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Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter

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World Journal of Gastroenterology 2013年第24期19卷 3723-3725页

作者： Raphael JF Felizardo niels OS Cmara Division of Nephrology Department of Medicine Federal University of Sao PauloSao Paulo CEP 05508-900 Brazil Department of Immunology Institute of Biomedical Sciences University of S o PauloSao Paulo CEP 05508-900 Brazil

Ochratoxin A (OTA) is a secondary metabolite of Asper-gillus and Penicillium, microorganisms that can be haz-ardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular car-cinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. In a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.

关键词： Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt

Modeling shoreline sand waves on the coasts of Namibia and Angola

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International Journal of Sediment Research 2013年第3期28卷 338-348页

作者： Francesca RIBAS Albert FALQUES niels VAN DEN BERG Miquel CABALLERIA Department of Applied Physics Universitat Politecnica de CatalunyaSpain

The southwestern（SW） coast of Africa（Namibia and Angola） features long sandy beaches and a wave climate dominated by energetic swells from the Southsouthwest（SSW）,therefore approaching the coast with a very high *** images reveal that along that coast there are many shoreline sand waves with wavelengths ranging from 2 to 8 km.A more detailed study,including a Fourier analysis of the shoreline position,yields the wavelengths（among this range） with the highest spectral density ***,it becomes apparent that at least some of the sand waves are dynamically active rather than being controlled by the geological setting.A morphodynamic model is used to test the hypothesis that these sand waves could emerge as free morphodynamic instabilities of the coastline due to the obliquity in wave *** is found that the period of the incident water waves,T;,is crucial to establish the tendency to stability or instability,instability increasing for decreasing period,whilst there is some discrepancy in the observed *** results for T;= 7-8 s clearly show the tendency for the coast to develop free sand waves at about 4 km wavelength within a few years,which migrate to the north at rates of 0.2-0.6 km yr;.For larger T;or steeper profiles,the coast is stable but sand waves originated by other mechanisms can propagate downdrift with little decay.

关键词： Shoreline evolution Shoreline sand waves High angle wave instability Longshore sediment transport

Organic geochemical and petrographic characteristics of the Cambrian-Ordovician organic-rich marine shales in Scandinavia

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Petroleum Science 2023年第5期20卷 2637-2647页

作者： Xiao-Wei Zheng niels-HSchovsbo Lei-Bo Bian Arka Rudra Hamed Sanei Lithospheric Organic Carbon(LOC)Group Department of GeoscienceAarhus University8000Denmark Department of Reservoir Geology Geological Survey of Denmark and Greenland(GEUS)Oster Voldgade 10Dk-1350Copenhagen KDenmark Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China

This work used organic geochemistry and organic petrology to study the depositional environment,organic matter characteristics,and thermal maturity of the Cambrian-Ordovician organic-rich marine shales in the Baltic *** main macerals in Cambrian samples include alginite,bituminite and solid bitumen,while zooclastic macerals become the major proportion of organic matter in the Ordovician *** the maturity increase,solid bitumen becomes abundant and ***-like maceral was observed only in Furongian of well DBH15/73,which probably indicates the local intrusion of Permo-Carboniferous dolerite *** programmed pyrolysis results show that immature,early mature,and over-mature samples are ***,the data of high-uranium Furongian samples were greatly altered by igneous intrusives from local *** calculation model is simulated based on pyrolysis data and fitted according to the least-square fitting *** simulated fitting HIo:400mg HC/g TOC(369.5 mg HC/g TOC,430.5 mg HC/g TOC as 95%confidence bounds)is within the worldwide marine shale HI_(o)and indicates a marine anoxia and transgressive sea with shallow water column(organofacies B).

关键词： Lower paleozoic Organic petrology Initial hydrogen index Original geochemical properties

Effects of Radix Ginseng on microbial infections: a narrative review

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Journal of Traditional Chinese Medicine 2014年第2期34卷 227-233页

作者： Hong Wu niels Hфiby Liang Yang Michael Givskov Zhijun Song Department of International Health Immunology & MicrobiologyUniversity of Copenhagen Department of Clinical Microbiology Singapore Centre on Environmental Life Sciences Engineering Nanyang Technological University Department of Clinical Microbiology RigshospitaletUniversity Hospital of Copenhagen Department of Clinical Microbiology Slagelse Hospital

OBJECTIVE: To summarized the antimicrobial-like effects of Radix Ginseng, which provide important information to the relevant researchers and clinicians, and will benefit the clinical treatment of infectious ***: PubMed and Google were used to search for and collect scientific publications related to Radix Ginseng and microbial infections. The authors read, classified, and discussed the associated scientific results or evidences, and summarized the corresponding ***: In this review, recent studies on the bene-ficial effects of Radix Ginseng extracts on microbial and biofilm infections were reviewed. The importance and significance of Radix Ginseng's beneficial effects are discussed. Evidence for the favorable effects of Radix Ginseng extracts on viral, bacterial,fungal, and parasitic infections and the possible underlying mechanisms are ***: Radix Ginseng might be a promising supplemental remedy for the prevention and treatment of infectious diseases.

关键词： Radix Ginseng Viruses Bacteria Fungi Biofilms Parasitology Review

Conflict resolution for connected automated vehicles at unsignalized roundabouts considering personalized driving behaviours

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Green Energy and Intelligent Transportation 2022年第1期1卷 26-36页

作者： Peng Hang Yiran Zhang niels de Boer Chen Lv School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore Energy Research Institute(ERIAN) Nanyang Technological UniversitySingapore

To address the driving conflicts of connected automated vehicles(CAVs)at unsignalized roundabouts,a cooperative decision-making framework is *** personalized driving preferences of CAVs are considered in the decision-making algorithm,which are reflected by different driving styles.A motion prediction algorithm is used to improve the decision-making *** effect of the motion prediction algorithm on the decisionmaking performance is evaluated,including the advancement of driving safety and the computational load for the *** cooperative game theoretic approach is applied to the interaction modelling and collaborative decision making of ***,hardware-in-the-loop(HIL)tests are carried out to evaluate the feasibility and real-time performance of the proposed algorithm.

关键词： Decision making Connected automated vehicles Conflict resolution Cooperative game theory Unsignalized roundabout

FLECH:A Danish market solution for DSO congestion management through DER flexibility services

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Journal of Modern Power Systems and Clean Energy 2014年第2期2卷 126-133页

作者： Chunyu ZHANG Yi DING niels Christian NORDENTOFT Pierre PINSON JacobØSTERGAARD Center for Electric Power and Energy Technical University of Denmark2800 Kgs.LyngbyDenmark Danish Energy Association 1970 FrederiksbergDenmark

Future electric power systems will face new operational challenges due to the high penetration of distributed energy resources(DERs).In Denmark,distribution system operator(DSO)expects a significant congestion increased in distribution *** order to manage these congestions and mobilize the DERs as economically efficient as possible in the future distribution grid,the brand new notion of flexibility clearing house(FLECH)is proposed in this *** the aggregator-based offers,the proposed FLECH market has the ability to promote small scale DERs(upto 5 MW)for actively participating in trading flexibility services,which are stipulated accommodating the various requirements of ***,the trading setups and processes of the FLECH market are also illustrated in detail.A quantitative example is utilized to illustrate the formulation and classification of flexibility services provided by the DERs in the proposed FLECH market.

关键词： Electricity market Distributed energy resources(DERs) Aggregator Flexibility clearing house(FLECH) Flexibility services

About the Article Entitled "Transplantation of Cryopreserved Teeth:a Systematic Review"

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International Journal of Oral Science 2010年第4期2卷 226-230页

作者： Poramate Pitak-Arnnop niels Christian Pausch Alexander Hemprich Department of Oral Craniomaxillofacial and Facial Plastic SurgeryScientific Unit for Clinical and Psychosocial Research Evidence-Based Surgery and Ethics in Oral and Maxillofacial SurgeryFaculty of MedicineUniversity Hospital of Leipzig

To Editor,We read with interest the article entitled ＂Transplantation of cryopreserved teeth： a systematic review＂（Osathanon, 2010）. Although the author is to be congratulated for his systematic approach to cryopreserved tooth transplantation （CTT）, we would like to draw your attention to some technical limitations of this review.

关键词： Transplantation of Cryopreserved Teeth About the Article Entitled PubMed CTT

Insect host-parasite coevolution in the light of experimental evolution

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Insect Science 2014年第4期21卷 401-414页

作者： niels A. G. Kerstes Oliver Y. Martin Experimental Ecology Institute for Integrative Biology D‐USYS ETH Zurich Zurich Switzerland

The many ways parasites can impact their host species have been the focus of intense study using a range of approaches. A particularly promising but under-used method in this context is experimental evolution, because it allows targeted manipulation of known populations exposed to contrasting conditions. The strong potential of applying this method to the study of insect hosts and their associated parasites is demonstrated by the few available long-term experiments where insects have been exposed to parasites. In this review, we summarize these studies, which have delivered valuable insights into the evolution of resistance in response to parasite pressure, the underlying mechanisms, as well as correlated genetic responses. We further assess findings from relevant artificial selection studies in the interrelated contexts of immunity, life history, and reproduction. In addition, we discuss a number of well-studied Tribolium castaneum-Nosema whitei coevolution experiments in more detail and provide suggestions for research. Specifically, we suggest that future experiments should also be performed using nonmodel hosts and should incorporate contrasting experimental conditions, such as population sizes or envi- ronments. Finally, we expect that adding a third partner, for example, a second parasite or symbiont, to a host-parasite system could strongly impact （co）evolutionary dynamics.

关键词： artificial selection immunity Nosema reproduction resistance Tribolium

Laminated Fe-34.5 Mn-0.04C composite with high strength and ductility

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Journal of Materials Science & Technology 2018年第10期34卷 1939-1943页

作者： Yuhui Wang Jianmei Kang Yan Peng Tiansheng Wang niels Hansen Xiaoxu Huang State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004 China Riso Campus Technical University of Denmark DK-4000 Roskilde Denmark College of Materials Sdence and Engineering Chongqing University Chongqing 400045 China Department of Mechanical Engneering Technical University of'Denmark DK-2800 Lyngby Denmark

To obtain a good combination of strength and ductility, a laminated composite structure composed of recovered hard lamellae and soft recrystallized lamellae has been produced in a single phase austenitic Fe-34.5 Mn-0.04C steel by cold rolling and partial recrystallization. Enhanced mechanical properties in both strength and ductility have been obtained in the composite structure compared to a fully recrystallized coarse grain structure. A further increase in strength with only minor loss in total elongation has been achieved by a slight cold rolling of the composite structure, which also removes the small yield drop and Luders elongation observed in the composite structure.

关键词： Laminated composite structure Partial recrystallization Constraint effect Strength Ductility