检索结果-南通市图书馆

Chinese Journal of Natural Medicines 2024年第7期22卷 582-598页

作者： JIA Kexin ma zhi ZHANG Yinhao XIE Kaihong LI Jianan WU Jianzhi QU Jiaorong LI Fanghong LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese materia Medica Beijing University of Chinese MedicineBeijing 100029China

Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar *** play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune *** II(PIC II),extracted from Picrorhizae Rhizoma,has demonstrated therapeutic potential for various liver ***,the mechanisms by which macrophage polarization initiates immune cascades and contributes to the development of liver fibrosis,and whether this process can be influenced by PIC II,remain *** the current study,RNA sequencing and multiple molecular approaches were utilized to explore the underlying mechanisms of PIC II against liver fibrosis in multidrug-resistance protein 2 knockout(Mdr2^(−/−))*** findings indicate that PIC II activates M1-polarized macrophages to recruit natural killer cells(NK cells),potentially via the CXCL16-CXCR6 ***,PIC II promotes the apoptosis of activated hepatic stellate cells(aHSCs)and enhances the cytotoxic effects of NK cells,while also reducing the formation of neutrophil extracellular traps(NETs).Notably,the anti-hepatic fibrosis effects associated with PIC II were largely reversed by macrophage depletion in Mdr2^(−/−)***,our research suggests that PIC II is a potential candidate for halting the progression of liver fibrosis.

关键词： Liver fibrosis Picroside II M1 macrophage Hepatic stellate cell Natural killer cell Neutrophil

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO Lei DOU Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan ma zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong WANG zhixing ma zhi JIA Kexin LI Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H19 remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H19 in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

Chuanxiong Rhizoma extracts prevent liver fibrosis via targeting CTCF-c-MYC-H19 pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2024年第1期16卷 82-93页

作者： Yajing Li Fanghong Li Mingning Ding zhi ma Shuo Li Jiaorong Qu Xiaojiaoyang Li School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese materia Medica Beijing University of Chinese MedicineBeijing 100029China

Objective:Hepatic fibrosis has been widely considered as a conjoint consequence of almost all chronic liver *** Rhizoma(Chuanxiong in Chinese,CX)is a traditional Chinese herbal product to prevent cerebrovascular,gynecologic and hepatic *** previous study found that CX extracts significantly reduced collagen contraction force of hepatic stellate cells(HSCs).Here,this study aimed to compare the protection of different CX extracts on bile duct ligation(BDL)-induced liver fibrosis and investigate plausible underlying ***:The active compounds of CX extracts were identified by high performance liquid chromatography(HPLC).Network pharmacology was used to determine potential targets of CX against hepatic *** duct hyperplasia and liver fibrosis were evaluated by serologic testing and histopathological *** expression of targets of interest was determined by quantitative real-time PCR(qPCR)and Western ***:Different CX extracts were identified by tetramethylpyrazine,ferulic acid and senkyunolide *** on the network pharmacological analysis,42 overlap targets were obtained via merging the candidates targets of CX and liver *** aqueous,alkaloid and phthalide extracts of CX(CX_(AE),CX_(AL) and CXP_(HL))significantly inhibited diffuse severe bile duct hyperplasia and thus suppressed hepatic fibrosis by decreasing CCCTC binding factor(CTCF)-c-MYC-long non-coding RNA H19(H19)pathway in the BDL-induced mouse ***,CX extracts,especially CX_(AL) and CX_(PHL) also suppressed CTCF-c-MYC-H19 pathway and inhibited ductular reaction in cholangiocytes stimulated with taurocholate acid(TCA),lithocholic acid(LCA)and transforming growth factor beta(TGF-β),as illustrated by decreased bile duct proliferation ***:Our data supported that different CX extracts,especially CX_(AL) and CX_(PHL) significantly alleviated hepatic fibrosis and bile duct hyperplasia via inhibiting CTCF-c-MYC-H19

关键词： Chuanxiong Rhizoma cholangiocytes ductular reaction Ligusticum chuanxiong Hort. liver fibrosis lncRNA H19

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song Xin Jin Zhong Luo Shu-Gen Liu Shao-Bo Liu Xing-zhi ma zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin The Member Deng-2 marginal microbial mound-bank complex Depositional model Exploration implications

Applying Hybrid Clustering in Pulsar Candidate Sifting with Multi-modality for FAST Survey

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第3期24卷 283-296页

作者： Zi-Yi You Yun-Rong Pan zhi ma Li Zhang Shuo Xiao Dan-Dan Zhang Shi-Jun Dang Ru-Shuang Zhao Pei Wang Ai-Jun Dong Jia-Tao Jiang Ji-Bing Leng Wei-An Li Si-Yao Li School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550025China College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Information and Computing Guizhou Province Guizhou Normal UniversityGuiyang 550001China School of Big data and Computer Science Guizhou Normal UniversityGuiyang 550025China Guizhou Software Engineering Research Center Guiyang 550000China

Pulsar search is always the basis of pulsar navigation,gravitational wave detection and other research ***,the volume of pulsar candidates collected by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)shows an explosive growth rate that has brought challenges for its pulsar candidate filtering ***,the multi-view heterogeneous data and class imbalance between true pulsars and non-pulsar candidates have negative effects on traditional single-modal supervised classification *** this study,a multi-modal and semi-supervised learning based on a pulsar candidate sifting algorithm is presented,which adopts a hybrid ensemble clustering scheme of density-based and partition-based methods combined with a feature-level fusion strategy for input data and a data partition strategy for *** on both High Time Resolution Universe SurveyⅡ(HTRU2)and actual FAST observation data demonstrate that the proposed algorithm could excellently identify pulsars:On HTRU2,the precision and recall rates of its parallel mode reach0.981 and 0.988 *** FAST data,those of its parallel mode reach 0.891 and 0.961,meanwhile,the running time also significantly decreases with the increment of parallel nodes within ***,we can conclude that our algorithm could be a feasible idea for large scale pulsar candidate sifting for FAST drift scan observation.

关键词： methods data analysis-surveys-methods numerical

在线全文

学校读者我要写书评

暂无评论

明清贺兰山主题诗词的书写维度及价值探论

北方民族大学学报（哲学社会科学版） 2024年第2期 120-126页

作者：马志英北方民族大学中华民族共同体学院宁夏银川750021

明清时期是贺兰山主题诗词发展的重要阶段,在政治环境、文教事业等地缘因素的共同构建下,诗词作品中的贺兰山突破以往单一的政治地缘形象而呈现出丰富多元的书写维度。一是地理空间维度,以山峦景致咏江山之胜,以贺兰晴雪为代表的景致呈... 详细信息

明清时期是贺兰山主题诗词发展的重要阶段,在政治环境、文教事业等地缘因素的共同构建下,诗词作品中的贺兰山突破以往单一的政治地缘形象而呈现出丰富多元的书写维度。一是地理空间维度,以山峦景致咏江山之胜,以贺兰晴雪为代表的景致呈现出书写群体对边地宁夏从疏离到欣赏的情感转向。二是文化空间维度,以塔林佛寺文庙反映儒释道三教相交融的文化氛围。三是心理空间维度,以历史遗迹抒怀古思今之情。明清贺兰山主题诗词的重要研究价值在于贺兰山文学景观的审美形象和文化内涵的变迁过程就是其逐渐与中原文化不断建立联结关系的过程,也见证了中华民族多元一体格局的演进轨迹。

关键词：明清贺兰山主题诗词地理空间文学景观中华民族共同体

民族心·民族情·民族风·民族魂:龙狮文化铸牢中华民族共同体意识路径

在线全文

学校读者我要写书评

暂无评论

体育文化导刊 2024年第4期 22-29页

作者：胡昌领马学智安徽工程大学体育学院安徽芜湖241000 北京体育大学中国武术学院北京100084

运用文献资料、逻辑分析等方法,分析龙狮文化铸牢中华民族共同体意识的价值、困境,并提出路径。价值:展现民族图腾的象征,促进民族交流互鉴的桥梁,构筑民族团结思想意识的支柱,引起民族文化集体的窗口。困境:西方文化冲击,削弱正确认知... 详细信息

运用文献资料、逻辑分析等方法,分析龙狮文化铸牢中华民族共同体意识的价值、困境,并提出路径。价值:展现民族图腾的象征,促进民族交流互鉴的桥梁,构筑民族团结思想意识的支柱,引起民族文化集体的窗口。困境:西方文化冲击,削弱正确认知;传统文化失语,导致话语式微;割裂文化现象,弱化内涵表达;商业娱乐倾向,消解传播内容。路径:提升文化认知,凝聚民族心;增强文化话语,谱写民族情;强化文化认同,共享民族风;优化文化内容,弘扬民族魂。

关键词：民族传统体育龙狮文化中华民族共同体意识

耐亚磷酸盐除草剂转基因油菜的创建和抗性评价

在线全文

学校读者我要写书评

暂无评论

作物学报 2024年第5期50卷 1158-1171页

作者：钟元朱天宇戴成马朝芝华中农业大学作物遗传改良全国重点实验室/国家油菜工程技术研究中心/洪山实验室湖北武汉430070

在油菜的生产过程中,大量伴生的杂草严重影响了其产量和品质。由于近年来田间抗除草剂杂草数量的增加,除草剂的选择正在迅速减少,这影响了未来农业的可持续发展。植物可以通过正磷酸盐(Pi)转运蛋白吸收亚磷酸盐(Phi),但Phi不能被代谢为... 详细信息

在油菜的生产过程中,大量伴生的杂草严重影响了其产量和品质。由于近年来田间抗除草剂杂草数量的增加,除草剂的选择正在迅速减少,这影响了未来农业的可持续发展。植物可以通过正磷酸盐(Pi)转运蛋白吸收亚磷酸盐(Phi),但Phi不能被代谢为作物的磷肥料,导致植物生长受到抑制。此前,从罗尔斯通菌属(Raltsonia *** 4506)中分离出了ptxD(phosphite dehydrogenase)基因,其139位的酪氨酸突变为谷氨酰胺(Y139Q)的突变蛋白ptxD_(Q)催化Phi转化为Pi的活性显著提高。为了评价ptxD_(Q)/Phi系统对甘蓝型油菜杂草的防治效果,本研究获得了带有密码子优化的ptxD(Y139Q,ptxD_(Q))基因的转基因甘蓝型油菜。在以Phi为单一磷元素的条件下,ptxD_(Q)转基因油菜可以正常生长,体内Pi含量显著提高,且Pi饥饿响应基因(PT21和PT24等)的表达水平被显著抑制,说明ptxD_(Q)在油菜体内可以促使Phi转化为Pi。此外,ptxD_(Q)转基因油菜具有比野生型油菜和单子叶杂草(狗尾草)更强的生长竞争优势。综上所述,ptxD_(Q)/Phi是一种有效的油菜磷利用和杂草控制系统,既可以抑制杂草的生长,又可以为作物提供充足的Pi营养,从而提高了农业的可持续性。

关键词：甘蓝型油菜除草剂亚磷酸盐 ptxD_(Q)

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

mNGS检测关节假体周围感染病原菌的分析

中国城乡企业卫生 2024年第4期39卷 69-71页

作者：马纪志天津金匙医学检验实验室天津301700

目的探析宏基因组二代测序技术(mNGS)在假体周围感染(PJI)病原菌检测中的作用。方法选取2020年1月—2021年12月天津金匙医学检验实验室收治的行关节翻修手术患者200例,其中包括膝关节126例,髋关节74例,对患者关节液或滑膜组织标本中的... 详细信息

目的探析宏基因组二代测序技术(mNGS)在假体周围感染(PJI)病原菌检测中的作用。方法选取2020年1月—2021年12月天津金匙医学检验实验室收治的行关节翻修手术患者200例,其中包括膝关节126例,髋关节74例,对患者关节液或滑膜组织标本中的病原菌行常规细菌培养和mNGS检测,比较两种检测方式诊断阳性率,诊断效能(敏感度、特异度、阳性预测值、阴性预测值、诊断符合率)和检测时间差异性。结果mNGS检测阳性率高于常规细菌培养检测,差异有统计学意义(P<0.05)。mNGS诊断敏感度、阴性预测值、诊断符合率高于常规细菌培养,但特异度、阳性预测值比常规细菌培养检测低,差异均有统计学意义(P<0.05)。mNGS检测检出时间为(1.87±0.29)d,短于常规细菌培养检测检出的(5.17±0.59)d,差异有统计学意义(P<0.05)。结论mNGS检测能有效识别PJI患者病原菌,具有较高诊断敏感度和诊断符合率,且在检出时间有明确优势,在PJI中具有较高的诊断效率,能为PJI诊治提供有效的指导建议。

关键词：关节假体周围感染宏基因组二代测序技术病原菌