检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Intensive Medicine 2023年第4期3卷 335-344页

作者： Hui Xiang Yuqian Zhao siqing ma Qi Li Kianoush B.Kashani Zhiyong Peng Jianguo Li Bo Hu Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Clinical Research Center of Hubei Critical Care Medicine Wuhan 430071HubeiChina Department of Critical Care Medicine Qinghai Provincial People's HospitalXining 810007QinghaiChina Division of Pulmonary and Critical Care Medicine Department of MedicineMayo ClinicRochesterMNUSA Division of Nephrology and Hypertension Department of MedicineMayo ClinicRochesterMNUSA

Background The benefits of early use of norepinephrine in endotoxemic shock remain *** aimed to elucidate the effects of different doses of norepinephrine in early-stage endotoxemic shock using a clinically relevant large animal *** Vasodilatory shock was induced by endotoxin bolus in 30 Bama suckling *** included fluid resuscitation and administration of different doses of norepinephrine,to induce return to baseline mean arterial pressure(maP).Fluid management,hemodynamic,microcirculation,inflammation,and organ function variables were *** animals were supported for 6 h after endotoxemic *** Infused fluid volume decreased with increasing norepinephrine *** to baseline maP was achieved more frequently with doses of 0.8µg/kg/min and 1.6µg/kg/min(Pma were higher in animals administered no or 0.2µg/kg/min norepinephrine(Pmall vessel density(PSVD)was higher in those receiving 0.8µg/kg/min(Pmacro-and micro-circulation in early-stage endotoxemic shock is dose-dependent,with very low and very high doses resulting in detrimental *** an appropriate norepinephrine dose was associated with improved tissue perfusion and organ function.

关键词： Norepinephrine Fluid resuscitation Endotoxemic shock Microcirculation Side stream dark-field Pigs

Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia ma Yumeng Huang siqing Fan Jie Peng Shiming Li Xiurong Su Yanbo Wang Chenyang Lu State Key Laboratory for managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary *** recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing *** article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability *** current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity *** addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical ***,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability ***,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

Ataxia,acute mountain sickness,and high altitude cerebral edema

在线全文

学校读者我要写书评

暂无评论

Engineering Sciences 2013年第2期11卷 38-46页

作者： Wu Tianyi ma siqing Bian Huiping Zhang Minming High Altitude Medical Research Institute High Altitude Medical Research Center Tibet University Intensive Care Unit of Qinghai Provincial People's Hospital Department of Inter. Med. Qinghai Cardio-Cerebral-Vascular Hospital Image Division of Qinghai Provincial People's Hospital

Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status.

关键词：脑水肿高山病高原病失调急性高海拔地区救援人员精神状态

死腔分数对急性呼吸窘迫综合征治疗指导及预后评价

在线全文

学校读者我要写书评

暂无评论

中华危重病急救医学 2022年第12期34卷 1333-1336页

作者：马四清王志健郭利涛青海省人民医院重症医学科西宁810007 西安交通大学第一附属医院重症医学科陕西西安710061

急性呼吸窘迫综合征(ARDS)是危重病及呼吸衰竭患者病死率高的常见原因。ARDS时死腔分数(VD/VT)增大与肺损伤加重及死亡独立相关。VD/VT可通过床旁测量动脉血气和呼气末二氧化碳容易获得。床旁早期重视和应用VD/VT这个指标,有助于更好理... 详细信息

急性呼吸窘迫综合征(ARDS)是危重病及呼吸衰竭患者病死率高的常见原因。ARDS时死腔分数(VD/VT)增大与肺损伤加重及死亡独立相关。VD/VT可通过床旁测量动脉血气和呼气末二氧化碳容易获得。床旁早期重视和应用VD/VT这个指标,有助于更好理解ARDS的病理生理特征,指导临床治疗,并能更好地评估病情严重程度及临床预后。

关键词：死腔分数急性呼吸窘迫综合征机械通气新型冠状病毒肺炎预后

Studies on monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome secondary to high altitude pulmonary edema

在线全文

学校读者我要写书评

暂无评论

Engineering Sciences 2013年第2期11卷 34-37页

作者： ma siqing Wu Tianyi Cheng Qiang Li Pei Bian Huiping Intensive Care Unit of Qinghai Provincial People's Hospital High Altitude Medical Research Institute High Altitude Medical Research Center Tibet University Qinghai Cardio-Cerebral-Vascular Hospital

To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who preliminarily developed high altitude cerebral edema (HACE) and then ARDS occurred at an altitude of 4 500 m. After an initial emergency treatment on high mountains,all the patients were rapidly transported to a hospital at a lower altitude of 2 808 m. The right cardiac catheterizations were carried out within 5 h after hospitalized. The monitoring hemodynamics and oxygen dynamics were studied via a thermodilution Swan-Gaze catheter. The results showed that before treatments at the beginning of monitoring,there presented a significant pulmonary artery hypertension with a decreased cardiac function,and a lower oxygen metabolism in all the 8 patients. However,after some effective treatments,including mechanical ventilation and using dexamethasone,furosemide,etc,four days later the result of a repeated monitoring showed that their pulmonary artery pressure had been decreased with an improved cardiac function with all the oxygen metabolic indexes increased significantly. Our studies suggested that performing monitoring hemodynamics in patients with ARDS secondary to HAPE will define the clinical therapeutic measures which will benefit the outcome.

关键词：血流动力学氧代谢肺水肿综合征监测高原继发呼吸

在线全文

学校读者我要写书评

暂无评论

透明装甲防护材料及其结构设计与应用评价

硅酸盐学报 2024年第3期52卷 1043-1064页

作者：邵岑张乐王思晴王彤邱凡马庆飞陈浩江苏师范大学物理与电子工程学院江苏省先进激光材料与器件重点实验室江苏徐州221116 江苏锡沂高新材料产业技术研究院江苏徐州221400

透明装甲是应对未来战争的“光学盾牌”,其具有高光学透明度、高硬度、高强度、可防弹道冲击与爆炸物碎片冲击等特性,被广泛应用于装甲战车、武装直升机、舰船航母等装备平台。目前,世界各军事强国竞相开发出抗弹性能优异的透明装甲,但... 详细信息

透明装甲是应对未来战争的“光学盾牌”,其具有高光学透明度、高硬度、高强度、可防弹道冲击与爆炸物碎片冲击等特性,被广泛应用于装甲战车、武装直升机、舰船航母等装备平台。目前,世界各军事强国竞相开发出抗弹性能优异的透明装甲,但是,透明装甲的防护性能提升与轻量化设计仍面临瓶颈。本文首先对现役透明防护材料的性质进行了详细介绍;重点分析了透明防护装甲的结构设计方案及其损伤机制,并指出了防护性能提升的重点方向;再者介绍了国内外透明防护材料性能考核的评价方法,特别是需要重点考核的项目;最后,对透明装甲的发展方向进行了展望,为新一代透明装甲的结构设计与应用评价提供借鉴。

关键词：透明装甲防护性能轻量化结构设计应用评价

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

水平轴风电机组叶片摆振与挥舞机理建模

机械工程学报 2024年第3期60卷 131-142页

作者：王思清滕伟王罗刘宇彭迪康马志勇柳亦兵华北电力大学电站能量传递转化与系统教育部重点实验室北京102206 中国长江三峡集团有限公司北京100038 中国绿发投资集团有限公司北京100020

水平轴风电机组叶片振动机理建模是研究叶片振动规律及进行故障诊断的基础。基于多坐标变换,考虑塔影效应、几何非线性和桨距角变化等因素的影响,建立结构动力学与空气动力学耦合的水平轴风电机组叶片摆振、挥舞振动机理模型。以某2 MW... 详细信息

水平轴风电机组叶片振动机理建模是研究叶片振动规律及进行故障诊断的基础。基于多坐标变换,考虑塔影效应、几何非线性和桨距角变化等因素的影响,建立结构动力学与空气动力学耦合的水平轴风电机组叶片摆振、挥舞振动机理模型。以某2 MW风电机组柔性叶片以及某场站3 MW风电机组叶片为对象,构建了多体动力学模型,分别与GH Bladed软件计算结果和机组实测数据相比,具有较高的吻合度。基于此模型,研究了稳态工况下,塔影效应、几何非线性以及桨距角变化对叶片运行参数和振动的影响。结果表明,叶片轴向推力和转矩在塔影区有明显下降,同时挥舞方向振动在塔影区存在显著波动。叶片的侧向弯曲刚度随着方位角的变化呈谐波式变化,转速影响叶片侧向弯曲刚度大小。当风速过大时,叶片通过桨距角变化可以有效抑制振动。

关键词：空气动力学结构动力学塔影效应几何非线性摆振与挥舞

肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展

在线全文

学校读者我要写书评

暂无评论

中华重症医学电子杂志 2022年第2期8卷 167-172页

作者：刘娟丽马四清陈强青海省人民医院重症医学科西宁810007 青海大学高原医学研究中心西宁810001

肺表面活性蛋白-D(SP-D)是凝集素家族糖蛋白,主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌,储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一,也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面... 详细信息

肺表面活性蛋白-D(SP-D)是凝集素家族糖蛋白,主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌,储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一,也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面活性剂池稳态外,还具有宿主防御和免疫调节功能。本文通过对近年来SP-D在肺部常见疾病中的部分相关研究进行总结,为众多肺部疾病,特别是肺部炎症性疾病潜在的治疗提供重要的方法理论基础。

关键词：表面活性蛋白-D 表面活性剂池稳态宿主防御免疫调节

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

急性高原反应发病的危险因素相关研究进展

第三军医大学学报 2019年第8期41卷 723-728页

作者：罗勇军马四清陆军军医大学(第三军医大学)陆军卫勤训练基地军事医学地理学教研室全军战救训练技术与器材研发实验室重庆400038 青海省人民医院重症医学科西宁810007

地理学上把海拔高于1 000 m,地势相对平坦或者有一定起伏的广阔地区称为高原;医学上将海拔高于3 000 m的地方称为高原。未经习服的人员,快速从平原进入高原,会出现呼吸加深加快,心率加快,头痛、头晕,失眠,胃肠胀气、腹泻等症状。

关键词：急性高原反应医学地理高原病危险因素