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Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-jing Mo Xiao-Yuan Deng Ru-Lan ma Kun Zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

Adaptive learning-based optimal tracking control system design and analysis of a disturbed nonlinear hypersonic vehicle model

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Science China(Technological Sciences) 2024年第6期67卷 1893-1906页

作者： AN kai WANG ZhenGuo HUANG Wei Hypersonic Technology Laboratory National University of Defense TechnologyChangsha410073China

We propose an adaptive learning-based optimal control scheme for height-velocity control models considering model uncertainties and external disturbances of hypersonic winged-cone *** longitudinal nonlinear model is first established and transformed into the control-oriented error equations,and the control scheme is organized by a steady-compensation *** overcome and eliminate the impact of model uncertainties and external disturbances,an adaptive radial basis function neural network(RBFNN)is designed by a q-gradient *** the height-velocity error system with estimated uncertainties into account,the adaptive learning-based optimal tracking control(ALOTC)scheme is proposed by combining the critic-only adaptive dynamic programming(ADP)framework and parameter optimization of system settling ***,a novel weight update law is proposed to satisfy the online iteration requirements,and the algorithm convergence and closedloop stability are discussed by the Lyapunov ***,four simulation cases are provided to prove the effectiveness,accuracy,and robustness of the proposed scheme for the hypersonic longitudinal control system.

关键词： optimal tracking control adaptive dynamic programming RBFNN hypersonic vehicle

Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

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Nano Research 2024年第7期17卷 6342-6352页

作者： Xinyang Li Binbin Ding jing Li Di Han Hao Chen Jia Tan Qi Meng Pan Zheng Ping’an ma Jun Lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Chemodynamic therapy(CDT),an inventive approach to cancer treatment,exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species(ROS).While offering advantages over conventional treatments,the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione(GSH).In this study,we aim to address this dual challenge by delving into the role of copper valence states in *** the unique attributes of copper-based nanoparticles,especially zero-valent copper nanoparticles(CuPd NPs),we aim to enhance the therapeutic potential of *** experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles(Ox-CuPd NPs)by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like(POD-like)activity and Cu+***,zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts,thereby intensifying CDT and inducing ferroptosis,ultimately resulting in high-efficiency tumor growth *** findings reveal the impact of valences on CDT,providing novel insights for the optimization and design of CDT agents.

关键词： CuPd nanoparticle ferroptosis chemodynamic therapy valance tailoring tumor therapy

LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： LING ma ZIRUI JIANG XIAO HOU YUTING XU ZIYUN CHEN SIYI ZHANG HANXUE LI SHAOJIE ma GENG ZHANG XIUJUN WANG jing JI Jiangsu Key Laboratory of marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in human cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment *** one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast *** this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast ***:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** cloning and migration abilities were determined by colony formation assay and wound healing *** invasion abilities and adhesion were determined by cell invasion assay and cell adhesion *** impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F *** in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)***:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle ***,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and *** results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor ***:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast *** findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

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World Journal of Psychiatry 2024年第3期14卷 445-455页

作者： Qun-Shan Lu Lin ma Wen-jing Jiang Xing-Bang Wang Mei Lu Department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and ***7 is a histone acetyltransferase that participates in the modulation of various *** To determine the effects of KAT7 on insulin patients with *** APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes,*** in vitro model of AD was established by Aβ*** resistance was induced by chronic stimulation with high insulin *** expression of microtubule-associated protein 2(maP2)was assessed using *** protein levels of maP2,Aβ,dual-specificity tyrosine phosphorylation-regulated kinase-1A(DYRK1A),IRS-1,p-AKT,total AKT,p-GSK3β,total GSK3β,DYRK1A,and KAT7 were measured via western *** of reactive oxygen species(ROS),malondialdehyde(MDA),and SOD activity was measured to determine cellular oxidative *** cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation,*** RNA levels of KAT7 and DYRK1A were examined using quantitative PCR.A chromatin immunoprecipitation assay was conducted to detect H3K14ac in *** KAT7 expression was suppressed in the AD *** of KAT7 decreased Aβaccumulation and maP2 expression in AD ***7 overexpression decreased ROS and MDA levels,elevated SOD activity in brain tissues and neurons,and simultaneously suppressed neuronal ***7 upregulated levels of p-AKT and p-GSK3βto alleviate insulin resistance,along with elevated expression of ***7 depletion suppressed DYRK1A expression and impaired H3K14ac of ***1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 *** We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylati

关键词： Alzheimer's disease Diabetes Insulin resistance KAT7 Dual-specificity tyrosine phosphorylation-regulated kinase-1A HMGN1

Diversification of interfaces triggered hydrogen storage properties enhancement

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Rare Metals 2024年第5期43卷 2324-2330页

作者： Jia-Xin Zhang Xin Ding Rui-Run Chen Xiang-Feng ma Wen-Chao Cao Yong Zhang jing-Jie Guo National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Dual effects of grain refinement and alloying are achieved and the mechanism of"diverse interfaces reinforcement"for hydrogen storage Mg alloys is first *** interface reinforced Mg-Y-Zn-Al alloy for hydrogen storage is *** work figures out that the adventurous Al-rich phase exhibits an ordered face-centered cubic(FCC)structure with composition of(31±2)at%Y-(28±1)at%Zn-(41±3)at%Al,i.e.,Y_(3)Zn_(3)Al_(4),and an incoherent interface between Y3Zn3Al4phase and Mg substrate is observed.

关键词： hydrogen alloying alloy

Dendritic mesoporous silica nanoparticles for enzyme immobilization

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Green Chemical Engineering 2024年第2期5卷 173-186页

作者： Shuling Zhang jing Bai Weixi Kong Haolei Song Yunting Liu Guanhua Liu Li ma Liya Zhou Yanjun Jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China College of Food Science and Biology Hebei University of Science&TechnologyShijiazhuang050018China Hebei Yanuo Bioscience Co. Ltd.Shijiazhuang052165China

Dendritic mesoporous silica nanoparticles(DMSNs)are a new class of solid porous materials used for enzyme immobilization support due to their intrinsic characteristics,including their unique open central-radial structures with large pore channels and their excellent *** this review,we review the recent progress in research on enzyme immobilization using DMSNs with different structures,namely,flower-like DMSNs and tree-branch-like *** DMSN synthesis methods are briefly compared,and the distinct characteristics of the two DMSN types and their effects on the catalytic performance of immobilized enzymes are comprehensively *** directions for future research on enzyme immobilization using DMSNs are also proposed.

关键词： Dendritic mesoporous silica nanoparticles Enzyme immobilization Flower-like Tree-branch-like Central-radial structure

Zircon U-Pb ages in the Nuratau ophiolitic mélange in the southern Tianshan,Uzbekistan:Implication for the closure of Paleo-Asian Ocean

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China Geology 2024年第2期7卷 365-368,I0004-I0007页

作者： kai Weng Ji-fei Cao Divayev-Farid Karibovich Jahongir-Jurabekovich Movlanov Bo Chen Zhong-ping ma Xi’an Center of Geological Survey China Geological SurveyXi’an 710119China The Center for Geoinnovation Technologies Doctor of Sciences in Geology and Mineralogy University of Geological ScienceTashkent 100060Uzbekistan

*** The Central Asian Orogenic Belt(CAOB),which is located between the European craton,Siberian craton,and Tarim-North China craton(Fig.1a),is the largest phanerozoic accretionary orogen in the *** resulted from the longterm subduction and accretion of the Paleo-Asian Ocean(PAO).The PAO has been in existence since at least the late Mesoproterozoic(about 1020 ma).However,there has been debate about the closing time of the PAO.

关键词： Asian Paleo Tianshan

Optical modification of nonlinear crystals for quasi-parametric chirped-pulse amplification

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Fundamental Research 2024年第1期4卷 43-50页

作者： Qian Lin jingui ma Zhe Yin Peng Yuan jing Wang Guoqiang Xie Liejia Qian Key Laboratory for Laser Plasmas(MOE) Collaborative Innovation Center of IFSASchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

Quasi-parametric chirped-pulse amplification(QPCPA),which features a theoretical peak power much higher than those obtained with Ti:sapphire laser or optical parametric chirped-pulse amplification,is promising for future ultra-intense *** doped rare-earth ion used for idler dissipation is critical for effective QPCPA,but is usually not compatible with traditional *** far,only one dissipative crystal of Sm^(3+)-doped yttrium calcium oxyborate has been grown and *** we introduce optical means to modify traditional crystals for QPCPA *** theoretically demonstrate two dissipation schemes by idler frequency doubling and sum-frequency generation with an additional *** contrast to absorption dissipation,the proposed nonlinear dissipations ensure not only high signal efficiency but also high small-signal *** demonstrated ability to optically modify crystals will facilitate the wide application of QPCPA.

关键词： Quasi-parametric amplifier Second-harmonic generation Sum-frequency generation Back conversion Idler dissipation