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The DNA damage repair complex moMMS21-moSMC5 is required for infection-related development and pathogenicity of Magnaporthe oryzae

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j.urnal of Integrative Agriculture 2024年第6期23卷 1956-1966页

作者： Yue j.ang Rong Wang Lili Du Xueyu Wang Xi Zhang Pengfei Qi Qianfei Wu Baoyi Peng Zonghua Wang mo Wang Ya Li State Key Laboratory of Ecological Pest Control for Fuj.an and Taiwan Crops Fujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China Fuj.an Universities Key Laboratory for Plant-Microbe Interaction Fujian Agriculture and Forestry UniversityFuzhou 350002China Ministerial and Provincial j.int Innovation Centre for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108China Fuj.an Key Laboratory for monitoring and Integrated Management of Crop Pests Fuzhou 350003China

The conserved DNA damage repair complex,MMS21-SMC5/6(Methyl methane sulfonate 21-Structural maintenance of chromosomes 5/6),has been extensively studied in yeast,animals,and ***,its role in phytopathogenic fungi,particularly in the highly destructive rice blast fungus Magnaporthe oryzae,remains *** this study,we functionally characterized the homologues of this complex,moMMS21 and moSMC5,in *** first demonstrated the importance of DNA damage repair in *** by showing that the DNA damage inducer phleomycin inhibited vegetative growth,infection-related development and pathogenicity in this ***,we discovered that moMMS21 and moSMC5 interacted in the nuclei,suggesting that they also function as a complex in *** deletion experiments revealed that both moMMS21 and moSMC5 are required for infection-related development and pathogenicity in ***,while only moMMS21 deletion affected growth and sensitivity to phleomycin,indicating its specific involvement in DNA damage ***,our results provide insights into the roles of moMMS21 and moSMC5 in ***,highlighting their functions beyond DNA damage repair.

关键词： Magnaporthe oryzae MMS21 SMC5 DNA damage repair pathogenicity

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Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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j.urnal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： Bei Li Yong Zhang Xinyuan Liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli mo Shuhai Lin Shicong Wang Chundong Yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fuj.an Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

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Surface Ligand Evolution:Sulfur-Directed Covalent Bonding of PPh_(3) on Pd_(4)S with Improved Semi-hydrogenation of Terminal Alkynes

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Precision Chemistry 2024年第5期2卷 200-207页

作者： Wentong j.ng Shiguang mo Weij.e Zhang Wenting Zhou Kunlong Liu j.e Wei Ruixuan Qin Nanfeng Zheng New Cornerstone Science Laboratory State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materialsand National&Local Joint Engineering Research Center of Preparation Technology of NanomaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China China Resources Cement Technology R&D(Guangxi)Co Ltd. Nanning 530008China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fuj.an Province(IKKEM) Xiamen 361102China

Surface modification of metallic nanocatalysts with organic ligands has emerged as an effective strategy to enhance catalytic selectivity,although offten at the expense of catalytic *** this study,we demonstrate a compelling approach by surface modifying Pd2S nanocrystals with PPhz ligands,resulting in a catalyst with excellent catalytic activity and durable selectivity for the semi-hydrogenation of terminal *** and theoretical investigations reveal that the presence of S sites on the Pd surface directs PPh_(3) ligands to preferentially form covalent bonds with S,creating distinctive surface S=PPh_(3) *** configuration induces a partial positive charge on Pd,facilitating hydrogen transfer and thus promoting catalytic ***,the covalent bond between the ligand and catalyst surface forms a robust network,ensuring ligand stability and increasing the hydrogenation energy barrier of ***,the Pd_(4)S@PPhz catalyst exhibits an improved catalytic selectivity with durability in terminal alkyne *** study introduces an effective strategy for designing selective hydrogenation catalysts with an enhanced performance.

关键词： Pd nanocatalysts surface modification selective hydrogenation catalytic stability alkyne semi-hydrogenation

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Where Is Phase Velocity in Minkowski Space?

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j.urnal of modern Physics 2024年第10期15卷 1555-1566页

作者： Antony j. Bourdillon Ultra-High Resolution Lithography San Jose CA USA

In the special theory of relativity, massive particles can travel at neither the speed of light c nor faster. Meanwhile, since the photon was quantized, many have thought of it as a point particle. How pointed? The idea could be a mathematical device or physical simplification. By contrast, the preceding notion of wave-group duality has two velocities: a group velocity vg and a phase velocity vp. In light vp = vg = c;but it follows from special relativity that, in massive particles, vp > c. The phase velocity is the product of the two best measured variables, and so their product constitutes internal motion that travels, verifiably, faster than light. How does vp then appear in Minkowski space? For light, the spatio-temporal Lorentz invariant metric is s2=c2t2−x2−y2−z2, the same in whatever frame it is viewed. The space is divided into 3 parts: firstly a cone, symmetric about the vertical axis ct > 0 that represents the world line of a stationary particle while the conical surface at s = 0 represents the locus for light rays that travel at the speed of light c. Since no real thing travels faster than the speed of light c, the surface is also a horizon for what can be seen by an observer starting from the origin at time t = 0. Secondly, an inverted cone represents, equivalently, time past. Thirdly, outside the cones, inaccessible space. The phase velocity vp, group velocity vg and speed of light are all equal in free space, vp = vg = c, constant. By contrast, for particles, where causality is due to particle interactions having rest mass mo > 0, we have to employ the Klein-Gordon equation with s2=c2t2−x2−y2−z2+mo2c2. Now special relativity requires a complication: *** = c2 where vg c and therefore vp > c. In the volume outside the cones, causality due to light interactions cannot extend beyond the cones. However, since vp > c and even vp >> c when wavelength λ is long, extreme phase velocities are then limited in their causal effects by the particle uncertainty σ,

关键词： Event Horizon Scattering Range Wave Packet Phase Velocity Group Velocity Dispersion Dynamics Quantum Physics

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Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World j.urnal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： mo-Wei Kong Feng-Di Sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World j.Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU j.SÉMANUEL LUQUE GONZÁLEZ FRANCISCO j.RADO-ROMERO ALEj.NDRO ORTEGA-moÑUX GLENN CHURCHILL j.MES C.GATES j.MES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI j.NS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN j.GONZALO WANGÜEMERT-PÉREZ ÑIGO moLINA-FERNÁNDEZ FREDERIC GARDES COSImo LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-mo Kim j.nnifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent j.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando montes Kathleen A.Clark Grant Tietj. j.stin Teeguarden Kristin E.Burnum-j.hnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding j.bs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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AI for organic and polymer synthesis

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Science China Chemistry 2024年第8期67卷 2461-2496页

作者： Xin Hong Qi Yang Kuangbiao Liao j.anfeng Pei Mao Chen Fanyang mo Hua Lu Wen-Bin Zhang Haisen Zhou j.axiao Chen Lebin Su Shuo-Qing Zhang Siyuan Liu Xu Huang Yi-Zhou Sun Yuxiang Wang Zexi Zhang Zhunzhun Yu Sanzhong Luo Xue-Feng Fu Shu-Li You Center of Chemistry for Frontier Technologies Department of ChemistryZhejiang UniversityHangzhou 310027China Center of Basic molecular Science Department of ChemistryTsinghua UniversityBeijing 100084China Guangzhou National Laboratory Guangzhou 510005China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China State Key Laboratory of molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China School of Materials Science and Engineering Peking UniversityBeijing 100871China Beij.ng National Laboratory for molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China AI for Science(AI4S)-Preferred Program Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Department of Chemical Sciences National Natural Science Foundation of ChinaBeijing 100085China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This synergy offers innovative and intelligent solutions to a range of classic problems in synthetic chemistry. These exciting advancements include the prediction of molecular property, multi-step retrosynthetic pathway planning, elucidation of the structure-performance relationship of single-step transformation, establishment of the quantitative linkage between polymer structures and their functions, design and optimization of polymerization process, prediction of the structure and sequence of biological macromolecules, as well as automated and intelligent synthesis platforms. Chemists can now explore synthetic chemistry with unprecedented precision and efficiency, creating novel reactions, catalysts, and polymer materials under the datadriven paradigm. Despite these thrilling developments, the field of artificial intelligence(AI) synthetic chemistry is still in its infancy, facing challenges and limitations in terms of data openness, model interpretability, as well as software and hardware support. This review aims to provide an overview of the current progress, key challenges, and future development suggestions in the interdisciplinary field between AI and synthetic chemistry. It is hoped that this overview will offer readers a comprehensive understanding of this emerging field, inspiring and promoting further scientific research and development.

关键词： organic synthesis polymer synthesis machine learning prediction chemical database automated synthesis

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Two Anderson-based supramolecular compounds modified by 4,4'-dipyridy synthesized in one-pot

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j.urnal of molecular Science 2024年第2期40卷 160-166页

作者： Li T. Tian A. Ying j. Department of Pharmacy Jinzhou Medical University Jinzhou 121001 China College of Chemistry and Materials Engineering Bohai University Jinzhou 121001 China

Using symmetrical rigid organic ligand 4,4'-dipyridy (4,4'-bipy), two new Anderson-based supramolecular compounds, namely, [H2(4,4'-bipy)]3·(Temo6O24)·(H2mo6O19) (1) and {Cu2[H(4,4'-bipy)] 2(H2O)6(Temo6O24)}·4H2O (2), were synthesized in one-pot under hydrothermal conditions. The compounds 1 and 2 have been tested by IR spectra, elemental analyses and single-crystal X-ray diffraction. Compound 1 contains one discrete Anderson anion, one Lindqvist anion and three 4,4'-bipy organic ligands. The anions and 4,4'-bipy alternate with each other by hydrogen bonding, building a supramolecular 1D chain. Adj.cent 1D chains are interlinked through hydrogen bonding interactions to further connect a supramolecular 2D layer. Compounds containing both Anderson and Lindqvist polyanions are not common in the crystal structure of POMs. Compound 2 contains one Anderson anion and two metal-organic subunits {Cu2[H(4,4'-bipy)]2 (H2O)6}6+ as modifiers. The Anderson anions and {Cu2 [H(4,4'-bipy)]2 (H2O)6}6+ subunits are organized into alternating through hydrogen bonding interactions to construct a supramolecular 1D chain. Additionally, the electrochemical properties of compounds 1 and 2 as well as photocatalytic properties are investigated. Results show that compounds 1 and 2 have photocatalytic activity, which can photocatalyze the degradation of organic dyes MB and AF. Also, compounds 1 and 2 have good electrochemical properties for amperometric detection of NO2- and Cr(?). Furthermore, Compound 2 can be used as materials of supercapacitor. © 2024, Department of Chemistry, Northeast Normal University. All rights reserved.

关键词： Anderson POM electrochemistry hydrothermal syntheses photocatalysis supramolecular structure

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Square wave volt-coulometry

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Chinese Science Bulletin 1997年第5期42卷 390-396页

作者： mo, j. Zhang, j.mo, SY Department of Chemistry Zhongshan Univenity Guangzhou China Department of Chemistry Hong Kong University Hong Kong

FOR a long time, people pay particular attention to the way to decrease the charging current and improve the Faraday current in the modern square wave voltammetry (SWV), but the effects of random noise on analytical result are ignored. However, it is impossible to avoid the random noise absolutely in the measuring process. Especially, when the concentration is low, the signal is affected seriously by the random noise and it is difficult to get a lower detection limit. So it is necessary to know how to decrease the random noise in order to get a lower detection limit, while trying to find out how to decrease the charging current. A new sampling technique using the square wave potential scan is proposed to smooth the random noise and decrease the detection limit in SWV. The foundation of this new method comes from one of the laws of mathematical statistics; that is, the positive and negative probable errors in a group of detected data exist equally and then the sum of all the errors is ze-

关键词： square wave voltammetry square wave volt-coulometry simple reverse system catalytic system.

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