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Remote Detection of Varying Water Storage in Relation to Surfacial Temperature of Aral Sea

Chinese Geographical Science 2019年第5期29卷 741-755页

作者： mu guangyi CHEN Li HU Liangjun SONG Kaishan Key Laboratory for Vegetation Ecology Science Ministry of EducationNortheast Normal UniversityChangchun130024China Jilin Provincial museum of Nature Northeast Normal UniversityChangchun130117China Northeast Institute of Geography andAgroecology Chinese Academy of SciencesChangchun130102China

Lake monitoring by remote sensing is of significant importance to understanding the lake and ambient ecological and environmental processes. In particular, whether lake water storage variation could predict lake surfacial temperature or vice versa has long fascinated the research community, in that it would greatly benefit the monitoring missions and scientific interpretation of the lake change processes. This study attempted to remotely detect the dynamics of the Aral Sea and pursue the relationships between varying lake water storage attributes and surface water temperature by using MODIS LST(Moderate-resolution Imaging Spectroradiometer Land Surface Temperature) 8-day composite products, satellite altimeter data, and actual meteorological measurements. Their associations with lake Surface Water Temperatures(SWT) were then analyzed. Results showed the lake water surface areas and elevations of the North Aral Sea tended to increasing trend from 2001(2793.0 km^2, 13.6 m) to 2015(6997.8 km^2, 15.9 m), while those of the South Aral Sea showed a decreasing trend during 2001(20 434.6 km^2, 3.9 m) and 2015(3256.1 km^2, 0.9 m). In addition, the annual daytime and nighttime lake SWT both decreased in the North Aral Sea, while only the daytime SWT in the South Aral Sea exhibited an increase, indicating a rising deviation of diurnal temperatures in the South Aral Sea during the past 15 yr. Moreover, a lower correlation was found between variations in the daytime SWT and storage capacity in the South Aral Sea(R^2 = 0.33;P < 0.05), no fair correlations were tested between lake water storage and daytime SWT in the North Aral Sea nor between lake water storage and nighttime SWT in either part of the sea. These results implied that climate change, if any at least during the research period, has no significant effects on lake dynamics over the two sectors of the Aral Sea with anthropogenic disturbances. However, climate change and human activities may overlap to explain complex co

关键词： Surface Water Temperature(SWT) lake water surface dynamics lake water storage Moderate-resolution Imaging Spectroradiometer(MODIS) the Aral Sea

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促进贵州赤水竹浆林基地可持续发展的建议

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世界竹藤通讯 2011年第1期9卷 29-31页

作者：方洪刚李继伟牟光仪贵州赤天化纸业股份有限公司竹科所贵州赤水564700

针对黔北20万t/年竹浆林纸一体化工程项目对竹原料的巨大需求,结合当前赤水项目区、周边及赤天化纸业公司竹林基地建设情况,剖析了影响和制约竹林基地可持续健康发展的突出问题,提出了调整竹种结构,培育竹林资源,实现生物多样性,促进竹... 详细信息

针对黔北20万t/年竹浆林纸一体化工程项目对竹原料的巨大需求,结合当前赤水项目区、周边及赤天化纸业公司竹林基地建设情况,剖析了影响和制约竹林基地可持续健康发展的突出问题,提出了调整竹种结构,培育竹林资源,实现生物多样性,促进竹林基地丰产稳产和可持续健康发展的具体对策及措施。

关键词：竹种结构生物多样性丰产稳产可持续发展

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兴凯湖春季水体悬浮颗粒物和CDOM吸收特性

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湖泊科学 2015年第5期27卷 941-952页

作者：李思佳宋开山陈智文赵莹邵田田穆光熠关莹吉林师范大学生态环境研究所四平136000 中国科学院东北地理与农业生态研究所长春130102 东北师范大学生命科学学院长春130000

为了分析兴凯湖水体光学活性物质的吸收特性、来源和空间分布以及对400~700 nm范围内总吸收的贡献,于2013年5月对该水体进行野外实验,对水体中浮游藻类、非藻类颗粒物和有色可溶性有机物的吸收特性和水质参数进行测定.结果表明：总悬浮... 详细信息

为了分析兴凯湖水体光学活性物质的吸收特性、来源和空间分布以及对400~700 nm范围内总吸收的贡献,于2013年5月对该水体进行野外实验,对水体中浮游藻类、非藻类颗粒物和有色可溶性有机物的吸收特性和水质参数进行测定.结果表明：总悬浮颗粒物的吸收光谱与非藻类颗粒物相似,色素颗粒物含量较少且单一,非藻类颗粒物在总悬浮颗粒物吸收中占主导地位,其贡献率始终在50%以上.CDOM吸收曲线的拟合函数斜率值Sg均高于其它水体.440 nm处总悬浮颗粒物和非藻类颗粒物的吸收系数ap（440）、ad（440）与总悬浮颗粒物、无机悬浮颗粒物和有机悬浮颗粒物浓度相关性均较好,与叶绿素a（Chl.a）浓度的相关性较差.兴凯湖与其它Ⅱ类水体的差异性表现在440 nm处CDOM吸收系数ag（440）与Chl.a浓度、溶解性有机碳（DOC）浓度均无显著相关性,说明DOC以无色部分为主.总体上,大兴凯湖各吸收系数和水质参数均值均低于小兴凯湖,后者水质受农耕区退水及周围渔业、旅游业的影响较大.

关键词：兴凯湖吸收光谱有色可溶性有机物非藻类颗粒物浮游植物

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基于指标分级的东北某城市污水处理厂耗电量与进水关系分析

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环境工程 2023年第S1期41卷 190-195,200页

作者：汪雪格俞双董艳红穆光熠曲红边德军长春工程学院水利与环境工程学院长春130012 中国市政工程东北设计研究总院有限公司长春130021

电耗是污水处理厂能源消耗中最大的部分,对于已建污水处理厂,进水水量、水质是能耗的关键影响因素。以东北某城市污水处理厂2018~2020年日均进水水量、水质指标与耗电量等实测数据为研究对象,提出并划分了进水量、进水COD和进水氨氮等... 详细信息

电耗是污水处理厂能源消耗中最大的部分,对于已建污水处理厂,进水水量、水质是能耗的关键影响因素。以东北某城市污水处理厂2018~2020年日均进水水量、水质指标与耗电量等实测数据为研究对象,提出并划分了进水量、进水COD和进水氨氮等级等进水指标。经统计分析得出:1)D污水处理厂进水量、进水COD、进水NH_(3)-N变化范围较大,但均在特定等级下存在最高出现频率;单位水量耗电量和削减单位COD耗电量变化范围也较大,但是也存在主导的耗电量水平;同时进水量、进水水质及耗电量水平随月份变化也较大。2)单位水量耗电量随进水量等级的提高呈降低趋势,而单位水量耗电量随进水COD和进水氨氮等级的提高略有增加;削减单位COD耗电量随进水COD等级的提高呈降低趋势,而削减单位COD耗电量随进水量增加呈不规则变化,随着进水氨氮的增加略有增加。3)当进水量等级处于频数最高的等级时,单位水量耗电量受进水COD的变化影响较大,随着进水COD等级的提高,单位水量耗电量也相应增加;而削减单位COD耗电量则随进水COD等级提高而减小,随着进水氨氮等级提高而略微增加。4)当进水COD等级处于高频数等级下,单位水量耗电量和削减单位COD耗电量均受进水量等级的影响大;当进水氨氮等级处于高频数等级下,单位水量耗电量受进水量影响大,而削减单位COD耗电量受进水COD等级影响较大。5)单位水量耗电量和削减单位COD耗电量均受季节影响较大,夏季耗电量处于较低水平,而冬季耗电量处于较高水平。因此,进水量、进水COD和月份是污水厂耗电量的主要影响指标,且不同的状态下,耗电量的主要影响因素不同。

关键词：单位水量耗电量削减单位COD耗电量进水量等级进水COD等级进水氨氮等级

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： mu-Hsien Lee Cheng-Hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Increasingly important role of numerical modeling in oceanic observation design strategy: A review

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Science China Earth Sciences 2020年第11期63卷 1678-1690页

作者： Kun ZHANG mu mu Qiang WANG CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Innovation Center of Ocean and Atmosphere System Zhuhai Fudan Innovation Research InstituteZhuhai 518057China Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China

Oceanic observation design is of considerable significance and has made remarkable progress during the past several *** study addresses the critical role of numerical modeling in oceanic observation *** a brief introduction of the characteristics of existing oceanic observation design studies,we present the advantages of the model-based observation design strategy and further review its decisive *** demonstrate the effectiveness of this strategy,the targeted observation applications using the conditional nonlinear optimal perturbation(CNOP)approach for improving the Kuroshio predictions are ***,the authors present their consideration for correcting model errors by targeted observations of sensitive model parameters and mitigating the model-dependency problem by utilizing multiple modeling *** on using observing system simulation experiments to validate the designed observations and extending the model-based observation design strategy into observing oceanic climatological mean states are also discussed.

关键词： Observation design Numerical modeling Targeted observation CNOP

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