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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK minsuk kwon MINAE AN JUNG YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model

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Cellular & Molecular Immunology 2021年第7期18卷 1652-1661页

作者： Jaya Lakshmi Thangaraj Seo-Yeon Ahn Sung-Hoon Jung Manh-Cuong Vo Tan-Huy Chu Minh-Trang Thi Phan minsuk kwon Kyung-Hwa Lee Mihee Kim Ga-Young Song Deok-Hwan Yang Jae-Sook Ahn Hyeoung-Joon Kim Duck Cho Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital and Chonnam National University Medical SchoolGwangjuKorea Department of Hematology-Oncology Chonnam National University Hwasun Hospital and Chonnam National University Medical SchoolGwangjuKorea Department of Molecular Medicine Chonnam National UniversityGwangjuKorea Stem Cell&Regenerative Medicine Institute Samsung Medical CenterSeoulKorea View author publications Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Pathology Chonnam National University Medical SchoolGwangjuKorea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoulKorea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea

The use of natural killer(NK)cells is a promising and safe immunotherapeutic approach in the field of cancer ***,combination treatments are required to enhance the effector functions and therapeutic efficacy of NK *** this study,we investigated the potential of daratumumab(Dara),bortezomib,and dexamethasone(Dvd)to augment the antitumor effects of NK cells in a multiple myeloma(MM)xenograft mouse *** cells were expanded and activated using the K562-OX40 ligand and membrane-bound IL-18 and IL-21 in the presence of IL-2 and IL-15 from peripheral blood mononuclear cells from MM patients.A human MM xenograft model was established using human RPMI8226-RFP-FLuc cells in NOD/SCID IL-2Rγnull(NSG)***-bearing mice were divided into six treatment groups:no treatment,expanded NK cells(eNKs),Dara,Dara+eNKs,Dvd,and Dvd+*** treatment strongly enhanced the cytotoxicity of eNKs by upregulating expression of NK cell activation ligands,downregulating expression of NK cell inhibitory ligands,and promoting antibody-dependent cellular *** combination of eNKs with Dvd significantly prolonged mouse survival and reduced the tumor burden and serum M-protein ***,Dvd pretreatment significantly increased eNK persistence and homing to MM *** findings suggest that Dvd treatment potentiates the antimyeloma effects of NK cells expanded and activated ex vivo by modulating immune responses in MM-bearing mice.

关键词： Multiple myeloma Natural killer cell Chemotherapy

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NOR logic function of a bendable combination of tunneling field-effect transistors with silicon nanowire channels

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Nano Research 2016年第2期9卷 499-506页

作者： Yoonjoong Kim Youngin Jeon minsuk Kim Sangsig Kim Department of Electrical Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 136-701 Republic of Korea

In this study, we propose a novel combination of tunneling field-effect transistors （TFETs） with asymmetrically doped p^＋-i-n^＋ silicon nanowire （SiNW） channels on a bendable substrate. The combination of two n-channel SiNW-TFETs （NWTFETs） in parallel and two p-channel NWTFETs in series operates as a two-input NOR logic gate. The component NWTFETs with the n- and p-channels exhibit subthreshold swings （SSs） of 69 and 53 mV·dec^-1, respectively, and the on/off current ratios are -106. The NOR logic operation is sustainable and reproducible for up to 1,000 bending cycles with a narrow transition width of -0.26 V. The mechanical bendability of the bendable NWTFETs shows that they are stable and have good fatigue properties. To the best of our knowledge, this is the first study on the electrical and mechanical characteristics of a bendable NOR logic gate composed of NWTFETs.

关键词： silicon nanowire array field-effect transistor tunneling NOR logic gate bendable substrate

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Low-power functionality of silicon-nanowire-assembled inverters on bendable plastics

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Nano Research 2016年第5期9卷 1409-1417页

作者： Youngin Jeon Myeongwon Lee minsuk Kim Yoonjoong Kim Sangsig Kim Department of Electrical Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 02841 Republic of Korea

In this paper, we demonstrate the low-power functionality of silicon nanowire （SiNW）-assembled inverters on bendable plastics. Our bendable inverters are capable of operating at supply voltages as low as 0.8 V with a switching （or standby） power consumption of -0.2 nW （or -6.6 pW）. The low-power inverting operation with a voltage gain of -18 is attributable to the near-ideal characteristics of the component transistors that have selectively thinned SiNW channels and exhibit low, symmetrical threshold voltages of 0.40 and -0.39 V and low subthreshold swing values of 81 and 65 mV/dec. Moreover, mechanical bendability reveals that the inverting operation has good, stable fatigue properties.

关键词： silicon nanowire inverter low-power functionality bendable electronics

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Nanowatt power operation of silicon nanowire NAND logic gates on bendable substrates

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Nano Research 2016年第12期9卷 3656-3662页

作者： Junggwon Yun Myeongwon Lee Youngin Jeon minsuk Kim Yoonjoong Kim Doohyeok Lim Sangsig Kim Department of Electrical Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 02841 Republic of Korea

In this paper, we propose a novel construction of silicon nanowire （SiNW） negative-AND （NAND） logic gates on bendable plastic substrates and describe their electrical characteristics. The NAND logic gates with SiNW channels are capable of operating with a supply voltage as low as 0.8 V, with switching and standby power consumption of approximately 1.1 and 0.068 nW, respectively. Superior electrical characteristics of each SiNW transistor, including steep subthreshold slopes, high Ion/off ratio, and symmetrical threshold voltages, are the major factors that enable nanowatt-range power operation of the logic gates. Moreover, the mechanical bendability of the logic gates indicates that they have good and stable fatigue properties.

关键词： negative-AND (NAND)logic gates bendable electronics silicon nanowires nanowatt operation

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Variable TDMA MAC Protocol For WDM EPON

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光学学报 2003年第S1期23卷 777-778页

作者： minsuk Jung Yongseok Chang Jonghoon Eom Sungho Kim Dept. of Computer Engineering Kyungpook National University Daegu KoreaDept. of Computer Engineering Kyungpook National University Daegu KoreaTelecommunication Network Laboratory Korea Telecom Jeonmin-dong Yusung-gu Daejeon KoreaDept. of Computer Engineering Kyungpook National University Daegu Korea

A MAC(Media Access Control) protocol, one of the most important technologies for an EPON(Ethernet Passive Optical Network), contains a scheduling algorithm to avoid collisions in shared links and assigns an effective bandwidth when ONUs (Optical Network Units) transfer signals upward. The current paper proposes a MAC Protocol that operates a TDMA(Time method with a variable slot assignment to overcome short of bandwidth using by the number of n wavelength., the next generation access network. To verify ...

关键词： Variable TDMA MAC Protocol For WDM EPON for OPNET MAC TDMA

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气体树林

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城市环境设计 2009年第7期 42-43页

作者： minsuk Cho Joungwon Lee Bumhyun Chun Kyungmin kwon Sungpil Won Mass建筑师事务所

城市公园位于丹佛市的东部中心,是丹佛市最大、最著名的公园。在这个面积1.3km2的有历史意义的公园里,有大面积的开放型草坪,中央是被绿树环绕的Ferril湖。Ferril湖主轴线为东西方向,开始于东侧的丹佛自然科学博物馆（这里是Ferril湖的... 详细信息

城市公园位于丹佛市的东部中心,是丹佛市最大、最著名的公园。在这个面积1.3km2的有历史意义的公园里,有大面积的开放型草坪,中央是被绿树环绕的Ferril湖。Ferril湖主轴线为东西方向,开始于东侧的丹佛自然科学博物馆（这里是Ferril湖的最高处）,终止于湖西侧的地标性建筑——船亭,通过这条轴线,可以看到丹佛的天际线和旁边的山峰。

关键词：树林六边形丹佛建筑师美术家

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Context-aware BPEL workflow system using aspect-oriented programming

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Journal of Measurement Science and Instrumentation 2012年第2期3卷 119-122页

作者： minsuk Kim Donggyu Kuak Jongsun Choi Jaeyoung Choi Computer Science and Engineering Soongsil University

Business process execution language(BPEL)is a most recognized standard workflow ***,it is difficult to be used in the ubiquitous system computing environment because it is difficult to describe the context information in the selection of the flow through the *** solve this problem,we propose a new BPEL workflow system with context-awareness by using aspect-oriented programming(AOP).This system is composed of a BPEL system module and a weaving module using AOP for *** BPEL system module generates a BPEL workflow *** the weaving module converts a context-aware mark-up language(CAML)document to the aspect-oriented program that is applied to context-aware code without modification of the existing BPEL *** also define a new document form that is called CAML,which provides a context-aware that is not available in *** system can generate a context-aware workflow *** is developed in a way that inserts context information using AOP to provide context-aware services.

关键词： aspect-oriented programming(AOP) business process execution language(BPEL) context-aware workflow

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The usefulness of positron emission tomography （PET） for cervical lymph node metastasis in oral cancer

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中国口腔颌面外科杂志 2008年第B5期6卷 101-102页

作者： Hongiu Park Mingi Yu Jinyong Cho minsuk Kook Heekyun Oh Department of Oromaxillofacial Surgery Choonam NationalUniversity Hospital Gwangju South Korea

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建筑的“青葱”岁月韩国某服饰店

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室内设计与装修 2008年第7期 64-69页

作者： minsuk Cho Samuele Martelli 许科

Mass Studies是由韩国设计师minsuk Cho2003年在首尔成立的韩国本土建筑设计事务所。成立至今，他们的作品已经遍及世界各地，成为韩国最红的建筑事务所。minsuk Cho毕业于韩国延世大学（Yonsei University）建筑工程系，在哥伦比亚大... 详细信息

Mass Studies是由韩国设计师minsuk Cho2003年在首尔成立的韩国本土建筑设计事务所。成立至今，他们的作品已经遍及世界各地，成为韩国最红的建筑事务所。minsuk Cho毕业于韩国延世大学（Yonsei University）建筑工程系，在哥伦比亚大学获得硕士学位。在回国成立自己的设计事务所之前，minsuk Cho先在纽约的两个设计公司Kolatan／Macdonald studio和Polshekand Partners中任职。

关键词：建筑设计韩国哥伦比亚大学建筑事务所饭店建筑工程系设计师硕士学位

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