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Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castusfruits extract, in vivoand in vivo

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Advances in Biological Chemistry 2012年第1期2卷 20-28页

作者： Masahiko Imai Bo Yuan Hidetomo Kikuchi Mai Saito Kunio Ohyama Chieko Hirobe Takashi Oshima Takahiro Hosoya hiroshi morita Hiroo Toyoda Department of Clinical Molecular Genetics School of Pharmacy Tokyo University of Pharmacy & Life Sciences Tokyo Japan Department of Cultural History Seisen University Tokyo Japan Faculty of Pharmaceutical Sciences Hoshi University Tokyo Japan Gastroenterological Center Yokohama City University Medical Center Yokohama Japan

An extract from ripe fruit of Vitex agnus-castus (Vitex) has been used to treat patients with various obstetric and gynecological disorders in Europe. We have demonstrated that Vitex showed cytocidal effects on various types of cancer cell lines including a human colon carcinoma cell line, COLO 201. In this study, we extended our previous study to investigate the detailed mechanisms underlying cytocidal effects of Vi- tex on COLO 201. Furthermore, a possible clinical application of Vitex was also explored in vivo using nude mice xenografted with the cells. Treatment with Vitex induced apoptosis in COLO 201 in a time-dependent manner, accompanying with activa-tion of caspase-9 and -3, but not caspase-8. An inhibitor for c-Jun NH2-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (MAPK), significantly suppressed the apoptosis induction along with caspase-3 activation. Endoplasmic reticulum (ER) stress-related genes were also upregulated by Vitex treatment. Most importantly, the in vivo efficacy of Vitex evaluated by assessing the tumor growth revealed that the administration of Vitex significantly suppressed tumor growth in COLO 201 xenografted mice. Collectively, current results suggest that apoptosis induction by Vitex in COLO 201 is mediated through the activation of JNK and caspase-9, -3 resulted from ER stress. Based on the current clinical application of Vitex, these results thus provide a new insight into the clinical use of Vitex and leave open a possibility of a new regimen as an alternative medicine approach for such devastating colon cancer treatment.

关键词： Colon Cancer Apoptosis Induction ER Stress JNK Flavonoids Vitex agnus-castus

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Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum acutangulum

Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum ac...

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13th Asian Chemical Congress

作者： ISMAIL Intan S. NAGAKURA,Yuta HIRASAWA Yusuke. HOSOYA Takahiro MOHD LAZIM M.I. LAJIS Nordin morita hiroshi Faculty of Pharmaceutical Sciences Hoshi University

＜正＞Acutaxylines A（1）and B（2）are a new class of triterpenes consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol（Figure 1）,were isolated from the ethyl acetate leaves fraction of Dysoxylum acutangulum,a species belonging to Meliaceae *** relative stereochemistry of 1 and 2 was determined by NOESY *** though there are many triterpenes,steroids,and

关键词： Acutaxylines triterpene Dysoxylum acutangulum Meliaceae cytotoxicity

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Temperature and Pressure Measurements at Cold Exit of Counter-flow Vortex Tube with Flow Visualization of Reversed Flow

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Journal of Thermal Science 2015年第1期24卷 67-72页

作者： Mohd Hazwan bin Yusof hiroshi Katanoda Hiromitsu morita Graduate School of Science and Engineering Kagoshima University National Institute of Advanced Industrial Science and Technology Hokkaido

In order to clarify the structure of the cold flow discharged from the counter-flow vortex tube(VT), the temperature and pressure of the cold flow were measured, and the existence and behavior of the reversed flow at the cold exit was studied using a simple flow visualization technique consisting of a 0.75mm-diameter needle, and an oil paint droplet. It is observed through this experiment that the Pitot pressure at the cold exit center can either be lower or higher than atmospheric pressure, depending on the inlet pressure and the cold fraction, and that a reversed flow is observed when the Pitot pressure at the cold exit center is lower than atmospheric pressure. In addition, it is observed that when reducing the cold fraction from unity at any arbitrary inlet pressure, the region of reversed and colder flow in the central part of cold exit extends in the downstream direction.

关键词： Vortex tube Reversed flow Flow visualization Pressure measurement Temperature measurement

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谈大学里地下管道工程人才的培养

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非开挖技术 2022年第3期 1-2页

作者：森田弘昭孙跃平(译) 曹井国(译) 王莹(译) 日本非开挖技术协会日本大学生产工学部不详

1前言大学常被称作“象牙塔”,许多人认为大学与社会脱节,但是我们学校的某些课程科目却能迅速地反映出社会趋势。学校会要求一线的教师们,不断更新负责课程的教育目标与教学内容,使其更加符合可持续发展、数字化、去碳化等社会发展趋势... 详细信息

1前言大学常被称作“象牙塔”,许多人认为大学与社会脱节,但是我们学校的某些课程科目却能迅速地反映出社会趋势。学校会要求一线的教师们,不断更新负责课程的教育目标与教学内容,使其更加符合可持续发展、数字化、去碳化等社会发展趋势,以激发学生的学习热情。城市基础设施的维护管理也是社会发展重要环节之一,在相关的和非相关的课程中都会或多或少涉及,部分高校还会专门开设基础设施维修维护课程。

关键词：社会发展趋势城市基础设施可持续发展激发学生的学习热情大学与社会维修维护教学内容象牙塔

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J波综合征专家上海共识:概念与认知的更新

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临床心电学杂志 2016年第3期25卷 161-179页

作者： Charles Antzelevitch 严干新 Michael J.Ackerman Martin Borggrefe Domenico Corrado 郭继鸿(审核) Ihor Gussak Can Hasdemir Minoru Horie Heikki Huikuri 马长生 hiroshi morita Gi-Byoung Nam Frederic Sacher Wataru Shimizu Sami Viskin Arthur A.M.Wilde 刘霄燕(译) 揭起强(译) 吴林(审核) 北京大学第一医院 100034 北京大学人民医院 100044 不详

序言J波综合征（J wave syndromes,JW Ss）,包括Brugada综合征（BrS）和早复极综合征（ERS）。有关Br S,在2000年和2004年分别举行了BrS的国际专家共识会议;有关ERS,直到2013年才在原发性遗传性心律失常专家共识里做出了针对ERS的指导... 详细信息

序言J波综合征（J wave syndromes,JW Ss）,包括Brugada综合征（BrS）和早复极综合征（ERS）。有关Br S,在2000年和2004年分别举行了BrS的国际专家共识会议;有关ERS,直到2013年才在原发性遗传性心律失常专家共识里做出了针对ERS的指导意见。在2015年4月,心脏节律协会（HRS）、欧洲心脏节律协会（EHRA）和亚洲太平洋心脏节律协会（APHRS）的主要专家成员组成的工作组聚集在中国上海，审查了有关JWSs的新证据，

关键词：心源性猝死 J波 Brugada综合征早复极综合征心律失常心室颤动遗传性心律失常综合征

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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

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Simple Kac-Moody groups with trivial Schur multipliers

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Science China Mathematics 2018年第2期61卷 311-316页

作者： Jun morita Institute of Mathematics University of Tsukuba

We obtain new examples of simple Kac-Moody groups with trivial Schur multipliers.

关键词： Kac-Moody group simple group Schur multiplier

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Experimental study on boundary lubricity of superficial area of articular cartilage and synovial fluid

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Friction 2024年第5期12卷 981-996页

作者： Wenxiao LI Takehiro morita Yoshinori SAWAE Departure of Mechanical Engineering Kyushu UniversityFukuoka8190395Japan International Institute for Carton-Neutral Energy Research Kyushu UniversityFukuoka8190395Japan Advanced Research Center for Biomechanics Kyushu UniversityFukuoka8190395Japan

The boundary lubrication mechanism at the articulating surface of natural synovial joints has been the subject of much discussion in *** this study,to elucidate the lubricating function of the superficial area of articular cartilage and synovial fluid(SF),cartilage specimens were processed with four different treatments:gentle and severe washing with detergent,incubation in NaCl solution,and trypsin digestion to selectively remove certain constituents from the cartilage ***,the frictional characteristics were examined in phosphate-buffered saline(PBS)and SF against *** reciprocating sliding tests with a spherical glass probe and square articular cartilage specimens were performed at low contact loads in the mN range to extract the frictional behavior in the superficial area of the cartilage ***,the cartilage surface was observed to confirm the effects of treatments on the morphology of the cartilage surface using a fluorescence microscope and water-immersion *** coefficient of friction(COF)of the prepared cartilage specimens was varied from 0.05 to over 0.3 in ***,a certain group of cartilage specimens exhibited a low COF of less than 0.1 with limited *** the low COF group of specimens,all four treatments increased the COF in PBS to different extents,and fluorescence microscopy revealed that the integrity of the cartilage surface was deteriorated by *** means that the intact cartilage surface had lubricating constituents to maintain low friction,and the removal of such constituents resulted in the loss of the intrinsic boundary lubricity of the cartilage *** variation in the COF of the cartilage specimens was suppressed in SF because it had a clear boundary lubrication effect on the cartilage *** lubricating effect of SF could be confirmed even after degenerative treatment.

关键词： articular cartilage synovial fluid the uppermost superficial layer boundary lubrication

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Numerical analysis of interaction between solute atom and extended dislocation using force multipoles

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Journal of Central South University 2014年第8期21卷 3000-3006页

作者： Hiroaki morita Akiyuki Takahashi Department of Mechanical Engineering Faculty of Science and TechnologyTokyo University of Science

The interaction between a solute atom and an extended dislocation was investigated using a continuum approximation method with force *** dislocation core structure of extended dislocation was modeled with the Peierls-Nabarro model discretized with a number of infinitesimal Volterra *** interaction energy and force between a nickel solute atom and perfect and extended dislocation in copper were successfully calculated using the force *** results clearly show that the core structure of extended dislocation weakens the interaction with solute *** interaction energy and force for extended dislocations are almost the half of those for perfect dislocations.

关键词： solution hardening force multipole solute atom extended dislocation Peierls-Nabarro model

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Unsteady Behavior of Surge and Rotating Stall in an Axial Flow Compressor

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Journal of Thermal Science 2012年第4期21卷 302-310页

作者： Yutaka OHTA Yutaka FUJITA Daisuke morita Department of Applied Mechanics and Aerospace Engineering Waseda University 3-4-1 Okubo Shinjuku Graduate Student Graduate School of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku

Unsteady behaviors as well as unsteady cascade flow fields of a single-stage axial flow compressor were experi- mentally investigated by detail measurements of unsteady performance characteristics and casing wall pressure and internal flow velocity fluctuations. The main feature of the test compressor is a capacity tank connected di- rectly to the compressor outlet in series through slits and a concentric duplex pipe, and also jet nozzles in order to inject compressed air toward the rotor tip region. Research attention is focused on the post-stall characteristics of surge and rotating stall which occur simultaneously. When the compressor was connected to the capacity tank, surge was generated with rotating stall in accordance with the capacitance increment of whole compressor system The surge behavior changed irregularly with throttling valve installed behind the compressor, and several types of surge cycles were observed. In addition, the surge cycle changed by jet injection to the rotor tip region. The re- suits suggested that the blockages of the cascade flow which were generated by a stall cell play an important role in deciding the surge behaviors.

关键词： Axial flow compressor Surge Rotating stall Stall cell Jet injection

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