 （hydroxyethyl starch [HES] 130/0.4＊） or delta daily fluid balance （i.e., daily fluid balance in HES group over or below control group） with the heterogeneity of risk ratio （RR） for mortality in randomized control trials （RCTs）. Methods： Three databases （PubMed, EMBASE, Cochrane） were searched to identify prospective RCTs reporting mortality in adult patients with sepsis to compare HES 130/0.4＊ with crystalloids or albumin. Meta-analysis was performed using random effects. Sensitivity and meta-regression analyses were used to examine the heterogeneity sources of RR for mortality, Results： A total number of 4408 patients from 11 RCTs were included. The pooled RR showed no significant difference for overall mortality in patients with administration of liES130/0.4＂ compared with treatment of control fluids （RR： 1.02, 95% confidence interval： 0.9-1.17; P = 0.73）. Heterogeneity was moderate across recruited trials （l^2 = 34%, P = 0.13）. But, a significant variation was demonstrated in subgroup with crystalloids as control fluids （l^2 = 42%, P 〈 0.1）. Sensitivity analysis revealed that trials with high risk of bias did not significantly impact the pooled estimates for mortality. Meta-regression analysis also did not determine a dose-effect relationship of HES 130/0.4＊ with mortality （P - 0.298）, but suggested daily delta fluid balance being likely associated with mortality in septic patients receiving HES130/130/0.4＊（P = 0.079）.Conclusions： Inappropriate daily positive fluid balance was likely an important source of heterogeneity in these trials reporting HES 130/0.4＊ associated with excess mortality in septic patients.

关键词： Hydroxyethyl Starch 130/0.4 or 0.42 Heterogeneity Mortality Sepsis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：