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A Piecewise Linear Isotropic-Kinematic Hardening Model with Semi-Implicit Rules for Cyclic Loading and Its Parameter Identification

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Computer Modeling in Engineering & Sciences 2016年第4期111卷 303-333页

作者： M.Ohsaki T.miyamura J.Y.Zhang Department of Architecture and Architectural Engineering Kyoto UniversityKyoto-Daigaku KatsuraNishikyoKyoto 615-8540Japan Department of Computer Science Nihon University1 NakagawaraTokusadaTamuraKoriyama 963-8642Japan Department of Architecture and Urban Design Nagoya City University2-1-10 Kita-ChigusaChigusaNagoya 464-0083Japan

A simple constitutive model,called semi-implicit model,for cyclic loading is proposed for steel materials used for structures such as building frames in civil *** constitutive model is implemented in the E-Simulator,which is a software package for large-scale seismic response *** constitutive relation is defined in an algorithmic manner based on the piecewise linear combined isotropic-kinematic *** rules are used for the first and subsequent loading states to incorporate characteristics such as yield plateau and Bauschinger effect of rolled mild steel *** optimization method is also presented for parameter identification from the results of cyclic and monotonic loading ***,the proposed model is readily applicable to practical elastoplastic analysis of building *** of the model is demonstrated in an example of a cantilever subjected to various types of cyclic loading.

关键词： Combined isotropic-kinematic hardening Piecewise linear hardening Steel material Parameter optimization Cyclic load

Study on Targeting and in vitro Anti-oxidation of Baicalin Solid Lipid Nanoparticles

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Chinese Herbal Medicines 2012年第4期4卷 335-339页

作者： miyamura Mitsuhiko YOKOTA Junko YOSHIOKA Saburo Department of Pharmacy Kochi Medical School Kochi 783-8505 Japan783850

Objective To prepare liver-targeted baicalin solid lipid nanoparticles(BSLNs) and to study their in vitro anti-oxidative *** BSLNs were prepared by emulsification ultrasonic dispersion method and characterized by transmission electron microscopy and laser particle size distribution;The tissue in vivo distribution was detected by pharmacokinetics;In vitro anti-superoxide dismutase(SOD) activity and reduction capacity of BSLNs were determined;The ability of removing hydroxyl radical was determined by phenanthroline-Fe2+ *** The best prescription was baicalin-soybean lecithin-glyceryl monostearate-poloxamer 188(1:5:15:30);The encapsulation efficiency and drug loading were 84.7% and 5.65%,respectively,mean size of particles was(68.6 ± 8) nm,Zeta potential was 22.13 mV;The in vitro anti-oxidant results showed that BSLNs had a significant inhibitory effect on SOD and a strong reducing capacity as well as a removing hydroxide radical *** targeting rate of BSLNs was 6.931 for *** The results demonstrate that BSLNs could enhance the liver targeting ability and in vitro anti-oxidative activity significantly.

关键词： baicalin in vitro anti-oxidative activity liver-targeted solid lipid nanoparticals tissue distribution

Lewis acid-driven reaction pathways in synergistic cooperative catalysis over gold/palladium bimetallic nanoparticles for hydrogen autotransfer reaction between amide and alcohol

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Chinese Journal of Catalysis 2016年第10期37卷 1662-1668页

作者： Hiroyuki miyamura Satoshi Isshiki Hyemin Min Shu Kobayashi 东京大学理学院化学系日本东京113-0033

Metal nanoparticle catalysts, especially gold and its bimetallic nanoparticle catalysts, have been widely used in organic transformations as powerful and green catalysts. The concept of employing two distinct catalysts in one reaction system, such as in cooperative and synergistic catalysis, is a powerful strategy in homogeneous catalysis. However, the adaption of such a strategy to metal nanoparticle catalysis is still under development. Recently, we have found that cooperative catalytic systems of gold/palladium bimetallic nanoparticles and Lewis acid can be used for the N‐alkylation of primary amides through hydrogen autotransfer reaction between amide and alcohol. Herein, the results of a detailed investigation into the effects of Lewis acids on this hydrogen autotransfer reac‐tion are reported. It was found that the choice of Lewis acid affected not only the reaction pathway leading to the desired product, but also other reaction pathways that produced several intermedi‐ates and by‐products. Weak Lewis acids, such as alkaline‐earth metal triflates, were found to be optimal for the desired N‐alkylation of amides.

关键词： Gold Palladium Bimetallic nanoparticle Lewis acid Amide synthesis Hydrogen autotransfer

Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

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World Journal of Gastroenterology 2014年第23期20卷 7197-7206页

作者： Xia Jiang Tatsuo Kanda Shuang Wu Masato Nakamura Tatsuo miyamura Shingo Nakamoto Arup Banerjee Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Molecular Virology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Vaccine and Infectious Disease Research Center and Translational Health Science and Technology Institute Gurgaon-122016HaryanaIndia

Hepatitis B virus(HBV)chronically infects more than350 million people *** causes acute and chronic hepatitis,and is one of the major causes of cirrhosis and hepatocellular *** exist complex interactions between HBV and the immune system including adaptive and innate *** receptors(TLRs)and TLR-signaling pathways are important parts of the innate immune response in HBV *** is well known that TLR-ligands could suppress HBV replication and that TLRs play important roles in anti-viral *** immunological studies demonstrated that HBV e antigen(HBeAg)is more efficient at eliciting T-cell tolerance,including production of specific cytokines IL-2 and interferon gamma,than HBV core *** downregulates cytokine production in hepatocytes by the inhibition of MAPK or NF-κB activation through the interaction with receptor-interacting serine/threonine protein ***(miRNAs)are also able to regulate various biological processes such as the innate immune *** the expressions of approximately 1000 miRNAs were compared between human hepatoma cells HepG2 and HepG2.2.15,which could produce HBV virion that infects chimpanzees,using real-time RT-PCR,we observed several different expression levels in miRNAs related to *** we and others have shown that HBV modulates the host immune response,several of the miRNAs seem to be involved in the TLR signaling *** possibility that alteration of these miRNAs during HBV infection might play a critical role in innate immunity against HBV infection should be *** article is intended to comprehensively review the association between HBV and innate immunity,and to discuss the role of miRNAs in the innate immune response to HBV infection.

关键词： Hepatitis B virus HepG2.2.15 Innate immunity MicroRNA Persistent infection Toll-like receptor

Direct-acting Antiviral Agents for the Treatment of Chronic Hepatitis C Virus Infection

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Journal of Clinical and Translational Hepatology 2014年第1期2卷 1-6页

作者： Tatsuo Kanda Shingo Nakamoto Masato Nakamura Xia Jiang Tatsuo miyamura Shuang wu Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine Inohana Chuo-ku Chiba Japan

Hepatitis C virus (HCV) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC) in the US and ***,eradication of HCV may reduce the occurrence of HCC in HCV-infected *** 2011,the use of firstgeneration HCV NS3/4A protease inhibitors such as telaprevir and boceprevir was initiated for clinical treatment of *** of telaprevir and boceprevir plus peginterferon and ribavirin increased rates of sustained virological response (SVR) in HCV genotype 1-infected ***,this treatment regimen also led to severe adverse ***-generation direct-acting antiviral agents (DAAs) for HCV,such as simeprevir plus peg-interferon and ribavirin also resulted in higher SVR rates,with similar adverse events to other peg-interferon and ribavirin *** SVR rates in HCV genotype 1-and 2-infected patients were achieved with 12-16 weeks of sofosbuvir plus other class DAAs with/without ribavirin and 12 weeks of sofosbuvir plus ribavirin,respectively,For "difficult-to-treat"HCV-infected patients,more therapeutic options are *** studies examining the efficacy and adverse effects of such therapies will be required for the development of additional treatments.

关键词： Daclatasvir Interferon-free Protease inhibitors Simeprevir Sofosbuvir

Structure-Based Study of Viral Replication 1st

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Single-Seed Casting Large-Size Monocrystalline Silicon for High-Efflciency and Low-Cost Solar Cells

2008年

作者： Cheng, R Holl miyamura, Tatsuo

ISBN: (数字)9789812790859

ISBN: (纸本)9789812704054

The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular *** book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scanning probes. The compilation and integration of the methodology provides time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. The book provides a broad introduction to the various fascinating virus systems and may be used as an advanced textbook by graduate students in biomedicine. It provides adequate background material to explore further the research problems of epidemics in the 21st century.

关键词： Viruses

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Engineering 2015年第3期1卷 378-383页

作者： Bing Gao Satoshi Nakano Hirofumi Harada Yoshiji miyamura Takashi Sekiguchi Koichi Kakimoto Research Institute for Applied Mechanics Kyushu University National Institute for Materials Science

To grow high-quality and large-size monocrystalline silicon at low cost, we proposed a single-seed casting technique. To realize this technique, two challenges—polycrystalline nucleation on the crucible wall and dislocation multiplication inside the crystal—needed to be addressed. Numerical analysis was used to develop solutions for these challenges. Based on an optimized furnace structure and operating conditions from numerical analysis, experiments were performed to grow monocrystalline silicon using the single-seed casting technique. The results revealed that this technique is highly superior to the popular high-performance multicrystalline and multiseed casting mono-like techniques.

关键词： single-seed casting monocrystalline silicon polycrystalline nucleation dislocation multiplication multicrystalline silicon

IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase

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World Journal of Hepatology 2013年第11期5卷 635-641页

作者： Tatsuo miyamura Tatsuo Kanda Masato Nakamura Xia Jiang Shuang Wu Shingo Nakamoto Shigeru Mikami Nobuo Takada Fumio Imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine Department of Internal Medicine Kikkoman General Hospital Department of Internal Medicine Toho University Sakura Medical Centre Safety and Health Organization Chiba University

AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with *** February 2010 and April2013,278 patients infected with HCV were enrolled in this *** of the patients were treated with peginterferon-alpha 2a or 2b plus *** addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected *** all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism *** RNA was measured using the COBAS TaqMan HCV ***:Female patients were dominant in the PNALT group(P<0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P<0.01)and the sustained virologic response(SVR)rates(P<0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG *** HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P<0.05)and having an EVR(P<0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with ***:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.

关键词： Hepatitis C virus Interleukin 28B Persistent normal alanine aminotransferase levels Standard of care Treatment response

Usage of Pythagorean Triple Sequence in OSPF

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Communications and Network 2012年第1期4卷 73-82页

作者： Simon Tembo Ken-ichi Yukimatsu Shohei Kamamura Takashi miyamura Kohei Shiomoto Atsushi Hiramatsu Department of Computer Science and Engineering Akita University Akita City Japan NTT Network Service Systems Laboratories NTT Corporation Tokyo Japan

Shutting down a link for the purposes of a scheduled routine maintenance does cause the forwarding path to change. If these changes are not done in a required order will cause not only transient micro loops but also an overload in some links. Currently, some ISP operators use a graceful link shutdown procedure by first setting up the Interior Gateway Protocol (IGP) link metric to MAX_METRIC -1 and then shutdown the link. In this paper, we present a Pythagorean Triple Metric Sequence as a method to use to shutdown a link during such network operations. Conducting a link shutdown of any desired link for maintenance purpose is a very delicate duty that requires extreme care to prevent transient loops during such topological changes. We thus wish to demonstrate that there exists a Pythagorean Triple Metric Sequence for any given link that can be used to shutdown a link during the routine maintenance by ISPs.

关键词： MAX_METRIC Link Shutdown Pythagorean Triple Metric Sequence Target Metric Forwarding Path Planned Failures