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A Pilot Test for A One-year Cognitive Training Intervention in Elderly Adults with Mild Cognitive Impairment

Biomedical and Environmental Sciences 2020年第10期33卷 796-802页

作者： MENDOZA-HOLGADO Cristina LOPEZ-ESPUELA Fidel moran jose maria RONCERO-MARTIN Raul LAVADO-GARCIA Jesus ALIAGA Ignacio PUERTO-PAREJO Luis Manuel LEAL-HERNANDEZ Olga VERA Vicente PEDRERA-CANAL maria Nursing Department Metabolic Bone Disease Research GroupUniversity of ExtremaduraNursing and Occupational Therapy CollegueAvd.Universidad s/n10003-CaceresSpain Facultad de Odontologia Universidad ComplutenseMadridSpain

In Spain,the proportion of elderly individuals has increased to 19.1%.By 2068,the proportion of elderly individuals is estimated to increase to 29.4% given the largest birth cohorts in Spain’s history(Instituto Nacional de Estadistica,INE).This challenge needs a supportive plan,as economic and caring problems may occur because of age-related health problems,including cognitive decline and dementia[1].

关键词： elderly Pilot Training

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino jose F.moran Institute for Multidisciplinary Research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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Quantification of the Mixture of Hydrothermal and Fresh Water in Tectonic Valleys

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Journal of Earth Science 2020年第5期31卷 1007-1015页

作者： Janete moran-Ramirez jose Ivan Morales-Arredondoc maria Aurora Armienta-Hernandez jose Alfredo Ramos-Leal National Council of Science and Technology National Autonomous University of MexicoInstitute of GeophysicsScientific Research CircuitUniversity CityCoyoacan 04150Mexico CityMexico National Autonomous University of Mexico Institute of GeophysicsUniversity CampusMexico CityMexico Potosino Institute for Scientific and Technological Research 78216 San Luis PotosiS.L.P.Mexico

This study was conducted to identify the origin, hydrogeochemical processes and evolution of groundwater in a tectonic valley. This study was carried out with the aim of quantifying the proportions of groundwater flows contributing to the water chemistry abstracted in a zone of convergence favored by the presence of active faults. The study area is located in the Trans-Mexican Volcanic Belt. End members methodology was applied to identify the mixing of hydrothermal with fresh groundwater, where changes in the aquifer geology result in distinct groundwater chemical signatures. Ternary mixing was quantified using conservative elements. Moreover, other evolutionary processes, such as ion exchange and silicate weathering occur due to changes in the geology of the area. In ternary mixing, each of the end members is associated with the lithology through which it circulates. The local flow contributes 70% of the water to the system, the intermediate flow contributes 14%, and the regional flow contributes 16%. Three types of water are produced: Na-HCO3, due to the interaction of water with volcanic rocks of rhyolitic composition, Na-Mg-HCO3, due to the interaction of water with volcanic rocks of basaltic-andesite composition, and Ca-HCO3, due to the interaction of water with sedimentary calcareous rocks.

关键词： hydrogeochemistry ternary mixing end members conservative elements local flow Mexico

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BRCA1,RAP80 and SUMO ligases (PIAS1 and PIAS4) mRNA expression levels and survival in advanced gastric cancer patients receiving second-line docetaxel chemotherapy

BRCA1,RAP80 and SUMO ligases (PIAS1 and PIAS4) mRNA expressi...

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2011医学科学前沿论坛第十二届全国肿瘤药理与化疗学术会议

作者： Carlota Costa jose Javier Sanchez Ana Gimenez-Capitan Teresa moran Susana Benlloch Miquel Taron Rafael Rosell Pangaea Biotech USP Dexeus University InstituteBarcelonaSpain Autonomous University of Madrid MadridSpain Catalan Institute of Oncology Hospita lGermans Trias i PujolMedical Oncology ServiceBadalonaSpain

BRCA1 and RAP80 are involved in chemotherapy response,and PIAS1 and PIAS4 are necessary for adequate DNA damage *** have examined the mRNA expression of BRCA1,RAP80,PIAS1 and PIAS4 by RT-QPCR in 133 advanced gastric cancer patients,59 of whom received docetaxel-based second-line *** survival time was 12.5 months *** the 59 patients receiving second-line docetaxel,median survival time was 25.8 months for patients with high BRCA1 levels vs 23.8 months for those with intermediate levels and 9.5 months for those with low levels (P=0.006).Hazard ratios for death were 2.49(P=0.04) for low BRCA1 levels and 2.84(P=0.02) for low PIAS4 levels. Customized chemotherapy based on the levels of BRCA1 and PIAS4 could help to optimize treatment.

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Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea （Aubl,） Jacks in vivo

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Journal of Pharmacy and Pharmacology 2017年第6期5卷 289-298页

作者： Miguel Angel Diaz C. Lorena H. Cruz M. Mahabir P. Gupta Dionisio Olmedo jose Luis Lopez-Perez Estela Guerrero De Leon Juan Antonio moran-Pinzon Direccidn Nacional de Farmacia y Drogas Ministerio de Salud Panama Apartado 06812-0816 Republica de Panama Centro de lnvestigaciones Farmacognosticas de la Flora Panamena (CIFLORPAN) Facultad de Farmacia Universidad de Panama Panama Apartado 0824-00172 Republica de Panama Departamento de Quimica FarmacOutica Facultad de Farmacia Universidad de Salamanca Salamanca Apartado 37007 Spain Departamento de Farmacologla Facultad de Medicina Universidad de Panama Panama Apartado 0824 Panama

The present study was conducted to evaluate the antinociceptive and anti-inflammatory activities of methanol extract of rachis of Ormosia coccinea （Aubl.） Jacks （MEOC） using animal models of nociception and inflammation. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Oral administration of MEOC （500 mg/kg） produced significant （t7 〈 0.05） antinociceptive effects when tested in mice using acetic acid-induced abdominal writhing test and on the inflammatory phase of the formalin test. It was also demonstrated that MEOC had no significant effect on the response latency time to the heat stimulus in the thermal model of the hot plate test. The anti-inflammatory activity of the extract was assessed using carrageenan, histamine and serotonin induced oedema in rat paw. The oral administration of MEOC showed maximum inhibition （64.29%） at 1 h on carrageenan edema, but it did not modify the edema induced by histamine and serotonin. The present results suggest that MEOC has a peripheral antinoeiceptive and anti-inflammatory action.

关键词： Ormosia coccinea antinociceptive anti-inflammatory fabaceae.

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