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Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China

World Journal of Gastroenterology 2022年第27期28卷 3503-3513页

作者： Min-Jun Liao Jun Li wei Dang Dong-Bo Chen Wan-Ying Qin Pu Chen Bi-Geng Zhao Li-Ying Ren Ting-Feng Xu Hong-Song Chen wei-Jia Liao Laboratory of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology and Hepatology UnitNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Genetics and Precision Medicine Laboratory The Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease Peking University People’s HospitalBeijing 100044China

BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly *** To develop a precise noninvasive test to stage liver fibrosis and *** With liver biopsy as the gold standard,we established a new index,[alkaline phosphatase(U/L)+gamma-glutamyl transpeptidase(U/L)/platelet(109/L)(AGPR)],to predict liver fibrosis and *** addition,we compared the area under the receiver operating characteristic curve(AUROC)of AGPR,gammaglutamyl transpeptidase to platelet ratio,aspartate transaminase to platelet ratio index,and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and *** Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage(P<0.001).In the training cohort,the AUROC of AGPR was 0.83(95%CI:0.78-0.87)for predicting fibrosis(≥F2),0.84(95%CI:0.79-0.88)for predicting extensive fibrosis(≥F3),and 0.87(95%CI:0.83-0.91)for predicting cirrhosis(F4).In the validation cohort,the AUROCs of AGPR to predict≥F2,≥F3 and F4 were 0.83(95%CI:0.77-0.88),0.83(95%CI:0.77-0.89),and 0.84(95%CI:0.78-0.89),*** The AGPR index should become a new,simple,accurate,and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients.

关键词： Liver Fibrosis Cirrhosis Prediction Novel noninvasive marker Chronic hepatitis B

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Chemical looping gasification characteristics and kinetic analysis of Chlorella and its organic components

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Carbon Resources Conversion 2022年第3期5卷 211-221页

作者： Song Wu Bo Zhang Bolun Yang Jianxuan Shang Hongzhi Zhang wei Guo Zhiqiang Wu Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049PR China Shaanxi Coal and Chemical Technology Institute Co. Ltd.ShaanxiXi’an710065PR China

Chemical looping gasification(CLG)characteristics and kinetic analysis of Chlorella(CHL),simulated Chlorella(V-CHL)and medium-chain triglycerides(MCT)were investigated using a thermogravimetric analyzer coupled with an online mass *** apparent activation energy was obtained via Kissinger-Akahira-Sunose(KAS)*** the result of the weightless behavior,the addition of oxygen carrier inhibited the decomposition of V-CHL at lower temperatures but promoted its decomposition at high *** values of chemical looping process characteristic parameters showed that a 10 wt%oxygen carrier would maximize the release of volatile products in the CLG of MCT,with 5.12×10^(-6)%⋅min^(-1)⋅℃^(-3).Oxygen carriers also affected gaseous *** LHV of gaseous products of CHL reached the largest when the oxygen carrier was 10 wt%,which was 8.13 mj/m^(3).And the gaseous product of MCT had the largest LHV with 30 wt%oxygen carrier,which was 8.83 mj/m^(3).According to the kinetic analysis,the minimum value of apparent activation energy of MCT chemical looping gasification was 89.54 kJ⋅mol^(-1) with the oxygen carrier of 30 wt%,which was 50%less than that of MCT *** the minimum value for V-CHL was obtained when the mass fraction of Fe2O3 was 50 wt%.This paper could provide a reference for the choice of algae,the design of reactors,and the targeted regulation of the gaseous product for the algae CLG process.

关键词： Chemical looping gasification Algae Organic components Gaseous product distribution Kinetic analysis

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Designing Tough,Printable,and Adaptable Eutectogels with Multinetworks via Synergy of Rapid Orthogonal Photopolymerizations and Solvent Effect in Seconds

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CCS Chemistry 2024年第2期6卷 390-402页

作者： Jupen Liu Lijun Zhou Ping Zhang Yanxia Zhao Hongqiu wei You Yu Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069

Achieving a straightforward design of tough,printable,and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes,and inherent contrasting multiple ***,we report a one-step synergistic strategy based on ruthenium chemistry-catalyzed photopolymerization and solvent effect for preparing high-performance *** orthogonal ruthenium photochemistry helps multinetworks formation via phenol-coupling of gelatin and copolymerization of acrylamide(AAm)and[2-(methacryloyloxy)ethyl]trimethylammonium tetrafluoroborate(META)monomers in *** obvious difference in the supramolecular interactions of free AAm monomers and polymerized units in P(AAm-co-META)with deep eutectic solvents(DESs)significantly promotes the microphase-separation behavior in ***,the in situ polymerization and microphase-separation behavior enable the as-prepared eutectogel materials to have excellent mechanical properties(stress of∼1.2 MPa),toughness(∼4.0 mj m^(−3)),elasticity,adaptivity,and conductivity(∼0.5 S m^(−1)at room temperature).Also,the critical strength of the resultant eutectogels can be modulated by varying the DES *** rapid and well-controlled synergistic approach is compatible with extrusion printing techniques to make flexible sensors with high sensitivities and response times to detect pressure in a range of 0–500 *** a general and simple strategy has application potential in biological,engineering,and material sciences.

关键词： orthogonal chemistry visible-light photopolymerization solvent effect microphase separation adaptable polymers printable eutectogels

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Persistent Heavy Rainfall over South China During May–August:Subseasonal Anomalies of Circulation and Sea Surface Temperature

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Acta meteorologica Sinica 2013年第6期27卷 769-787页

作者：洪伟任雪娟 School of Atmospheric Sciences Nanjing University

This study investigates the relationship between subseasonal variations of the circulation and sea surface temperature（SST） over the South China–East Asian coastal region（EACR） in association with the persistent heavy rainfall（PHR） events over South China during May–August through statistical analysis. Based on the intensity threshold and duration criterion of the daily rainfall, a total of 63 May–June（mj） and 59July–August（JA） PHR events are selected over South China from 1979 to 2011. The lower-level circulation anomalies on subseasonal timescale exhibit an anomalous cyclone over South China and an anomalous anticyclone shaped like a tongue over the South China Sea（SCS） during the PHR events for mj *** anomalous cyclone over South China in mj originates from low-value systems in the mid-high latitudes before the rainfall. The anomalous anticyclone over the SCS is due to the westward extension of the western Pacific subtropical high（WPSH） and the southeastward propagation of the anomalous anticyclone from South China before the rainfall. For JA group, the lower-level anomalous circulation pattern is similar to that for mj over the South China–EACR, but with di？erent features of propagation. The subseasonal anomalous anticyclone is also related to the westward stretch of the WPSH, while the anomalous cyclone is traced back to the weak anomalous cyclone over the Philippine Sea several days before the rainfall *** SST anomaly（SSTA） is observed over the SCS and the Philippine Sea during the mj PHR events on the subseasonal timescale. It is closely linked with the variation of local anomalous anticyclone. In contrast, negative SSTA occupies the South China coastal region for the JA PHR events, and it is driven by the anomalous cyclone which propagates northwestward from the Philippine Sea. The subseasonal positive（negative） SSTAs are generated via the local processes of above（below）-normal incident solar radiation and below（above）-normal latent heat fl

关键词： persistent heavy rainfall western Pacific subtropical high subseasonal variations of sea surface temperature South China

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高氮链状含能纳米颗粒尺寸效应的理论研究

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火炸药学报 2023年第6期46卷 495-501,I0002页

作者：吴小伟朱卫华爆炸科学与技术国家重点实验室北京100081 南京理工大学化学与化工学院江苏南京210094

为了揭示凝聚态炸药的尺寸效应对炸药稳定性和感度的影响机制,采用DFTB和DFT方法,研究了不同氮链长度含能材料N_(4)、N_(8)和N_(10)的纳米颗粒、单分子和晶体的能量及电子特性。结果表明,粒径0.6nm的N_(4)、N_(8)和N_(10)纳米颗粒的额... 详细信息

为了揭示凝聚态炸药的尺寸效应对炸药稳定性和感度的影响机制,采用DFTB和DFT方法,研究了不同氮链长度含能材料N_(4)、N_(8)和N_(10)的纳米颗粒、单分子和晶体的能量及电子特性。结果表明,粒径0.6nm的N_(4)、N_(8)和N_(10)纳米颗粒的额外能为99.18、95.90和93.56kJ/mol,粒径3.0nm的N_(4)、N_(8)和N_(10)纳米颗粒的额外能为40.39、34.20和29.20kJ/mol,表明其额外能随粒径或氮链长度增加而减小;粒径1.2nm的N_(4)、N_(8)和N_(10)纳米颗粒的表面能为108.35、101.44和98.36mj/m^(2),粒径1.4nm的N_(4)、N_(8)和N_(10)纳米颗粒的表面能为115.08、102.22和93.48mj/m^(2),表明其表面能随氮链长度增加而减小,而随粒径增加无规律变化;粒径0.8nm的N_(4)、N_(8)和N_(10)纳米颗粒的升华焓为21.87、20.99和20.54kJ/mol,粒径2.0nm的N_(4)、N_(8)和N_(10)纳米颗粒的升华焓为1416.02、1607.58和1571.87kJ/mol,粒径1.8nm的N_(4)、N_(8)和N_(10)纳米颗粒的熔点为2.90、3.79和8.52K,粒径3.0nm的N_(4)、N_(8)和N_(10)纳米颗粒的熔点为345.92、300.77和223.52K,表明其升华焓和熔点均随纳米尺寸的增大或氮链长度的减小单调增加。能量性质研究结果表明,纳米粒子越小或氮链越长,纳米粒子越不稳定。基于HOMO、LUMO、能隙、表面态和Fukui函数的电子特性研究表明,HOMO能级随尺寸增加而增加,LUMO能级随尺寸增加而减小,能隙随尺寸增加而减小;纳米颗粒的表面态主要局域于五元环形成的π键和叠氮基的π键;小尺寸纳米颗粒比大尺寸具有更高的反应活性。

关键词：量子化学氮链高氮含能材料纳米颗粒尺寸效应

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Effect of Temperature on Microstructure and Deformation Mechanism of Fe-30Mn-3Si-4Al TWIP Steel at Strain Rate of 700 s^(-1)

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Journal of Iron and Steel Research International 2015年第2期22卷 179-184页

作者： Zhi-ping XIONG Xue-ping REN Jian SHU Zhe-lei WANG wei-ping BAO Shu-xia LI School of Materials Science and Engineering University of Science and Technology Beijing School of Mechanical Materials and Mechatronic EngineeringUniversity of Wollongong China Nuclear Power Engineering Co. Ltd. School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

As twinning-induced plasticity （TWIP） steel is one potential material for shaped charge liner due to the combination of high strength and high plasticity, deformation mechanism at high strain rate and high temperature is required to study. Compression experiments of Fe 30Mn-3Si-4Al TWIP steel were conducted using a Gleeble 1500 thermal simulation machine and a split-Hopkinson pressure bar （SHPB） between 298 and 1073 K at strain rates of 10 3 and 700 s-1 , respectively. Microstructures were observed using optical microscopy （OM） and transmission e- lectron microscopy （TEM）. Results show that flow stress and densities of deformation twins and dislocations de crease with increasing deformation temperature at strain rates of 10 3 and 700 s -1. The stack fault energy （SFE） values （Г） of Fe-30Mn-3Si-4Al TWIP steel at different temperatures were calculated using thermodynamic data. Based on corresponding microstructures, it can he inferred that at 700 s -1 , twinning is the main deformation mecha- nism at 298-573 K for 30 mj/m2≤Г≤63 mj/m2 , while dislocation gliding is the main deformation mechanism above 1 073 K for Г≥145 mj/m2. In addition, with increasing strain rate from 10-3 to 700 s -1 , the SFE range of twinning is enlarged and the SEF value of twinning becomes higher.

关键词： TWIP steel stack fault energy deformation mechanism SHPB

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Diagnostics of Femtosecond Laser-Plasmas Using Fundamental and Second Harmonic Emission

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Chinese Physics Letters 2000年第11期17卷 818-820页

作者： ZHAO Li-Zeng ZHANG Ping FENG Bao-Hua wei Zhi-Yi ZHANG Jie Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039

By observing the fundamental and second harmonic emission from a plasma produced by a 150fs,5mj laser at 800nm,the electron temperature,the expansion speed and the scalelength of the plasma have been *** the polarization of the fundamental and second harmonic emission has been *** could be a useful diagnostic for modulation at the critical surface of the plasma.

关键词： polarization Femto second

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Superconductivity in chromium nitrides Pr3Cr10-xN11 with strong electron correlations

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National Science Review 2020年第1期7卷 21-26页

作者： wei Wu Kai Liu Yanjie Li Zhenhai Yu Desheng Wu Yuting Shao Shihang Na Gang Li Ruizhen Huang Tao Xiang Jianlin Luo Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials & Micro-nano Devices Renmin University of China School of Physical Science and Technology Shanghai Tech University Songshan Lake Materials Laboratory Kavli Institute for Theoretical Sciences

Exploration of superconductivity in Cr-based compounds has attracted considerable interest because only a few Cr-based superconductors(CrAs, A2Cr3As3and ACr3As3（A = K, Rb, Cs, Na）) have been discovered so far and they show an unconventional pairing mechanism. We report the discovery of bulk superconductivity at 5.25 K in chromium nitride in Pr3Cr10-xN11with a cubic lattice structure. A relatively large upper critical field of Hc2（0）～12.6 T is determined, which is larger than the estimated Pauli-paramagnetic pair-breaking magnetic field. The material has a large electronic specific-heat coefficient of 170 mj K-2mol-1—about 10 times larger than that estimated by the electronic structure calculation,which suggests that correlations between 3d electrons are very strong in Pr3Cr10-xN11, and thus quantum fluctuations might be involved. Electronic structure calculations show that the density of states at the Fermi energy are contributed predominantly by Cr 3d electrons, implying that the superconductivity results mainly from the condensation of Cr 3d electrons. Pr3Cr10-xN11represents a rare example of possible unconventional superconductivity emerging in a 3D system with strong electron correlations. Nevertheless,clarification of the specific pairing symmetry needs more investigation.

关键词： Cr-based superconductors nitrides strong electron correlations unconventional superconductivity

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Hazard evaluation of ignition sensitivity and explosion severity for three typical MH_(2) (M=Mg,Ti,Zr)of energetic materials

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Defence Technology（防务技术） 2021年第4期17卷 1262-1268页

作者： Xing-liang Wu Sen Xu Ai-min Pang wei-guo Cao Da-bin Liu Xin-yu Zhu Fei-yang Xu Xu Wang School of Chemical Engineering Nanjing University of Science and TechnologyNanjingJiangsu210094PR China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang441003PR China School of Environmental and Safety Engineering North University of ChinaTaiyuan030051ShanxiPR China

MgH_(2),TiH_(2),and ZrH_(2) are three typical metal hydrides that have been gradually applied to composite explosives and propellants as additives in recent *** evaluate ignition sensitivity and explosion severity,the Hartmann device and spherical pressure vessel were used to test ignition energy and explosion pressure,*** results showed that the ignition sensitivity of ZrH_(2),TiH_(2) and MgH_(2) gradually *** the concentration of MgH_(2) is 83.0 g/m^(3) in Hartmann device,the ignition energy attained a minimum of 10.0 *** explosion pressure of MgH_(2) were 1.44 times and 1.76 times that of TiH_(2) and ZrH_(2),respectively,and the explosion pressure rising rate were 3.97 times and 9.96 times that of TiH_(2) and ZrH_(2),respectively,through the spherical pressure *** indicated that the reaction reactivity and reaction rate of MgH_(2) were higher than that of TiH_(2) and ZrH_(2).In addition,to conduct in edepth theoretical analysis of ignition sensitivity and explosion severity,gas production and combustion heat per unit mass of ZrH_(2),TiH_(2) and MgH_(2) were tested by mercury manometer and oxygen bomb *** experimental results revealed that MgH_(2) had a relatively high gas production per unit mass(5.15 mL/g),while TiH_(2) and ZrH_(2) both had a gas production of less than 2.0 mL/*** thermal stability gradually increased,leading to a gradual increase in ignition ***,compared with theoretical combustion heat,the combustion ratio of MgH_(2),TiH_(2) and ZrH_(2) was more than 96.0%,with combustion heat value of 29.96,20.94 and 12.22 mj/kg,respectively,which was consistent with the explosion pressure and explosion severity test results.

关键词： Ignition energy Explosion pressure Reaction activity Combustion heat

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Acousto-Optic Q-Switched Operation Ho:YAP Laser Pumped by a Tm-Doped Fiber Laser

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Chinese Physics Letters 2011年第7期28卷 152-155页

作者： ZHOU Ren-Lai JU You-Lun WANG wei ZHU Guo-Li WANG Yue-Zhu National Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150080

We report on the acousto-optic Q-switched operation of a Ho:YAP laser double-passed pumped by an all-fiber Tm-doped fiber *** output characteristics of the Ho:YAP laser are studied at pulse repetition frequencies of 1,2,5 and 10 *** shortest pulse width,the maximum pulse energy and the highest peak power are measured to be 17 ns,1.71 mj and 71.25 kW,*** output wavelength is centered at 2115.96 nm with a bandwidth of about 1.5 *** beam quality factor M^(2)=2.41±0.03 at the output power of 3.54 W was measured by using the traveling knife-edge method.

关键词： fiber pumped switched

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