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Multicentric recurrence of intraductal papillary neoplasm of bile duct after spontaneous detachment of primary tumor:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1000-1007页

作者： Hiroki Fukuya Akifumi Kuwano Shigehiro Nagasawa yusuke morita Kosuke Tanaka Masayoshi Yada Akihide Masumoto Kenta Motomura Department of Hepatology Iizuka HospitalIizuka 820-8505FukuokaJapan

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)rarely recurs in a multicentric *** encountered a patient with multiple recurrences of the gastric subtype of IPNB one year after spontaneous detachment of the primary tumor during peroral cholangioscopy(POCS).CASE SUMMARY A 68-year-old woman on maintenance hemodialysis because of lupus nephritis had several cardiovascular diseases and a pancreatic intraductal papillary mucinous neoplasm(IPMN).She was referred to our department for dilation of the common bile duct(CBD)and a tumor in the lumen,detected using *** had no complaints,and blood tests of hepatobiliary enzymes were *** resonance cholangiopancreatography(MRCP)showed a papillary tumor in the CBD with a filling defect detected using endoscopic retrograde cholangiography(ERC).Intraductal ultrasonography revealed a papillary tumor and stalk at the *** POCS,the tumor spontaneously detached with its stalk into the *** showed low-intermediate nuclear atypia of the gastric subtype of *** 1 year,follow-up MRCP showed multiple tumors distributed from the left hepatic duct to the *** and POCS showed multicentric *** was alive without hepatobiliary symptoms at least two years after initial diagnosis of *** The patient experienced gastric subtype of IPNB without curative *** may be reasonable for patients with this subtype.

关键词： Bile duct neoplasm Neoplasm Recurrence Pancreatic intraductal neoplasms Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiography Peroral cholangioscopy Case report

A case study of WebGIS technology for distance learning between Korea and Japan

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重庆邮电学院学报（自然科学版） 2004年第5期16卷 23-27页

作者： JUN Byungdug LEE Sangsoo FUJIKI Takashi morita yusuke Faculty of Education Nagasaki University 1 14 Bunkyo Nagasaki City852 8521JapanCollege of Education Chonnam National University 300 Yongbong Dong Buk Gu Kwangju City 500 757 KoreaFaculty of Education Nagasaki University 1 14 Bunkyo Nagasaki City852 8521JapanFaculty of Education Nagasaki University 1 14 Bunkyo Nagasaki City852 8521Japan

Recently, some case study of distance learning by internet line are widely carried out. Until now, the cultural or friendship exchange was a main purpose using distance learning program. In our research group, a distance learning which connected 3 sites (Nagasaki and Omura and Kagoshima in Japan) was tried as a domestic example[1]. In this case, internet exclusive line and portable telephone were utilized for DVTS technical support of distance learning. Nowadays, the international distance learning for education is also beginning. Our research group also tried international distance learning between Kwangju city of Korea and Nagasaki city of Japan using DVTS techniques with the tools of WebGIS education materials.

关键词： WebGIS 数学视频传输韩国日本电缆网远程学习

Use of Cryopreserved Osteogenic Matrix Cell Sheets for Bone Reconstruction

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Stem Cell Discovery 2016年第1期6卷 13-23页

作者： Tomohiko Kura Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara Yasuaki Tohma yusuke morita Munehisa Koizumi Kenji Kawate Yasuhito Tanaka Department of Orthopedic Surgery Nara Medical University School of Medicine Kashihara Japan Department of Public Health Health Management and Policy Nara Medical University School of Medicine Kashihara Japan Departmentof Biomedical Engineering Doshisha University Kyotanabe Japan Department of Artificial Joint and Regenerative Medicine Nara Medical University Kashihara Japan

Skeletal diseases, such as nonunion and osteonecrosis, are now treatable with tissue engineering techniques. Single cell sheets called osteogenic matrix cell sheets (OMCSs) grown from cultured bone marrow-derived mesenchymal stem cells show high osteogenic potential;however, long preparation times currently limit their clinical application. Here, we report a cryopreservation OMCS transplantation method that shortens OMCS preparation time. Cryopreserved rat OMCSs were prepared using slow- and rapid-freezing methods, thawed, and subsequently injected scaffold-free into subcutaneous sites. Rapid- and slow-frozen OMCSs were also transplanted directly to the femur bone at sites of injury. Slow-freezing resulted in higher cell viability than rapid freezing, yet all two cryopreservation methods yielded OMCSs that survived and formed bone tissue. In the rapid- and slow-freezing groups, cortical gaps were repaired and bone continuity was observed within 6 weeks of OMCS transplantation. Moreover, while no significant difference was found in osteocalcin expression between the three experimental groups, the biomechanical strength of femurs treated with slow-frozen OMCSs was significantly greater than those of non-transplant at 6 weeks post-injury. Collectively, these data suggest that slow-frozen OMCSs have superior osteogenic potential and are better suited to produce a mineralized matrix and repair sites of bone injury.

关键词： Bone Marrow Stromal Cell Cryopreservation Cell Sheet Injectable Bone Bone Reconstruction

Utility of tricalcium phosphate and osteogenic matrix cell sheet constructs for bone defect reconstruction

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World Journal of Stem Cells 2015年第5期7卷 873-882页

作者： Tomoyuki Ueha Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara yusuke morita Naoya Nitta Akira Kido yusuke Inagaki Kenji Kawate Yasuhito Tanaka Department of Orthopedic Surgery Nara Medical University Department of Public Health Health Management and Policy Nara Medical University Faculty of Medicine Department of Biomedical Engineering Doshisha University Department of Arthroplasty and Regenerative Medicine Nara Medical University

AIM: To determine the effects of transplanting osteogenic matrix cell sheets and beta-tricalcium phosphate(TCP) constructs on bone formation in bone ***: Osteogenic matrix cell sheets were prepared from bone marrow stromal cells(BMSCs), and a porous TCP ceramic was used as a scaffold. Three experimental groups were prepared, comprised of TCP scaffolds(1) seeded with BMSCs;(2) wrapped with osteogenic matrix cell sheets; or(3) both. Constructs were implanted into a femoral defect model in rats and bone growth was evaluated by radiography, histology, biochemistry, and mechanical testing after 8 wk. RESULTS: In bone defects, constructs implanted with cell sheets showed callus formation with segmentalor continuous bone formation at 8 wk, in contrast to TCP seeded with BMSCs, which resulted in bone nonunion. Wrapping TCP constructs with osteogenic matrix cell sheets increased their osteogenic potential and resulting bone formation, compared with conventional bone tissue engineering TCP scaffolds seeded with BMSCs. The compressive stiffness(mean ± SD) values were 225.0 ± 95.7, 30.0 ± 11.5, and 26.3 ± 10.6 MPa for BMSC/TCP/Sheet constructs with continuous bone formation, BMSC/TCP/Sheet constructs with segmental bone formation, and BMSC/TCP constructs, respectively. The compressive stiffness of BMSC/TCP/Sheet constructs with continuous bone formation was significantly higher than those with segmental bone formation and BMSC/TCP ***: This technique is an improvement over current methods, such as TCP substitution, and is useful for hard tissue reconstruction and inducing earlier bone union in defects.

关键词： Bone marrow stromal cells Osteogenesis Bone regeneration Tissue engineering Calcium phosphate

Pulmonary tumor thrombotic microangiopathy of hepatocellular carcinoma: A case report and review of literature

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World Journal of Gastroenterology 2019年第48期25卷 6949-6958页

作者： Shinichi morita Kenya Kamimura Hiroyuki Abe Yukari Watanabe-Mori Chiyumi Oda Takamasa Kobayashi Yoshihisa Arao yusuke Tani Riuko Ohashi Yoichi Ajioka Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Division of Molecular and Diagnostic Pathology Niigata University Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Histopathology Core Facility Niigata University Faculty of MedicineNiigata UniversityNiigata 951-8510Japan

BACKGROUND Pulmonary tumor thrombotic microangiopathy(PTTM)is a rare condition in patients with hepatocellular carcinoma(HCC);to date,few cases have been *** hepatic dysfunction has been focused on the later stages of HCC,the management of symptoms in PTTM is important for supportive care of the *** the better understanding of PTTM in HCC,the information of our recent case and reported cases have been *** SUMMARY A patient with HCC exhibited acute and severe respiratory *** and computed tomography of the chest revealed the multiple metastatic tumors and a frosted glass–like shadow with no evidence of infectious *** diagnosed his condition as acute respiratory distress syndrome caused by the lung metastases and involvement of the pulmonary vessels by tumor *** of prednisolone to alleviate the diffuse alveolar damages including edematous changes of alveolar wall caused by the tumor cell infiltration and ischemia showed mild improvement in his symptoms and imaging *** autopsy showed the typical pattern of PTTM in the lung with multiple *** PTTM is caused by tumor thrombi in the arteries and thickening of the pulmonary arterial endothelium leading to the symptoms of dyspnea in terminal staged ***,supportive management of symptoms is necessary in the cases with PTTM and hence we believe that the information presented here is of great significance for the diagnosis and management of symptoms of PTTM with HCC.

关键词： Pulmonary tumor thrombotic microangiopathy Hepatocellular carcinoma Respiratory dysfunction Prednisolone Supportive care Case report

Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum acutangulum

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Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum ac...

Salvage Photodynamic Therapy Is an Effective and Safe Treatment for Patients with Local Failure after Definitive Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

13th Asian Chemical Congress

作者： ISMAIL Intan S. NAGAKURA,Yuta HIRASAWA yusuke. HOSOYA Takahiro MOHD LAZIM M.I. LAJIS Nordin morita Hiroshi Faculty of Pharmaceutical Sciences Hoshi University

＜正＞Acutaxylines A（1）and B（2）are a new class of triterpenes consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol（Figure 1）,were isolated from the ethyl acetate leaves fraction of Dysoxylum acutangulum,a species belonging to Meliaceae *** relative stereochemistry of 1 and 2 was determined by NOESY *** though there are many triterpenes,steroids,and

关键词： Acutaxylines triterpene Dysoxylum acutangulum Meliaceae cytotoxicity

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Journal of Cancer Therapy 2014年第7期5卷 647-656页

作者： Yoko Mashimo Yasumasa Ezoe Kosuke Ueda Yoshinao Ozaki yusuke Amanuma Ikuo Aoyama Takahiro Horimatsu Shuko morita Shin’ichi Miyamoto Tomonori Yano Koji Higashino Tsutomu Chiba Manabu Muto Department of Experimental Therapeutics Institute for Advancement of Clinical and Translational Science (iACT) Kyoto University Hospital Kyoto Japan Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University Kyoto Japan Department of Gastrointestinal Oncology Osaka Medical Centre for Cancer and Cardiovascular Diseases Osaka Japan Department of Therapeutic Oncology Graduate School of Medicine Kyoto University Kyoto Japan Division of Digestive Endoscopy and Gastrointestinal Oncology National Cancer Center Hospital East Kashiwa Japan

Although chemoradiotherapy (CRT) is one curative treatment option for patients with esophageal squamous cell carcinoma (ESCC), local failure after CRT remains a major problem for patients’ curability. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy (PDT) as a salvage treatment for local failure. From August 2007 to March 2012, 193 consecutive ESCC patients were treated with definitive CRT in Kyoto University Hospital. Eighteen of the patients with T2 or earlier T-stage local failure after CRT underwent salvage PDT. After the salvage PDT, 11 patients (61.1%) achieved a complete response at the primary site. Over a median follow-up period of 28.3 months, the 1-year survival and progression-free survival rates were 77.8% and 38.9%, respectively;and the 2-year survival and progression-free survival rates were 60.6% and 33.3%, respectively. Adverse events were mild esophageal stricture in seven (38.9%), esophageal obstruction because of necrotic tissue in nine (50.0%), and photosensitivity in three (16.7%) patients. There were no severe complications or treatment-related deaths. Salvage PDT may be a promising treatment option for the patients with a local residual or recurrent tumor after CRT for ESCC when the lesion is suspected to be in T2 or earlier.

关键词： Esophageal Cancer Salvage Treatment Photodynamic Therapy Chemoradiotherapy Local Failure

Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

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Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya Nagasawa Yu Takahashi Wataru Itani Hitoshi Watanabe yusuke Hidaka Shotaro morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein