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墨西哥中部流域农地生产力恢复的研究

水土保持科技情报 2001年第1期19卷 1-3页

作者： MTiscareńo-López A.DBez-Gonzlez mvelzquez-valle K.N.Potter J.J.Stone MTapia-Vargas R.Clavera-Alonso 阴云康谢小丽杨国蓉湖南省岳阳市云溪区水利局

墨西哥 6 0 %以上的水土资源处于严重退化状态 ,为探求墨西哥中部陡坡上的农用土地的最佳管理措施 ,进行农地生产力恢复的研究。在坡度为 8%的坡地上实行作物残茬覆盖和采用免耕与传统耕作方式相比 ,可减少土壤流失 80 % ,径流 76 %。... 详细信息

墨西哥 6 0 %以上的水土资源处于严重退化状态 ,为探求墨西哥中部陡坡上的农用土地的最佳管理措施 ,进行农地生产力恢复的研究。在坡度为 8%的坡地上实行作物残茬覆盖和采用免耕与传统耕作方式相比 ,可减少土壤流失 80 % ,径流 76 %。降雨模拟试验表明 ,采用免耕水分入渗能力几乎增加了 30 % ,水分入渗能力和深水渗透的增强表明当地湖泊水文特征和耕作区土壤湿度有明显改善。利用水文基本模拟和卫星图像以及地理信息系统 ,将试验点数据向全流域推广应用。

关键词：保护耕作侵蚀陡坡农业模拟径流土壤侵蚀墨西哥中部流域

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá Heather Hampel Laura valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

Reduction Discoloration of Reactive Dyed Cotton Waste and Chemical Recycling via Ionic Liquid

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Journal of Renewable Materials 2024年第9期12卷 1557-1571页

作者： Aline Ferreira Knihs Larissa Klen Aragão Miguel Angelo Granato Andrea Cristiane Krause Bierhalz Rita de Cassia Siqueira Curto valle Department of Textile Engineering Federal University of Santa CatarinaBlumenau89036-256Brazil

The textile industry generates large volumes of waste throughout its production *** of this waste is colored,therefore,discoloration is an important step toward recycling and reusing this *** study focused on the chemical reductive discoloration of textile waste composed of cotton dyed with reactive *** experimental design demonstrated the significant influence of the concentration of reducing agent and time of reaction on the degree of whiteness of the cotton *** concentration of the alkaline agent was not significant in the *** optimization of the reaction conditions lead to Berger degree of 50.5±*** discolored cotton was chemically recycled through dissolution in ionic liquid 1-ethyl-3-methylimidazolium chloride and regeneration in film form in *** microstructure of the regenerated cellulose films was evaluated by Scanning Electron Microscopy(SEM)indicating complete dissolution and uniform *** discoloration process reduced the polymerization degree and crystallinity index of the cotton fibers but retained the cellulose I *** dissolution and cellulose regeneration process results in transparent films with an amorphous *** thermal behavior,evaluated by thermogravimetric analysis,indicated that residues and regenerated film presented a main decomposition *** maximum decomposition rate temperature of the regenerated films was approximately 40℃lower than the cotton fibers,which correlates well with the reduction in polymerization degree and amorphous *** general,the study demonstrated that textile cotton waste dyed with reactive dyes can be chemically discolored to form transparent and amorphous films,contributing to the development of sustainable strategies for the textile industry.

关键词： Reactive dyed cotton waste reactive discoloration ionic liquid dissolution and regeneration recycling and reusing

Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-López Iva Tic David valle-García Marta Ribalta-Vilella Luis Labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

Genetic predisposition to colorectal cancer:Where we stand and future perspectives

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World Journal of Gastroenterology 2014年第29期20卷 9828-9849页

作者： Laura valle Hereditary Cancer Program Catalan Institute of OncologyIDIBELL08908 BarcelonaSpain

The development of colorectal cancer(CRC)can be influenced by genetic factors in both familial cases and sporadic *** CRC has been associated with genetic changes in high-,moderate-and low-penetrance susceptibility ***,despite the availability of current gene-identification techniques,the genetic causes of a considerable proportion of hereditary cases remain ***-wide association studies of CRC have identified a number of common lowpenetrance alleles associated with a slightly increased or decreased risk of *** accumulation of low-risk variants may partly explain the familial risk of CRC,and some of these variants may modify the risk of cancer in patients with mutations in high-penetrance *** the predisposition to develop CRC will require investigators to address the following challenges:the identification of genes that cause uncharacterized hereditary cases of CRC such as familial CRC type X and serrated polyposis;the classification of variants of unknown significance in known CRC-predisposing genes;and the identification of additional cancer risk modifiers that can be used to perform risk assessments for individual mutation *** performed a comprehensive review of the genetically characterized and uncharacterized hereditary CRC syndromes and of lowand moderate-penetrance loci and variants identified through genome-wide association studies and candidate-gene *** challenges and future perspectives in the field of CRC predisposition are also discussed.

关键词： Hereditary colorectal cancer Familial colorectal cancer High penetrance Low penetrance Cancer syndromes Cancer susceptibility Hereditary cancer genes Risk variants Heritability

Debate about TGFBR1 and the susceptibility to colorectal cancer

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World Journal of Gastrointestinal Oncology 2012年第1期4卷 1-8页

作者： Laura valle Hereditary Cancer Program Catalan Institute of Oncology IDIBELL 08908 Hospitalet de Llobregat Spain

Recent years have witnessed enormous progress in our understanding of the genetic predisposition to colorectal cancer (CRC). Estimates suggest that all or most genetic susceptibility mechanisms proposed so far, ranging from high-penetrance genes to low-risk alleles, account for about 60% of the population-attributable fraction of CRC predisposition. In this context, there is increasing interest in the gene encoding the transforming growth factor β receptor 1 (TGFBR1 ); first when over a decade ago a common polymorphism in exon 1 (rs11466445, TGFBR1 *6A/9A) was suggested to be a risk allele for CRC, then when linkage studies identified the chromosomal region where the gene is located as susceptibility locus for familial CRC, and more recently when the allele-specific expression (ASE) of the gene was proposed as a risk factor for CRC. Published data on the association of TGFBR1 with CRC, regarding polymorphisms and ASE and including sporadic and familial forms of the disease, are often contradictory. This review gives a general overview of the most relevant studies in order to clarify the role of TGFBR1 in the field of CRC genetic susceptibility.

关键词： Transforming growth factor β receptor 1 Transforming growth factor β receptor 1*6A 9q linkage peak Allele-specific expression Colorectal cancer risk

An Efficient Representation of Quadtrees and Bintrees for Multiresolution Terrain Models

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Geo-Spatial Information Science 2011年第3期14卷 198-206页

作者： Yusnier valle José Ortiz Center of Geoinformatics and Digital Signals University of Informatics Sciences Dean of the Faculty 1 University of Informatics Sciences

A space-filling curve in 2,3,or higher dimensions can be thought as a path of a continuously moving *** its main goal is to preserve spatial proximity,this type of curves has been widely used in the design and implementation of spatial data structures and nearest neighbor-finding *** paper is essentially focused on the efficient representation of Digital Ele-vation Models(DEM) that entirely fit into the main *** propose a new hierarchical quadtree-like data structure to be built over domains of unrestricted size,and a representation of a quadtree and a binary triangles tree by means of the Hilbert and the Sierpinski space-filling curves,respectively,taking into account the hierarchical nature and the clustering properties of this kind of *** triangulation schemes are described for the space-filling-curves-based approaches to efficiently visualize multiresolu-tion surfaces.

关键词： bintrees quadtrees space-filling curves spatial data structures digital terrain models

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布拉德伯里工作坊综合体

世界建筑导报 2024年第2期39卷 126-128,F0003页

作者： Maegan Icke Elena Gruber Roxani Tseranidou Margherita Zompa Carolina Borgatti Ezmira Peraj Ainhoa valle French+Tye(摄影) 不详

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该... 详细信息

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该地区以社区为中心、最独特的公共空间,代表了该建筑类型发展历程的未来。

关键词：工作坊扩建部分公共空间综合体发展历程

3D Modal Solution for Tidally Induced Lagrangian Residual Velocity with Variations in Eddy Viscosity and Bathymetry in a Narrow Model Bay

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Journal of Ocean University of China 2019年第1期18卷 69-79页

作者： DENG Fangjing JIANG Wensheng valle-LEVINSON Arnoldo FENG Shizuo Physical Oceanography Laboratory/CIMST Ocean University of China and Qingdao National Laboratory for Marine Science and Technology Laboratory of Marine Environment and Ecology Ocean University of China Department of Civil and Coastal Engineering University of Florida

In this study, we examine the results obtained by the Finite-volume Coastal Ocean Circulation Model(FVCOM) regarding the effects of eddy viscosity and bathymetry on the three-dimensional(3 D) Lagrangian residual velocity(LRV) in a narrow bay. The results are cast in terms of two nondimensional numbers: the ratio of friction to local acceleration(δ) and the ratio of the minimum depth over shoals to the maximum depth in the channel(ε). The ratio δ depends on the eddy viscosity and mean depth. For a given eddy viscosity, when ε > 0.5, the along-estuary LRV tends to be vertically sheared and when ε < 0.5, the exchange is laterally sheared. When ε << 1, the structure of the 3 D, depth-integrated, and breadth-averaged LRV changes only slightly as δ increases. For ε values between 0.33 and 0.5, the structure of the 3 D LRV is mainly laterally sheared. In the same ε range, the 3 D and depth-integrated LRV exhibit reversed structures from high to low δ values. In addition, the breadth-averaged LRV weakens the typical twolayered circulation when δ decreases. When ε is 1, the two-layered vertical structure reverses direction, and a three-layered vertical structure develops in the outer bay as δ decreases.

关键词： eddy viscosity bathymetric effects Lagrangian residual velocity 3D narrow bay