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基于GPC的水泥粉磨磨内流速控制与应用

水泥 2024年第5期 27-29,34页

作者：聂明明张宏图陈薇合肥水泥研究设计院有限公司安徽合肥230051

水泥磨磨内流速对水泥粒度、产量和能耗等指标具有重要影响。基于ARMAX模型的GPC预测控制算法应用在水泥磨磨内流速控制中具有多项优点,如良好的稳定控制性能和可适应性等。通过预测算法控制磨尾风机转速将磨头负压稳定在合适的范围,能... 详细信息

水泥磨磨内流速对水泥粒度、产量和能耗等指标具有重要影响。基于ARMAX模型的GPC预测控制算法应用在水泥磨磨内流速控制中具有多项优点,如良好的稳定控制性能和可适应性等。通过预测算法控制磨尾风机转速将磨头负压稳定在合适的范围,能有效提高水泥磨产量,提高粉磨效率并防止空磨和饱磨情况的发生。经现场实际验证,该系统提高了磨机稳定运行能力和磨机产量,减少了操作人员的劳动强度。

关键词：水泥磨磨内流速 ARMAX模型 GPC算法

13.5 mJ polarized 2.09μm fiber-bulk holmium laser and its application to a mid-infrared ZnGeP2 optical parametric oscillator

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Chinese Optics Letters 2017年第9期15卷 71-75页

作者： Encai Ji mingming nie qiang Liu State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision Instrument Tsinghua University Beijing 100084 China

A high pulse repetition frequency（PRF）, high energy Ho：YAG laser directly pumped by a Tm-doped fiber laser and its application to a mid-infrared ZnGeP_2（ZGP） optical parametric oscillator（OPO） is *** maximum polarized 2.09 μm laser pulse energy is 13.46 mJ at a PRF of 1 k Hz. The corresponding peak power reaches 504 kW. In a double-resonant ZGP-OPO, a maximum mid-infrared laser pulse energy of 1.25 m J,corresponding to a peak power of 79 kW, is accomplished at a PRF of 3 kHz. The nonlinear conversion efficiency reaches 41.7%. The nonlinear slope efficiency reaches 53.3%.

关键词： OPO YAG Ho PRF mJ polarized 2.09 m fiber-bulk holmium laser and its application to a mid-infrared ZnGeP2 optical parametric oscillator

Dissipative soliton generation and real-time dynamics in microresonator-filtered fiber lasers

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Light(Science & Applications) 2022年第11期11卷 2676-2686页

作者： mingming nie Bowen Li Kunpeng Jia Yjun Xie Jingjie Yan Shining Zhu Zhenda Xie Shu-Wei Huang Department of Electrial Computer and Energy EngineeringUniversity of Colorado BoulderBoulderColorado 80309USA School of Electronic Science and Engineering National Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesSchool of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Optical frequency combs in microresonators(microcombs)have a wide range of applications in science and technology,due to its compact size and access to considerably larger comb *** recent successes,the problems of self-starting,high mode efficiency as well as high output power have not been fully addressed for conventional soliton *** demonstration of laser cavity soliton microcombs by nesting a microresonator into a fiber cavity,shows great potential to solve the *** we study the dissipative soliton generation and interaction dynamics in a microresonator-fltered fiber laser in both theory and *** bring theoretical insight into the mode-locking principle,discuss the parameters effect on soliton properties,and provide experimental guidelines for broadband soliton *** predict chirped bright dissipative soliton with flat-top spectral envelope in microresonators with normal dispersion,which is fundamentally forbidden for the externally driven ***,we experimentally achieve soliton microcombs with large bandwidth of~10 nm and high mode efficiency of 90.7%.Finally,by taking advantage of an ultrahigh-speed time magnifier,we study the real-time soliton formation and interaction dynamics and experimentally observe soliton Newton's *** study will benefit the design of the novel,high-efficiency and self-starting microcombs for real-world applications.

关键词： resonator fiber soliton

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

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Acta Pharmaceutica Sinica B 2021年第3期11卷 609-620页

作者： Jinghui Zhang Jiajun Fan Xian Zeng mingming nie Jingyun Luan Yichen Wang Dianwen Ju Kai Yin Department of Gastrointestinal Surgery Changhai HospitalSecond Military Medical UniversityShanghai 200433China Department of Biological Medicines Fudan University School of PharmacyShanghai 201203China Shanghai Engineering Research Center of Immunotherapeutics Shanghai 201203China

The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug *** interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities.

关键词： Hedgehog Carcinogenesis Tumor microenvironment Gastrointestinal cancer Cancer stem cells Drug resistance

From VIB‑to VB‑Group Transition Metal Disulfides:Structure Engineering Modulation for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第2期16卷 218-257页

作者： Junye Cheng Yongheng Jin Jinghan Zhao Qi Jing Bailong Gu Jialiang Wei Shenghui Yi mingming Li Wanli nie Qinghua Qin Deqing Zhang Guangping Zheng Renchao Che Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China

The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various fields,such as catalysis,energy storage,sensing,*** recent years,a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption(EMA)has been carried ***,it is of great significance to elaborate the influence of TMDs on EMA in time to speed up the *** this review,recent advances in the development of electromagnetic wave(EMW)absorbers based on TMDs,ranging from the VIB group to the VB group are *** compositions,microstructures,electronic properties,and synthesis methods are presented in ***,the modulation of structure engineering from the aspects of heterostructures,defects,morphologies and phases are systematically summarized,focusing on optimizing impedance matching and increasing dielectric and magnetic losses in the EMA materials with tunable EMW absorption *** as well as the challenges are also identified to guide the design of new TMDs based dielectric EMA materials with high performance.

关键词： Transition metal disulfides Electromagnetic wave absorption Impedance matching Structure engineering modulation

基体合金对连续M40石墨纤维/Al复合材料纤维损伤及断裂机制的影响

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复合材料学报 2016年第12期33卷 2797-2806页

作者：聂明明徐志锋余欢王振军姚菁南昌航空大学轻合金加工科学与技术国防重点学科实验室南昌330063

选用M40石墨纤维为增强体,采用真空气压浸渗法制备了纤维体积分数为40%,基体合金分别为ZL102、ZL114A、ZL205A及ZL301合金的连续M40/Al复合材料,并用NaOH溶液萃取出M40纤维,研究了基体合金对连续M40/Al复合材料纤维损伤和断裂机制的影... 详细信息

选用M40石墨纤维为增强体,采用真空气压浸渗法制备了纤维体积分数为40%,基体合金分别为ZL102、ZL114A、ZL205A及ZL301合金的连续M40/Al复合材料,并用NaOH溶液萃取出M40纤维,研究了基体合金对连续M40/Al复合材料纤维损伤和断裂机制的影响。结果表明:不同的基体合金对M40纤维造成的损伤差异较大,从M40/ZL301复合材料中萃取的纤维拉伸强度最高,其拉伸强度为1 686MPa,约为纤维原丝拉伸强度的38.3%;而从M40/ZL102复合材料中萃取的纤维拉伸强度最低,其拉伸强度仅为687MPa,且纤维表面粗糙程度不一。不同M40/Al复合材料的断裂机制存在明显差别,M40/ZL102和M40/ZL114A复合材料断裂时无纤维拔出及界面脱粘,裂纹横向穿过纤维导致复合材料在低应力下失效;M40/ZL205A复合材料则表现为少量纤维拔出,界面轻微脱粘;同时,M40/ZL301复合材料表现为大量纤维拔出,裂纹沿界面纵向扩展,界面脱粘明显,纤维充分发挥其承载作用,复合材料的拉伸强度最高,达到了670.2 MPa。

关键词：连续M40/Al复合材料真空气压浸渗基体合金纤维损伤断裂机制

纤维预热温度对连续Al2O3f/Al复合材料力学性能的影响

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材料研究学报 2019年第5期33卷 361-370页

作者：胡银生余欢徐志锋蔡长春聂明明南昌航空大学轻合金加工科学与技术国防重点学科实验室

选用Nextel610型Al2O3纤维为增强体、ZL210A连续氧化铝合金为基体,采用真空压力浸渗法制备纤维增强铝基复合材料(Al2O3f/Al),纤维的体积分数为40%,预热温度分别为500、530、560和600℃,研究了纤维预热温度对Al2O3f/Al复合材料的微观组... 详细信息

选用Nextel610型Al2O3纤维为增强体、ZL210A连续氧化铝合金为基体,采用真空压力浸渗法制备纤维增强铝基复合材料(Al2O3f/Al),纤维的体积分数为40%,预热温度分别为500、530、560和600℃,研究了纤维预热温度对Al2O3f/Al复合材料的微观组织、纤维损伤和力学性能的影响。结果表明:随着纤维预热温度的提高复合材料的致密度随之提高,最大达到99.2%,材料的组织缺陷最少,纤维的分布均匀;随着纤维预热温度的提高从复合材料中萃取出来的Al2O3纤维的拉伸强度不断降低,纤维预热温度为600℃的复合材料中Al2O3纤维的拉伸强度仅为1150 MPa,纤维表面粗糙,有大尺寸附着物。纤维的预热温度对Al2O3f/Al复合材料的拉伸强度有显著的影响。预热温度为500、530、560和600℃的复合材料其拉伸强度分别对应于298、465、498和452 MPa。组织缺陷、纤维损伤和界面结合强度,是影响连续Al2O3f/Al复合材料强度的主要因素。

关键词：金属基复合材料纤维预热温度真空压力浸渗界面反应纤维损伤力学性能

恩格列净联合利格列汀治疗2型糖尿病的临床效果分析

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继续医学教育 2021年第9期35卷 155-156页

作者：聂明明黑龙江省佳木斯市中心医院内分泌科黑龙江佳木斯154002

目的探讨恩格列净联合利格列汀治疗2型糖尿病的临床效果。方法选取2019年2-10月在医院诊疗的96例2型糖尿病患者,按照治疗方式分为利格列汀组(46例)和恩格列净组(50例)。利格列汀组口服利格列汀片治疗,恩格列净组联用恩格列净片治疗,监... 详细信息

目的探讨恩格列净联合利格列汀治疗2型糖尿病的临床效果。方法选取2019年2-10月在医院诊疗的96例2型糖尿病患者,按照治疗方式分为利格列汀组(46例)和恩格列净组(50例)。利格列汀组口服利格列汀片治疗,恩格列净组联用恩格列净片治疗,监测两组血糖、肾功能、体质量及不良反应情况。结果恩格列净组治疗后空腹血糖(5.36±1.03)mmol/L、餐后2 h血糖(6.86±1.02)mmol/L、糖化血红蛋白(6.45±1.67)%指标水平低于利格列汀组(6.59±1.34)mmol/L、(7.98±1.11)mmol/L、(7.75±0.98)%,差异具有统计学意义(P<0.05)。恩格列净组治疗后血清肌酐清除率、血尿素氮、血清肌酐、血清胱抑素C均低于利格列汀组(P<0.05)。结论恩格列净+利格列汀联合治疗,可提升2型糖尿病患者的降糖效果,并可有效改善患者肾功能,有助于防控相关并发症,该方案疗效可靠,且安全性较高。

关键词：恩格列净利格列汀 2型糖尿病:血糖糖化血红蛋白疗效

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胰岛素持续皮下输注对妊娠糖尿病患者的影响

继续医学教育 2021年第12期35卷 160-162页

作者：聂明明黑龙江省佳木斯市中心医院内分泌科黑龙江佳木斯154002

目的探讨胰岛素持续皮下输注对妊娠糖尿病患者血糖控制及妊娠结局的影响。方法选择2018年2月—2019年12月期间在医院收治的90例妊娠糖尿病患者,根据治疗方式分为持续组(46例)和常规组(44例)。对照组行胰岛素皮下注射治疗,持续组采用... 详细信息

目的探讨胰岛素持续皮下输注对妊娠糖尿病患者血糖控制及妊娠结局的影响。方法选择2018年2月—2019年12月期间在医院收治的90例妊娠糖尿病患者,根据治疗方式分为持续组(46例)和常规组(44例)。对照组行胰岛素皮下注射治疗,持续组采用胰岛素持续皮下输注治疗,对比分析两组血糖控制效果和妊娠结局。结果持续组治疗8周空腹血糖(4.23±0.78)mmol/L和餐后2 h血糖(7.33±1.45)mmol/L指标显著低于对照组[(5.78±0.98)mmol/L、(8.26±1.32)mmol/L],差异有统计学意义(P <0.05)。持续组不良妊娠结局发生率(4.35%,2/46)显著低于对照组(20.45%,9/44),差异有统计学意义(P <0.05)。结论胰岛素持续皮下输注可有效控制妊娠糖尿病患者血糖水平,有助于降低不良妊娠结局风险,改善母婴预后,临床疗效安全可靠。

关键词：胰岛素持续皮下输注妊娠糖尿病血糖控制妊娠结局影响疗效