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Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

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Frontiers of Medicine 2019年第3期13卷 330-343页

作者： Xuefei ma Wei Zhang Rong Zhang Jingming Li Shufen Li yunlin ma Wen Jin Kankan Wang State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China Department of Hematology Xi'an Gaoxin HospitalXi'an 710075China

Alternative splicing is a tightly regulated process that contributes to cancer *** is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several ***,whether deregulated expression of CRNDE is common and which isoforms are mainly involved in cancers remain *** this study,we report that CRNDE is aberrantly expressed in the majority of solid and hematopoietic *** investigation of CRNDE expression in normal samples revealed that CRNDE was expressed in a tissue- and cell-specific *** comparison of CRNDE expression in 2938 patient samples from 15 solid and hematopoietic tumors showed that CRNDE was significantly overexpressed in 11 malignancies,including 3 reported and 8 unreported,and also implicated that the overexpressed isoforms differed in various cancer ***,anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and primary samples,and even had different impacts on the expression of CRNDE ***,experimental profiles of 12 alternatively spliced isoforms demonstrated that the spliced variant CRNDE-g was the most highly expressed isoform in multiple cancer ***,our results emphasize the cancer-associated feature of CRNDE and its spliced isoforms,and may provide promising targets for cancer diagnosis and therapy.

关键词： long noncoding RNA CRNDE alternative splicing

Research on Vehicle OTA Design Based on Electronic and Electrical Architecture

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Research on Vehicle OTA Design Based on Electronic and Elect...

2023中国汽车工程学会年会暨展览会

作者： ma yunlin Liu Jun Cai Chunmao Wang Zhongcai Wen Yong Sun Xiaowu Chongqing Changan Automotive Software Technology Co. Ltd.

OTA is an over-the-air upgrade technology,which provides the ability to continuously update software through *** OTA is limited by the electronic and electrical architecture,the upgrade time is long,and the controller is difficult to *** order to improve the stability of the vehicle OTA,shorten the upgrade time,and upgrade the large version of the vehicle,this paper proposes an OTA architecture design scheme,which realizes the standardization of the vehicle OTA upgrade,the unified control of the upgrade process,and the platformization of the *** design scheme can be applied to cross vehicle OTA design and can solve many problems such as mixed ECU controllers,long upgrade time,and *** solution has become a complete cloud to vehicle full link continuous update capability,which has great promoting significance for enhancing the value of intelligent connected vehicles.

关键词：

Research on Quality management Based on Continuous Integration Tool Chain

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Research on Quality Management Based on Continuous Integrati...

2022中国汽车工程学会年会暨展览会

作者： ma yunlin Gang Yi Cai Chunmao Wang Wei Sun Xiaowu Liu Jun Wen Yong Yang Xiaoming Chongqing Changan Automotive Software Technology Co. Ltd.

Standing at the forefront of the "software-defined car" era,intelligent network connection has become the focus of automotive software *** order to improve the delivery efficiency of software integration and the quality of software version,this paper proposes a quality management method based on continuous integration tool *** on the construction and layout of software quality *** 3 iterations of pilot project demonstrations,the software delivery time was shortened from 8 hours to less than 2 hours,and the version quality was significantly better than that of traditional *** quality management method is not only safe and stable,but also improves the efficiency of code construction and development,especially *** quality management provides a good reference and achieves the research purpose.

关键词：

Research on Software Project Configuration management Based on Iterative Development

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Research on Software Project Configuration Management Based ...

2021中国汽车工程学会年会暨展览会

作者： ma yunlin Gang Yi He Dongping Tan Xiuquan Chongqing Changan Automobile Software Technology Co. Ltd.

Standing at the forefront of the " software-defined car" era,intelligent network connection has become the focus of automotive software *** the process of research and development of automotive software,we are faced with the dilemma of frequent changes in requirements and rapid update of design and testing *** order to improve the quality of research and development of automotive software,embedded software generally adopts an iterative development *** to solve the problems of frequent update of requirements and frequent design changes requires a powerful software project configuration management *** article proposes a software project configuration management method based on iterative development;combining the requirements of Automobile SPICE,the configuration management layout and construction work of software projects are carried out from five aspects:project status,configuration management strategy,project baseline,configuration audit and research *** one-year project practice,this method not only significantly improves the research and development efficiency of software projects,but also provides more efficient research ideas for the quality of automotive software,and achieves the research goals.

关键词： software-defined automobile intelligent network connection automobile SPICE configuration management strategy R&D efficiency

Research on Software Product R＆D Mode Based on New Function Development

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Research on Software Product R＆D Mode Based on New Function...

2020中国汽车工程学会年会暨展览会

作者： ma yunlin He Dongping Tan Xiuquan He Jugang Chongqing Changan Automobile Co. Ltd

This paper takes the research and development model of a company’s core component software products（new function development） as the research object,through the entire project from the pre-research to mass production stage,and successfully entered the B-sample development stage with the support of partners,and proposed A brand-new software technology research and development model was created,which creatively proposed four points for integration with the mass production product development process,and it worked well in the pilot *** model fully guarantees the achievement of project objectives,provides a specific implementation path for the organization’s pre-research and mass production product development models,and also provides a new methodology for software product development with new technology development.

关键词： new functions pre-research stage mass production stage new methodology

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田园综合体模式下的养老设施环境设计研究

设计艺术研究 2022年第1期12卷 31-36页

作者：马云林熊浩杰昆明理工大学艺术与传媒学院云南昆明650000

近年我国养老设施的发展观念,已从最初注重量的增长转变为关注品质的提升,高品质的养老设施已然成为大多数人的养老夙愿。采用田园综合体与养老设施相结合的模式,能够给养老产业带来优势,不仅符合我国乡村振兴战略的基本内涵,而且有助... 详细信息

近年我国养老设施的发展观念,已从最初注重量的增长转变为关注品质的提升,高品质的养老设施已然成为大多数人的养老夙愿。采用田园综合体与养老设施相结合的模式,能够给养老产业带来优势,不仅符合我国乡村振兴战略的基本内涵,而且有助于改善乡村地区的基础设施,为发展注入了新的活力。在总结我国养老模式现状及其需求变化的基础上,以田园养老的需求分析为前提,结合田园综合体模式下养老设施的概念及服务模式,从传承乡村传统风貌、丰富田园生活属性、依循老人个体特征、根据功能逐项设计等4个方面提出了具体的设计策略。

关键词：田园综合体养老设施养老模式乡村振兴

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基于通信连通保持约束的多智能体覆盖控制

北京航空航天大学学报 2024年第2期50卷 519-528页

作者：张蕴霖麻壮壮石磊邵晋梁电子科技大学自动化工程学院成都611731 电磁空间认知与智能控制技术实验室北京100089

覆盖控制会根据环境信息,尽量分散智能体以达到较好的空间覆盖效果,实现对于任务区域的最优监视。在这一过程中,智能体之间的协同依赖于连通的通信网络。受限于智能体在复杂电磁环境下有限的通信范围,覆盖控制中的分散行为可能造成通信... 详细信息

覆盖控制会根据环境信息,尽量分散智能体以达到较好的空间覆盖效果,实现对于任务区域的最优监视。在这一过程中,智能体之间的协同依赖于连通的通信网络。受限于智能体在复杂电磁环境下有限的通信范围,覆盖控制中的分散行为可能造成通信网络的中断,导致任务失败。因此,将通信网络连通作为约束,基于梯度下降方法,提出了有界的分布式控制律,以保证在覆盖代价函数下降的同时,网络连通度不小于设定阈值。为减少通信连通保持对于覆盖效果的影响,提出了一种基于关键智能体辨识的分段控制方法。通过动态分配覆盖和通信连通保持的控制增益,以减少因二者运动趋势相反而产生的控制震荡和冗余。针对陷入局部最优的死锁现象,提出一种死锁消除控制,以及时消除死锁,提升覆盖性能。基于高频结构仿真(HFSS)软件生成的信号场的覆盖仿真实验表明了控制律的有效性。

关键词：多智能体系统覆盖控制通信连通性保持维诺划分死锁

Software Development management Research Based on Vehicle-controlled ECU

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Software Development Management Research Based on Vehicle-co...

2019中国汽车工程学会年会

作者： ma yunlin Zhang Hui He Dongping Zhou Yu Tan Xiuquan Chongqing Changan Automobile Co. Ltd.

In this paper,base on software development management strategy of a vehicle-controlled ECU as the research object,through the analysis of the vehicle software industry status and technical management bottleneck,put forward software development management process system and quality operation mode suitable for automotive ECU,namely "Double-V iteration mode".Through verified by pilot project,which has achieved gratifying phased *** the stage results,it has perfonned well and improved the quality management and configuration management level of the enterprise,and providing high-quality management strategy for the newly developed vehicle-controlled ECU software management.

关键词： vehicle-controled ECU technical management bottleneck double-V iteration mode

带阈值补偿功能的峰值电流模式LED驱动芯片

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电子元件与材料 2014年第2期33卷 52-55页

作者：马云林电子科技大学物理电子学院四川成都610051

设计了一款带阈值补偿功能的峰值电流模式大功率LED驱动芯片。该芯片在传统的斜率补偿技术的基础上，采用电压电流转换的跨导结构，将输入端电压和负载端电压的变化转化为对应的电流变化的方式，实现在峰值电流模式下对斜率补偿的阈值... 详细信息

设计了一款带阈值补偿功能的峰值电流模式大功率LED驱动芯片。该芯片在传统的斜率补偿技术的基础上，采用电压电流转换的跨导结构，将输入端电压和负载端电压的变化转化为对应的电流变化的方式，实现在峰值电流模式下对斜率补偿的阈值进行补偿的目的，此结构提高了电路斜率补偿的精度和准确度以及峰值电流模式下电流环路反馈控制的精度。通过1μmBCD工艺进行仿真验证，结果表明在20-40V的输入电压范围内输出电流最高可达到1A，电流精度在士0．1％以内。

关键词： LED驱动芯片峰值电流模式电压电流转换电流环反馈阈值补偿高精度