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Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project

World Journal of Hepatology 2015年第22期7卷 2418-2426页

作者： Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally Community Medicine Research Department National Research Center Child Health Department National Research Center Micro--biology and Immunology Department Faculty of Medicine (for girls)Al-Azhar University Pediatrics Department Faculty of MedicineAin-Shams University Dermatology and Venereology Department National Research Center Environmental and Occupational Medicine Department National Research Center

AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated ***:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory.

关键词： Hepatitis B virus Immunization Seroprotection Brea

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Antimicrobial Activities of Seed Extracts of Mango (Mangifera indica L.)

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Advances in Microbiology（微生物学） 2012年第4期

作者： Amgad A. Awad El-Gied Martin R. P. Joseph Ismail M. Mahmoud Abdelkareem M. Abdelkareem Ahmad M. Al Hakami Mohamed E. hamid

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行脑深部刺激丘脑底核定位时在手术前后用MRI精确放置电极的方法研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 27-27页

作者： hamid N.A. Mitchell R.D. Mocroft P. 陈云春 Department of Neurosurgery Queen ElizMabeth edical CentreUniversity Hospital BirminghamBirmingham B152THUnited Kingdom

Objectives: To define the role of magnetic resonance imaging(MRI) and intraope rative electrophysiological recording in targeting the subthalamic nucleus (STN) in Parkinson’s disease and to determine accuracy of electrode placement. Patie nts and methods: We implanted 54 electrodes into the STN in 27 patients. Target planning was done by coordinate guidelines and visualising the STN on MRI and de fined in relation to the mid-point of the AC-PC line. Intraoperative microelec trode recording was used. We adjusted electrode positions for placement in the c entre of the STN electrical activity and verified this on postoperative MRI in 1 6 cases, which were fused to the preoperative images to measure actual error in electrode placement in the three axes. Results: Based on coordinate calculation and MRI localisation, the mean of the target was 11.5 mm lateral,2.5 mm posterio r and 4.1 mm inferior to the mid-point of the AC-PC line. Fifty good electroph ysiological recordings of the STN (average length 4.65 mm) were achieved and tar get point adjusted in 90%of lead placements. The mean of the final target after electrophysiological correction was 11.7 mm lateral,2.1 mm posterior, and 3.8 m m inferior to the mid-point. The distance from the centre of the electrode arte fact to the final target used after electrophysiological recording on the fused images was 0.48 mm, 0.69 mm, and 2.9 mm in the x, y, and zaxes, respectively. No postoperative MRI related complication was observed. Conclusion: Both direct vi sualisation of the STN on MRI and intraoperative electrophysiological recording are important in defining the best target. Individual variations exist in the lo cation of the STN target. Fewer tracks were required to define STN activity on t he side operated first. Our current stereotactic method of electrode placement i s relatively accurate.

关键词：丘脑底核脑深部刺激 MRI 电极位置帕金森病电生理 inferior placement 定位点 intraoperative

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Impact of past HBV exposure on virological response to combined interferon ribavirin therapy in patients with chronic HCV genotype 4

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Open Journal of Internal Medicine（内科学期刊） 2011年第2期

作者： M. Said M. S. El-Raziky M. Abdel-hamid Y. Saad M. Hashem S. Zakaria M. K. Mohamed G. Esmat

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新疆于田绿洲弃耕地浅层地下水化学特征

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干旱地区农业研究 2010年第1期28卷 218-222页

作者：王庆峰海米提.依米提刘国华赛迪古丽.哈西木吕云海张丽娜艾合买提江.吾买尔熊超新疆大学资源与环境科学学院新疆乌鲁木齐830046 绿洲生态教育部重点实验室新疆乌鲁木齐830046

在于田绿洲弃耕地典型地段布设两条基本平行的地下水采样带,用GPS定位,共设置13个样点,现场采样并送实验室分析,以研究其化学特征。运用统计分析发现,地下水离子平均含量,阳离子K^＋＋Na^＋〉Mg^2＋〉Ca^2＋,阴离子Cl^-〉HCO3^-〉SO4^2-... 详细信息

在于田绿洲弃耕地典型地段布设两条基本平行的地下水采样带,用GPS定位,共设置13个样点,现场采样并送实验室分析,以研究其化学特征。运用统计分析发现,地下水离子平均含量,阳离子K^＋＋Na^＋〉Mg^2＋〉Ca^2＋,阴离子Cl^-〉HCO3^-〉SO4^2-〉CO3^2-,就变异系数而言,CO32^-和SO42^-较大,其余离子均介于30%-65%; 地下水埋深、溶解性总固体和电导率的变异系数较大,均大于50%,pH值的变异系数最小,为3.06%,且pH值的变化范围在8.35-9.28之间,呈弱碱性。通过主成分分析发现,影响研究区浅层地下水化学特征的主成分共有3个,第一主成分F1与K^＋＋Na^＋、Cl^-和CO3^2-具有显著的相关性,第二主成分F2与埋深和SO42-具有较显著的相关关系,第三主成分F3与Mg^2＋相关关系显著,且这3个主成分已涵盖所有8项指标信息的83%以上。线性回归分析显示,溶解性总固体与K^＋＋Na^＋和Cl^-的相关关系显著,且拟合方程具有显著的统计学意义。

关键词：弃耕地浅层地下水化学特征于田绿洲

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埃及丙型肝炎的家族内传染

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 50-50页

作者： Mohamed M.K. Abdel-hamid M. Mikhail N.N. G.T. Strickland 张欣 International Health Division Department of Epidemiology and Preventive Medicine University of Maryland School of Medicine 660 West Redwood Street Baltimore MD 21201 United States

The incidence of hepatitis C (HCV) infection and associated risk factors were prospectively assessed in a cohort of 6,734 Egyptians from 2 rural villages who were negative for antibodies to HCV (anti-HCV). Initial and follow-up sera were tested for anti-HCV by enzyme immunoassay (EIA), and possible incident cases were confirmed by using the microparticle enzyme immunoassay (MEIA) and tested for HCV RNA. All follow-up serum samples converting from negative to positive without detectable HCV-RNA were further tested by recombinant immunoblot assay. Over an average of 1.6 years, asymptomatic anti-HCV seroconversion occurred in 33 people (3.1/1,000 person- years [PY]), including 28 (6.8/1,000 PY) in the Nile Delta village (AES), where prevalence was 24% and 5 (0.8/1,000 PY) in the Upper Egypt village (baseline prevalence of 9% ). The strongest predictor of incident HCV was having an anti- HCV-positive family member. Among those that did, incidence was 5- 8/1,000 PY, compared (P < .001) with 1.0/1,000 PY; 27 of 33 incident cases had an anti-HCV-positive family member. Parenteral exposures increased the risk of HCV but were not statistically significant; 67% of seroconverters were younger than 20 years of age, and the highest incidence rate (14.1/1,000 PY) was in children younger than 10 who were living in AES households with an anti-HCV-positive parent. In conclusion, young children would especially benefit from measures reducing exposures or preventing infection with HCV.

关键词：丙型肝炎酶免疫测定法血清学转换随访者免疫印迹血清转化无症状清抗

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2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南

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胃肠病学 2010年第9期15卷 548-558页

作者： Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌杨川华钱本余

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和... 详细信息

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。

关键词：炎症性肠病克罗恩病溃疡性结肠炎实践指南级联

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时间自动机的事务级形式验证(英文)

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上海师范大学学报（自然科学版） 2010年第5期39卷 462-471页

作者：阿米拉里高弗兰尼法特穆加瓦河瑞哈米德诺瑞在那拉贝定纳瓦比德黑兰大学电子计算机工程系

提出了一种形式方法用于验证TLM-2.0的设计方案.该方法中TLM-2.0设计方案将被转换成定时自动机形式模型.定义若干种属性,验证将根据这些属性执行,并引入一种模拟事务级设计方案差错的故障模型来评估这些属性.然后这些属性通过使用形式UP... 详细信息

提出了一种形式方法用于验证TLM-2.0的设计方案.该方法中TLM-2.0设计方案将被转换成定时自动机形式模型.定义若干种属性,验证将根据这些属性执行,并引入一种模拟事务级设计方案差错的故障模型来评估这些属性.然后这些属性通过使用形式UPPAAL验证工具在系统的定时自动机表示上针对这些故障被验证.最后通过一个实例研究说明该方法的有效性.

关键词：形式验证定时自动机事务级模型 UPPAAL

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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