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The Effects of dietary restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular dNA

Biomedical and Environmental sciences 1991年第Z1期 134-143页

作者： ming w.chou,rex a.pegram,pu gao,s.r.hansard,j.g.shaddock,d.a.casciano National Center for Toxicological research jefferson National Center for Toxicological research jefferson National Center for Toxicological research jefferson National Center for Toxicological research jefferson National Center for Toxicological research jefferson National Arkansas Ar 72079 To whom repucsts for reprints should be addressed Arkansas Ar 72079 Us EPA HErL Md-74 research Triangle Park NC 27711 Arkansas Ar 72079 Arkansas Ar 72079 Arkansas Ar 72079 Center for Toxicological research jefferson Arkansas Ar 72079

Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzyme activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-dNA binding. dNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB 1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB 1-dNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFBI-dNA binding. Our preliminary results obtained from the AF

关键词： The Effects of dietary restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular dNA AFB

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The Effects of dietary restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B_1 to Cellular dNA

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Biomedical and Environmental sciences 1991年第1期4卷 134-143页

作者： ming w.chou rex a.pegram pu gao s.r.hansard j.g.shaddock d.a.casciano National Center for Toxicological research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Arkansas AR 72079 To whom repucsts for reprints should be addressed Arkansas AR 72079 US EPA HERL MD-74 Research Triangle Park NC 27711 Arkansas AR 72079 Arkansas AR 72079Arkansas AR 72079Center for Toxicological Research Jefferson Arkansas AR 72079

Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzyme activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-dNA binding. dNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB1 -dNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFB 1-dNA binding. Our preliminary results obtained from the AFB 1-dNA binding experiments in isolated hepatocytes suggest that the observed age-dependent reduction in AFB 1-dNA binding which may be attributed to a loss of metabolic activating capability was delayed in the diet-restricted rats.

关键词： The Effects of dietary restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular dNA AFB

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