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BIOCELL 2017年第2期41卷 33-40页

作者： SARA SOLTANIAN HELIA RIAHIRAD ATHAREH PABARJA mohammad reza karimzadeh KOLSOUM SAEIDI Department of Biology Faculty of ScienceShahid Bahonar University of KermanKermanIran Department of Medical Genetics Afzalipour School of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Kerman University of Medical SciencesKermanIran Department of Medical Genetics Kerman University of Medical SciencesKermanIran

Cancer stem cells(CSCs)are a small subpopulation of cancer cells whose resistance to chemotherapy and radiotherapy plays a pivotal role in treatment failure,tumor recurrence and ***,the ability of many phytochemicals in targeting of CSCs has been *** is a plant phytoestrogen that was recognized as a useful agent for targeting cancer cells by apoptosis induction,cell cycle arrest and inhibition of angiogenesis,migration,and invasion of cancer *** this study,we compared the effect of docetaxel as a common breast cancer chemotherapy drug and kaempferol on MCF-7 breast *** showed that both docetaxel and kaempferol caused a dose-dependent reduction in cell *** 123 dye staining and flow cytometry analysis revealed that after docetaxel and kaempferol treatment,SP cells proportion of MCF-7 decreased to 11.83±2.2% and 3±0.25% respectively relative to proportion of untreated control cells(23±3.2%).Moreover,real time PCR results showed that kaempferol treatment of MCF-7 was more effective than docetaxel in down-regulating the CSC-associated markers(***4,nanog,abcb1 and aldh1a1).Taken together,these results indicate that kaempferol is an effective anti-CSCs agent,therefore it may be a therapeutic strategy for eradicating breast cancer through the elimination of CSCs.

关键词： Breast cancer Cancer stem like cells Kaempferol Docetaxel

Fabrication of Bulk (Fe,Cr)_3Al/Al_2O_3 Intermetallic Matrix Nanocomposite Through Mechanical Alloying and Sintering

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 911-919页

作者： Sayyed Erfan Aghili mohammad Hossein Enayati Fathallah karimzadeh Department of Materials Engineering Isfahan University of Technology

In the present study, （Fe,Cr）3Al/20 vol% A1203 nanocomposite was prepared through mechanochemical reactions during ball milling and successfully bulked using a combination of cold isostatic press and sintering at 1400℃ for 1 h. Two processing approaches were utilized to produce （Fe,Cr）3A1/A1203 nanocomposite： The first was milling of Fe, Cr, AI and Fe203, while the second one was milling of Fe, Cr, Al and Cr203, both in stoichiometric condition, to synthesize （Fe,Cr）3Al/20 vol% Al2O3. Structural changes of powder particles during mechanical alloying were studied by X-ray diffraction. The microstructure and the morphology of powder particles and bulk samples were also studied by scanning electron microscopy and transmission electron microscopy. Microstructural analysis showed that mechanochemical reactions took place during milling, and nanometric Al2O3 was uniformly distributed in the matrix. The results also showed that the second approach required a considerably higher milling time to produce （Fe,Cr）3Al/Al2O3 nanocomposite, as compared to the first one. For this reason, bulk samples were produced from the synthesized nanocomposite in the first approach. The microstructure of the sintered samples consisted of a network structure of （Fe,Cr）3Al and Al2O3 phases with superior mechanical properties.

关键词： Iron aluminide Mechanical alloying Nanocomposite Mechanochemical treatment

Characterization of NbSi_2–Al_2O_3 nanocomposite coatings prepared with plasma spraying mechanically alloyed powders

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International Journal of Minerals,Metallurgy and Materials 2015年第7期22卷 748-754页

作者： Zohreh Yazdani Fathallah karimzadeh mohammad-Hasan Abbasi Abbas Amini Department of Materials Engineering Isfahan University of Technology

The present study characterized NbSi2-Al2O3 nanocomposite powders plasma-sprayed on Ti-6Al-4Vsubstrates. The powders were agglomerated to obtain suitable particle sizes for spraying. The agglomerated powders were then plasma-sprayed using atmospheric plasma spraying. The structural transformations of the powders along with the morphological and mechanical changes of the coatings were examined by X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, and hard- ness testing. The results showed that after plasma spraying, the grain size increased, and the lattice strain decreased. However, the grain size of this compound after spraying was still in the nanometer range. The coating was uniform and exhibited good adhesion to the substrate. The microhardness and fracture toughness of the nanocomposite coating were higher than those of a nanostructured NbSi2 coating.

关键词： nanocomposites coatings plasma spraying mechanical alloying

Phase Stability in Mechanically Alloyed Mg–Ni System Studied by Experiments and Thermodynamic Calculations

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1002-1007页

作者： mohammad Hossein Enayati Fathallah karimzadeh Soheil Sabooni Majid Jafari Department of Materials Engineering Isfahan University of Technology

In this study, microstructural evolution of Mg–Ni alloy during mechanical alloying（MA） was ***, a thermodynamic approach was utilized to predict the most stable phases formed in Mg–Ni alloy after MA. The phase composition and microstructural properties of Mg–Ni alloy were assessed by X-ray diffractometry, high-resolution field emission scanning electron microscopy and high-resolution transmission electron microscopy. The results showed that ball milling of magnesium and nickel powder mixture for 70 h yields nanostructural Mg2Ni compound with an average grain size of ~20 nm. Thermodynamic calculations revealed that in the composition ranges of 0.0 ／ XMg／ 0.03（at.%）and 0.97 ／ XMg／ 1, there is no driving force for amorphous phase formation. In the composition range of 0.07 ／ XMg／ 0.93, the change of Gibbs free energy for amorphous phase formation was more negative than solid *** for XMg= 0.66（nominal composition of Mg2Ni intermetallic phase）, the change of Gibbs free energy for intermetallic phase was found to be more negative than both amorphous and solid solution phases indicating that Mg2Ni intermetallic compound is the most stable phase, in agreement with the experimental observations.

关键词： Mechanical alloying Nanocrystalline Hydrogen storage material Mg2Ni Thermodynamics

Stabilizing silica nanoparticles in high saline water by using polyvinylpyrrolidone for reduction of asphaltene precipitation damage under dynamic condition

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1021-1029页

作者： mohammad reza Aghajanzadeh mohammad Sharifi Department of Petroleum Engineering Amirkabir University of Technology

In this study, the performance of stable nanofluid containing SiO2 nanoparticles dispersed and stabilized in high salinity brine for asphaltene inhibition in dynamic condition is evaluated. In the first stage of this work, the stability of silica nanoparticles in different range of water salinity(0–100000 mg·L-1) is investigated. Next, stable nanofluid containing highest salinity is selected as asphaltene inhibitor agent to inject into the damaged core sample. The estimated values of oil recovery for base case, after damage process and after inhibition of asphaltene precipitation using nanofluid are 51.6%, 36.1% and 46.7%, respectively. The results showed the reduction in core damage after using nanofluid. In addition, the relative permeability curves are plotted for the base case, after damage process and also after inhibition of asphaltene precipitation using nanofluid. Comparison of relative permeability curves shows, relative permeability of oil phase decreased after damage process as compared with the base case. But after using nanofluid the oil relative permeability curve has shifted to the right and effective permeability of oil phase has been improved.

关键词： Formation damage Enhanced oil recovery Salinity Asphaltene Core flooding Nano particles

Experimental investigation of different brines imbibition influences on co-and counter-current oil flows in carbonate reservoirs

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Chinese Journal of Chemical Engineering 2021年第5期34卷 17-29页

作者： Pouyan Ahmadi mohammad reza Aghajanzadeh Masoud Riazi mohammad reza Malayeri mohammad Sharifi Enhanced Oil Recovery(EOR)Research Centre IOR/EOR Research InstituteShiraz UniversityShirazIran Helmholtz Centre for Environmental Research-UFZ LeipzigGermany Department of Petroleum Engineering Amirkabir University of TechnologyTehranIran Institut für Verfahrenstechnik und Umwelttechnik Technische Universität DresdenGermany

Imbibition of water,as wetting phase in oil-wet fractured carbonate reservoirs,plays a key role in fluid flow between matrix and fracture *** type of injected seawater and its chemistry would profoundly influence the imbibition *** this study,the impact of smart water(a brine that its ions have been adjusted to facilitate oil recovery)and low salinity water on co-and counter-current imbibition processes for oil-wet carbonate cores has been experimentally *** results show an increase of about 10% in oil recovery for co-and counter-currents for smart seawater imbibition compared to that of low salinity *** addition,as a result of the influence of co-and counter-current on each other,by co-current removal from one core face,the countercurrent in the other face would be intensified by as much as about 75%.A close examination of different lengths(5,7 and 9 cm)of carbonate cores with the same permeability revealed that by decreasing porous medium length,the amount of counter-current producing oil would be decreased so that in the 5 cm core,counter current oil production will not *** similar core lengths by increasing permeability,the share of counter current flow would be decreased approximately 18% since the capillary pressure could not overcome non-wetting phase viscous *** the role of matrix length along with a modified brine(which is designed according to the matrix mixture)strengthen the relevant mechanisms to have more oil production so that the higher thickness of matrix causes the higher amount of co-current oil producing and consequently more total recovery.

关键词： Smart water Co-current Counter current Wettability alteration Oil recovery

Stochastic price based coordinated operation planning of energy storage system and conventional power plant

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1020-1032页

作者： mohammad reza SHEIBANI Gholam reza YOUSEFI mohammad Amin LATIFY Department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahan 84156-83111Iran

A generation company(GENCO)which has a conventional power plant(CPP)intends to add an energy storage system(ESS)beside the CPP to increase its flexibility and *** this purpose,a new model is proposed for coordinated operation planning of the CPP and ESS in energy and spinning reserve markets in the presence of a bilateral *** proposed model is based on the stochastic price based unit commitment(PBUC)and price based storage commitment(PBSC).The uncertainties of the energy and spinning reserve prices and delivery requests in the spinning reserve market are modeled via scenarios based upon historical *** proposed model maximizes the profitability of the ESS beside the CPP and encourages the GENCO to invest the *** technology options to use beside the CPP are determined by economic *** results show that utilization of ESSs improves the technical operation of CPPs,as well as GENCOs’profitability.

关键词： Energy storage system Conventional power plant Operation planning Price based unit commitment

Enhanced empirical models for predicting the drift capacity of less ductile RC columns with flexural,shear,or axial failure modes

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1251-1270页

作者： mohammad reza AZADI KAKAVAND reza ALLAHVIRDIZADEH Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversity of InnsbruckInnsbruck 6020Austria ISISE Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal

Capacity of components subjected to earthquake actions is still a widely interesting research topic. Hence, developing precise tools for predicting drift capacities of reinforced concrete (RC) columns is of great interest. RC columns are not only frequently constructed, but also their composite behavior makes the capacity prediction a task faced with many uncertainties. In the current article, novel empirical approaches are presented for predicting flexural, shear and axial failure modes in RC columns. To this aim, an extensive experimental database was created by collecting outcomes of previously conducted experimental tests since 1964, which are available in the literature. It serves as the basis for deriving the equations for predicting the drift capacity of RC columns by different regression analyses (both linear with different orders and nonlinear). Furthermore, fragility curves are determined for comparing the obtained results with the experimental results and with previously proposed models, like the ones of ASCE/SEI41-13. It is demonstrated that the proposed equations predict drift capacities, which are in better agreement with experimental results than those computed by previously published models. In addition, the reliability of the proposed equations is higher from a probabilistic point of view.

关键词： flexural-shear-axial failure drift capacity reinforced concrete columns statistical analysis fragility curves

Evaluation of attraction terms in equations of state on the prediction of solubility of some biomolecules in supercritical carbon dioxide

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Chinese Chemical Letters 2009年第4期20卷 501-505页

作者： mohammad reza Bozorgmehr mohammad reza Housaindokht Department of Chemistry Faculty of Science.Islamic Azad UniversityMashad BranchMashhadIran Department of Chemistry Faculty of ScienceFerdowsi University of MashhadMashadIran

In the present work, effect of the attraction terms of four recently modified Peng-Robinson （MPR） equations of state on the prediction of solubility of caffeine, cholesterol, uracil and erythromycin was studied. The attraction terms of two of these equations are linear relative to the acentric factor and for the other two are exponential. It is found that the later show less deviation. Also interaction parameters for the studied systems are obtained and the percentage of average absolute relative deviation （%AARD） in each calculation is displayed.

关键词： Equation of state Solubility Supercritical carbon dioxide Biomolecules

Proportional integral derivative controller design using Legendre orthogonal functions

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Journal of Central South University 2016年第10期23卷 2616-2629页

作者： reza Moradi mohammad Tabatabaei Department of Electrical Engineering Khomeinishahr Branch Islamic Azad University

The Legendre orthogonal functions are employed to design the family of PID controllers for a variety of plants. In the proposed method, the PID controller and the plant model are represented with their corresponding Legendre series. Matching the first three terms of the Legendre series of the loop gain with the desired one gives the PID controller parameters. The closed loop system stability conditions in terms of the Legendre basis function pole(λ) for a wide range of systems including the first order, second order, double integrator, first order plus dead time, and first order unstable plants are obtained. For first order and double integrator plants, the closed loop system stability is preserved for all values of λ and for the other plants, an appropriate range in terms of λ is obtained. The optimum value of λ to attain a minimum integral square error performance index in the presence of the control signal constraints is achieved. The numerical simulations demonstrate the benefits of the Legendre based PID controller.

关键词： PID controllers orthogonal functions legendre functions moment matching PI controller PD controller