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Uncoupling tumor necrosis factor-αand interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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BIOCELL 2022年第3期46卷 769-783页

作者： RAGHDA A.SOLIMAN RANA A.YOUNESS TAMER M.MANIE EMAD KHALLAF mohamed EL-SHAzLY MONA ABDELMOHSEN HEBA HANDOUSSA mohamed z.gad Pharmaceutical Biology Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt School of Life and Medical Sciences University of Hertfordshire Hosted by Global Academic FoundationNew Administrative Capital11578Egypt Breast Surgery Department National Cancer InstituteCairo UniversityCairoEgypt General Surgery Department Faculty of MedicineCairo UniversityCairoEgypt Department of Phytochemistry National Research CentreGiza12622Egypt Biochemistry Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Triple Negative Breast Cancer(TNBC)immunotherapy has recently shown promising ***,some TNBC patients presented with *** of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment(TME)such as Tumor necrosis factor alpha(TNF-α)and Interleukin-10(IL-10).Fine regulation of these cytokines’levels via non-coding RNAs(ncRNAs)might alleviate the immune quiescent nature of TME at TNBC ***,the extrapolation of ncRNAs as therapeutic tools is highly ***,disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational therapeutic ***,this study aimed to targeting the chief immune suppressive cytokines at the TME(TNF-αand IL-10)via ncRNAs and to examine the effects of Rosemary aerial parts extract on the expression levels of these ncRNAs in *** revealed miR-17-5p as a dual regulator of TNF-αand ***,an intricate interaction has been shown between miR-17-5p and the oncogenic lncRNAs:MALAT1 and *** down of MALAT1 and/or H19 caused an induction in miR-17-5p and reduction in TNF-αand IL-10 expression ***-17-5p was found to be down-regulated,while TNF-α,IL-10,MALAT1 and H19 were up-regulated in BC *** expression of miR-17-5p in MDA-MB-231 cells reduced TNF-α,IL-10,MALAT1 and H19 expression levels,as well as several BC *** a translational approach,ursolic acid(UA)isolated from rosemary induced the expression of miR-17-5p,MALAT1 and decreased H19 expression *** conclusion,this study suggests miR-17-5p as a tumor suppressor and an immune-activator miRNA in BC through tuning up the immunological targets TNF-α,IL-10 at the TME and the oncological mediators MALAT1 and H19 lncRNAs.

关键词： Breast cancer Tumor microenvironment Cytokines TNF-α IL-10 miR-17-5p MALAT1 H19 lncRNAs miRNA Ursolic acid

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Exploring dielectric phenomena in sulflower-like nanostructures via Monte Carlo technique

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Communications in Theoretical Physics 2024年第4期76卷 188-198页

作者： N Saber z Fadil Hussein Sabbah A Mhirech B Kabouchi L Bahmad Chaitany Jayprakash Raorane Siva Sankar Sana Hassan Fouad mohamed Hashem Laboratory of Condensed Matter and Interdisciplinary Sciences(LaMCScI) Research Unit Labelled CNRSTURL-CNRST-17.Faculty of SciencesPO Box 1014Mohammed Ⅴ University in RabatMorocco College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait School of Chemical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Applied Medical Science Department Community CollegeKing Saud UniversityPO Box 11433Riyadh Saudi Arabia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityPO Box 12372RiyadhSaudi Arabia

This research focuses on the electric behavior of a mixed ferrielectric sulflower-like *** structure includes a core with spin S_(i)^(z)-1 atoms and a shell with spin σ_(j)^(z)-5/2 *** Blume–Capel model and the Monte Carlo technique(MCt)with the Metropolis algorithm are *** are established for absolute zero,investigating stable spin configurations correlated with various physical *** MCt method explores phase transition behavior and electric hysteresis cycles under different physical parameters.

关键词： sulfower-like nanostructure dielectric characteristics Monte Carlo technique phase transition phase diagrams electric hysteresis

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed mohamed z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Preliminary Palynostratigraphic Data on the Middle Albian-Lower Cenomanian of the Tarfaya Basin, Southwest Morocco

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Open Journal of Geology 2024年第4期14卷 548-568页

作者： Khaoula Chafai Touria Hssaida Wafaa Maatouf mohamed z. Yousfi Sara Chakir Soukaina Jaydawi Hanane Khaffou Department of Geology Faculty of Sciences Ben M&#8217Sik University Hassan II Casablanca Morocco Department of Petroleum Laboratory Office National des Hydrocarbures et des Mines Rabat Morocco Department of Geology Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University Fes Morocco Department of Geology Faculty of Sciences Mohammed V University Rabat Morocco

The Tarfaya-Laayoune-Boujdour basin is of great interest to oil exploration;on this aspect, there has been exploration by the Moroccan National Office of Hydrocarbons and Mining, which has shown indices of oil and/or gas recorded in most wells drilled in the Moroccan Atlantic margin. FD-1 well, object of this study, is one of these wells located in the offshore Tarfaya-Laayoune-Boujdour basin. A palynological examination of the processed samples revealed the existence of organic palynomorphs, well conserved and rich in dinoflagellate cysts. The latter are composed of worldwide marker taxa of high stratigraphic resolutions. Thus, the middle upper Albian (3408 - 3408.5 m) is determined by the presence of Cribroperidinium tensiftense, Tehamadinium coummia, Spiniferella cornuta, Chichaouadinium vestitum, Dinopterygium alatum and Litosphaeridium arundum. The upper Albian (3406.5 - 3408 m) is characterized by the FOs of marker taxa: Cyclonephelium chabaca, Cribroperidinium auctificum and Chichaouadinium vestitum. Lastly, the upper Albian-lower Cenomanian transition is defined between 3404 m and 3406.50 m, as suggested by the FOs of Chichaouadinium boydii, Dinopterygium tuberculatum, Sepispinula ancorifera, Litosphaeridium conispinum, Prolixosphaeridium conulum and Xenascus ceratioides.

关键词： Morocco Tarfaya-Laayoune-Boujdour Basin Albian-Cenomanian Transition Dinoflagellate Cysts Palynostratigraphy

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Strain engineering in electrocatalysis:Strategies,characterization,and insights

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Nano Research 2024年第5期17卷 3603-3621页

作者： Qibo Deng Peng Xu Hassanien Gomaa mohamed A.Shenashen Sherif A.El-Safty Cuihua An Li-Hua Shao Ning Hu School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China Department of Chemistry Faculty of ScienceAl-Azhar University71524AssiutEgypt Department of Petrochemical Egyptian Petroleum Research Institute(EPRI)Nasr City11727CairoEgypt Center for Functional Materials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki-ken305-0047Japan State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of Educationand School of Mechanical EngineeringHebei University of TechnologyTianjin 300401China National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191China Advanced Equipment Research Institute Co. Ltd.of HEBUTTianjin 300401China

Strain engineering,as a cutting-edge method for modulating the electronic structure of catalysts,plays a crucial role in regulating the interaction between the catalytic surface and the adsorbed *** electrocatalytic performance is influenced by the electronic structure,which can be achieved by introducing the external forces or stresses to adjust interatomic spacing between surface *** challenges in strain engineering research lie in accurately understanding the mechanical impact of strain on *** paper first introduces the basic strategy for generating the strain,summarizes the different strain generation forms and their advantages and *** progress in researching the characterization means for the lattice strains and their applications in the field of electrocatalysis is also ***,the challenges of strain engineering are introduced,and an outlook on the future research directions is provided.

关键词： strain electrocatalysis characterization chemical reaction kinetics lattice mismatch

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Microchemical Characterization of Natural Gold and Copper Alloys from the Ancient Um Shashoba Gold Mine, South Egypt

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Acta Geologica Sinica(English Edition) 2014年第1期88卷 196-212页

作者： mohamed Abdallah gad DARWISH Geology Department Faculty of Science Aswan University

The SEM-EDX technique was applied to investigate Au, and Cu＋Sn alloyed grains in the mineralization of the Um Shashoba mine for achieving further understanding of occurrences, internal structures and microchemistry of Au and Cu alloys and associated minerals, and mineralization type. This study is aiming at the genetic history of ore-bearing fluid events, geochemical evaluation and exploration significance. The results showed that the mineralization could be considered as a single major episode generated by metamorphic mesothermal solution rich in sulfides and unsaturated respect to Au. It was differentiated into many stages; started with formation of auriferous pyrite that was pseudomorphed by secondary hematite, limonite and goethite. Three phases of Au alloy were precipitated, and Cu＋Sn and Ag-rich alloys were produced respectively and followed by deposition of two generations of barren pyrite. Calcite and ankerite were crystalized, surrounded and partially replaced some of early formed minerals. Finally, barren muscovite recrystallized around and inside both later formed carbonate minerals that were free of any sign of Au in their structures. The processes of deformation, recrystallization, annealing, dissolution, remobilization and re-precipitation played the most important roles in the genetic history of the mineralization.

关键词： SEM–EDX analyses Au and Cu alloy grains Um Shashoba gold mine Egypt

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Geochemical Stream Sediment Survey in the Wadi Umm Rilan Area,South Eastern Desert,Egypt:A New Occurrence for Gold Mineralization

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 1041-1062页

作者： mohamed Abdallah gad DARWISH Geology Department Faculty of ScienceAswan University

The present paper investigates the stream sediment geochemistry, behavior of gold and associated elements, delineates Au-anomalous sites and defines related sources in the Wadi Umm Rilan area. Fifty three major and trace elements were analyzed using ICP-MS and treated applying various statistical and mapping techniques. The results showed a significant difference of mean and median Au and most chemical elements in the three portions of the area, and higher values were recorded in the western portion. Furthermore, Au-anomalous sites appeared in upper and lower parts of the Wadi Umm Rilan, along the tributaries of metavolcanic unit and near granitoid contacts. This indicates the main source of Au mineralization is related to emplacement of granitoid plutons and accompanying hydrothermal solutions. There are significant indications for the presence of more than one mineralization event forming a probable single major episode of mineralization in the area, involving Au, Pb and U mineralizations. Geology, geomorphologic aspects and weathering processes could control stream sediment geochemistry, anomalies of Au and associated elements, elemental association and their dispersion patterns. Therefore, the area is fruitful and regarded as a promising target for Au exploration, using Ag, As, Sb, Cd, Cs, and TI as pathfinder elements.

关键词： geochemical survey stream sediments Au mineralization Wadi Umm Rilan area southEastern Desert Egypt

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Geochemical and Environmental Evaluation of Um Shashoba Gold Mine Area,Southeastern Desert,Egypt

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Acta Geologica Sinica(English Edition) 2011年第4期85卷 881-898页

作者： mohamed Abdallah gad DARWISH Geology Department Aswan Faculty of ScienceSouth Valley UniversityPost No.81528 AswanEgypt

A suite of elements（Ag,Au,Ba,Bi,Cd,Co,Cr,Cu,Ga,Hf,Hg,Mn,Mo,Ni,Pb,Rb,Sb,Se, Sr,Te and zn）,total organic carbon（TOC）and pH were analyzed in stream sediment and tailing samples from Um Shashoba area,in order to evaluate Au placer and the sediments being impacted by old mining *** results were examined using statistical,graphical and mapping *** spite of the results revealing that Au and most of the elements in sediments were in general significantly lower than those in tailing,Au was concentrated in the NE and SW parts forming Au *** is remarkably a close association of Au with Hg and Sb;both are useful as pathfinder elements for Au *** of pH could not control a fate of analyzed elements,whereas TOC and Mn oxides and hydroxides could uptake some elements Au,Ba,Co,Cr,Hg,Ni,and *** results also indicated that the sediments were contaminated by anthropogenic factors causing moderate,strong to very strong pollution with respect to Bi,Se and Te,***,geogenic factors could also contribute elemental enrichment to the drainage system and cause significant toxicity level.

关键词： geochemical exploration environmental evaluation Um Shashoba gold mine Egypt

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Geochemistry of the High Dam Lake sediments,south Egypt:implications for environmental significance

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International Journal of Sediment Research 2013年第4期28卷 544-559页

作者： mohamed Abdallah gad DARWISH Geology department Faculty of ScienceAswan University

The goal of the present work is to perform a geochemical assessment of High Dam Lake bottom sediments for determining the fate,dispersion and levels of trace elements causing environmental pollution,and provided an access to their probable *** sediment samples were analyzed using ICP-MS for 20 elements;Ag,Ba,Cr,Cu,Ga,Hf,Mn,Pb,Rb,Sc,Sc,Sn,Sr,Ta Th Ti,T1,U,V and zr,and their obtained data were treated using statistical,graphical and mapping *** results showed the data set of all analyzed elements affected by outliers and extreme values that caused deviation away from *** Wallis test revealed that median of some trace clement levels in Lake sediments,was not significantly different and other elements rejected the Null *** analyzed elements had high values of median and mean in sediments of Lake Nubia rather than Lake Nasser and their normalization gave the same results of calculated environment ***,Lake Nubia sediments possessed high combined EF levels of Th,Sc,Sn,Ag,zr,Hf,Ta,Sr,U,Ti,V,Cr,and Mn,causing significant contamination,which was great potentially related to industrial,agricultural,urbanization and mining ***,combined EF of Se,Cu,Ga,Pb,Ba,Rb,and Tl,which are highly elevated in southern Lake Nasser sediments owing to their source are great possibly derived from Lake Nubia and geogenic *** decreasing distance towards the High Dam body,the contaminant elements were diminished due to reduction in the environmental factors and Sudanese pollution sources leading to the northern Lake Nasser considered to be less ***,the present study is an environmental alert for contaminated sediments that carried contaminants and considered the secondary source of pollution impact on ecosystem,and subsequently,their environmental risk on Human health.

关键词： Geochemistry High Dam Lake sediments Environmental significance South Egypt

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Is aggressive intravenous fluid resuscitation beneficial in acute pancreatitis? A meta-analysis of randomized control trials and cohort studies

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World Journal of Gastroenterology 2020年第10期26卷 1098-1106页

作者： mohamed M gad C.Roberto Simons-Linares Internal Medicine Department Medicine InstituteCleveland ClinicClevelandOH 44195United States Gastroenterology and Hepatology Department Digestive Disease InstituteCleveland ClinicClevelandOH 44195United States

BACKGROUND There is conflincting evidence on the intravenous fluid(IVF)strategy for acute pancreatitis(AP).We perform a metaanalysis of the available *** To investigate if aggressive IVF therapy in AP patients is beneficial to decrease mortality and improve *** Metaanalysis of available randomized controlled trials and cohort studies comparing aggressive IVF vs non-aggressive IVF *** There was no significant difference in mortality between the aggressive(n=1229)and non-aggressive IVF(n=1397)*** receiving aggressive IVF therapy had higher risk for acute kidney injury and acute respiratory distress *** also was no significant difference in the overall incidence of systemic inflammatory response syndrome,persistent organ failure,pancreatic necrosis when comparing both study *** Early aggressive IVF therapy did not improve ***,aggressive IVF therapy could potentially increase the risk for acute kidney injury and pulmonary edema leading to respiratory failure and mechanical *** are needed to investigate which subset of AP patients could benefit from aggressive IVF therapy.

关键词： Acute pancreatitis Intravenous fluid resuscitation Aggressive fluid resuscitation

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