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基于遗传算法与支持向量回归的水轮机综合特性建模研究

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水力发电 2016年第12期42卷 81-84页

作者：庄明福建水口发电集团有限公司福建福州350004

针对水轮机复杂的非线性特性以及水轮机调节系统仿真与分析所需的水轮机流量与力矩特性难以准确描述的情况,介绍了基于遗传算法参数寻优的支持向量回归水轮机综合特性建模。由已知的综合特性曲线、飞逸特性曲线得到离散数据,向导叶小开... 详细信息

针对水轮机复杂的非线性特性以及水轮机调节系统仿真与分析所需的水轮机流量与力矩特性难以准确描述的情况,介绍了基于遗传算法参数寻优的支持向量回归水轮机综合特性建模。由已知的综合特性曲线、飞逸特性曲线得到离散数据,向导叶小开度区和低转速区数据进行合理延拓;利用具有很强全局优化搜索能力的遗传算法寻找支持向量回归(SVR)模型的最优参数,训练获得流量和力矩特性的SVR模型。仿真结果表明,与传统的BP神经网络模型比较,所提出基于遗传算法参数寻优的支持向量回归模型具有更高的精确度。

关键词：水轮机综合特性支持向量回归核函数遗传算法

Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

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Cancer Communications 2024年第2期44卷 205-225页

作者： Chen ming-Kun Chen Zi-Xian Cai Mao-Ping Chen Hong Chen zhuang-Fei Zhao Shan-Chao Department of Urology The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China The Third Clinical College Southern Medical UniversityGuangzhouGuangdongP.R.China Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyangHenanP.R.China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Targeted delivery of anti-tumor drugs and overcoming drug resistance in malig-nant tumor cells remain significant clinical ***,there are only few effective methods to address these *** vesicles(EVs),actively secreted by cells,play a crucial role in intercellular information transmis-sion and cargo *** studies have demonstrated that engineered EVs can serve as drug delivery carriers and showed promising application ***,there is an urgent need for further improvements in the isolation and purification of EVs,surface modification techniques,drug assem-bly processes,and precise recognition of tumor cells for targeted drug delivery *** this review,we summarize the applications of engineered EVs in cancer treatment and overcoming drug resistance,and current challenges asso-ciated with engineered EVs are also *** review aims to provide new insights and potential directions for utilizing engineered EVs as targeted delivery systems for anti-tumor drugs and overcoming drug resistance in the near future.

关键词： drug delivery drug resistance extracellular vesicles nanoparticles

水轮发电机组水力不平衡故障的自动化辨识及其应用研究

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水力发电 2017年第7期43卷 85-88页

作者：庄明福建水口发电集团有限公司福建福州350004

在大中型水力发电机组中,水力不平衡故障是较为常见的故障。为了实现对该故障的自动化判定和诊断,分析了水力不平衡故障产生的机理,阐述了水力不平衡对机组稳定运行的影响,提出了用于辨识水力不平衡故障的指标参数和自动化辨识模型。通... 详细信息

在大中型水力发电机组中,水力不平衡故障是较为常见的故障。为了实现对该故障的自动化判定和诊断,分析了水力不平衡故障产生的机理,阐述了水力不平衡对机组稳定运行的影响,提出了用于辨识水力不平衡故障的指标参数和自动化辨识模型。通过多个电站的实际应用表明,该研究方法能够实现由于转轮叶道不一致、叶型不一致、叶端间隙不一致等原因造成的水力不平衡故障的自动化的检测和诊断。该研究方法可用于水电站机组在线状态监测和故障诊断系统的设计和实现。

关键词：轴流转桨式水轮机水力不平衡自动化辨识模型

Risk assessment of coastal flooding disaster by storm surge based on Elevation-Area method and hydrodynamic models:Taking Bohai Bay as an example

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China Geology 2024年第3期7卷 494-504页

作者： Fu Wang Xue-zheng Liu Yong Li Heng Yu ming-zheng Wen Yun-zhuang Hu Tianjin Center(North China Center of Geoscience Innovation) China Geological SurveyTianjin 300170China Key Laboratory of Coast Geo-Environment China Geological SurveyTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China Hebei University of Environmental Engineering Qinhuangdao 066102China Hebei Engineering Research Center for Ecological Restoration of seaward Rivers and Coastal Waters Qinhuangdao 066102China Department of Earth and Environment Boston UniversityBoston 02215USA

The future inundation by storm surge on coastal areas are currently *** increasing global sealevel due to climate change,the coastal flooding by storm surge is more and more frequently,especially in coastal lowland with land ***,the risk assessment of such inundation for these areas is of great significance for the sustainable socio-economic *** this paper,the authors use Elevation-Area method and Regional Ocean Model System(ROMS)model to assess the risk of the inundation of Bohai Bay by storm *** simulation results of Elevation-Area method show that either a 50-year or 100-year storm surge can inundate coastal areas exceeding 8000 km^(2);the numerical simulation results based on hydrodynamics,considering ground friction and duration of the storm surge high water,show that a 50-year or 100-year storm surge can only inundate an area of over 2000 km^(2),which is far less than 8000 km^(2);while,when taking into account the land subsidence and sea level rise,the very inundation range will rapidly increase by 2050 and *** storm surge will greatly impact the coastal area within about 10-30 km of the Bohai Bay,in where almost all major coastal projects are *** prompt response to flood disaster due to storm surge is urgently needed,for which five suggestions have been proposed based on the geological background of Bohai *** study may offer insight into the development of the response and adaptive plans for flooding disasters caused by storm surge.

关键词： Storm surge ROMS Elevation-Area method Numerical simulation Land subsidence Flooding disaster Sea level rise Marine geological survey engineering Geological disaster survey engineering Bohai Bay

Evaluation of n+144,148,154Sm Reaction Data

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中国核科技报告 2000年第S3期 136-139页

作者： ming Jianchuan zhuang Youxiang (China Nuclear Data Center, CIAE)

Sm is an important nucleus in nuclear science and engineering. The theory data were given by Shen Qingbiao. Spline function was used in the experimental data fit calculation. The corresponding JENDL-3 data are accepte... 详细信息

关键词： Sm Reaction Data Evaluation of n data

卫星星历残存误差对差分GPS精度影响的分析

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集美大学学报（自然科学版） 2000年第4期5卷 65-69页

作者：庄铭杰集美大学计算机与通信系福建厦门361021

对经差分GPS修正后的卫星星历之残存误差 ,随用户与基准台之间距离变化进行理论研究和分析 ,所得到结果将有助于用户确定高精度DGPS的服务范围 .

关键词：差分GPS 卫星星历误差残存误差卫星导航

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非开挖技术在过海供水管道施工中的应用

中国给水排水 2009年第22期25卷 101-104页

作者：庄明芳蒋明舟山市自来水有限公司浙江舟山316021

结合舟山市某过海供水管道的工程实践,分析了非开挖技术在过海供水管道施工中的特点及工作流程,并提出相应的技术注意事项,以期为今后过海供水管道的施工提供借鉴。

关键词：非开挖技术过海供水管道管道敷设

Roles of AKR1C3 in malignancy

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Chinese Medical Journal 2021年第9期134卷 1052-1054页

作者： Xin-Zhu Xiao Li-Ying Lin ming-Kai zhuang Can-Mei Zhong Feng-Lin Chen Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhouFujian 350001China

The superfamily of aldo-keto reductases(AKRs)is composed of over 190 members and can be classified into 16 different families(visit ***/akr).AKR1C3(C3 subtype of aldosterone reductase family 1)refers to the first AKR in family 1,subfamily C,and is encoded by the AKR1C3 ***1C3 was first cloned and expressed from a human prostate cDNA *** protein is a soluble monomeric NADP(H)(nicotinamideadenine dinucleotide phosphate or reduced form of nicotinamide adenine dinucleotide phosphate)dependent oxidoreductase.

关键词： dinucleotide AKR1C3 adenine

基于智能控制算法的高速电机功率转换系统设计

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吉林大学学报（工学版） 2022年第4期52卷 934-941页

作者：王礼恒庄明袁恺中国科学院合肥物质科学研究院等离子体物理研究所合肥230031 中国科学技术大学科学岛分院合肥230026

为了解决传统功率转换系统中存在的转换误差大的问题,提出基于智能控制算法的高速电机功率转换系统设计。在传统硬件系统的基础上,结合智能控制算法中模糊神经网络的运行原理设计控制器设备,实现对双向Buck转换器、移相电抗器、整流器... 详细信息

为了解决传统功率转换系统中存在的转换误差大的问题,提出基于智能控制算法的高速电机功率转换系统设计。在传统硬件系统的基础上,结合智能控制算法中模糊神经网络的运行原理设计控制器设备,实现对双向Buck转换器、移相电抗器、整流器和逆变器等设备的改装,并调整系统的硬件连接电路。以高速电机为研究对象,分析其基本工作特性。搭建模糊神经网络控制模型,在该模型下以高速电机的工作数据为基础,计算电机瞬时功率,利用转换器设备通过产生反向电流或转矩脉动信号增益的方式,实现高速电机功率的转换功能。实验结果表明:与传统功率转换系统的对比,设计转换系统的平均转换误差降低了1.7 kW,且通过功率转换系统的应用能够实现对高速电机功率的有效控制,在实际应用中具有较高的利用价值。

关键词：智能控制算法高速电机电机功率功率转换系统