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Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai Li Wei‑Wei Qiu Zheng‑Fa Liao Zi‑Yue Zhuang xiao‑Ping Zhang Sheng‑Li Chen Chen‑Chen Guo Er‑Xi xiao xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing Jiang Jin‑Cheng Wang jie Ren Wen Luo Zhi‑Chao Zhu Hao‑Yang lan Zong‑Wei Cao Xu ma Ying‑Du Liu Pu‑Sen Wang Yi Yang Ping Su Xian‑Gai Deng Wan‑Bing He Chun‑Wang ma Yu‑Ting Wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang tang Tao zhou jing Wang Han Yi Yue Zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑Qing Gao Qiang Li Kang Sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao jing jing‑Yu tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical maxwell average cross sections(maCSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the maCS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections maxwell average cross sections

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DWI诊断肿块型胰腺炎及胰腺癌的价值观察

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中国CT和MRI杂志 2024年第6期22卷 118-120页

作者：樊琦王强荣顾菲孔琳常春周健文姜小兰汤泽宇东台市人民医院影像科江苏东台224200 东台市人民医院检验科江苏东台224200

目的观察DWI诊断肿块型胰腺炎及胰腺癌的价值。方法以2020年3月—2023年3月东台市人民医院影像科接受检查的肿块型胰腺炎及胰腺癌96例为研究对象,根据病历资料分为肿块型胰腺炎41例(胰腺炎组)、胰腺癌55例(胰腺癌组)。比较两组影像学... 详细信息

目的观察DWI诊断肿块型胰腺炎及胰腺癌的价值。方法以2020年3月—2023年3月东台市人民医院影像科接受检查的肿块型胰腺炎及胰腺癌96例为研究对象,根据病历资料分为肿块型胰腺炎41例(胰腺炎组)、胰腺癌55例(胰腺癌组)。比较两组影像学特征、表观弥散系数(ADC)值,并进行肿块型胰腺炎及胰腺癌鉴别诊断的二元Logistic分析,受试者工作特征曲线分析常规DWI及ADC值对胰腺癌鉴别诊断效能。结果胰腺癌组T_(2)WI混杂高信号占比明显高于胰腺炎组(P1%较两者单项诊断的高。结论 DWI对肿块型胰腺炎及胰腺癌的鉴别诊断有一定价值,有望为胰腺癌早期诊治提供必要参考。

关键词：胰腺癌肿块型胰腺炎 DWI 鉴别诊断

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《仙传拾遗·马周》的文本建构及寓意——兼论神仙传记对历史人物的神性叙述

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北京社会科学 2024年第8期 17-24页

作者：刘湘兰中山大学中文系

神仙传记的一般模式为“仙真养成记”或“仙真灵验记”,而《仙传拾遗·马周》一文打破了既往的写作模式。杜光庭在文中着意表达的是一位迷失本性的仙官如何寻回本真的过程。杜光庭将马周设定为华山素灵宫仙官,奉仙王之命赴长安辅佐李世... 详细信息

神仙传记的一般模式为“仙真养成记”或“仙真灵验记”,而《仙传拾遗·马周》一文打破了既往的写作模式。杜光庭在文中着意表达的是一位迷失本性的仙官如何寻回本真的过程。杜光庭将马周设定为华山素灵宫仙官,奉仙王之命赴长安辅佐李世民安邦定国的情节设定,说明他把道教与李唐王朝的天命紧密结合在一起。不论是长安与华山的地理位置,还是马周与李世民“君臣道合”的关系,杜光庭都对此进行了周密构思,以强化道教的“国教”地位。此文虽是为马周立传,但主旨却是在传递“君权神授”的天命观。这种天命观深植于中国的古史文化传统中。

关键词：杜光庭《仙传拾遗》马周神仙传

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Metal–organic framework-derived Co_(3)O_(4)modified nickel foam-based dendrite-free anode for robust lithium metal batteries

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中国化学快报:英文版 2023年第8期34卷 382-386页

作者： Tao Wei Jiahao Lu pan Zhang Guang Yang Cheng Sun Yanyan zhou Quanchao Zhuang Yongfu tang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Li-ion Batteries Lab School of Materials Science and EngineeringChina University of Mining and TechnologyXuzhou 221116China

For several decades,the promise of implementing of lithium(Li)metal anodes for Li batteries has been a"holy grail"for ***,we have proposed a facile design of a MOF-derived Co_(3)O_(4)nanoparticles modified nickel foam,i.e.,Co_(3)O_(4)-NF,as a 3D host to achieve a uniform infusion of the molten *** molten Li was uniformly absorbed on the Co_(3)O_(4)-NF host only in 10 s due to its high Li *** obtained Li-Co_(3)O_(4)-NF composite electrode shows high cycling stability in symmetric cells with low voltage hysteresis even at a high current density of 5 ma/*** full cells of Li-Co_(3)O_(4)-NF/LiFePO_(4)can cycle for more than 500 cycles at 2C without obvious capacity *** after cycling and in situ optical microscope results suggest that the unique 3D host structure of the Li-Co_(3)O_(4)-NF anode plays key roles on suppressing the dendrite growth and decreasing the local current *** believe this work might provide a new strategy for fabricating dendrite-free Li metal anodes and facilitate practical applications in Li batteries.

关键词： All solid-state lithium-ion batteries Metal-organic frameworks(MOFs) Lithium metal anodes Dendrite-free anode Three-dimensional anode

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Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China

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Biomedical and Environmental Sciences 2023年第2期36卷 127-134页

作者： XI Hui LIU Qin XIE Dong Hua zhou Xu tang Wang lan tang De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan zhou Shu Xiang HE Jun zhou Shi Hao zhou Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen ma xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410028HunanChina Yongzhou Hospital for maternal and Child Health Care Yongzhou 425000HunanChina Changde Hospital for maternal and Child Health Care Changde 415099HunanChina Hengyang Hospital for maternal and Child Health Care Hengyang 421009HunanChina Shaoyang Hospital for maternal and Child Health Care Shaoyang 422001HunanChina Yiyang Hospital for maternal and Child Health Care Yiyang 413099HunanChina Yueyang Hospital for maternal and Child Health Care Yueyang 414021HunanChina Center of Prenatal Diagnosis Chenzhou No.1 People’s HospitalChenzhou 423099HunanChina Loudi Hospital for maternal and Child Health Care Loudi 417599HunanChina Huaihua Hospital for maternal and Child Health Care Huaihua 418099HunanChina Xiangtan Hospital for maternal and Child Health Care Xiangtan 411104HunanChina Zhuzhou Hospital for maternal and Child Health Care Zhuzhou 412008HunanChina Changsha Hospital for maternal and Child Health Care Changsha 410007HunanChina Xiangxi Tujia and Miao Autonomous Prefecture Hospital for maternal and Child Health Care Jishou 416000HunanChina Zhang Jiajie Centre for maternal and child health family planning services Zhangjiajie 427299HunanChina BGI Genomics BGI-ShenzhenShenzhen 518083GuangdongChina Clinical Laboratory of BGI Health BGI-ShenzhenShenzhen 518083GuangdongChina BGI-Wuhan Clinical Laboratories BGI-ShenzhenWuhan 430074HubeiChina SEBIA Representative Office Shanghai 200001China

Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan *** We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan *** screening was performed,and molecular parameters were *** The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-*** highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),***α-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in ***,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,*** Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan *** results should facilitate genetic counselling and the prevention of severe thalassemia in this region.

关键词： Thalassemia Carrier rate Molecular spectrum Abnormal hemoglobin variants α-globin triplication

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Corrosion engineering boosting bulk Fe_(50)Mn_(30)Co_(10)Cr_(10)high-entropy alloy as high-efficient alkaline oxygen evolution reaction electrocatalyst

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Journal of materials Science & Technology 2022年第14期109卷 267-275页

作者： Pengfei zhou Dong Liu Yuyun Chen Mingpeng Chen Yunxiao Liu Shi Chen Chi Tat Kwok Yuxin tang Shuangpeng Wang Hui pan Institute of Applied Physics and materials Engineering University of Macao999078Macao Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of Macao999078Macao Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of Macao999078Macao College of Chemical Engineering Fuzhou UniversityFuzhou 350116China

Oxygen evolution reaction(OER)is a critical process in electrocatalytic water ***,the development of low-cost,highly efficient OER electrocatalysts by a simple method that can be used for industrial application on a large scale is still a huge ***,high entropy alloy(HEA)has acquired extensive attention,which may provide answers to the current ***,we report bulk Fe_(50)Mn_(30)Co_(10)Cr_(10),which is prepared by 3D printing on a large scale,as electrocatalyst for OER with high catalytic ***,an easy approach,corrosion engineering,is adopted for the first time to build an active layer of honeycomb nanostructures on its surface,leading to ultrahigh OER performance with an overpotential of 247 mV to achieve a current density of 10 ma cm^(-2),a low Tafel slope of 63 mV dec^(-1),and excellent stability up to 60 h at 100 ma cm^(-2)in 1 M *** excellent catalytic activity mainly originates from:(1)the binder-free self-supported honeycomb nanostructures and multi-component hydroxides,which improve intrinsic catalytic activity,provide rich active sites,and reduce interfacial resistance;and(2)the diverse valence states for multiple active sites to enhance the OER *** findings show that corrosion engineering is a novel strategy to improve the bulk HEA catalytic *** expect that this work would open up a new avenue to fabricate large-scale HEA electrocatalysts by 3D printing and corrosion engineering for industrial applications.

关键词： Electrocatalysis High entropy alloy Corrosion engineering Self-supporting Oxygen evolution reaction

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Use of glycated albumin to distinguish occult diabetes mellitus from stress-induced hyperglycemia in Chinese orthopedic trauma patients

Use of glycated albumin to distinguish occult diabetes melli...

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中华医学会糖尿病学分会第十六次全国学术会议

作者： pan jie-min zhou Jian BAO Yu-qian ZHANG Lei tang Jun ling ma xiao-jing LI Qing JIA Wei-ping Department of Endocrinology and Metabolism Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Department of Orthopaedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’ s Hospital

Objective To investigate whether glycated albumin(GA) was an effective tool for detecting occult diabetes mellitus(ODM) in orthopedic trauma patients with elevated glucose levels. Methods A cross-sectional,sequential case series study of adult patients presenting to the OrthopedicTraumaCenter between September 2009 and march 2010 with new limb fractures was performed. Hemoglobin Alc(HbAlc) and GA levels were measured in hyperglycemic patients with no prior diabetes mellitus.A

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Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 maPK pathway

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Journal of Pharmaceutical Analysis 2020年第2期10卷 130-146页

作者： xiaoli Liang Yuan Huang Xiping pan Yanbing Hao xiaowei Chen Haiming Jiang jing Li Beixian zhou Zifeng Yang State Key Laboratory of Respiratory Diseases Guangzhou Institute of Respiratory HealthNational Clinical Centre of Respiratory DiseaseThe First Affiliated HospitalGuangzhou Medical UniversityGuangzhou510120China Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. LtdGuangzhou510515China Institute of Combination Chinese and Western Medicine Guangzhou Medical UniversityGuangzhou511436China Department of Pharmacy The People's Hospital of GaozhouGaozhou525200GuangdongChina State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyAvenida Wai LongTaipaMacao999078PR China

Isatis indigotica Fort.(Ban-lan-Gen)is an herbal medicine prescribed for influenza ***,its active components and mode of action remain mostly *** the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in *** results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription *** acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 maPK ***,the NF-kB and p38 maPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized ***,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic *** vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens ***,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-ma(H1N1)strain *** findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza.

关键词： Influenza A virus Isatis indigotica Fort. Erucic acid Antiviral Anti-inflammatory NF-kB p38 maPK Lung injury

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METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

METTL3-dependent m6A modification of PSEN1 mRNA regulates cr...

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2023年中华口腔医学会口腔遗传病与罕见病专业委员会第五次学术年会

作者： lan ma Xi zhou Yongchu pan Jiangsu Province Key Laboratory of Oral Diseases The Affiliated Stomatology hospital of Nanjing Medical University

Craniofacial malformations, often associated with syndromes,are prevalent birth defects. Emerging evidence underscores the significance of ma modifications in various bioprocesses such as stem cell differentiation, tissue development and tumorigenesis. Here, in vivo experiments with zebrafish models revealed that mettl3-knockdown embryos at 144 h post-fertilization exhibited aberrant craniofacial features, including altered mouth opening, jaw dimensions, ethmoid plate and tooth formation. Similarly, low METTL3 expression inhibited cell proliferation and migration of BMSC, HEPM and DPSC cells. Depleted METTL3 led to reduced m RNA ma methylation and PSEN1 expression,impacting craniofacial phenotypes. Co-injection of mettl3 or psen1m RNA rescued the level of Sox10 fused protein and mitigated abnormal craniofacial phenotypes induced by mettl3 knockdown in ***, YTHDF1 enhanced the m RNA stability of ma-modified PSEN1, while decreased METTL3-mediated ma methylation hindered β-catenin binding to PSEN1, suppressing Wnt/β-catenin signaling. Pharmacological activation of the Wnt/β-catenin pathway partially alleviated mettl3 morphant phenotypes. This study elucidates the pivotal role of METTL3 in craniofacial development via the METTL3/YTHDF1/PSEN1/β-catenin signaling axis.

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