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中国基础科学 2008年第4期10卷 47-51页

作者：姜世军墨宏山北京市教育委员会科学技术与研究生工作处科技部基础研究管理中心

研究论文是基础研究成果的主要表现形式之一,一个国家或科研机构发表特别是在高水平学术期刊上发表论文的情况可从一个角度反映该国家或科研机构的基础研究状况和水平.

关键词：学术期刊论文统计科研机构中国大陆基础研究 Nature 研究论文研究成果

Reconstruction using artificial intelligence,a promising way to explore the cosmic web

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 179-179页

作者： Houjun mo Department of Astronomy University of MassachusettsAmherst MA 01003USA

One of the most important goals in modern cosmology is to understand the large-scale mass distribution of the universe(the cosmic web),and how galaxies form and evolve in the ecosystem of the cosmic *** this is done by large redshift surveys of galaxies,which can be used to trace the large-scale structure and to sample the properties of galaxies.

关键词： galaxies cosmic universe

Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming

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Journal of Bionic Engineering 2024年第1期21卷 177-191页

作者： Yiwei Hao Yonghui Cao Yingzhuo Cao Xiong mo Qiaogao Huang Lei Gong Guang Pan Yong Cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo 315103China Key Laboratory of Unmanned Underwater Vehicle Technology of Ministry of Industry and Information Technology Xi'an 710072China

Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral *** is still difficult for a robotic fish to swim autonomously in a confined area as a real ***,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding *** generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw *** verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave *** experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic ***,the swimming ability of the robotic manta is verified by field tests.

关键词： Biomimetic robotic manta Central Pattern Generator Closed-loop control Backward swimming

Magnetic properties and magnetocaloric effects in Eu(Ti,Nb,Mn)O_(3) perovskites

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Journal of Rare Earths 2024年第8期42卷 1560-1567,I0006页

作者： Junfeng Wang Huicai Xie Quanyi Liu Zhihong Hao Zhaojun mo Qi Fu Xinqiang Gao Jun Shen Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China School of Rare Earth and New Materials Engineering Gannan University of Science and TechnologyGanzhou341000China Department of Energy and Power Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing100081China

In perovskite EuTiO_(3),the magnetic characteristics and magnetocaloric effect(MCE) can be flexibly regulated by converting the magnetism from antiferromagnetic to *** the present work,a series of Eu(Ti,Nb,Mn)O_(3) compounds,abbreviated as ETNmo for convenience of description,was fabricated and their crystallography,magnetism together with cryogenic magnetocaloric effects were systematically *** crystallographic results demonstrate the cubic perovskite structure for all the compounds,with the space group of *** magnetic phase transitions are observed in these second-order phase transition(SOPT) *** joint substitution of elements Mn and Nb can considerably manipulate the magnetic phase transition process and magnetocaloric performance of the ETNmo *** the Mn content increases,gradually widened-ΔS_(M)-T curves are obtained,and two peaks with a broad shoulder are observed in the-ΔS_(M)-T curves for Δμ_(0)H≤0-1 *** a field change of 0-5 T,the values of maximum magnetic entropy change(-ΔS_(M)^(max)) and refrigeration capacity(RC) are evaluated to be 34.7 J/(kg·K) and 364.9 J/kg for EuTi_(0.8625)Nb_(0.0625)Mn_(0.075)O_(3), 27.8 J/(kg·K) and367.6 J/kg for EuTi_(0.8375)Nb_(0.0625)Mn_(0.1)O_(3),23.2 J/(kg·K) and 369.2 J/kg for EuTi_(0.8125)Nb_(0.0625)Mn_(0.125)O_(3),17.1 J/(kg·K) and 357.6 J/kg for EuTi_(0.7875)Nb_(0.0625)Mn_(0.15)O_(3),*** co nsiderable MCE parameters make the ETNmo compounds potential candidates for cryogenic magnetic refrigeration.

关键词： ETNmo perovskites Cryogenic refrigeration Magnetic phase transition Magnetocaloric effect Rare earths

Coupling WO_(3-x) dots-encapsulated metal-organic frameworks and template-free branched polymerization for dual signal-amplified electrochemiluminescence biosensing

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Chinese Chemical Letters 2024年第4期35卷 469-474页

作者： Fei Yin Erli Yang Xue Ge Qian Sun Fan mo Guoqiu Wu Yanfei Shen Medical School Southeast UniversityNanjing 210009China Center of Clinical Laboratory Medicine Zhongda HospitalSoutheast UniversityNanjing 210009China Jiangsu Provincial Key Laboratory of Critical Care Medicine Southeast UniversityNanjing 210009China

Developing accurate and sensitive DNA methyltransferase(MTase) analysis methods is essential for early clinical diagnosis and development of antimicrobial drug targets. In this work, by coupling WO_(3-x) dotsencapsulated metal-organic frameworks(moFs) as co-reactants and terminal deoxynucleotidyl transferase(Td T)-mediated template-free branched polymerization, a dual signal-amplified electrochemiluminescent(ECL) biosensor was constructed to detect DNA adenine methylation(Dam) MTase. The employment of WO_(3-x) dots-encapsulated moFs(i.e., NH_(2)-UIO66@WO_(3-x) ) was not only beneficial for biomolecule conjugation because of the abundant amino groups but also led to a 7-fold enhanced ECL response due to the increased loading of WO_(3-x). moreover, Td T-mediated template-free branched polymerization promoted the capture of ECL emitters on the electrode surface, achieving 20-fold enhanced signal amplification. The presented ECL biosensor demonstrated a low detection limit of 2.4 × 10^(-4)U/m L, and displayed high reliability for the detection of Dam MTase in both spiked human serum and E. coli cell samples, and for the screening of potential inhibitors. This study opens a new avenue for designing a dual signal amplificationbased ECL bioassay for Dam MTase and screening inhibitors in the fields of clinical diagnosis and drug development.

关键词： Dual signal-amplified electrochemiluminescence WO_(3-x)dots moFs Template-free branched polymerization DNA methyltransferase

Innovative construction of macroporous–mesoporous structured spherical alumina and its hydrothermal stability

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Particuology 2024年第7期90卷 429-435页

作者： Yufan mo Chunli Li Huiyu Li Wei Han He Wen Yinghong Han Chunxia Che Yongjun Feng State Key Laboratory of Chemical Resource Engineering Beijing Engineering Center for Hierarchical CatalystsCollege of ChemistryBeijing University of Chemical TechnologyBeijing100029China Lanzhou Petrochemical Research Center Petrochemical Research InstitutePetroChinaLanzhou730060China

The pore structure of spherical alumina supports is closely related to the dispersion of catalytically active components and the diffusion of *** excellent pore structure under strict reaction conditions is of utmost *** this work,sphericalγ-Al_(2)O_(3)support with a bimodal pore structure,composed of macropores and mesopores,was successfully synthesized using dodecane as the pore-forming agent through the oil–ammonia column-shaping *** morphology and internal pore structure of the alumina were found to be influenced by the amount of surfactant added and ultrasound treatment ***,when concentration of surfactant was 4‰and ultrasound voltage of 20 V was applied,the resultingγ-Al_(2)O_(3)-4‰-20 displayed a highly concentrated distribution of macropores with an average pore size of 100 nm,resulting in an impressive porosity of 69.21%.In contrast,the untreated sample ofγ-Al_(2)O_(3)-0-0 only exhibited a mesoporous distribution with a porosity of 54.03%.moreover,after being subjected to a hydrothermal treatment in a high temperature(600°C)and high humidity(water vapor)environment for 120 h,theγ-Al_(2)O_(3)-4‰-20 sample maintained a high BET specific surface area of 170.9 m^(2)g^(−1)and mercury intrusion porosimetry specific surface area of 263.3 m^(2)g^(−1).

关键词： Spherical alumina supports Pore-forming agent Oil-ammonia column shaping method Hydrothermal treatment Hydrothermal stability

Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways

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Food Science and Human Wellness 2024年第1期13卷 115-123页

作者： Yue Yu Haibin Zhu Mingyue Shen Qiang Yu Yi Chen Shiru mo Jianhua Xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated *** this study,the immunomodulatory effect of sulfated Cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were *** showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 ***,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated *** on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB *** summary,SCP3 has significant immunomodulatory *** underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

Comprehensive treatment of von Hippel-Lindau disease:A case report

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Cancer Innovation 2024年第2期3卷 63-67页

作者： Xuesong Li Zheng mo Zhuo Yu School of Clinical Medicine Tsinghua UniversityBeijingChina Department of Oncology Beijing Tsinghua Changgung HospitalBeijingChina

von Hippel-Lindau(VHL)disease is a rare autosomal dominant multiorgan disease characterized by several benign and malignant tumors rich in vascular,as well as cysts in other organs.A great clinical treatment strategy is significantly warranted for good prognosis of patients with VHL ***,we reported a case of a 45-year-old woman diagnosed with VHL disease with spinal hemangioblastoma(HB)and clear cell renal cell carcinoma(ccRCC).Four years after the resection of the right kidney,a recurrent RCC in the right kidney and a malignant lesion in the left kidney were *** patient was started on sorafenib(800 mg,daily)and tislelizumab(200 mg per 3 weeks).After 6 months of treatment,the size of renal cell carcinoma was dramatically reduced and renal function *** importantly,she achieved partial response during the whole ***,intramedullary masses resection was done and the HB in T4-5 thoracic spinal was *** symptoms such as numbness and pain were remarkably ***,tislelizumab-induced elevation in liver transaminase levels and hypothyroidism were revered by hepatoprotector and levothyroxine,*** short,comprehensive treatment strategies may benefit patients with VHL disease,especially with HB and ccRCC.

关键词： sorafenib surgery tislelizumab treatment von Hippel-Lindau disease

Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1442-1447页

作者： U Chul Ju Woo Dae Kang Seok mo Kim Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young *** report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian *** SUMMARY A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 *** received laparoscopic bilateral ovarian cystectomy,and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right *** left salpingo-oophorectomy and staging procedures were performed *** mother,maternal aunt,and maternal grandmother had also received surgeries for mature ovarian *** It is important to have guidance on management of patient and family members with familial ovarian teratomas.

关键词： Familial ovarian teratomas Adolescent female Immature ovarian teratoma Management Case report

Ferroptosis in chronic obstructive pulmonary disease:From cellular mechanisms to therapeutic applications

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Chinese Medical Journal 2024年第10期137卷 1237-1239页

作者： Mengli Yan Shiyu Xu Han Wang Shoujin Dong Chunheng mo The Key Laboratory of Birth Defects and Related Diseases of Women and Children of moE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Nephrology Henan Provincial Clinical Research Center for Kidney DiseaseHenan Provincial Key Laboratory of Kidney Disease and ImmunologyHenan Provincial People’s Hospital and People’s Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department of Biochemistry School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Center for RNA Science and Therapeutics School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Department of Pulmonary and Critical Care Medicine Chengdu First People’s HospitalChengduSichuan 610095China

To the Editor:Chronic obstructive pulmonary disease(COPD)is a global public health challenge without effective treatment currently available,affecting>300 million individuals *** understanding the pathogenesis of this disease is ***,ferroptosis,a form of cell death driven by iron-dependent lipid peroxidation,has been associated with the pathogenesis of COPD.[1]Multiple signaling pathways,such as glutathione peroxidase 4(GPX4),ferroptosis suppressor protein 1(FSP1),and tetrahydrobiopterin-dependent pathways,as well as iron metabolism,are involved in regulating ferroptosis[2,3][Figure 1A].Here,we provide a comprehensive overview of recent advances in understanding the role of ferroptosis in COPD,highlighting potential therapeutic strategies targeting ferroptosis for treating the disease.

关键词： therapeutic metabolism peroxidation