检索结果-南通市图书馆

The Effects of Dietary Restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B_1 to Cellular DNA

Biomedical and Environmental Sciences 1991年第1期4卷 134-143页

作者： ming w.chou REX A.PEGRAM PU GAO S.R.HANSARD J.G.SHADDOCK D.A.CASCIANO National Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Center for Toxicological Research JeffersonNational Arkansas AR 72079 To whom repucsts for reprints should be addressed Arkansas AR 72079 US EPA HERL MD-74 Research Triangle Park NC 27711 Arkansas AR 72079 Arkansas AR 72079Arkansas AR 72079Center for Toxicological Research Jefferson Arkansas AR 72079

Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzyme activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-DNA binding. DNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB1 -DNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFB 1-DNA binding. Our preliminary results obtained from the AFB 1-DNA binding experiments in isolated hepatocytes suggest that the observed age-dependent reduction in AFB 1-DNA binding which may be attributed to a loss of metabolic activating capability was delayed in the diet-restricted rats.

关键词： The Effects of Dietary Restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular DNA AFB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effects of Dietary Restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular DNA

引用

Biomedical and Environmental Sciences 1991年第Z1期 134-143页

作者： ming w.chou,REX A.PEGRAM,PU GAO,S.R.HANSARD,J.G.SHADDOCK,D.A.CASCIANO National Center for Toxicological Research Jefferson National Center for Toxicological Research Jefferson National Center for Toxicological Research Jefferson National Center for Toxicological Research Jefferson National Center for Toxicological Research Jefferson National Arkansas AR 72079 To whom repucsts for reprints should be addressed Arkansas AR 72079 US EPA HERL MD-74 Research Triangle Park NC 27711 Arkansas AR 72079 Arkansas AR 72079 Arkansas AR 72079 Center for Toxicological Research Jefferson Arkansas AR 72079

Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary restriction on laboratory animals have been suggested to be related to a deceleration of the aging process. The inhibition of age-related changes in xenobiotic metabolizing enzyme activities by dietary restriction has previously been reported. Alterations of these enzyme activities may cause changes in metabolic activation of carcinogens and, therefore, carcinogen-DNA binding. DNA-repair capability has also been reported to be enhanced in diet-restricted rats. Using AFB 1 as a model carcinogen, we have studied in vivo and in vitro hepatic AFB 1-DNA binding, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1, and subsequently reduce AFBI-DNA binding. Our preliminary results obtained from the AF

关键词： The Effects of Dietary Restriction and Aging on in Vivo and in Vitro Binding of Aflatoxin B1 to Cellular DNA AFB

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High-dense nanocrystalline w-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

引用

Tungsten 2025年第1期7卷 120-136页

作者： Zao-ming wu Lin He Lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline w-10wt.% Cr-5wt.% Y（w-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.w-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of w-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline w-based alloys has been *** microstructure analysis of nanocrystalline w-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of w and leads to the formation of nanocrystalline w-10Cr-5Y alloy.w-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that w-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A novel method for clustering cellular data to improve classification

引用

Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling postpartum depression in rats： theoretic and methodological issues

引用

Zoological Research 2016年第4期37卷 229-236页

作者： ming LI Shinn-Yi chou Department of Psychology University of Nebraska-Lincoln Lincoln Nebraska 68588-0308 USA

The postpartum period is when a host of changes occur at molecular, cellular, physiological and behavioral levels to prepare female humans for the challenge of maternity. Alteration or prevention of these normal adaptions is thought to contribute to disruptions of emotion regulation, motivation and cognitive abilities that underlie postpartum mental disorders, such as postpartum depression. Despite the high incidence of this disorder, and the detrimental consequences for both mother and child, its etiology and related neurobiological mechanisms remain poorly understood, partially due to the lack of appropriate animal models. In recent decades, there have been a number of attempts to model postpartum depression disorder in rats. In the present review, we first describe clinical symptoms of postpartum depression and discuss known risk factors, including both genetic and environmental factors. Thereafter, we discuss various rat models that have been developed to capture various aspects of this disorder and knowledge gained from such attempts. In doing so, we focus on the theories behind each attempt and the methods used to achieve their goals. Finally, we point out several understudied areas in this field and make suggestions for future directions.

关键词： Postpartum depression Rat models HPA axis Stress Estrogen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genistein:a possible solution for the treatment of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glia-to-neuron reprogramming to the rescue?

引用

Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Perspective of Deep-sea Science Research and the Establishment of Modern Hydrothermal Laboratories in China

引用

地质学报 2013年第S1期 3-4页

作者： I-ming chou Laboratory for Experimental Study Under Deep-sea Extreme Conditions Sanya Institute of Deep-sea Science and Engineering Chinese Academy of Sciences

In addition to the outer space, sea floor is another frontier for current and future human explorations. The successful dive of manned submersible Jiaolong at the depth of 7062 m last summer(Cui et al., 2013) was one ...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A New Method for Determining Fluid Compositions in the H_2O-NaClCaCl_2 System with Cryogenic Raman Spectroscopy

引用

Acta Geologica Sinica(English Edition) 2014年第4期88卷 1169-1182页

作者： CHI Guoxiang CHU Haixia Ryan SCOTT chou I-ming Department of Geology University of Regina Laboratory for Experimental Study Under Deep-sea Extreme Conditions Sanya Institute of Deep-sea Science and EngineeringChinese Academy of Sciences

Raman peaks of various hydrates in the H20-NaCl-CaCl2 system have been previously identified, but a quantitative relationship between the Raman peaks and XNaCl （i.e.,NaCl/ （NaCl＋CaCl2）） has not been established, mainly due to the difficulty to freeze the solutions. This problem was solved by adding alumina powder to the solutions to facilitate nucleation of crystals. Cryogenic （-185℃） Raman spectroscopic studies of alumina-spiced solutions indicate that XNaCl is linearly correlated with the total peak area fraction of hydrohalite. Capsules of solutions made from silica capillary were prepared to simulate fluid inclusions. Most of these artificial fluid inclusions could not be totally frozen even at temperatures as low as -185℃, and the total peak area fraction of hydrohalite is not correlated linearly with XNaCI. However, the degree of deviation （△XNaCl） from the linear correlation established earlier is related to the amount of residual solution, which is reflected by the ratio （r） of the baseline ＂bump＂ area, resulting from the interstitial unfrozen brine near 3435 cm^-1, and the total hydrate peak area between 3350 and 3600 cm^-1. A linear correlation between △XNaCl and r is established to estimate XNaCl from cryogenic Raman spectroscopic analysis for fluid inclusions.

关键词： cryogenic Raman H20-NaCl-CaCl2 XNaCI fluid inclusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glucose Oxidase/Polypyrrole Biosensor Fabricated by Galvanostatic Electropolymerization Accompanied with a Potential Jumping

引用

稀有金属材料与工程 2006年第A3期35卷 277-281页

作者： Yuh-ming Uangl Hung-Te Chung Tse-Chuan chou Department of Chemical Engineering WuFeng Institute of TechnologyChiayiTaiwan62153China Dpartment of Chemical Engineering National Cheng Kung UniversityTainanTaiwan70101China

A galvanostatic glucose oxidase (GOD_x)/polypyrrole (Ppy) biosensor fabricated through a potential jumping process was *** spite of the instantaneous voltage jumping from 0.95 V to 1.7 V versus Ag/AgCl in the galvanostatic polymerization of pyrrole with commercial GOD_x,this GOD_x enzyme still could be successfully bundled with polypyrrole (Ppy).And,the results also confirmed that this glucose sensor not only possessed of better sensitivity to glucose than that fabricated from potentiometry or mild voltage elevating galvanometry for the similar preparing conditions but also exhibited two-week long-term ***,the kinetic data of Michalis constant (K_m) and Maximum current (I_m) for the optimized sensor were *** discovery this electro-modification process may disclose a novel method for fabricating the other enzyme biosensors.

关键词： conformation conducting galvanostatic dentritic jumping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：