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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-Yu Ye Jun-ji ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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厚壳贻贝对重金属的生物积累及释放规律研究

台湾海峡 2009年第1期28卷 52-59页

作者：沈盎绿马继臻平仙隐沈新强中国水产科学研究院东海水产研究所、农业部海洋与河口渔业重点开放实验室上海200090 中国科学院海洋研究所山东青岛266071

应用实验生态方法研究了厚壳贻贝对8种常见的重金属生物积累和释放情况,得出了厚壳贻贝对重金属的生物富集系数、生物半衰期及生物富集曲线.结果表明:到积累实验结束时,厚壳贻贝对Pb、Zn、Cd、Cr、Ni、As和Hg的生物富集系数分别是45.01... 详细信息

应用实验生态方法研究了厚壳贻贝对8种常见的重金属生物积累和释放情况,得出了厚壳贻贝对重金属的生物富集系数、生物半衰期及生物富集曲线.结果表明:到积累实验结束时,厚壳贻贝对Pb、Zn、Cd、Cr、Ni、As和Hg的生物富集系数分别是45.01、79.65、71.67、15.21、7.91、2.45和44.65.以积累实验结束时的生物富集系数为基准,厚壳贻贝对这几种重金属的富集能力为Zn>Cd>Pb>Hg>Ni>Cr>As.到释放实验结束时,厚壳贻贝对Cu、Pb、Zn、Cd、Cr、Ni、As和Hg的生物半衰期分别是43.6、29.1、38.1、31.0、26.5、35.6、127.6、36.1d.以释放实验结束时的生物半衰期为基准,厚壳贻贝对这几种重金属的释放速度呈Cr>Pb>Cd>Hg>Ni>Zn>Cu>As,而且厚壳贻贝是Hg、Pb、Zn和Cd的净积累者.因此,厚壳贻贝是比较理想的重金属Hg、Pb、Zn和Cd污染的指示生物.

关键词：重金属生物富集系数生物半衰期生物富集曲线厚壳贻贝

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褶牡蛎对重金属的生物富集动力学特性研究

农业环境科学学报 2009年第4期28卷 783-788页

应用实验生态方法研究了褶牡蛎对8种常见的重金属生物富集动力学特性,得出了褶牡蛎对重金属的生物富集系数、生物半衰期以及生物富集曲线。结果表明,到积累实验结束时褶牡蛎对Pb、Zn、Cd、Cr、Ni和Hg的生物富集系数分别是15.60、26.53、... 详细信息

应用实验生态方法研究了褶牡蛎对8种常见的重金属生物富集动力学特性,得出了褶牡蛎对重金属的生物富集系数、生物半衰期以及生物富集曲线。结果表明,到积累实验结束时褶牡蛎对Pb、Zn、Cd、Cr、Ni和Hg的生物富集系数分别是15.60、26.53、60.06、7.61、5.82和47.88,褶牡蛎对Cu和As的富集规律不明显,生物富集曲线分别为yPb=0.4046e0.1168xR2=0.7378,yZn=0.0408x2+0.2909x+59.969R2=0.9307,yCd=2.5263e0.0867xR2=0.7089,yCr=0.6832e0.0942xR2=0.8544,yNi=0.4178e0.0714xR2=0.6856和yHg=0.0015x2+0.0444x+0.0644R2=0.8301,以积累实验结束时的生物富集系数为基准,褶牡蛎对这几种重金属的富集能力为Cd>Hg>Zn>Pb>Cr>Ni;到释放实验结束时褶牡蛎对Pb、Zn、Cd、Cr和Hg的生物半衰期分别是23.1、13031.7、67.7、32.9和36.1d,褶牡蛎是Zn、Cd和Hg的强的净积累者,以释放实验结束时的生物半衰期为基准,褶牡蛎对这几种重金属的排毒释放顺序为Pb>Cr>Hg>Cd>Zn。

关键词：褶牡蛎重金属生物富集系数生物半衰期生物富集曲线

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复合材料在风力发电上的应用发展

高科技纤维与应用 2005年第4期30卷 5-8,14页

作者：马振基林育锋清华大学化工系

成本是制约风力发电的瓶颈,要突破风电成本低于3美分/(kW.h)的目标,采用新材料及其制程是关键。从性能、成型工艺、价格等方面对可回收的低成本和环保型的热塑型树脂取代热固性树脂,以及碳纤维取代玻纤的必要性和可行性展开详细阐述。... 详细信息

成本是制约风力发电的瓶颈,要突破风电成本低于3美分/(kW.h)的目标,采用新材料及其制程是关键。从性能、成型工艺、价格等方面对可回收的低成本和环保型的热塑型树脂取代热固性树脂,以及碳纤维取代玻纤的必要性和可行性展开详细阐述。指出随着风电叶片的超大型化、轻量化及长寿化,选择碳纤维热塑性复合材料和技术是必然趋势。

关键词：风力发电风叶片热塑性树脂碳纤维

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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排水采气工艺技术的研究

内蒙古石油化工 2008年第11期34卷 103-105页

作者：李振银马继振廖作才克拉玛依职业技术学院

排水采气工艺技术是有水气田采气工艺的主要方法,已成为国内外气田开采后期的一项主要采气工艺措施。本文介绍了排水采气的概念及目前国内外的各种排水采气的方法原理。

关键词：排水采气采气工艺

Surface coating of electrocatalysts boosts battery performance

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Rare Metals 2020年第6期39卷 613-615页

作者： ji-zhen ma jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Bifunctional electrocatalyst is crucial to boost the performance of a zinc-air *** electrocatalysts beyond noble metals are highly desirable to lower the energy barriers for oxygen reduction and evolution reactions in... 详细信息

关键词： battery boost alkaline

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长江口及其邻近水域油污染分布特征及其评价

海洋渔业 2007年第3期29卷 251-256页

作者：马继臻袁骐蒋玫沈新强中国水产科学研究院东海水产研究所

根据2006年春夏季对长江口及其临近海域的海水和沉积物中的油污染物的监测结果,分析该海域表层水体和表层沉积物的油分布特征,采用单项指数法评估该海域的油污染程度。结果表明,调查水域表层水体中油含量分布范围为0.018-0.111 mg/L,平... 详细信息

根据2006年春夏季对长江口及其临近海域的海水和沉积物中的油污染物的监测结果,分析该海域表层水体和表层沉积物的油分布特征,采用单项指数法评估该海域的油污染程度。结果表明,调查水域表层水体中油含量分布范围为0.018-0.111 mg/L,平均含量为0.055 mg/L,其中春季平均含量为0.060 mg/L,夏季平均含量为0.050 mg/L。表层沉积物的油含量分布范围为（61.2-1062.4）×10^-6,平均含量为246.1×10^-6,其中春季平均含量为176.9×10^-6,夏季平均含量为272.8×10^-6。以《海水水质标准》Ⅱ类和《海洋沉积物质量》Ⅰ类标准计算,表层水体春夏季超标率分别为60.0%和35.0%,表层沉积物均未超标。无论是水体还是沉积物,均以长江口水域的污染最为严重。

关键词：长江口及其邻近水域油分布特征单项指数