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Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1019-1028页

作者： Jun-jie Shen Min-Chang Li Shao-Qi Tian Wen-ming Chen Department of Oncology Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Hepatopancreatobiliary Surgery Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Clinical Medical School Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Oncology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

BACKGROUND Through experimental research on the biological function of GATA6-AS1,it was confirmed that GATA6-AS1 can inhibit the proliferation,invasion,and migration of gastric cancer cells,suggesting that GATA6-AS1 plays a role as an anti-oncogene in the occurrence and development of gastric *** experi-ments confirmed that the overexpression of fat mass and obesity-associated protein(FTO)inhibited the expression of GATA6-AS1,thereby promoting the occurrence and development of gastric *** To investigate the effects of GATA6-AS1 on the proliferation,invasion and migration of gastric cancer cells and its mechanism of *** We used bioinformatics methods to analyze the Cancer Genome Atlas(https://***/.The Cancer Genome Atlas)and download expression data for GATA6-AS1 in gastric cancer tissue and normal *** also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation,migration and invasion,and thereby clarify the expression of GATA6-AS1 in gastric cancer and its biological role in the genesis and development of gastric ***,we used a database(http://***/starbase2/)to analysis GATA6-AS1 whether by m6A methylation modify regulation and predict the methyltransferases that may methylate ***,RNA immunoprecipitation experiments confirmed that GATA6-AS1 was able to bind to the m6A methylation modification *** data allowed us to clarify the ability of m6A methylase to influence the action of GATA6-AS1 and its role in the occurrence and development of gastric *** Low expression levels of GATA6-AS1 were detected in gastric *** also determined the effects of GATA6-AS1 overexpression on the biological function of gastric cancer ***6-AS1 had strong binding ability with the m6A demethylase FTO,which was expressed at high levels in gastric cancer and negatively correlat

关键词： Long non-coding RNA GATA6-AS1 N6-methyladenine modification Fat mass and obesity-associated protein Gastric cancer

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Biocrusts impact soil properties and ecological stoichiometry characteristics in frozen ground regions on the Qinghai-Tibet Plateau

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Soil Ecology Letters 2024年第3期6卷 151-162页

作者： Jiao ming Yunge Zhao Yingying sun Zhe Liu The Research Center of Soil and Water Conservation and Ecological Environment Chinese Academy of Sciences and Ministry of EducationYangling 712100China College of Soil&Water Conservation Science and Engineering(Institute of Soil and Water Conservation) Northwest A&F UniversityYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences&Ministry of Water ResourcesYangling 712100China Shaanxi Provincial Land Engineering Construction Group Co. Ltd.Xi'an 710075China

Biocrusts(BSCs)are widely distributed in frozen ground regions on the Qinghai-Tibet Plateau,and they are considered an important component of cold ***,the specific impacts of BSCs on frozen soil remains relatively *** aim of our study was to clarify the influence of BSCs(light BSCs and dark BSCs in two different succession stages)on the physical properties and ecological stoichiometry characteristics of frozen *** results showed that BSCs increased the silt particle content in 20–40 cm soil layer,leading to a decrease in soil bulk *** the field water capacity increased about 10%–40%compared to bare ***,BSCs significantly increased the contents of soil organic carbon(SOC,22.6–30.8 g kg^(-1))and total nitrogen(TN,2.1–2.8 g kg^(-1))in the upper 40 cm soil layer,both of them were approximately 1.3–2.0 and 1.3–4.0 times higher than those observed in bare ***,BSCs did not have significant influence on soil total phosphorus(TP).BSCs had a significant impact on the stoichiometric ratios within 40 *** C/N ratios of the two types of BSCs ranged from 8.8 to 13.5,the C/P ratios ranged from 6.6 to 13.8,and the N/P ratios ranged from 0.6 to 1.2,which were all higher than those of the bare *** were no significant differences among the C/N,C/P,and N/P ratios between two types of ***,the increment of C/P and N/P ratios of dark BSCs were significantly higher than those of light BSCs within 0–30 cm,which indicated that a reduction in the availability of phosphorus during the later stages of BSCs *** findings provided a theoretical basis for further research on the ecological functions of BSCs in frozen ground regions.

关键词： biocrusts frozen soil soil properties stoichiometry characteristics Qinghai-Tibet Plateau

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Reliability-BasedModel for Incomplete Preventive ReplacementMaintenance of Photovoltaic Power Systems

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Energy Engineering 2024年第1期121卷 125-144页

作者： Wei Chen ming Li Tingting Pei Cunyu sun Huan Lei School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

At present,the operation and maintenance of photovoltaic power generation systems mainly comprise regular maintenance,breakdown maintenance,and condition-based maintenance,which is very likely to lead to over-or under-repair of ***,a preventive maintenance and replacement strategy for PV power generation systems based on reliability as a constraint is ***,a hybrid failure function with a decreasing service age factor and an increasing failure rate factor is introduced to describe the deterioration of PV power generation equipment,and the equipment is replaced when its reliability drops to the replacement threshold in the last ***,based on the reliability as a constraint,the average maintenance cost and availability of the equipment are considered,and the non-periodic incomplete maintenance model of the PV power generation system is established to obtain the optimal number of repairs,each maintenance cycle and the replacement cycle of the PV power generation system ***,the inverter of a PV power plant is used as a research *** model in this paper is compared and analyzed with the equal cycle maintenance model without considering reliability and the maintenance model without considering the equipment replacement threshold,Through model comparison,when the optimal maintenance strategy is(0.80,4),the average maintenance cost of this paper’s model are decreased by 20.3%and 5.54%and the availability is increased by 0.2395% and 0.0337%,respectively,compared with the equal-cycle maintenance model without considering the reliability constraint and the maintenance model without considering the equipment replacement ***,this maintenance model can ensure the high reliability of PV plant operation while increasing the equipment availability to improve the system economy.

关键词： Reliability photovoltaic power system average maintenance cost availability incomplete preventive maintenance hybrid failure rate

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Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengyu Zhang Zhiyang Zhang Heng sun jie Li Yi Chen Jiang Wang Chuanlang Zhan Key Laboratory of Advanced Materials Chemistry and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent years, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have exceeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of *** ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency *** this review, a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.

关键词： Organic solar cell Ternary/quaternary strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

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Single-atom catalysis for advanced oxidation and reduction systems in water decontamination

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Rare Metals 2024年第8期43卷 3576-3606页

作者： jie Teng Jin-Hui Xu Wen-Xin sun Xue-Feng Liu Xia Xu Guo-Shuai Liu School of Urban Construction Changzhou UniversityChangzhou 213164China School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China

Water scarcity is an escalating global crisis,posing a severe threat to populations ***,exploring various materials to remove emerging contaminants from freshwater sources has garnered significant *** this regard,single-atom catalysis(SACs) has emerged as a catalyst of scientific progress in water purification and treatment methodologies during recent *** exhibit exceptional catalytic activity,selectivity and stability,due to their near-perfect atom utilization,highly unsaturated coordination environment and uniform reaction ***,a comprehensive and critical review encompassing the successful integration of SACs into water purification processes needs to be *** review aims to accentuate recent trends by presenting the synthesis,structure,and environment and energy application-relevant properties of *** results show that a comprehensive and multi-perspective summary of the advantages of SACs in environmental remediation can have significant benefits,such as fast kinetics,costeffectiveness,*** oxidation and reduction processes of SACs and functional SACs materials in water purification were ***,the last section is devoted to the current research gaps and further perspectives on the application of SACs in water treatment,which are summarized and analyzed.

关键词： Single-atom catalysis Water treatment Oxidation Reduction

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Experimental study on the effect of unloading rate on gneiss rockburst

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2064-2076页

作者： Dongqiao Liu jie sun Ran Li Manchao He Binghao Cao Chongyuan Zhang Wen Meng State Key Laboratory for Tunnel Engineering China University of Mining and TechnologyBeijing100083China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing100081China School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing100083China

Rockburst are often encountered in tunnel construction due to the complex geological *** study the influence of unloading rate on rockburst,gneiss rockburst experiments were conducted under three groups of unloading rates.A high-speed photography system and acoustic emission(AE)system were used to monitor the entire process of rockburst process in *** results show that the intensity of gneiss rockburst decreases with decrease of unloading rate,which is manifested as the reduction of AE energy and fragments ejection *** mechanisms are proposed to explain this effect:(i)The reduction of unloading rate changes the crack propagation mechanism in the process of *** makes the rockbursts change from the tensile failure mechanism at high unloading rate to the tension-shear mixed failure mechanism at low unloading rate,and more energy released in the form of shear crack ***,less strain energy is converted into kinetic energy of fragments ejection.(ii)Less plate cracking degree of gneiss has taken shape due to decrease of unloading rate,resulting in the destruction of rockburst incubation *** enlightenments of reducing the unloading rate for the project are also described *** rockburst magnitude is reduced from the medium magnitude at the unloading rate of 0.1 MPa/s to the slight magnitude at the unloading rate of 0.025 MPa/s,which was judged by the ejection velocity.

关键词： Rockburst Unloading rate Crack propagation Influence mechanisms

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Dynamic response mechanism and precursor characteristics of gneiss rockburst under different initial burial depths

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Journal of Mountain Science 2024年第3期21卷 1004-1018页

作者： LIU Dongqiao sun jie MENG Wen HE Manchao ZHANG Chongyuan LI Ran CAO Binghao State Key Laboratory for Tunnel Engineering China University of Mining and TechnologyBeijing 100083China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing 100081China School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing 100083China

To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system and acoustic emission(AE)monitoring system were used to monitor the entire rockburst process in real *** experimental results show that when the initial burial depth increases from 928 m to 1320 m,the proportion of large fracture scale in rockburst increases by 154.54%,and the AE energy increases by 565.63%,reflecting that the degree and severity of rockburst increase with the increase of burial *** then,two mechanisms are proposed to explain this effect,including(i)the increase of initial geostress improves the energy storage capacity of gneiss,and then,the excess energy which can be converted into kinetic energy of debris ejection increases,consequently,a more pronounced violent ejection phenomenon is observed at rockburst;(ii)the increase of initial geostress causes more sufficient plate cracks of gneiss after unloading ofσh,which provides a basis for more severe ejection of ***’s more,a precursor with clear physical meaning for rockburst is proposed under the framework of dynamic response process of crack ***,potential value in long term rockburst warning of the precursor obtained in this study is shown via the comparison of conventional precursor.

关键词： Traffic Engineering Gneiss Rockburst Crack propagation Excess energy Precursor characteristic

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Enhanced cycle stability of aprotic Li-O_(2) batteries based on a self-defensed redox mediator

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Chinese Chemical Letters 2024年第3期35卷 449-452页

作者： Guiru sun Yan Wang Daming Yang Zexu Zhang Wei Lu ming Feng Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun 130103China College of Information Technology Jilin Engineering Research Center of Optoelectronic Materials and DevicesJilin Normal UniversitySiping 136000China

LiBr as a promising redox mediator(RM)has been applied in Li-O_(2)batteries to improve oxygen evolution reaction kinetics and reduce ***,the redox shuttle of Br_(3)^-can induce the unexpected reactions and thus cause the degradation of LiBr and the corrosion of Li anode,resulting in the poor cyclability and the low round-trip ***,MgBr_(2)is firstly employed with dual functions for Li-O_(2)batteries,which can serve as a RM and a SEI film-forming *** Br^(–)is beneficial to facilitating the decomposition of Li_(2)O_(2)and thus decreasing the ***,a uniform SEI film containing Mg and MgO generates on Li anode surface by the in-situ spontaneous reactions of Mg^(2+)and Li anode in an O_(2)environment,which can suppress the redox shuttle of Br_(3)^-and improve the interface stability of Li anode and *** from these advantages,the cycle life of Li-O_(2)battery with MgBr_(2)electrolyte is significantly extended.

关键词： MgBr_(2) Redox mediator Redox shuttle Li anode SEI film

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Transient Damping of Virtual Synchronous Generator for Enhancing Synchronization Stability during Voltage Dips

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 143-151页

作者： Shitao sun Yu Lei Guowen Hao Yi Lu Jindong Liu Zhaoxin Song jie Zhang North China Electric Power Research Institute Co. Ltd.Beijing 100045China State Grid Xinyuan Co. Ltd.Beijing 100761China Hebei Fengning Pumped Storage Energy Co.Ltd. Chengde 068350China

Virtual synchronous generators(VSGs)are widely introduced to the renewable power generation,the variablespeed pumped storage units,and so on,as a promising gridforming *** is noted that VSGs can provide virtual inertia for frequency support,but the larger inertia would worsen the synchronization stability,referring to keeping synchronization with the grid during voltage ***,this paper presents a transient damping method of VSGs for enhancing the synchronization stability during voltage *** is revealed that the loss of synchronization(LOS)of VSGs always accompanies with the positive frequency deviation and the damping is the key factor to remove LOS when the equilibrium point *** order to enhance synchronization stability during voltage dips,the transient damping is proposed,which is generated by the frequency deviation in active power ***,the proposed method can realize seamless switching between normal state and grid ***,detailed control design for transient damping gain is given to ensure the synchronization stability under different inertia requirements during voltage ***,the experimental results are presented to validate the analysis and the effectiveness of the improved transient damping method.

关键词： Virtual synchronous generator(VSG) Transient damping Synchronization stability Voltage dips

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Yr5-virulent races of Puccinia striiformis *** possess relative parasitic fitness higher than current main predominant races and potential risk

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Journal of Integrative Agriculture 2024年第8期23卷 2674-2685页

作者： Gensheng Zhang Mudi sun Xinyao Ma Wei Liu Zhimin Du Zhensheng Kang jie Zhao State Key Laboratory of Crop Resistance and High-Efficiency Production College of Plant ProtectionNorthwest A&F UniversityYangling 712100China

Wheat stripe rust,caused by Puccinia striiformis ***(Pst),is one of the most destructive fungal diseases of wheat,and seriously threatens safe production of the crop *** China,new races historically appeared and rapidly developed to be predominant races and have resulted in ineffectiveness and replacement of wheat resistance cultivars as well as massive reduction in *** the present study,the relative parasitic fitness of the two newlyemerged Yr5-virulent races(TSA-6 and TSA-9)were compared with those of four currently predominant Chinese races(CYR31,CYR32,CYR33,and CYR34)based on evaluation on 10 Chinese wheat *** a result,there were significant differences in the relative parasitic fitness parameters among overall tested races based on multiple comparison(LSD)analysis(PTSA-9(0.95)>TSA-6(0.92)>CYR34(0.29)>CYR31(–1.54)>CYR33(–1.77).The results indicated that two Yr5-virulent races TSA-9 and TSA-6 possessed relative parasitic fitness higher than races CYR34,CYR31,and CYR33,but lower than race CYR32,and have potential risks in developing to be predominant ***,continual monitoring of both Yr5-virulent races,and their variants is *** use of wheat cultivars(lines)with Yr5 resistance gene singly in wheat breeding is essential for being avoided,and is suggested to combine with other effective stripe rust resistance genes.

关键词： wheat stripe rust Puccinia striiformis f.sp.tritici parasitic fitness Yr5 new race

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