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英语学习 1994年第5期 28-28页

作者： mocco wollert

Normal Perfusion Pressure Breakthrough Following AVM Resection: A Case Report and Review of the Literature

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Open Journal of Modern Neurosurgery 2013年第4期3卷 66-71页

作者： T. E. O’Connor K. M. Fargen J. mocco College of Medicine University of Florida Gainesville USA Department of Neurological Surgery University of Florida Gainesville USA Department of Neurological Surgery Vanderbilt University Nashville USA

Objective: To report a patient’s clinical course illustrative of the NPPB mechanism for hyperperfusion-induced injury. Methods: A 65-year-old female presented with a severe headache and was found to have a 6-cm right parietal AVM on imaging. The patient underwent staged, pre-operative embolization and the AVM was surgically resected without intra-operative complication. After the patient emerged from anesthesia she exhibited left hemiplegia and hemispatial neglect. Her systolic blood pressure (SBP) at that time was between 110-120 mmHg. SBP was reduced to 90-100 mmHg and the patient’s symptoms resolved shortly thereafter. The patient’s strict blood pressure goal was relaxed the next morning. However, with her SBP 110-120 mmHg in the ensuing hours, the patient’s left-sided neglect and hemiparesis returned. Her SBP was reduced again to 90-100 mmHg, leading to resolution of her symptoms. Results: This patient’s clinical course supports the NPPB theory of hyperperfusion-induced injury. Despite CT imaging demonstrating no residual AVM following resection, the patient developed neurological deficits in the immediate postoperative period. Aggressive systemic hypotension improved clinical symptoms repeatedly, whereas a brief period of normotension triggered a return of neurological deficits. As a result, there was a direct correlation between fluctuations of neurological status and SBP. This case suggests that the intrinsic autoregulatory capacity was altered in our patient, and that aggressive hypotension was necessary to compensate for diminished autonomic reactivity. Conclusions: This case provides further evidence that NPPB plays a role in hyperperfusion-induced injury following AVM excision and that blood pressure control is vital in managing hyperemic complications following complete resection of cerebral AVMs.

关键词： Blood Pressure Hemorrhage Intracranial Arteriovenous Malformations Normal Perfusion Pressure Breakthrough

心肌梗死后冠状动脉内自体骨髓细胞输注:BOOST随机对照临床试验

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 9-10页

作者： wollert K.C. Meyer G.P. Lotz J. H. Drexler 高峰 Abteilung Kardiologi e und Angiologie Medizinische Hochschule Hannover Carl-Neuberg Strasse 1 30625 Hannover GermanyProf.

Background Emerging evidence suggests that stem cells and progenitor ce lls der ived from bone marrow can be used to improve cardiac function in patients after acute myocardial infarction. In this randomised trial, we aimed to assess whethe r intracoronary transfer of autologous bone-marrow cells could improve global l eft-ventricular ejection fraction (LVEF) at 6 months’follow-up. Methods After successful percutaneous coronary intervention (PCI) for acute ST-segment eleva tion myocardial infarction, 60 patients were randomly assigned to either a contr ol group (n=30) that received optimum postinfarction medical treatment, or a bon e-marrow-cell group (n=30) that received optimum medical treatment and intraco ronary transfer of autologous bone-marrow cells 4.8 days (SD 1.3) after PCI. Pr imary endpoint was global left-ventricular ejection fraction (LVEF) change from baseline to 6 months’follow-up, as determined by cardiac MRI. Image analyses were done by two investigators blinded for treatment assignment. Analysis was pe r protocol. Findings Global LVEF at baseline (determined 3.5 days > after PCI) was 51.3 (9.3%) in controls and 50.0(10.0%) in the bone-marrow cell group (p=0.59). After 6 months, mean global LVEF had increased by 0.7 percentage points in the c ontrol group and 6.7 percentage points in the bone-marrow-cell group (p=0.0026 ). Transfer of bone-marrow cells enhanced left-ventricular systolic function p rimarily in myocardial segments adjacent to the infarcted area. Cell transfer di d not increase the risk of adverse clinical events, in-stent restenosis, or pro arrhythmic effects. Interpretation Intracoronary transfer of autologous bone-ma rrow-cells promotes improvement of left-ventricular systolic function in patie nts after acute myocardial infarction.

关键词： BOOST 自体骨髓细胞输注心脏功能支架内再狭窄收缩功能梗死区心肌节段药物治疗射血分数

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如何建立一个杂交手术室

中国心血管病研究 2010年第8期8卷 636-636页

作者： H.-G. wollert 梅克伦堡-前波莫瑞心脏糖尿病中心胸心血管外科德国卡尔斯堡

Due to increasing life expectancy,the number of patients presenting with any form of degenerative aortic valve and aortic disease which should be treated(surgically),growths constantly.

关键词：瓣膜及主动脉疾病杂交手术外科治疗

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TAVA：经皮主动脉瓣置换术后结果

中国心血管病研究 2010年第8期8卷 639-639页

作者： H.-G. wollert 梅克伦堡-前波莫瑞心脏糖尿病中心胸心血管外科德国卡尔斯堡

The number of older patients presenting any form of degenerative aortic valve disease growths constantly due to increasing life *** many patients with severe symptomatic aortic stenosis,advanced age and extensive co-m... 详细信息

关键词： TAVI 心脏瓣膜疾病心血管外科干预治疗

C1q-肿瘤坏死因子相关蛋白9促进心脏肥大和心力衰竭

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中华高血压杂志 2016年第11期24卷 1002-1002页

作者：刘莉叶鹏 Appari M Breitbart A Brandes F Szaroszyk M Froese N Korf-Klingebiel M Malek Mohammadi M Grund A Scharf GM Wang H Zwadlo C Fraccarollo D Schrameck U Nemer M Wong W Katus HA wollert KC Müller OJ Bauersachs J Heineke J

心肌内皮细胞可能通过释放生长因子,促进心肌细胞肥大。然而,这些因子在很大程度上仍然是未知的,研究人员假设分泌的C1q-肿瘤坏死因子相关蛋白9（C1q-tumor necrosis factor-related protein-9,CTRP9）可能作为压力超负荷时调节心脏重... 详细信息

心肌内皮细胞可能通过释放生长因子,促进心肌细胞肥大。然而,这些因子在很大程度上仍然是未知的,研究人员假设分泌的C1q-肿瘤坏死因子相关蛋白9（C1q-tumor necrosis factor-related protein-9,CTRP9）可能作为压力超负荷时调节心脏重塑的内皮衍生蛋白。该研究的目的为检测心脏CTRP9的来源及其在压力超负荷期间的功能。方法和结果：CTRP9主要来源于心肌毛细血管内皮细胞。

关键词：肿瘤坏死因子 C1q 心脏肥大压力超负荷内皮细胞心肌细胞肥大生长因子心肌毛细血管基因敲除小鼠小鼠心肌细胞

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胆囊切除术预防性使用抗生素的疗效

肝胆外科杂志 2009年第6期17卷 408-408页

作者： B. Darkahi G. Sabdblom S. wollert M. Ljungdahl H. liljeholm B. Karlson P. Videhult I. Rasmusen 张正东赵红川 Surgery Lassareter Enkoping Sugerry Uppsala University Sugery Ersta Stockholmn

背景尽管缺乏随机对照实验研究表明在胆囊切除术后预防性使用抗生素的益处，但抗生素还是经常被预防性使用，本实验的目的就是为了研究胆囊结石病人术后发生感染的风险，以及比较使用抗生素和没有使用抗生素治疗的病人之间感染的发生率。

关键词：抗生素治疗胆囊切除术后预防性使用疗效实验研究胆囊结石病随机对照发生率

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞