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HBP1 inhibits chicken preadipocyte differentiation by activating the STAT3 signaling via directly enhancing JAK2 expression

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Journal of Integrative Agriculture 2022年第6期21卷 1740-1754页

作者： CHEN Hong-yan CHENG Bo-han ma yan-yan ZHANG Qi LENG Li WANG Shou-zhi LI Hui Key Laboratory of Chicken Genetics and Breeding Ministry of Agriculture and Rural AffairsHarbin 150030P.R.China Key Laboratory of Animal Genetics Breeding and ReproductionEducation Department of Heilongjiang ProvinceHarbin 150030P.R.China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030P.R.China

Obesity presents a serious threat to human health and broiler *** expansion of adipose tissue is mainly regulated by the differentiation of *** differentiation of preadipocytes is a complex biological process regulated by a variety of transcription factors and signaling *** studies have shown that the transcription factor HMG-box protein 1(HBP1)can regulate the differentiation of mouse 3T3-L1 preadipocytes by activating the Wnt/β-catenin signaling ***,it is unclear whether HBP1 involved in chicken preadipocyte differentiation and which signaling pathways it *** aim of the current study was to explore the biological function and molecular regulatory mechanism of HBP1 in the differentiation of chicken *** expression patterns of chicken HBP1 in abdominal adipose tissue and during preadipocyte differentiation were analyzed by RT-qPCR and Western *** preadipocyte stably overexpressing HBP1 or knockout HBP1 and their control cell line were used to analyze the effect of HBP1 on preadipocyte differentiation by oil red O staining,RT-qPCR and Western *** 45-Pathway Reporter Array was used to screen the signal pathways that HBP1 regulates in the differentiation of chicken *** inhibitor and siRNA for signal transducer and activator of transcription 3(STAT3)were used to analyze the effect of STAT3 on preadipocyte *** preadipocyte stably overexpressing HBP1 was transfected by the siRNA of STAT3 or treated with a chemical inhibitor of STAT3 for the rescue *** results of gene expression analysis showed that the expression of HBP1 was related to abdominal fat deposition and preadipocyte differentiation in *** results of function gain and loss experiments indicated that overexpression/knockout of HBP1 in chicken preadipocytes could inhibit/promote(P<0.05)lipid droplet deposition and the expression of adipogenesis-related ***,HB

关键词： chicken HBP1 preadipocyte differentiation STAT3 signaling pathway

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Prediction study of hydrocarbon reservoir based on time-frequency domain electromagnetic technique taking Ili Basin as an example

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Applied Geophysics 2020年第5期17卷 687-699,900,901页

作者： Tian Yu-Kun Zhou Hui ma yan-yan Li Juan The Key Laboratory of unconventional oil and gas geology Oil and Gas resources Survey CenterChina Geological SurveyBeijing 100083China

The time-frequency domain electromagnetic(TFEM)sounding technique can directly detect oil and gas characteristics through anomalies in resistivity and *** recent years,it has made some breakthroughs in hydrocarbon *** was applied to predict the petroliferous property of the Ili *** accordance with the geological structure characteristics of the study area,a two-dimensional layered medium model was constructed and forward modeling was *** used the forward-modeling results to guide fi eld construction and ensure the quality of the fi eld data *** used the model inversion results to identify and distinguish the resolution of the geoelectric information and provide a reliable basis for data *** the basis of our results,key technologies such as 2D resistivity tomography imaging inversion and polarimetric constrained inversion were developed,and we obtained abundant geological and geophysical *** characteristics of the TFEM anomalies of the hydrocarbon reservoirs in the Ili Basin were summarized through an analysis of the electrical logging data in the study ***,the oil-gas properties of the Permian and Triassic layers were predicted,and the next favorable exploration targets were optimized.

关键词： Time–Frequency Domain Electromagnetic Hydrocarbon Detection Polarizability Anomaly Favorable Area Prediction

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Experiments on excitation and data processing of low-frequency vibroseis in permafrost area of the tibetan plateau

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Applied Geophysics 2020年第5期17卷 834-843,904页

作者： Tian Yu-Kun Kang Hai-xia Cao Jie Li Juan Zhou Hui ma yan-yan OGS CGSBeijing 100083China

Few seismic exploration work was carried out in Tibetan Plateau due to the characteristics of alpine hypoxia and harsh environmental protection *** near surface geological conditions,especially the signal shielding and static correction of permafrost make the quality of seismic data is not ideal,the signal to noise ratio(SNR)is low,and deep target horizon imaging is *** data cannot provide high quality information for oil and gas geological survey and structural sedimentary research in the *** solve the issue of seismic exploration in Tibetan Plateau,this test used low frequency vibroseis wide-line and high-density acquisition *** view of the actual situation of the study area,the terrain,the source and the diff erent observation system were simulated,and the processing technique was adopted to improve the quality of seismic ***-frequency components with a minimum of 1.5Hz of vibroseis ensure the deep geological target imaging quality in the area,the seismic profi le wave group is clear,and the SNR is relatively high,which can meet the needs of oil and gas *** data can provide the support for the development of oil and gas survey in the Tibet plateau.

关键词： Tibetan Plateau permafrost region low frequency vibroseis wide-line and high-density 2D seismic static correction noise attenuation

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应力偶流体润滑轴承性能计算方法的比较

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上海理工大学学报 2007年第1期29卷 95-98页

作者：马艳艳上海理工大学出版印刷学院上海200093

研究了负压力充零算法和质量守恒空穴算法对应力偶流体润滑轴承油膜压力分布及轴承特性参数的影响.数值分析表明,在油膜完整区,两种算法所得油膜压力几乎相同,只是在接近油膜破裂处有小的偏差;在空穴区,两者不同.两种算法所得轴承特性... 详细信息

研究了负压力充零算法和质量守恒空穴算法对应力偶流体润滑轴承油膜压力分布及轴承特性参数的影响.数值分析表明,在油膜完整区,两种算法所得油膜压力几乎相同,只是在接近油膜破裂处有小的偏差;在空穴区,两者不同.两种算法所得轴承特性参数相差较大,随应力偶参数增大差别减小.充零算法与实际情况不符,空穴算法更符合实际.

关键词：滑动轴承充零算法空穴算法

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yanJI CITY ORIENTATION AND INDUSTRYDEVELOPMENT TOWARDS 21ST CENTURY

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Chinese Geographical Science 2001年第1期11卷 70-75页

作者： ZHANG Ping-yu, ma yan-ji, ZHAO yan-xia, PAN Li-li (Changchun Institute of Geography, the Chinese Academy of Sciences, Changchun 130021, P. R. China) Changchun Institute of Geography the Chinese Academy of Sciences Changchun P. R. China

yanji is the biggest China Korean inhabited city. Based on a newly finished research project, this paper discusses strategic problems about yanji towards 21st century. The general point of the authors is that at the beginning of new century, yanji will play a more important role in Tumen River Delta development, regional economy cooperation in Korea Peninsula as well as Northeast Asia, and it will develop to be an important central city in this area. This paper puts forwards yanji City’s developing goal, urban nature, and urban size, probes its regional orientation, and further probes how to establish The yanji Urban Economy Cooperation Zone. The authors think that yanji should depend on its intellect resources and other characteristic resources. Industry development need to pay much attention to modern agriculture, tertiary industry (especially commerce, trade and tourism) and dominant industries, and high-tech industry must give a special care, in order to establish a light industrial structure.

关键词： yanji China Korean city orientation industry development

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内燃机滑动轴承气蚀损伤破坏过程

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上海交通大学学报 2005年第7期39卷 1178-1181页

作者：马艳艳程先华上海交通大学机械与动力工程学院上海200030

用***大型非线性有限元分析软件建立了轴瓦气蚀损伤模型,基于损伤力学理论对气蚀发生过程中气泡溃灭产生的微射流对轴瓦表面材料的力学作用过程进行了数值分析.结果表明:随时间增加,等效塑性应变和损伤量基本上为逐渐增大的趋势;轴瓦表... 详细信息

用***大型非线性有限元分析软件建立了轴瓦气蚀损伤模型,基于损伤力学理论对气蚀发生过程中气泡溃灭产生的微射流对轴瓦表面材料的力学作用过程进行了数值分析.结果表明:随时间增加,等效塑性应变和损伤量基本上为逐渐增大的趋势;轴瓦表面和接近表面的损伤量较大,越接近摩擦层和镍栅层的结合面附近损伤量越小.采用本方法可以有效计算轴瓦材料受微射流冲击载荷作用时的应变过程和损伤演变,由此提出了一种分析轴瓦表面气蚀磨损的损伤力学方法.

关键词：滑动轴承气蚀冲击损伤数值分析

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Cytosolic calcium oscillations in submandibular gland cells

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Acta Pharmacologica Sinica 2006年第7期27卷 843-847页

作者： Li SU Chun-yan ma yan-dong ZHOU yan-hong JIA Zong-jie CUI~2 Institute of Cell Biology,Beijing Normal University,Beijing 100875,China InstituteofCellBiology BeijingNormalUniversityBeijing100875China

Calcium oscillations can,by default,encode diverse and specific signals by differ-ent modes of *** modulation is illustrated by the activation ofcalcium/calmodulin-dependent protein kinase Ⅱ at unit Hz,and of calcineurin at 10mHz frequencies,*** submandibular gland secretory axis is charac-terized by both potassium and osmolarity gradients from the luminal side of thesecretory *** gradients may play significant physiological roles throughthe feedback modulation of cholinergic *** potassium transformsplateau calcium increases induced by cholinergic stimulation of the submandibu-lar acinar cells into oscillatory calcium *** ductal cells may have simi-lar mechanisms of feedback modulation both by high potassium and by *** feedback mechanisms could modulate the decision-making pro-cess for determining which secretory products are selectively released after nervestimulation.

关键词： submandibular gland secretory axis calcium oscillation

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Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure

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World Journal of Gastroenterology 2007年第3期13卷 462-466页

作者： Bao-Shan yang Ying-Ji ma yan Wang Li-yan Chen man-Ru Bi Bing-Zhu yan Lu Bai Hui Zhou Fu-Xiang Wang Department of Infectious Diseases the First Clinical Hospital of Harbin Medical University Harbin 150001 Heilongjiang Province China

AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.

关键词： Stronger neo-minophagen C Fulminant hepatic failure Cytochrome C Caspase-3

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Ti/RuO_2电氧化法降解藻毒素MCLR影响因素的研究

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中国环境科学 2008年第8期28卷 709-713页

作者：王金丽梁文艳马炎炎王珂北京林业大学环境科学与工程学院省部共建森林培育与保护教育部重点实验室北京100083

使用Ti/RuO2阳极,对电氧化法降解微囊藻毒素MCLR的效能及其影响因素进行了研究.结果显示,电流密度增大有利于MCLR的降解,当电流密度为8ma/cm2,水力停留时间(HRT)为23min时,MCLR的去除率可达到100%.以0.02mol/LNa2SO4作为电解质时,MCLR... 详细信息

使用Ti/RuO2阳极,对电氧化法降解微囊藻毒素MCLR的效能及其影响因素进行了研究.结果显示,电流密度增大有利于MCLR的降解,当电流密度为8ma/cm2,水力停留时间(HRT)为23min时,MCLR的去除率可达到100%.以0.02mol/LNa2SO4作为电解质时,MCLR降解效果较好,去除率可达到100%,而以0.02mol/LNaNO3为电解质时,MCLR降解效果较差,去除率只有50%.MCLR初始浓度对降解效率影响较大,MCLR初始浓度为3.3μg/L时,去除率可达到96%;MCLR初始浓度为198μg/L时,去除率只有60%.Na2SO4电解质浓度和水样流速对藻毒素MCLR降解效果影响不明显.

关键词：藻毒素 MCLR 电氧化影响因素

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印刷机械传动部件表面接触问题研究

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包装工程 2008年第3期29卷 93-95页

作者：马艳艳上海理工大学上海200093

对印刷机械传动部件表面接触问题的研究进展进行了综述,分析了粗糙表面基于统计分析的接触模型、粗糙表面接触分形模型以及使用表面测量仪数字化真实粗糙表面的方法,根据粗糙表面接触模型还分析了接触方程的基本方程、统计方法、逆矩阵... 详细信息

对印刷机械传动部件表面接触问题的研究进展进行了综述,分析了粗糙表面基于统计分析的接触模型、粗糙表面接触分形模型以及使用表面测量仪数字化真实粗糙表面的方法,根据粗糙表面接触模型还分析了接触方程的基本方程、统计方法、逆矩阵法、数学规划法几种求解方法,并提出了未来表面接触问题研究所要解决的问题,为印刷机械传动部件表面接触问题研究提供借鉴。

关键词：印刷机传动部件粗糙表面接触

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