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Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERKpathways

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Chinese Journal of Natural Medicines 2023年第7期21卷 527-539页

作者： FU San SONG Xianrui HU Yingying ZHU Qingwei LV Xinmiao TANG Xiaoyan zhang mian School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China

Activated fibroblasts and M2-polarized macrophages may contribute to the progression of pulmonary fibrosis by forming a positive feedback *** study was aimed to investigate whether fibroblasts and macrophages form this loop by secreting SDF-1 and TGF-β and the impacts of neotuberostemonine(NTS)and tuberostemonine(TS).Mice were intratracheally injected with 3 U·kg^(-1)bleomycin and orally administered with 30 mg·kg^(-1)NTS or *** pulmonary fibroblasts(PFBs)and MH-S cells(alveolar macrophages)were used in *** animal experiments showed that NTS and TS improved fibrosis related indicators,inhibited fibroblast activation and macrophage M2 polarization,and reduced the levels of TGF-β and SDF-1 in alveolar lavage *** experiments showed that TGF-β1 may activated fibroblasts into myofibroblasts secreting SDF-1 by activating the PI3K/AKT/HIF-1αand PI3K/PAK/RAF/ERK/HIF-1α*** was also found for the first time that SDF-1 was able to directly polarize macrophages into M2 phenotype secreting TGF-β through the same pathways as mentioned ***,the results of the cell coculture confirmed that fibroblasts and macrophages actually developed a feedback loop to promote fibrosis,and the secretion of TGF-β and SDF-1 was crucial for maintaining this *** and TS may disturb this loop through inhibiting both the PI3K/AKT/HIF-1αand PI3K/PAK/RAF/ERK/HIF-1α pathways to improve pulmonary *** and TS are stereoisomeric alkaloids with pyrrole[1,2-ajazapine skeleton,and their effect on improving pulmonary fibrosis may be largely attributed to their parent ***,this study found that inhibition of both the AKT and ERK pathways is essential for maximizing the improvement of pulmonary fibrosis.

关键词： Fibroblast Macrophage SDF-1 PI3K/AKT PI3K/PAK/RAF/ERK Pulmonary fibrosis Pyrrole[1,2-a]azapine skeleton

The principal moments of inertia calculated with the hydrostatic equilibrium figure of the Earth

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Geodesy and Geodynamics 2017年第3期8卷 201-205页

作者： Chengjun Liu Chengli Huang mian zhang CAS Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China University of Chinese Academy of Sciences Beijing 100049 China

As an indication of the Earth＇s mass distribution, the principal moments of inertia （PMOI, i.e., A, B, C） of the Earth are the basic parameters in studies of the global dynamics of the earth, like earth nutation, and the geophysics. From the aspect of observation, the PMOI can be calculated from the spherical coefficients of observed gravity field. In this paper, the PMOI are calculated directly according to its definition with the figures of the Earth＇s interior derived by a generalized theory of the hydrostatic equilibrium figure of the Earth. We obtain that the angle between the principal axis of the maximum moment of PMOI and the rotational axis is 0.184~, which means that the other two principal axes are very closely in the equatorial plane. Meanwhile, B-A is 1.60 x 10-5 MR2, and the global dynamical flattening （H） is calculated to be 3.29587 ~ 10-3, which is 0.67% different from the latest observation derived value Hobs（3.273795 × 10 ^-3）（Petit and Luzum, 2010）, and this is a significant improvement from the 1.1% difference between the value of H derived from traditional theories of the figure of the Earth and the value of Hobs. It shows that we can calculate the PMOI and H with an appropriate accuracy by a gener- alized theory of the hydrostatic equilibrium figure of the Earth.

关键词： Principal moments of inertia (PMOI) Hydrostatic equilibrium figure The Earth's dynamical flattening

Acoustic signal dominance in the multimodal communication of a nocturnal mammal

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Current Zoology 2022年第5期68卷 592-599页

作者： Chun-mian zhang Cong-Nan Sun Jeffrey R Lucas Jiang Feng Ting-Lei Jiang Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization Northeast Normal University2555 Jingyue StreetChangchun 130117China Key Laboratory of Vegetation Ecology of Education Ministry Institute of Grassland ScienceNortheast Normal University2555 Jingyue StreetChangchun 130117China Department of Biological Sciences Purdue UniversityWest LafayetteIN 47907USA College of Life Science Jilin Agricultural University2888 Xincheng StreetChangchun 130118China

Multimodal communication in animals is common,and is particularly well studied in signals that include both visual and auditory *** signals that combine acoustic and olfactory components are less well *** communication plays a crucial role in agonistic interactions in many mammals,but relatively little is known about this type of communication in nocturnal ***,we used male Great Himalayan leaf-nosed bats Hipposideros armiger to investigate multimodal signal function in acoustic and olfactory aggressive *** monitored the physiological responses(heart rate[HR])when *** was presented with 1 of 3 stimuli:territorial calls,forehead gland odors,and bimodal signals(calls+odors).Results showed that *** rapidly increased their HR when exposed to any of the 3 ***,the duration of elevated HR and magnitude of change in HR increased significantly more when acoustic stimuli were presented alone compared with the presentation of olfactory stimuli *** contrast,the duration of elevated HR and magnitude of change in HR were significantly higher with bimodal stimuli than with olfactory stimuli alone,but no significant differences were found between the HR response to acoustic and bimodal *** previous work showed that acoustic and chemical signals provided different types of information;here we describe experiments investigating the responses to those *** results suggest that olfactory and acoustic signals are non-redundant signal components,and that the acoustic component is the dominant modality in male ***,at least as it related to *** study provides the first evidence that acoustic signals dominate over olfactory signals during agonistic interactions in a nocturnal mammal.

关键词： acoustic agonistic interactions heart rate Hipposideros armiger multimodal communication olfaction

Time-sensitivity of the Kaiser effect of acoustic emission in limestone and its application to measurements of in-situ stress

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Petroleum Science 2009年第2期6卷 176-180页

作者： Jin Yan Qi Zili Chen mian zhang Guangqing Xu Guangqiang Key Laboratory of Petroleum Engineering Ministry of Education China University of Petroleum Beijing 102249 China

Measuring in-situ stress by using the Kaiser effect in rocks has such advantages as timeefficiency, low cost and little limitation, but the precision of the method is dependent on rock properties and delay time of the measurement. In this paper, experiments on the Kaiser effect in limestones were performed, and it was found that the limestones had good ability to retain a memory of their recent stress history and high time-sensitivity. The longer the experiment was delayed from the extraction of the stone, the larger the Felicity ratio was. As the Felicity ratio approached l, significant Kaiser effect was observed. In-situ stress should be determined by the limestone measurements when the delay time was 40-120 days. Finally, the in-situ stress in a limestone formation could be successfully measured in practice.

关键词： In-situ stress Kaiser effect limestone time sensitivity

Tight gas production model considering TPG as a function of pore pressure,permeability and water saturation

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Petroleum Science 2020年第5期17卷 1356-1369页

作者： Atif Zafar Yu-Liang Su Lei Li Jin-Gang Fu Asif Mehmood Wei-Ping Ouyang mian zhang School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Petroleum Technology University of KarachiUniversity RoadKarachi 75270Pakistan Changqing Downhole Technology Company Chuangqing Drilling Engineering Co.LtdCNPCXi’an 710018ShaanxiChina

Threshold pressure gradient has great importance in efficient tight gas field development as well as for research and laboratory *** experimental study is carried out to investigate the threshold pressure gradient in *** are carried out with and without back pressure so that the effect of pore pressure on threshold pressure gradient may be *** trend of increasing or decreasing the threshold pressure gradient is totally opposite in the cases of considering and not considering the pore *** results demonstrate that the pore pressure of tight gas reservoirs has great influence on threshold pressure *** effects of other parameters like permeability and water saturation,in the presence of pore pressure,on threshold pressure gradient are also examined which show that the threshold pressure gradient increases with either a decrease in permeability or an increase in water *** new correlations of threshold pressure gradient on the basis of pore pressure and permeability,and pore pressure and water saturation,are also *** on these equations,new models for tight gas production are *** gas slip correction factor is also considered during derivation of this proposed tight gas production *** performance relationship curves based on these proposed models show that production rates and absolute open flow potential are always be overestimated while ignoring the threshold pressure gradients.

关键词： Inflow performance relationship Pore pressure Threshold pressure gradient Tight gas field development Tight gas sand reservoir

HLA Class I Expressions on Peripheral Blood Mononuclear Cells in Colorectal Cancer Patients

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Chinese Journal of Cancer Research 2012年第1期24卷 77-82页

作者： Zhi-mian zhang Xiao Guan Ying-jie Li Ming-chen Zhu Xiao-jing Yang Xiong Zou Department of Health Examination Center Qilu HospitalShandong UniversityJinan 250012China Department of Clinical Laboratory Medicine Qilu HospitalShandong UniversityJinan 250012China

Objective： To investigate the expression change of human leukocyte antigen （HLA） class I on human peripheral blood mononuclear ceils （PBMCs） at both mRNA and protein levels, and to evaluate its roles in the development of colorectal cancer （CRC）. Methods： In the present study, 50 patients with CRC, 35 patients with benign colorectal lesion and 42 healthy volunteers were enrolled. Expression levels of HLA class I mRNA and protein were determined using real-time quantitative reverse transcription PCR （RT-PCR） and flow cytometry analysis, respectively. Results： The expression levels of HLA class I mRNA and proteins were not influenced by age and gender. The relative ratios of HLA class I mRNA were 0.99±0.27 in healthy controls, 0.76±0.19 in benign patients, and 0.48±0.21 in CRC patients. Mean fluorescence intensities of HLA class I were 145.58±38.14 in healthy controls, 102.05±35.98 in benign patients and 87.44±34.01 in CRC patients. HLA class I on PBMCs was significantly down-regulated at both mRNA and protein levels in patients with stage III and IV CRC. CRC patients with lymph node metastasis also showed a decreased HLA class I expression at protein level. Conclusion： HLA class I expressions on PBMCs are associated with staging of CRC and lymph node metastasis. Monitoring the expression of HLA class I on PBMCs may provide useful information for diagnosis and metastasis judgement of CRC.

关键词： HLA class I Peripheral blood mononuclear cells RT-PCR Flow cytometry Colorectal cancer

A new model for predicting irreducible water saturation in tight gas reservoirs

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Petroleum Science 2020年第4期17卷 1087-1100页

作者： Yu-Liang Su Jin-Gang Fu Lei Li Wen-Dong Wang Atif Zafar mian zhang Wei-Ping Ouyang School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Petroleum Technology University of KarachiKarachiPakistan Changqing Downhole Technology Company Chuanqing Drilling Engineering Co.LtdCNPCXi’an 710018ShaanxiChina

The irreducible water saturation(Swir) is a significant parameter for relative permeability prediction and initial hydrocarbon reserves ***,the complex pore structures of the tight rocks and multiple factors of the formation conditions make the parameter difficult to be accurately predicted by the conventional methods in tight gas *** this study,a new model was derived to calculate Swir based on the capillary model and the fractal *** model incorporated different types of immobile water and considered the stress *** dead or stationary water(DSW) was considered in this model,which described the phenomena of water trapped in the dead-end pores due to detour flow and complex pore *** water film,stress effect and formation temperature were also considered in the proposed *** results calculated by the proposed model are in a good agreement with the experimental *** proves that for tight sandstone gas reservoirs the Swir calculated from the new model is more *** irreducible water saturation calculated from the new model reveals that Swir is controlled by the critical capillary radius,DSW coefficient,effective stress and formation temperature.

关键词： Fractal theory Stress dependence effect Capillary model Tight sandstone gas reservoir Irreducible water saturation

Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats

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World Journal of Gastroenterology 2009年第11期15卷 1339-1345页

作者： Wen-Peng Yuan Bing Liu Chang-Heng Liu Xiao-Jun Wang mian-Song zhang Xiu-Mei Meng Xue-Kui Xia Biology Institute of Shandong Academy of Sciences Jinan 250014 ShandongProvince China Chinese Academy of Inspection and Quarantine Beijing 100025 China

AIM:To investigate the antioxidant activity of chitooligosaccharides(COSs)on pancreatic islet cells in diabetic rats induced by streptozotocin. METHODS:The antioxidant effect of COSs on pancreatic islet cells was detected under optical microscopy and with colorimetric assay and gel *** activities of glutathione peroxidase and superoxide dismutase,total antioxidant capacity,and content of malondialdehyde in serum and tissue slices of pancreas were examined after 60 d to determine the effect of COSs in streptozotocin-induced diabetes in rats. RESULTS:COSs can prohibit the apoptosis of pancreatic islet *** concentrations of COSs can improve the capability of total antioxidant capacity and activity of superoxide dismutase and decrease the content of malondialdehyde *** investigation in the pancreas showed that COSs have resulted in the reduction of islets,loss of pancreatic cells,and nuclear pyknosis of pancreatic cells. CONCLUSION:COSs possess various biological activities and can be used in the treatment of diabetes mellitus.

关键词： Chito-oligosaccharides Diabetes mellitus Apoptosis Antioxidant ability Pancreastic islet cells Streptozotocin

Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats

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Chinese Journal of Natural Medicines 2015年第7期13卷 540-549页

作者： ZHAO Wei-Man JIANG Shu-Wen CHEN Yang ZHONG Ze-Yu WANG Zhong-Jian zhang mian LI Ying XU Ping LIU Li LIU Xiao-Dong State Key Laboratory of Natural Medicines Department of Complex Prescription of TCMChina Pharmaceutical University

The present study was designed to investigate the effects of Laminaria japonica(Laminaria) on pharmacokinetics of glycyrrhetinic acid(GA) following oral administration of Liquorice extract in *** oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract,respectively,plasma samples were obtained at various times and the concentrations of GA,liquiritigenin,and isoliquiritigenin were measured by *** effects of Laminaria extract on pharmacokinetics of GA were also investigated,following single-dose and multidose of glycyrrhizic acid(GL).The effects of Laminaria extract on intestinal absorption of GA and GL were studied using the in situ single-pass intestinal perfusion *** metabolism of GL to GA in the contents of small and large intestines was also *** results showed Liquorice-Laminaria extract markedly increased the plasma concentration of GA,accompanied by a shorter *** alteration was observed following multidose ***,pharmacokinetics of neither liquiritigenin nor isoliquiritigenin was affected by ***,Laminaria markedly increased concentration and decreased Tmax of GA following oral GL were *** data from the intestinal perfusion model showed that Laminaria markedly increased GL absorption in duodenum and jejunum,but did not affect the intestinal absorption of *** was found that Laminaria enhanced the metabolism of GL to GA in large *** conclusion,Laminaria increased plasma exposures of GA following oral administration of liquorice or GL,which partly resulted from increased intestinal absorption of GL and metabolism of GL to GA in large intestine.

关键词： Pharmacokinetics Liquorice Laminaria japonica Glycyrrhizic acid Glycyrrhetinic acid In situ single-pass intestinal perfusion Intestinal contents