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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw ali Khan mohsin ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

Impact of dark current on pinned photo-diode capacitance of CMOS image sensor in low illumination regime

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Optoelectronics Letters 2024年第11期20卷 654-657页

作者： mohsin Suharwerdi Gausia Qazi Department of Electronics & Communication Engineering National Institute of Technology

Applications for quanta and space sensing both depend on efficient low-light imaging. To precisely optimize and design image sensor pixels for these applications, it is crucial to analyze the mechanisms behind dark cu... 详细信息

关键词： A

基于芳香亲核取代反应生物硫醇荧光探针的构建及其应用研究

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基于芳香亲核取代反应生物硫醇荧光探针的构建及其应用研究

作者： mohsin ali 湖北大学

学位级别：硕士

Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani Syed M Faiq Rahma Rashid Tariq ali Kalwar Rehan mohsin Tahir Aziz Nida Amin Khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

新型PCV2衣壳融合蛋白在HEK293F细胞瞬时表达研究

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华东理工大学学报（自然科学版） 2024年第1期50卷 62-70页

作者：罗清平彭妍 ali mohsin 庄英萍郭美锦华东理工大学生物反应器工程国家重点实验室上海200237 上海国佳生化工程技术研究中心有限公司上海200237

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示... 详细信息

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示,采用宿主HEK293F细胞及PEI-40kDa转染试剂能获得35%病毒PCV2 Capsid基因细胞转染效率。转染试剂PEI(Polyethylenimine)与DNA比例差异会影响复合物形成大小及形态,复合物形成15~80 nm颗粒有利于转染效率的提高。实验以免疫逃逸型猪圆环病毒2b型NDSU41513病毒株,设计了新型PCV2 Capsid (△1-41aa)-Fc(pig) protein(PCFP)分子。在3 L反应器中成功实现了HEK293F细胞瞬时表达PCFP,表达水平达到3.8 mg/L。PCFP蛋白能够自主装形成约为41 nm类病毒颗粒,诱导小鼠机体内产生强烈的体液免疫反应,具有很高的应用潜力。

关键词：猪圆环病毒2型瞬时表达 HEK293F 类病毒颗粒疫苗

Smart Breeding Platform:A web-based tool for high-throughput population genetics,phenomics,and genomic selection

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Molecular Plant 2024年第5期17卷 677-681页

作者： Huihui Li Xin Li Peng Zhang Yingwei Feng Junri Mi Shang Gao Lele Sheng mohsin ali Zikun Yang Liang Li Wei Fang Wensheng Wang Qian Qian Fei Gu Wenbin Zhou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Nanfan Research Institute CAASSanyaHainan 572024China DAMO Academy Alibaba GroupHangzhou 310023China Hupan Lab Hangzhou 310023China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhouZhejiang 310006China

Dear Editor,In the era of big data and artificial intelligence,"smart breeding"has become a broad conceptual framework encompassing the paradigm shift of crop breeding to relying on analysis of high-throughput population genetics and phenomics data to conduct genomic selection,allowing identification and optimal use of the genetic potential in crop species(Xiao et al.,2022;Xu et al.,2022;Wang et al.,2023).Most existing tools for analyzing high-throughput breeding data require extensive computational power,complex installation processes,and command-line expertise and are therefore challenging and inconvenient for the majority of researchers and breeders(Brandies and Hogg,2021).

关键词： breeding artificial breed

Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence

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Virologica Sinica 2024年第3期39卷 369-377页

作者： Shengyao Chen Muhammad Saqib Hafiz Sajid Khan Yuan Bai Usman ali Ashfaq Muhammad Khalid Mansoor Abulimti Moming Jing Liu Min Zhou Saifullah Khan Niazi Qiaoli Wu Awais-Ur-Rahman Sial Shuang Tang Muhammad Hassan Sarfraz Aneela Javed Sumreen Hayat mohsin Khurshid Iahtasham Khan Muhammad Ammar Athar Zeeshan Taj Bo Zhang Fei Deng ali Zohaib Shu Shen Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Faculty of Veterinary Science University of Agriculture FaisalabadFaisalabad 38040Pakistan The Children's Hospital Faisalabad 38000Pakistan Department of Bioinformatics and Biotechnology Government College University FaisalabadFaisalabad 38000Pakistan f Department of Microbiology Faculty of Veterinary and Animal SciencesThe Islamia University of BahawalpurBahawalpur 63100Pakistan Hubei Jiangxia Laboratory Wuhan 430200China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Armed Forces Institute of Pathology(AFIP) Rawalpindi 46000Pakistan Department of Clinical Studies Faculty of Veterinary&Animal SciencesPir Mehr Ali Shah Arid Agriculture UniversityRawalpindi 46300Pakistan Institute of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan l Atta-ur-Rahman School of Applied Biosciences National University of Science and TechnologyIslamabad 44000Pakistan Department of Clinical Sciences University of Veterinary and Animal SciencesLahore Sub-campusJhang 35200Pakistan Department of Molecular Pathology National Medical Center DHA Phase 1Karachi 75500Pakistan

Infectious diseases caused by arboviruses are a public health concern in ***,studies on data prevalence and threats posed by arboviruses are *** study investigated the seroprevalence of arboviruses in a healthy population in Pakistan,including severe fever with thrombocytopenia syndrome virus(SFTSV),Crimean-Congo hemorrhagic fever virus(CCHFV),Tamdy virus(TAMV),and Karshi virus(KSIV)based on a newly established luciferase immunoprecipitation system(LIPS)assays,and Zika virus(ZIKV)by enzyme-linked immunosorbent assays(ELISA).Neutralizing activities against these arboviruses were further examined from the antibody positive *** results showed that the seroprevalence of SFTSV,CCHFV,TAMV,KSIV,and ZIKV was 17.37%,7.58%,4.41%,1.10%,and 6.48%,respectively,and neutralizing to SFTSV(1.79%),CCHFV(2.62%),and ZIKV(0.69%)were identified,as well as to the SFTSV-related Guertu virus(GTV,0.83%).Risk factors associated with the incidence of exposure and levels of antibody response were ***,co-exposure to different arboviruses was demonstrated,as thirty-seven individuals were having antibodies against multiple viruses and thirteen showed neutralizing ***,individuals aged40 years,and outdoor workers had a high risk of exposure to *** these results reveal the substantial risks of infection with arboviruses in Pakistan,and indicate the threat from co-exposure to multiple *** findings raise the need for further epidemiologic investigation in expanded regions and populations and the necessity to improve health surveillance in Pakistan.

关键词： Arbovirus Pakistan Seroprevalence Tick-borne virus Mosquito-borne virus

Recent progress in two-dimensional metallenes and their potential application as electrocatalyst

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Journal of Energy Chemistry 2024年第7期94卷 577-598页

作者： Umer Shahzad mohsin Saeed Muhammad Fazle Rabbee Hadi M.Marwani Jehan Y.Al-Humaidi Muhammad Altaf Raed H.Althomali Kwang-Hyun Baek Md.Rabiul Awual Mohammed M.Rahman Department of Chemistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongsanSouth Korea Center of Excellence for Advanced Materials Research(CEAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Chemistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In this article,we looked at metallenes,a novel class of two-dimensional(2D)metals that are attracting interest in the energy and catalysis *** is one area where their exceptional physicochemical and electrical characteristics might be *** are unique because they include several metal atoms that are not in a coordinated *** makes them more active and improves their atomic uti-lization,which in turn increases their catalytic *** article delves into the potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in the context of sustainable energy *** to the exception-ally high surface-to-volume ratio,large surface area as well as their optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such as high conductivity and the ability to enhance the exposure of active metal sites,2D metallenes have recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** their highly mobility,adjustable surface states,and electrical struc-tures that can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with the sustainable applications.

关键词： Metallenes Electrocatalysts Electrochemical processes Atomically thin structure

Mass-Casualty Distribution for Emergency Healthcare:A Simulation Analysis

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International Journal of Disaster Risk Science 2020年第3期11卷 364-377页

作者： mohsin Nasir Jat Raza ali Rafique Edwards School of Business University of SaskatchewanSaskatoonSK S7N5A7Canada School of Management and Marketing Kean UniversityUnionNJ 07083USA

This study focuses on the casualty-load distribution problem that arises when a mass casualty incident(MCI)necessitates the engagement of multiple medical *** discrete event simulations,the study analyzed different MCI response regimes in Lahore,Pakistan,that vary in terms of the level of casualty-load distribution and the required coordination between the incident site and the responding *** terrorist attacks in this major metropolitan area were considered to set up experiments for comparing delays in treatment under the modeled *** analysis highlights that the number of casualties that are allowed to queue up at the nearest hospital before diverting the casualty traffic to an alternate hospital can be an important factor in reducing the overall treatment *** diverting the casualty traffic from the incident site to an alternate hospital can increase the travel time,while a delay in diversion can overload the nearest hospital,which can lead to overall longer waiting times in the *** casualty distribution mechanisms based only on the responding hospitals’available capacity and current load can perform inefficiently because they overlook the trade-off between the times casualties spend in traveling and in queues.

关键词： Casualty distribution Emergency response Mass casualty incidents Pakistan Urban terrorism