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宋代赦免制度的实施及影响探析

西部学刊 2024年第4期 128-134页

作者：马列河北师范大学历史文化学院石家庄050024

赦免制度是中国古代司法制度的重要组成部分,深刻影响着封建社会的方方面面。至宋代,赦免制度进一步发展,主要包括大赦、曲赦、德音、录囚四种形式,而大赦作为赦免制度的核心,是其中最有影响力的部分。一方面,赦免作为一种司法特权,破... 详细信息

赦免制度是中国古代司法制度的重要组成部分,深刻影响着封建社会的方方面面。至宋代,赦免制度进一步发展,主要包括大赦、曲赦、德音、录囚四种形式,而大赦作为赦免制度的核心,是其中最有影响力的部分。一方面,赦免作为一种司法特权,破坏了吏治和法治的秩序与公平;另一方面,赦免制度在一定程度上缓解了阶级矛盾,巩固了封建统治的稳定。

关键词：赦免制度大赦司法特权阶级矛盾

TREVO支架取栓联合rt-PA溶栓治疗缺血性脑卒中的临床效果观察

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实用中西医结合临床 2024年第20期24卷 97-100页

作者：江天丽马烈广东省东莞康华医院东莞523080

目的观察TREVO支架取栓联合重组组织型纤溶酶原激活剂(rt-PA)溶栓治疗缺血性脑卒中(CIS)的临床效果。方法按照治疗方案不同将2020年6月至2023年10月于医院治疗的60例CIS患者分为对照组和观察组,各30例。对照组采用注射用阿替普酶溶栓治... 详细信息

目的观察TREVO支架取栓联合重组组织型纤溶酶原激活剂(rt-PA)溶栓治疗缺血性脑卒中(CIS)的临床效果。方法按照治疗方案不同将2020年6月至2023年10月于医院治疗的60例CIS患者分为对照组和观察组,各30例。对照组采用注射用阿替普酶溶栓治疗,观察组于对照组基础上加用TREVO支架取栓治疗。比较两组血管再通情况、神经功能、认知功能、预后、脑血流动力学指标、血清学指标和并发症发生情况。结果观察组血管再通改良脑梗死溶栓分级(mTICI)优于对照组(P<0.05);观察组治疗后神经功能缺损程度评分、预后评分低于对照组,认知功能评分高于对照组(P<0.05);观察组治疗后脑血流量(CBF)高于对照组,达峰时间(TTP)和平均通过时间(MTT)短于对照组(P<0.05);观察组治疗后神经元特异性烯醇化酶(NSE)、S100β蛋白和谷氨酸(Glu)水平均低于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05)。结论TREVO支架取栓联合rt-PA溶栓治疗缺血性脑卒中可有效提高血管再通率,改善脑血流,降低NSE、S100β和Glu水平,减轻神经功能缺损程度,改善患者认知功能与预后,减少并发症的发生。

关键词：缺血性脑卒中 TREVO支架重组组织型纤溶酶原激活剂脑血流量预后

基于MPLC提高卡塞格林天线传输效率的方法

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激光与光电子学进展 2024年第13期61卷 224-231页

作者：阮铖高世杰马烈王晞名于溪畅张国强中国科学院长春光学精密机械与物理研究所吉林长春130031 中国科学院大学北京100049

卡塞格林天线作为重要的光学天线,广泛应用于空间激光通信中,但卡塞格林天线不可避免的次镜遮挡问题严重影响了传输效率。为了消除次镜遮挡所带来的不利影响,提出一种基于多平面光转换(MPLC)技术提高卡塞格林天线传输效率的方法,利用MPL... 详细信息

卡塞格林天线作为重要的光学天线,广泛应用于空间激光通信中,但卡塞格林天线不可避免的次镜遮挡问题严重影响了传输效率。为了消除次镜遮挡所带来的不利影响,提出一种基于多平面光转换(MPLC)技术提高卡塞格林天线传输效率的方法,利用MPLC将通信高斯光转换为与卡塞格林天线遮拦比相匹配的双高斯环形光,使出射光充满卡塞格林天线有效范围的同时避开次镜遮挡。所提方法适用于任意遮拦比的卡塞格林天线,均可以大幅提升传输效率,降低了通信难度,对于远距离传输的空间激光通信研究具有一定意义。

关键词：卡塞格林天线激光通信传输效率多平面光转换

干旱胁迫下丛枝菌根真菌对月季生理指标的影响

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分子植物育种 2024年第16期22卷 5415-5423页

作者：于明华郑婷马烈田静徐峻育汪成忠苏州市园艺站苏州215128 太仓市农业农村科技服务中心太仓215400 苏州华创欣美生物种业科技有限公司苏州215300 苏州花语吴娘园艺专业合作社苏州215100 苏州农业职业技术学院苏州215008

为探讨接种丛枝菌根真菌(AMF)后月季对干旱胁迫的耐受性机制,采用盆栽试验研究了丛枝菌根真菌对干旱胁迫下月季品种抗氧化酶活性和光合特性的影响。结果表明:3个月季品种在正常浇水情况下接种Ri的菌根侵染率达到47%以上,在干旱胁迫下为... 详细信息

为探讨接种丛枝菌根真菌(AMF)后月季对干旱胁迫的耐受性机制,采用盆栽试验研究了丛枝菌根真菌对干旱胁迫下月季品种抗氧化酶活性和光合特性的影响。结果表明:3个月季品种在正常浇水情况下接种Ri的菌根侵染率达到47%以上,在干旱胁迫下为20%左右;干旱胁迫抑制了菌根的形成,但接种AMF组叶片厚度和比叶质量、可溶性蛋白含量、SOD含量、CAT含量较干旱胁迫组有显著提高,MDA含量较干旱胁迫组显著降低。表明接种AMF使月季抗氧化潜在能力得到提升;干旱胁迫下,显著降低了3个月季品种的光合能力,接种AMF后均能有效提升3个月季品种的LSP、P_(max)值,并和未接种处理达到显著差异。接种AMF能够促进3个月季品种维持抗氧化系统的稳定性,调节渗透平衡,提升光合作用能力,有效缓解干旱胁迫对3个月季品种生长的不良影响。

关键词：从枝菌根真菌干旱胁迫抗氧化酶光合特性月季品种

Development of data-driven thermal sensation prediction model using quality-controlled databases

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Building Simulation 2022年第12期15卷 2111-2125页

作者： Xiang Zhou Ling Xu Jingsi Zhang lie ma Mingzheng Zhang maohui Luo School of Mechanical Engineering Tongji UniversityShanghai200092China Guangdong Midea Air-Conditioning Equipment Co. LTDGuangdong 528311China

Predicting the thermal sensations of building occupants is challenging,but useful for indoor environment *** this study,a data-driven thermal sensation prediction model was developed using three quality-controlled thermal comfort *** machine-learning algorithms were compared in terms of prediction accuracy and *** model was further improved by adding categorical inputs,and building submodels and general models for different contexts.A comprehensive data-driven thermal sensation prediction model was *** results indicate that the multilayer perceptron(MLP)algorithm achieves higher prediction accuracy and more rational results than the other four algorithms in this specific *** AC and NV scenarios,climate zones,and cooling and heating seasons can improve model *** submodels for specific scenarios can result in better thermal sensation vote(TSV)predictions than using general models with or without *** 11 submodels corresponding to 11 scenarios,and three general models without labels,the final TSV prediction model achieved higher prediction accuracy,with 64.7%–90.7%fewer prediction errors(reducing SSE by 3.2–4.9)than the predicted mean vote(PMV).Possible applications of the new model are *** findings of this study can help in development of simple,accurate,and rational thermal sensation prediction tools.

关键词： thermal comfort machine learning adaptive thermal comfort multilayer perceptron

降钙素原与C-反应蛋白/血清白蛋白比值对结直肠癌术后患者吻合口漏的预测

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临床与病理杂志 2024年第2期44卷 307-312页

作者：贾天航周善一马列黄河山西医科大学第一临床医学院太原030001 山西医科大学附属第一医院胃肠外科太原030001

结直肠癌是消化道中较为常见的恶性肿瘤,其目前多采用手术切除的方式进行治疗,术后吻合口漏(anastomotic leakage,AL)是外科手术常见感染性并发症。术后发生AL会影响患者预期化学治疗时间,增加患者经济负担及二次手术可能,延长住院时长... 详细信息

结直肠癌是消化道中较为常见的恶性肿瘤,其目前多采用手术切除的方式进行治疗,术后吻合口漏(anastomotic leakage,AL)是外科手术常见感染性并发症。术后发生AL会影响患者预期化学治疗时间,增加患者经济负担及二次手术可能,延长住院时长,加剧医患矛盾等。炎症指标可用于AL的早期预测,便于临床科室给予治疗方案。降钙素原(procalcitonin,PCT)是具有广泛生物学活性的多效性蛋白质,在结直肠癌术后AL的预测或排除中有重要作用,C-反应蛋白/血清白蛋白比值(C-reactive protein/serum albumin ratio,CAR)是反映全身炎症、免疫水平和营养状态的重要指标。二者均在早期对AL的预测有效,二者的联合应用可能存在更大的预测价值。

关键词：结直肠癌吻合口漏降钙素原 C-反应蛋白/血清白蛋白比值

In situ assembly of fibrinogen/hyaluronic acid hydrogel via knob-hole interaction for 3D cellular engineering

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Bioactive materials 2017年第4期2卷 253-259页

作者： Shengjie Huang Chunfen Wang Jingwei Xu lie ma Changyou Gao MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Hyaluronic acid(HA)-based hydrogels have applied widely for biomedical applications due to its biocompatibility and ***,the use of initiators or crosslinkers during the hydrogel formation may cause cytotoxicity and thereby impair the *** by the crosslinking mechanism of fibrin gel,a novel HA-based hydrogel was developed via the in situ supramolecular assembly based on knob-hole interactions between fibrinogen and knob-grafted HA(knob-g-HA)in this *** knob-grafted HA was synthesized by coupling knob peptides(GPRPAAC,a mimic peptide of fibrin knob A)to HA via Michael *** the translucent fibrinogen/knob-g-HA hydrogels were prepared by simply mixing the solutions of knob-g-HA and fibrinogen at the knob/hole ratio of *** rheological behaviors of the fibrinogen/knob-g-HA hydrogels with the fibrinogen concentrations of 50,100 and 200 mg/mL were evaluated,and it was found that the dynamic storage moduli(G0)were higher than the loss moduli(G00)over the whole frequency range for all the *** SEM results showed that fibrinogen/knob-g-HA hydrogels presented the heterogeneous mesh-like structures which were different from the honeycomb-like structures of fibrinogen/ma-HA ***,a higher swelling ratio was obtained in the groups of fibrinogen/knob-g-HA ***,the cytocompatibility of fibrinogen/knob-g-HA hydrogels was proved by live/dead stainings and MTT assays in the 293T cells encapsulation *** these results highlight the biological potential of the fibrinogen/knob-g-HA hydrogels for 3D cellular engineering.

关键词： Fibrinogen Knob-hole interactions Hyaluronic acid In situ assembly Cell encapsulation

Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes

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Bioactive materials 2021年第11期6卷 4065-4072页

作者： Yilun Luo Xiaowen Zheng Peiqi Yuan Xingyao Ye lie ma MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Due to the critical roles of macrophage in immune response and tissue repair,harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many *** there have developed many advanced platforms with dynamic features for cell manipulation,few studies have designed a dynamic chemical pattern to sequentially polarize macrophage phenotypes and meet the immune requirements at various tissue repair ***,we propose a novel strategy for spatiotemporal manipulation of macrophage phenotypes by a UV-induced dynamic Arg-Gly-Asp(RGD)*** employing a photo-patterning technique and the specific interaction between cyclodextrin(CD)and azobenzene-RGD(Azo-RGD),we prepared a polyethylene glycol-dithiol/polyethylene glycol-norbornene(PEG-SH/PEG-Nor)hydrogel with dynamic RGD-patterned *** irradiation with 365-nm UV light,the homogeneous RGD surface was transformed to the RGD-patterned surface which induced morphological transformation of macrophages from round to elongated and subsequent phenotypic transition from pro-inflammation to *** mechanism of phenotypic polarization induced by RGD pattern was proved to be related to Rho-associated protein kinase 2(ROCK2).Sequential modulation of macrophage phenotypes by the dynamic RGD-patterned surface provides a remote and non-invasive strategy to manipulate immune reactions and achieve optimized healing outcomes.

关键词： Light-responsive Dynamic RGD pattern macrophage phenotype Immune response Tissue repair

Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis

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Bioactive materials 2020年第3期5卷 667-679页

作者： Dong Lou Yu Luo Qian Pang Wei-Qiang Tan lie ma MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016PR China

Diabetic chronic wound,characterized by prolonged inflammation and impaired angiogenesis,has become one of the most serious challenges in clinic and pose a significant healthcare burden *** a great variety of wound dressings have been developed,few of encouraged achievements were obtained so *** this study,the gene-activated strategy was applied to enhance sustained expression of vascular endothelial growth factor(VEGF)and achieve better healing outcomes by regulating inflammation and promoting *** gene-activated bilayer dermal equivalents(Ga-BDEs),which has good biocompatibility,were fabricated by loading the nano-sized complexes of Lipofectamine 2000/plasmid DNA-encoding VEGF into a collagen-chitosan scaffold/silicone membrane bilayer dermal *** DNA complexes were released in a sustained manner and showed the effective transfection capacities to up-regulate the expression of VEGF in *** overcome cutaneous contraction of rodents and mimic the wound healing mechanisms of the human,a reformative rat model of full-thickness diabetic chronic wound was *** the treatment of Ga-BDEs,speeding wound healing was observed,which is accompanied by the accelerated infiltration and phenotype shift of macrophages and enhanced angiogenesis in early and late healing phases,*** proved that Ga-BDEs possess the functions of immunomodulation and pro-angiogenesis ***,the better regeneration outcomes,including deposition of oriented collagen and fast reepithelialization,were *** these results indicated that,being different from traditional pro-angiogenic concept,the up-regulated expression of VEGF by Ga-BDEs in a sustained manner shows versatile potentials for promoting the healing of diabetic chronic wounds.

关键词： Gene-activated dermal equivalent Vascular endothelial growth factor Inflammation Angiogenesis Diabetic chronic wounds