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涨套参数化设计方法研究与实现

制造业自动化 2024年第3期46卷 190-193页

作者：王英明张胜兰莫杰李莹程书澳湖北汽车工业学院车辆工程学院十堰442002

为了提高零件模型设计的工作效率,在分析比较两种型号涨套结构的基础上,提取了9个尺寸参数和8个特征参数,拟定并实现了分类型、同类型和超级副本三种参数化设计方案。基于涨套的设计方案,指出了参数化设计方案与一般设计方案相比的优点... 详细信息

为了提高零件模型设计的工作效率,在分析比较两种型号涨套结构的基础上,提取了9个尺寸参数和8个特征参数,拟定并实现了分类型、同类型和超级副本三种参数化设计方案。基于涨套的设计方案,指出了参数化设计方案与一般设计方案相比的优点,并对比分析了三种参数化设计方案的特点,指出三种参数化设计方案在实际生产设计中的适用范围。通过CATIA软件中的catalog功能,在以上不同的参数化设计方案的基础上,分别建立了零件库与特征库。

关键词：涨套参数化设计超级副本 catalog

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麻醉护理风险管理培训课程的构建

护理学报 2024年第14期31卷 33-37页

作者：姚呈高翔杨明莹何艳琳李明烨昆明医科大学第二附属医院麻醉手术科云南昆明650032 昆明医科大学第二附属医院护理部云南昆明650032

目的构建适合我国麻醉护理人员麻醉护理风险管理培训课程,为麻醉护理教育提供实践依据。方法以ADDIE教学模型为理论基础,结合文献分析、质性访谈拟定培训课程初稿,通过德尔菲法对26名专家进行2轮函询,根据咨询结果筛选、优化条目池,构... 详细信息

目的构建适合我国麻醉护理人员麻醉护理风险管理培训课程,为麻醉护理教育提供实践依据。方法以ADDIE教学模型为理论基础,结合文献分析、质性访谈拟定培训课程初稿,通过德尔菲法对26名专家进行2轮函询,根据咨询结果筛选、优化条目池,构建麻醉护理风险管理培训课程。结果2轮专家函询问卷回收率为73%、85%;专家权威系数为0.895、0.909;肯德尔和谐系数为0.347~0.497(P<0.001)、0.371~0.372(P<0.001);变异系数为0~0.30、0~0.18。最终形成麻醉护理风险管理培训课程,由29个条目组成。结论研究构建的麻醉护理风险管理培训课程较为可靠,且具有科学性,对麻醉护理风险培训具有参考意义。

关键词：麻醉护理风险管理课程构建

数据驱动的脉冲风洞气动热试验数据分析方法探索

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气体物理 2024年第4期9卷 65-82页

作者：易翔宇鄢明陈星林键姚大鹏纪锋应明张占一中国航天空气动力技术研究院北京100074 北京东方振动与噪声技术研究所北京100085

脉冲风洞的有效运行时间短,气动热测量信号易受干扰,通常采用人工判读的方式在大量的脉冲风洞测热试验数据中遴选有效数据,数据分析过程效率低、标准不统一。研究基于中国航天空气动力技术研究院1 m量级炮/激波双模式风洞气动热试验数... 详细信息

脉冲风洞的有效运行时间短,气动热测量信号易受干扰,通常采用人工判读的方式在大量的脉冲风洞测热试验数据中遴选有效数据,数据分析过程效率低、标准不统一。研究基于中国航天空气动力技术研究院1 m量级炮/激波双模式风洞气动热试验数据开展信号特征分析,确定了Fourier变换后的电压信号、总压-热流相关系数曲线、热流时间导数等参数对流动起止时间、运行模式分界时间、信号质量等关键信息的表征作用。在此基础上,基于卷积神经网络和密度基聚类算法,发展了传感器信号有效性判断模型、风洞有效运行时间段选取算法和传感器信号取值区间选取算法,实现了脉冲风洞气动热试验数据的智能处理。结果表明,智能算法对传感器信号有效性的判断准确度达到98%;针对3568条原始试验曲线进行处理,智能算法与人工方式得到的热流均值差异小于10%的数据约占91%,具有应用于风洞试验的价值。

关键词：脉冲风洞气动热试验热流卷积神经网络密度基聚类

紫花苜蓿耐盐性相关NAC转录因子的挖掘及表达分析

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草地学报 2024年第4期32卷 1055-1067页

作者：荣梦茹余如刚韦英铭王国良杜雪玲杨改梅高佳佳淮北师范大学生命科学学院安徽淮北235000 山东省农业科学院休闲农业研究所山东济南250010

NAC(NAM,ATAF1/2,CUC2)是植物特有的一类转录因子家族,可调控植物响应盐胁迫。本研究基于盐胁迫下紫花苜蓿(Medicago sativa L.)耐盐品种GIB和盐敏感品种LS根和叶的转录组数据,通过生物信息学方法筛选出17个差异表达的MsNAC转录因子家... 详细信息

NAC(NAM,ATAF1/2,CUC2)是植物特有的一类转录因子家族,可调控植物响应盐胁迫。本研究基于盐胁迫下紫花苜蓿(Medicago sativa L.)耐盐品种GIB和盐敏感品种LS根和叶的转录组数据,通过生物信息学方法筛选出17个差异表达的MsNAC转录因子家族成员,并对其序列特征、系统进化、顺式作用元件及盐胁迫下的表达模式等进行分析。结果显示,17个MsNACs均具有NAC典型的NAM结构域,且蛋白结构相似。系统进化分析将17个MsNACs分成8个亚族,各亚组成员具有高度相似的保守基序。顺式作用元件分析发现,有15个MsNACs具有ABA响应顺式元件ABRE。转录组数据表达模式分析与RT-qPCR验证结果显示MsNAC1,MsNAC2,MsNAC35,MsJUB1和MsNAC40基因在盐处理下GIB叶中上调表达,在LS叶中下调或者未发生变化,推测这些基因参与调控紫花苜蓿的耐盐反应。本研究为进一步研究紫花苜蓿NAC转录因子响应盐胁迫功能提供参考依据。

关键词：紫花苜蓿 NAC 盐胁迫生物信息学分析表达模式

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Modulation instability of dispersion-shifted fiber couplers

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Optoelectronics Letters 2008年第4期4卷 264-268页

作者： ZHOU Yan-yong JIA Wei-guo HAN ying-ming ying Chun BAO Hong-mei Department of Physics Inner Mongolia University Hohhot 010021China The Institute of product＇s quality inspection Inner Mongolia Hohhot 010010China Inner Mongolia Polytechnic University Hohhot 010062 China

The nonlinear coupled-mode equations are rewritten by even and odd *** study modulation instability(MI) of dispersion-shifted fiber couplers when either even or odd mode is launched alone by using zero-dispersion wavelength relatively long(quasi-cw) *** result shows that there are new types of MI in both the normal-dispersion and the anomalous-dispersion *** is concerned with forth-order dispersion and has no relation with third-order ***-cw can be changed into pulses array under certain *** can extract super short pulse from ***,the bandwidth of gain spectra widens and its strength accretes as the input power increases.

关键词：光纤耦合器非线性耦合方程调制不稳定性光学器件

Retroperitoneal laparoscopic partial nephrectomy for unilateral synchronous multifocal renal carcinoma with different pathological types:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6879-6885页

作者： ying-ming Xiao Sheng-Ke Yang ying Wang Dun Mao Fang-Lei Duan Shu-Kui Zhou Department of Urology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina Department of Urology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Pathology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina

BACKGROUND The majority of renal cell carcinomas are single lesions;unilateral synchronous multifocal renal carcinoma(USMRC)is rarely reported and poses a treatment challenge for urological *** SUMMARY A 56-year-old man was hospitalized for pain and discomfort in the right kidney area for 6 ***-enhanced computed tomography demonstrated cT1a renal tumors at the lower pole of the right kidney and a cT1b renal tumor at the middle dorsal portion of the right *** patient underwent retroperitoneal laparoscopic partial nephrectomy(RLPN).There were no complications *** revealed a low-grade,pathologic stage T1a(pT1a),clear cell renal cell carcinoma at the lower pole of the right kidney and a pT1b,chromophobe renal cell carcinoma at the middle dorsal portion of the right *** tumor bed recurrence or metastasis was observed on imaging and his renal function remained stable during the 12-mo follow-up *** RLPN is a safe,effective,and feasible for the management of USMRC,which can obtain equivalent oncological results with optimal renal function preservation.

关键词： Kidney neoplasm Multifocal Retroperitoneal laparoscopic operation Partial nephrectomy Case report

天天胶囊及其原料芦荟在大鼠体内的存在形式研究

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中国中药杂志 2024年第6期49卷 1641-1660页

作者：张静郝北泉李寅庆王光路徐风刘广学尚明英蔡少青北京大学药学院生药学研究室北京100191 河北御芝林药业有限公司河北石家庄050035

为了阐明组方药材芦荟对天天胶囊体内存在形式(原形成分和代谢产物)的贡献,首次对芦荟、天天胶囊及去芦荟天天胶囊在大鼠体内的存在形式进行了研究。大鼠灌胃给药,每天1次,连续灌胃7 d。收集给药7 d的全部尿液和粪便,最后一次灌胃给药... 详细信息

为了阐明组方药材芦荟对天天胶囊体内存在形式(原形成分和代谢产物)的贡献,首次对芦荟、天天胶囊及去芦荟天天胶囊在大鼠体内的存在形式进行了研究。大鼠灌胃给药,每天1次,连续灌胃7 d。收集给药7 d的全部尿液和粪便,最后一次灌胃给药后分别于0.5、1、1.5 h收集血液。采用UHPLC⁃Q⁃TOF⁃MS检测和鉴定生物样品中的存在形式,分别鉴定了芦荟给药组、天天胶囊给药组、去芦荟天天胶囊给药组生物样品中的原形成分34、28、2个及代谢产物64、94、0个。代谢反应类型主要为甲基化、氢化、羟基化、脱羟基、葡萄糖醛酸结合、硫酸结合等。该研究首次阐明了芦荟、天天胶囊、去芦荟天天胶囊在大鼠体内的存在形式和部分代谢途径,为进一步揭示其显效形式奠定基础,并对中药芦荟和天天胶囊的作用机制及质量控制研究具有重要意义。

关键词：天天胶囊芦荟 UHPLC⁃Q⁃TOF⁃MS 体内代谢

A novel and convenient synthesis of thiazolo[3,2-a]pyrimidin-7-ones and pyrido[1,2-a]pyrimidin-2-ones using Vilsmeier reagent

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Chinese Chemical Letters 2012年第8期23卷 911-914页

作者： Yi Yi Weng Lei ming ying Qi Xu Chen Wei Ke Su Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education College of Pharmaceutical SciencesZhejiang University of TechnologyHangzhou 310014China

A novel route for the synthesis of thiazolo[3,2-a]pyrimidin-7-ones and pyrido[1,2-a]pyrimidin-2,ones from acetylated 2- aminothiazoles and 2-aminopyridines under Vilsmeier conditions has been developed. The plausible ... 详细信息

关键词： Thiazolo[3,2-a]pyrimidin-7-ones Pyrido[1,2-a]pyrimidin-2-ones Bis-(trichloromethyl) carbonate Vilsmeier-Haack reaction

An in vitro study on the efficacy of removing calcium hydroxide from curved root canal systems in root canal therapy

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International Journal of Oral Science 2017年第2期9卷 110-116页

作者： ying Wang Li-Yang Guo Hong-Zhi Fang Wen-Ling Zou ying-ming Yang Yuan Gao Hui Yang Tao Hu State Key Laboratory of Oral Disease National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Department of Endodontics The Affiliated Stomatology Hospital School of Medicine Zhejiang University Hangzhou China Department of Stomatology The Third People's Hospital of Chengdu Chengdu China State Key Laboratory of Oral Disease National Clinical Research Center for Oral Diseases Department of Preventive Dentistry West China Hospital of Stomatology Siehuan University Chengdu China State Key Laboratory of Oral Disease National Clinical Research Center for Oral Diseases Department of General Dentistry West China Hospital of Stomatology Sichuan University Chengdu China

To compare the efficacy of various irrigants(citric acid, ethylenediaminetetraacetic acid(EDTA) and Na OCl) and techniques in removing Ca(OH)2in two types of curved root canal systems, simulated root canals with specific curvatures were used to investigate the effects of different irrigants and instruments on Ca(OH)2removal. The optimal methods were verified on extracted human teeth. Simulated root canals were assigned to one of two groups based on the irrigation solution: 10% citric acid or2.5% Na OCl. Each group was divided into four subgroups according to the technique used to remove Ca(OH)2. The percentage of Ca(OH)2removal in different sections of root canals was calculated. On the basis of the results obtained for the simulated canals, 10% citric acid and 17% EDTA were applied to remove Ca(OH)2from the extracted human teeth with curved root canal systems. The teeth were scanned by micro computed tomography to calculate the percentage of Ca(OH)2removal in the *** simulated root canals, we found that 10% citric acid removed more Ca(OH)2than 2.5% NaOCl in the 0–1 mm group from the apex level(Po0.05). Ultrasonic and Endo Activator activation significantly removed more Ca(OH)2than a size 30 K file in the apical third(Po0.05). However, there were no significant differences in any sections of the canals for 10% citric acid or 17%EDTA in removing Ca(OH)2in extracted human teeth. We concluded that it was effective to remove residual Ca(OH)2using the decalcifying solution with Endo Activator or Passive Ultrasonic Irrigation in a curved root canal system. A protocol for Ca(OH)2removal was provided based on the conclusions of this study and the methods recommended in previous studies.

关键词： calcium hydroxide curved root canal system irrigation removal