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Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

BIOCELL 2022年第3期46卷 677-687页

作者： ABDELKADER HASSANI SITI ASLINA HUSSAIN mothanna sadiq al-qubaisi MOHAMED LAKHDER BELFAR HAKIM BELKHalFA HAMID HAMMAD ENEZEI HAMID ZENTOU WISAM NABEEL IBRAHIM ABD alMONEM DOOLAANEA Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University MalaysiaKuantanMalaysia Department of Chemical and Environmental Engineering University Putra MalaysiaSerdang43400Malaysia Department of Chemistry Faculty of Mathematics and Material SciencesUniversity of kasdi MurbahOuarglaAlgeria UPM-MAKNA Cancer Research Laboratory Institute of BioscienceUniversity Putra MalaysiaSerdangMalaysia Scientific and Technical Research Center in Physicochemical Analysis Bou-IsmailTipazaAlgeria Department of Oral&Maxillofacial Surgery College of DentistryUniversity of AnbarRamadiIraq Department of Biomedical Sciences College of Health SciencesQU HealthQatar UniversityDohaQatar Pharmaceutical Research Unit QU HealthQatar UniversityDohaQatar

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin(Cur)through nanoformulation with gum Arabic(GA)as a coating agent through an efficient synthetic *** antioxidant properties of the developed nanoparticles(Cur/GANPs)were assessed through several in vitro assays,such asβ-carotene bleaching activity,DPPH,and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensinconverting enzyme(ACE).The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer(MCF7,MDA-MB231),liver cancer(HepG2),and colon cancer(HT29)*** prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of–15 *** Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500μg/*** Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations ***,the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of ***,Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.

关键词： Curcumin Gum arabic Nanoparticles Cancer cells Antioxidants

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