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Excess Activity Tuned by Distorted Tetrahedron in Comoo_(4) for Oxygen Evolution

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Energy & Environmental Materials 2024年第1期7卷 247-252页

作者： Hengbo Xiao kai Chi Hongxia Yin Xiangji Zhou Pengxiang Lei Peizhi Liu Jiakun Fang Xiuhong Li Songliu Yuan Zhen Zhang Yaqiong Su Junjie Guo Lihua Qian School of Physics Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Material Chemistry for Energy Conversion and Storage School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Chemistry and Chemical Engineering Hubei University of TechnologyWuhan 430068China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China State Key Lab of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering Hubei University of TechnologyWuhan 430068China Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China School of Chemistry Xi'an Jiaotong UniversityXi'an 710049China

Oxygen vacancies enable modulating surface reconstruction of transition metal oxides containing metal-oxygen polyhedrons into metallic oxyhydroxide for oxygen evolution reaction(OER),while revealing reconstructing mechanism is stuck by the requirement to precisely control exact sites of these ***,oxygen vacancies are localized only within moo_(4)tetrahedrons rather than CoO_(6)octahedrons in Comoo_(4)catalyst,guaranteeing coherent reconstruction of CoO_(6)octahedrons into pure CoOOH with tunable activities for ***,distorted tetrahedron accelerates the dissolution of Mo atoms into alkaline electrolyte,triggering spontaneous transition of partial Comoo_(4)into Co(OH)_(2).CoO_(6)octahedrons in both Comoo_(4)and Co(OH)_(2)can transform pure CoOOH completely at lower potential,resulting in excess intrinsic activity whose summit is identified by overpotential at 10 mA cm^(-2)with 22.9%reduction and Tafel slope with 65.3%***-defined manipulation over the distorted polyhedrons offers one versatile knob to precisely modulate electronic structure of oxide catalysts with outstanding OER performance.

关键词： metal-oxygen polyhedron oxygen evolution reaction oxygen vacancy Raman spectroscopy

Pathophysiological significance of gallbladder volume changes in gallstone diseases

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World Journal of Gastroenterology 2010年第34期16卷 4341-4347页

作者： shing-moo Huang Chung-Chin Yao Huichin Pan Kuang-Ming Hsiao Ji-Kuen Yu Te-Jen Lai Shueh-Ding Huang Institute and School of Medicine Chung Shan Medical University and Division of General Surgery Department of Surgery Chung Shan Medical University Hospital Department and Institute of Biomedical Sciences Chung Shan Medical University Department of Medical Research Chung Shan Medical University Hospital Department of Life Science National Chung Cheng University Division of General Surgery Department of Surgery Taichung Metroharbor Tung's Memorial Hospital Institute and School of Medicine Chung Shan Medical University Department of Applied Mathematics National Chengchi University

AIM: To study the pathophysiological significance of gallbladder volume (GBV) and ejection fraction changes in gallstone ***: The fasting GBV of gallstone patients with acute cholecystitis (n = 99), chronic cholecystitis (n = 85) and non-gallstone disease (n = 240) were measured by preoperative computed tomography. Direct saline injection measurements of GBV after cholecystectomy were also performed. The fasting and postprandial GBV of 65 patients with gallstones and chronic cholecystitis and 53 healthy subjects who received health examinations were measured by abdominal ultrasonography. Proper adjustments were made after the correction factors were calculated by comparing the preoperative and postoperative measurements. Pathological correlations between gallbladder changes in patients with acute calculous cholecystitis and the stages defined by the Tokyo International Consensus Meeting in 2007 were made. Unpaired Student's t tests were used. P < 0.05 was deemed statistically significant. RESULTS: The fasting GBV was larger in late stage than in early/second stage acute cholecystitis gallbladders (84.66 ± 26.32 cm 3 , n = 12, vs 53.19 ± 33.80 cm 3 , n = 87, P = 0.002). The fasting volume/ejection fraction of gallbladders in chronic cholecystitis were larger/lower than those of normal subjects (28.77 ± 15.00 cm 3 vs 6.77 ± 15.75 cm 3 , P < 0.0001)/(34.6% ± 10.6%, n = 65, vs 53.3% ± 24.9%, n = 53, P < 0.0001). CONCLUSION: GBV increases as acute cholecystitis progresses to gangrene and/or empyema. Gallstone formation is associated with poorer contractility and larger volume in gallbladders that contain stones.

关键词： Gallbladder volume Pathophysiology Gallbladder ejection fraction Gallstone formation Acute cholecystitis

Prognostic value of alcohol consumptionand some other dietary habits for survival in a cohort of Chinese men with lung cancer

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Chinese Journal of Cancer 2017年第7期36卷 298-305页

作者： Wentao Li Lap Ah Tse Joseph S.K.Au kai shing Yu Feng Wang Ignatius Tak-sun Yu JC School of Public Health and Primary Care The Chinese University of Hong Kong4F School of Public Health and Primary CarePrince of Wales Hospital Department of Clinical Oncology Hong Kong Adventist Hospital

Background:Alcohol consumption and some other dietary habits are thought to be associated with lung cancer ***,the effects of these habits on lung cancer prognosis have been studied *** purpose of this study was to address these gaps in ***:We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung *** proportional hazards models were used to determine the prognostic values of consumption of alcohol,fresh fruits or vegetables,meat,and fried or preserved ***:Compared with never drinkers,men who drank alcohol 1-3 days per week had a more favorable lung cancer prognosis(hazard ratio[HR]:0.82,95%confidence interval[CI]0.68-0.97);however,this survival advantage was not significant in men who drank alcohol more frequently(HR:0.91,95%CI 0.73-1.14).Compared with men who consumed preserved or fried food only occasionally,men who consumed these foods frequently had a higher risk of lung cancer mortality(HR:1.20,95%CI 1.00-1.42).Conclusions:Occasional consumption of alcohol was a favorable survival factor for Chinese men with lung ***,this survival benefit did not exist for frequent drinkers of *** men with lung cancer who were frequent consumers of fried or preserved food had a worse prognosis than those who consumed these foods only occasionally.

关键词： Dietary habits Alcohol Lung cancer Prognosis Epidemiology

Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui Kin Lam Eric Ho Yin Lau Wai Lam Yip Joe kai shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

自动化建模与优化平台开发及其在切削吸能结构的应用

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中南大学学报（自然科学版） 2024年第5期55卷 2048-2060页

作者：王晖田凯高乾宸王明猛郝伟江王晋乐朱涛中车青岛四方机车车辆股份有限公司山东青岛266111 西南交通大学轨道交通运载系统全国重点实验室四川成都610031

传统优化设计受限于几何参数化和六面体单元生成困难等问题,优化过程繁琐,效率低下。为规范开发流程,提高优化设计效率,本文搭建以moo(multi-objective optimization)系统为核心,集成了几何、有限元建模、数据处理以及代理优化等模块的... 详细信息

传统优化设计受限于几何参数化和六面体单元生成困难等问题,优化过程繁琐,效率低下。为规范开发流程,提高优化设计效率,本文搭建以moo(multi-objective optimization)系统为核心,集成了几何、有限元建模、数据处理以及代理优化等模块的自动化建模与优化平台。自动化建模模块以CAE为核心,基于三次样条函数构造特征截面和映射路径实现自动几何参数化建模,并在扫掠法和模型分解法的基础上,提出基于多截面扫掠法的六面体网格自动化生成方法;此外,在常规基于代理模型的优化流程上,通过数据转换和处理算法实现从数值计算结果提取到代理优化的自动化。研究结果表明:该平台能建立具有较小几何误差和高质量单元的有限元模型,结构耐撞性指标整体上有一定提升,可以显著地提高优化工作流程的效率。

关键词：优化平台几何参数化建模六面体网格生成切削吸能结构被动安全

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau Lee Ernest H.Y.Ng William S.B.Yeung kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

α-moo_(3)的结构形貌与其催化合成季戊四醇正辛酸酯的构效关系研究

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分子催化（中英文） 2024年第2期38卷 146-153,I0003,I0004页

作者：谭益凤曹平李莹马楷王雨恒李金桐重庆理工大学化学化工学院重庆400054 贵州天威建材科技有限责任公司贵州贵阳550009 中国石化润滑油有限公司合成油脂分公司重庆400039

通过溶胶-凝胶法制备一种用于季戊四醇(PER)和正辛酸(OTA)酯化合成季戊四醇正辛酸酯(POE)的α-moo_(3)催化剂.采用XRD、SEM、XPS和FITR分析手段对α-moo_(3)粉体进行了表征.结果表明,焙烧温度对α-moo_(3)的晶相结构、表观形貌及催化性... 详细信息

通过溶胶-凝胶法制备一种用于季戊四醇(PER)和正辛酸(OTA)酯化合成季戊四醇正辛酸酯(POE)的α-moo_(3)催化剂.采用XRD、SEM、XPS和FITR分析手段对α-moo_(3)粉体进行了表征.结果表明,焙烧温度对α-moo_(3)的晶相结构、表观形貌及催化性能的影响显著.当焙烧温度达到450℃时,催化剂为正交晶面结构(021)和(110)同时择优取向的α-moo_(3),样品表面光洁平整、大小均匀、分散性好,同时表现出较高的催化活性.在适宜的反应条件下(T=200℃, t=4 h,酸醇摩尔比n(OTA)∶n(PER)=4.0∶1,催化剂用量n(α-moo_(3)-450)∶n(PER)=0.005),PER转化率可达98.8%, POE的选择性可达100%.

关键词： α-moo_(3) 溶胶-凝胶法焙烧温度结构形貌酯化反应

三维有序大孔结构脱硝催化剂制备及其抗重金属中毒机理

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硅酸盐学报 2024年第5期52卷 1608-1620页

作者：谭晨晨韩宇轩吴鹏沈凯庄柯许芸胡亚琴张亚平东南大学能源与环境学院能源热转换及其过程测控教育部重点实验室南京210096 国家能源集团科学技术研究院有限公司南京210023

Cd、Pb、Zn等重金属广泛存在于工业废气中,会降低脱硝催化剂的活性。采用聚甲基丙烯酸甲酯(PMMA)模板制备得到具有三维有序大孔结构(3DOM)的Ce0.2Mn0.2/3DOMTiO_(2)(Fresh-CMT-3DOM),作为对比,制备普通结构TiO_(2)载体负载Ce-Mn得到Ce0.... 详细信息

Cd、Pb、Zn等重金属广泛存在于工业废气中,会降低脱硝催化剂的活性。采用聚甲基丙烯酸甲酯(PMMA)模板制备得到具有三维有序大孔结构(3DOM)的Ce0.2Mn0.2/3DOMTiO_(2)(Fresh-CMT-3DOM),作为对比,制备普通结构TiO_(2)载体负载Ce-Mn得到Ce0.2Mn0.2/3DOM(Fresh-CMT)催化剂。活性测试结果表明:相较于Fresh-CMT,Fresh-CMT-3DOM催化剂在100~300℃时的NO转化率超过85%,且在100~150℃低温下具有更高的脱硝活性。引入Cd、Pb、Zn后,Fresh-CMT-3DOM催化剂仍保持较高活性,在175~300℃时的NO转化率均超过85%;而Fresh-CMT催化剂活性明显下降,其中Cd、Pb中毒后催化剂的NO最高转化率分别不足85%、100%。结果表明:相较于Fresh-CMT催化剂,Fresh-CMT-3DOM具有优异的Mn^(4+)/Mn^(3+)/Mn^(2+)及Ce^(4+)/Ce^(3+)氧化还原循环、更高的氧化还原能力及更多的酸性位点,从而促进了Fresh-CMT-3DOM催化剂的低温脱硝活性及抗重金属性能。

关键词：三维有序大孔催化剂低温氨选择性催化还原脱硝抗重金属中毒

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan kaiming Tang Jian-Piao Cai Kenn Ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics