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An Adjusted Gray Map Technique for Constructing Large Four-Level Uniform Designs

Journal of systems science & Complexity 2023年第1期36卷 433-456页

作者： ELsAWAh A M VIshWAKARMA G K mohamed h s FANG Kai-Tai Department of statistics and Data science Faculty of Science and TechnologyBeijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087China Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data science BNU-HKBU United International CollegeZhuhai 519087China Department of Mathematics Faculty of ScienceZagazig UniversityZagazig 44519Egypt Department of Mathematics&Computing Indian Institute of Technology DhanbadDhanbad 826004India College of Transportation and Civil Engineering Fujian Agriculture and Forestry UniversityFuzhou 350002China The Key Lab of Random Complex structures and Data Analysis The Chinese Academy of SciencesBeijing 100190China

A uniform experimental design(UED)is an extremely used powerful and efficient methodology for designing experiments with high-dimensional inputs,limited resources and unknown underlying models.A UED enjoys the following two significant advantages:(i)It is a robust design,since it does not require to specify a model before experimenters conduct their experiments;and(ii)it provides uniformly scatter design points in the experimental domain,thus it gives a good representation of this domain with fewer experimental trials(runs).Many real-life experiments involve hundreds or thousands of active factors and thus large UEDs are *** large UEDs using the existing techniques is an NP-hard problem,an extremely time-consuming heuristic search process and a satisfactory result is not *** paper presents a new effective and easy technique,adjusted Gray map technique(AGMT),for constructing(nearly)UEDs with large numbers of four-level factors and runs by converting designs with s two-level factors and n runs to(nearly)UEDs with 2^(t−1)s four-level factors and 2tn runs for any t≥0 using two simple transformation *** justifications for the uniformity of the resulting four-level designs are given,which provide some necessary and/or sufficient conditions for obtaining(nearly)uniform four-level *** results show that the AGMT is much easier and better than the existing widely used techniques and it can be effectively used to simply generate new recommended large(nearly)UEDs with four-level factors.

关键词： Aberration adjusted Gray map technique Gray map technique hamming distance moment aberration threshold accepting algorithm uniform design

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Mitigating diabetes-related complications:Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

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World Journal of Diabetes 2024年第8期15卷 1778-1792页

作者： Mai s Attia Fadwa Ayman mohamed s Attia Galal Yahya Mansour h Zahra Magdi mohamed Ibrahim Khalil Abdel Aziz A Diab Department of Zoology Faculty of ScienceZagazig 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig 44519Egypt Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt Department of Biochemistry Faculty of MedicineZagazig 44519Egypt

BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of *** treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular *** To propose the supplementation of cholecalciferol(ChO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated *** The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by *** experimental rats were further subdivided into positive control and treatment *** four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either ChO,TAU,or *** Diabetic rats exhibited elevated levels of glucose,insulin,homeostasis Model Assessment of Insulin Resistance(hOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of ChO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet *** antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned *** The supplementation of ChO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.

关键词： Diabetes complications Metformin Cholecalciferol Taurine Glycated hemoglobin% Antioxidant

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Assessment of plant diversity of endemic species of the saharo-Arabian region in Egypt

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Journal of Arid Land 2024年第7期16卷 1000-1021,I0002-I0044页

作者： Asmaa s ABO hATAB Yassin M AL-sODANY Kamal h shALTOUT soliman A hAROUN mohamed M EL-KhALAFY Botany and Microbiology Department Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33511Egypt Botany Department Faculty of ScienceTanta UniversityTanta 31527Egypt

savanna, semi-deserts, and hot deserts characterize the saharo-Arabian region, which includes Morocco, Mauretania, Algeria, Tunisia, Libya, Egypt, Palestine, Kuwait, saudi Arabia, Qatar, Bahrain, the United Arab Emirates, Oman, Yemen, southern Jordan, syria, Iraq, Iran, Afghanistan, Pakistan, and northern India. Its neighboring regions, the sudano-Zambezian region belonging to the Paleotropical Kingdom and the Mediterranean and Irano-Turanian regions included in the holarctic Kingdom, share a large portion of their flora with the saharo-Arabian region. Despite the widespread acknowledgment of the region's global importance for plant diversity, an up to date list of the saharo-Arabian endemics is still unavailable. The available data are frequently insufficient or out of date at both the whole global and the national scales. Therefore, the present study aims at screening and verifying the saharo-Arabian endemic plants and determining the phytogeographical distribution of these taxa in the Egyptian flora. hence, a preliminary list of 429 saharo-Arabian endemic plants in Egypt was compiled from the available literature. Indeed, by excluding the species that were recorded in any countries or regions outside the saharo-Arabian region based on different literature, database reviews, and websites, the present study has reduced this number to 126 taxa belonging to 87 genera and 37 families. Regarding the national geographic distribution, south sinai is the richest region with 83 endemic species compared with other eight phytogeographic regions in Egypt, followed by the Isthmic Desert(the middle of sinai Peninsula, 53 taxa). sahara regional subzone(ss1) distributes all the 126 endemic species, Arabian regional subzone(ss2) owns 79 taxa, and Nubo-sindian subzone(ss3) distributes only 14 endemics. seven groups were recognized at the fourth level of classification as a result of the application of the two-way indicator species analysis(TWINsPAN) to the saharo-Arabian endemic sp

关键词： endemism phytogeographical regions saharo-Arabian floristic region Egyptian flora plant diversity two-way indicator species analysis(TWINsPAN)

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Physicochemical, heavy Metals and Phenolic Compounds Analysis of Libyan honey samples Collected from Benghazi during 2009-2010

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Food and Nutrition sciences 2013年第1期4卷 33-40页

作者： mohamed h. s. Ahmida saleh Elwerfali Ali Agha mohamed Elagori Nagwa h. s. Ahmida Environmental health Department Faculty of Public Health Benghazi University Benghazi Libya. Nutrition Department Faculty of Public Health Benghazi University Benghazi Libya

In the present work, the results of analysis of 10 Libyan honey samples, representing various floral honeys, collected from Benghazicity during different seasons in 2009-2010 were demonstrated. All samples were examined for the physicochemical quality parameters, phenolic compounds and heavy metals contents. The moisture;optical density (O. D.);electrical conductivity;water insoluble solids;ash content;ph;total acidity;hydroxylmethyl furfural (hMF);sugar contents and phenolic compounds content were detected according to AOAC 1990-Official Methods and reference methods. The results were compared with Libyan standard Legislation and the European standard Legislation. The obtained results indicated that the quality of the tested Libyan honey samples were very good and worth to the world standard properties of honey. Even more, the tested Libyan honey samples have high level of phenolic compounds content. On the basis of heavy metals content, three metals were determined (Cadmium, copper and lead) using atomic absorption spectrophotometer. The level of each metal-content was variable, which may be due to the conditions of processing, packing and storage conditions of Libyan honey samples.

关键词： Libyan honey Physicochemical Parameters Phenolic Compounds heavy Metals Contents

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A new technique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements

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high Voltage 2024年第2期9卷 319-335页

作者： mohamed M.F.Darwish mohamed h.A.hassan Nagat M.K.Abdel-Gawad Matti Lehtonen Diaa-Eldin A.Mansour Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland Department of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Department of Electrical Power and Machines Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Condition monitoring of the insulating system within power transformers has a massive importance according to the electrical *** gas analysis(DGA)is frequently used for this ***,DGA lacks the necessary level of accuracy to identify all equipment faults,particularly in their initial stages of ***,it does not have the capability for real-time monitoring and relies on manual sampling and laboratory testing,causing potential delays in fault ***,the interpretation of DGA data necessitates specialised expertise,which may pose difficulties for smaller entities that have limited access to ***,the contribution of this research is to use infrared spectroscopy measurements as a new effective technique substituting the DGA method for fault diagnosis in insulating *** inception faults that were considered in this study were the electrical fault(discharges of high energy)and the thermal fault(300°Chat,two test cells were crafted especially for serving the simulation processes inside the laboratory for both types of inception ***,six samples of pure paraffinic mineral oil were taken to be degraded in the *** that,all of them besides another sample that were not subjected to any kind of faults were taken to be examined by Fourier transform infrared(FTIR)spectroscopy to obtain an overview of the oil's behaviour in each fault *** that,the FTIR analysis was initially verified utilising the DGA ***,for further affirmation,the dielectric dissipation factor(DDF)for all samples was *** the final analysis,the verification tests provide experimental evidence about the outperformance of this new optical technique in detecting the transformer's inception faults in addition to proving its potential for being a superior alternative to the well-known traditional diagnostic techniques.

关键词： fault diagnosis spectroscopy

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Phytoconstituents Profiling of Indigenous herbal Drugs and Its in vitro Microbial,in silico Biological Examination against severe Acute Respiratory syndrome Coronavirus 2

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 121-136页

作者： T.h.mohamed Ahadu shareef Mmohamed Divan Masood Irfan Navabshan Msaiyad Musthafa Department of Chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia school of Computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Crescent school of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:habb-E-shifa,hamdard sualin,and hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing south Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,COVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1h-NMR,and Mass spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid Chromatography(hPLC),Gas Chromatography-Mass spectrometry(GC-Ms),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using hPLC and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as habb-E-shifa,hamdard sualin,and hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(sARs-Co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely streptococcus oralis,staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with sARs-Co V-2 NsP5(PDB ID:7nxh)and sARs-Co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

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A hybrid machine-learning model for solar irradiance forecasting

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Clean Energy 2024年第1期8卷 100-110页

作者： Ameera M.Almarzooqi Maher Maalouf Tarek h.M.El-Fouly Vasileios E.Katzourakis mohamed s.El Moursi Constantinos V.Chrysikopoulos Department of Industrial and systems Engineering Khalifa UniversityAbu DhabiPO Box 127788UAE Electrical Engineering and Computer science Department Khalifa University Abu DhabiUAE Department of Civil Infrastructure and Environmental Engineering Khalifa UniversityAbu DhabiPO Box 127788UAE school of Chemical and Environmental Engineering Technical University of CreteChaniaGreece

Nowcasting and forecasting solar irradiance are vital for the optimal prediction of grid-connected solar photovoltaic(PV)power *** plants face operational challenges and scheduling dispatch difficulties due to the fluctuating nature of their power *** the generation capacity within the electric grid increases,accurately predicting this output becomes increasingly essential,especially given the random and non-linear characteristics of solar irradiance under variable weather *** study presents a novel prediction method for solar irradiance,which is directly in correlation with PV power output,targeting both short-term and medium-term forecast *** proposed hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression *** proposed method excels in forecasting solar irradiance,especially during highly intermittent weather periods.A key strength of our model is the incorporation of multiple historical weather parameters as inputs to generate accurate predictions of future solar irradiance values in its scalable *** evaluated the performance of our model using data sets from both cloudy and sunny days in seattle and Medford,UsA and compared it against three forecasting models:persistence,modified 24-hour persistence and least *** on three widely accepted statistical performance metrics(root mean squared error,mean absolute error and coefficient of determination),our hybrid model demonstrated superior predictive accuracy in varying weather conditions and forecast horizons.

关键词： solar power generation kernel ridge regression hybrid model forecasting

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A statistical approach to enhance the productivity of streptomyces baarensis Mh-133 for bioactive compounds

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synthetic and systems Biotechnology 2024年第2期9卷 196-208页

作者： mohamed h.Kalaba Gamal M.El-sherbiny Osama M.Darwesh saad A.Moghannem Botany and Microbiology Department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt Agricultural Microbiology Department National Research CentreDokkiCairoEgypt

The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that streptomyces baarensis Mh-133 could make more active *** trials were used to screen for critical variables influencing productivity using the Placket-Burman Design *** Mh-133 is significantly influenced by elicitation,yeast extract,inoculum size,and incubation period in terms of antibacterial activity.A total of 27 experimental trials with various combinations of these factors were used to carry out the response surface technique using the Box-Behnken *** analyses revealed that the model was highly significant(ph a lack-of-fit of 0.212 and a coefficient determination(R2)of ***,the model predicted that the response as inhibition zone diameter would reach a value of 27 *** optimal conditions,*** Mh-133 produced 18.0 g of crude extract to each 35L and was purified with column *** active fraction exhibiting antibacterial activity was characterized using spectroscopic *** MIC and MBC values varied between 37.5 and 300μg/ml and 75 and 300μg/ml,*** conclusion,the biostatistical optimization of the active fraction critical variables,including environmental and nutritional conditions,enhances the production of bioactive molecules by streptomyces species.

关键词： s.baarensis Mh-133 Placket-Burman designBox-Behnken design EsKAPE Antibacterial activity

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Risk scores for allograft failure: Are they still useful in liver recipients from donation after circulatory death?

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World Journal of Transplantation 2024年第4期14卷 95-100页

作者： mohamed h mohamed Chairi Mónica Mogollón González Jennifer Triguero Cabrera Inmaculada segura Jiménez Maria T Villegas herrera Jesús M Villar del Moral Transplant surgery Division Department of SurgeryVirgen de las Nieves University HospitalGranada 18013AndalusiaSpain

BACKGROUND Liver grafts from donation after circulatory death(DCD)are associated with a higher risk of early graft dysfunction,determined by the warm ischemia and cold ischemia *** is essential to have precise criteria to identify this complication in order to guide therapeutic *** To validate different graft and recipient survival scores in patients undergoing liver transplantation(LT)with DCD *** A retrospective and observational unicentric study was conducted on 65 LT patients with grafts obtained from controlled DCD donors from November 2013 to November *** United Kingdom(UK)risk score,early allograft dysfunction(EAD)Olthoff score,and model for early allograft function(MEAF)score were used to evaluate the risk of graft and recipient survival *** survival analysis purposes,we used the Kaplan-Meier method,and the differences between subgroups were compared using the log-rank(Mantel-Cox)*** sixty-five patients were included in the *** UK risk score did not demonstrate predictive capacity for recipient or graft ***,in donors aged over 70 years old(18.4%),it significantly predicted graft survival(Psurvival curves,graft survival rates at 6 months,2 years,and 5 years in the futility group dramatically decreased to 50%compared to the other groups(log-rank 8.806,Phe EAD Olthoff and MEAF scores did not demonstrate predictive capacity for recipient or graft *** on Kaplan-Meier survival curves,patients with a MEAF score≥7 had a lower graft survival rate at 6 months,2 years,and 5 years compared to patients with a lower MEAF score(log-rank 4.667,PsION In our series,both UK DCD risk score and MEAF score showed predictive capability for graft survival.

关键词： Liver transplantation Donation after circulatory death Early allograft dysfunction Risk scores Graft surviva

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid h.A.L-hashem salah O.Bashir Amal F.Dawood Moutasem s.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni mohamed D.Morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic Medical sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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