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Actively contractible and antibacterial hydrogel for accelerated wound healing

Nano Research 2024年第8期17卷 7394-7403页

作者： Zhaoxin Ji Ting Wei Jiafei Zhu Jiaying Hu Zhisheng Xiao Boxiong Bai Xinying Lv yu miao Muchao Chen Cheng Wang Feng Pan Yang Yang Meng Li Qian Chen Institute of Functional Nano and Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Central Laboratory Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Department of dermatology Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200025China

Adhesive hydrogel has drawn great attention for wide applications in wound healing owing to its excellent biocompatibility and lasting ***,traditional adhesive hydrogels only keep the wound moist to promote wound *** is still imperative to fabricate adhesive hydrogels that exhibit efficient antibacterial ability,active driving dynamic wound closure,and reactive oxygen species(ROS)scavenging together with excellent mechanical ***,a novel hydrogel based on poly(N-isopropyl acrylamide)(PNIPAAm),a thermoresponsive polymer,and tannic acid(TA)-Ag nanoparticles(TA-Ag NPs)exhibiting active contraction,tissue adhesion,anti-inflammatory and antibacterial functions was ***-Ag dispersed in the hydrogel not only functioned as the catalyst to polymerize the reaction but also provided additional anti-inflammatory and antibacterial ***,tannic acid containing catechol groups endowed the hydrogel with adhesive *** interestingly,the obtained hydrogel exhibited the thermoresponsive shrinkage ability,which could mechanically drive wound closure due to the presence of PNIPAAm *** vivo mouse full-thickness skin defect model demonstrated that this actively contractible and antibacterial hydrogel is a promising dressing to improve wound healing process by accelerating tissue regeneration and preventing bacterial ***,this multi-functional adhesive hydrogel developed here may provide a new possibility for wound healing.

关键词： anti-inflammatory antibacterial active contraction hydrogel patch wound healing

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姿态的森林:“偶像”框架下云南媒介形象的建构与传播

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西南民族大学学报（人文社会科学版） 2024年第5期45卷 37-47页

作者：于淼云南艺术学院电影电视学院云南昆明650500

云南媒介形象的建构应在保持传统文化本真性的同时,以现代化的网络技术、智慧化的平台创造精神符号、传播文化精神、设计消费生活,保持地方的可见性。由此所带动的旅游,不再是一种空间挪移,更是时间的增殖,不再是一种个体行为,而是一种... 详细信息

云南媒介形象的建构应在保持传统文化本真性的同时,以现代化的网络技术、智慧化的平台创造精神符号、传播文化精神、设计消费生活,保持地方的可见性。由此所带动的旅游,不再是一种空间挪移,更是时间的增殖,不再是一种个体行为,而是一种社会现象。通过“现象世界”符号化的表征、创新性的传播话语,以及PUGC整合传播呈现的地方,以避世、异域、慢活的地方感,驱动人们在实际的物理空间中产生空间的实践和符号的采集。通过媒介有机整合建构的移动时空环境和动态连结所呈现出的虚拟和真实相融合、公域与私域边界消融、在场与在线同在的“姿态的森林”,使地方感得以形塑和再造。

关键词：地方现象 ICON 云南形象

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Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 382-395页

作者： Jing-Yao Ren Meng Xu Xiang-Dong Niu Shi-Xun Ma Ya-Jun Jiao Da Wang miao yu Hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina Gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The systemic inflammatory response index(SIRI)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the SIRI to patients who undergo robotic radical gastric cancer *** To validate the applicability of the SIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SIRI levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** Initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBASE,Web of Science,and Scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the SIRI in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative SIRI levels and 5-year overall survival(OS)and disease-free survival(DFS)was *** The findings demonstrated an extensive connection between SIRI values and the outcome of patients with gastric *** SIRI levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,T-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** SIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： Systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

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非封闭式热斗篷热防护特性

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物理学报 2024年第3期73卷 43-49页

作者：苗钰钊唐桂华西安交通大学能源与动力工程学院热流科学与工程教育部重点实验室西安710049

高超声速飞行器在飞行过程中产生大量气动热,高效的热防护技术对保证其正常工作具有重要意义.本文基于热超材料调控热流传播路径思想,针对高超声速飞行器头锥,采用坐标变换法设计非封闭式点变换热斗篷及简化近似的多层结构.COMSOL数值... 详细信息

高超声速飞行器在飞行过程中产生大量气动热,高效的热防护技术对保证其正常工作具有重要意义.本文基于热超材料调控热流传播路径思想,针对高超声速飞行器头锥,采用坐标变换法设计非封闭式点变换热斗篷及简化近似的多层结构.COMSOL数值模拟研究表明,两种结构均有效实现导热和辐射热流的热绕流,使部分热量沿头锥表面传播,头锥前端温度显著降低,机体升温速率减缓.但其热防护性能的提升要求材料固相和辐射热导率低于原隔热材料.进一步设计了非封闭式域变换热斗篷,材料固相和辐射热导率均可高于原隔热材料.模拟结果表明,热绕流显著提升了域变换热斗篷的热防护能力,相比于纯隔热材料,头锥前端温度降低达100 K,机体降温达10 K,展现出重要的热防护应用潜力.

关键词：热超材料坐标变换 COMSOL 热防护

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Linkage of mineral inclusions and zoning of magnetite with fluid evolution of hydrothermal systems: A case study of the Fenghuangshan Cu-Fe-Au skarn deposit， Eastern China

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Journal of Earth Science 2024年

作者： Xiao-Wen Huang Yiping Yang Mei-Fu Zhou yu-miao Meng Jian-Feng Gao Liang Qi State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials， Guangzhou Institute of Geochemistry， Chinese Academy of Sciences

Magnetite from hydrothermal deposits may show compositional zoning with various mineral inclusions in response to the evolution of hydrothermal fluids. Magnetite from the Fenghuangshan Cu-Fe-Au skarn deposit (Eastern China) is a common mineral formed in the earlier stage of skarnization. Magnetite grains have dark gray and light gray zones and contain diverse mineral inclusions. Dark gray zones have higher Si， Ca， Al， and Mg contents than light gray zones. The magnetite matrix from dark gray zones shows superstructure along the [0-11] zone axis in fast Fourier transform patterns， different from magnetite from light gray zones with normal structure. Three types of mineral inclusions are identified within magnetite: nano-， micron- and submicron-nanometer inclusions. Nanoinclusions hosted in dark gray zones are actinolite， diopside， and trace element-rich magnetite， and these are likely formed by growth entrapment during magnetite crystallization at the skarn stage. The chain-width order-disorder intergrowths of diopside nanoinclusion likely indicate fluctuating fluid compositions in a lattice scale. Submicron to nanometer inclusions at the boundary between dark gray and light gray zones are quartz， titanite， and Ti-rich magnetite， which were formed via a dissolution and reprecipitation process at the quartz-sulfide stage. Micron-inclusions randomly distributed in both dark and light gray zones include calcite， ankerite， quartz， and chlorite， and these were formed via penetration of fluids at the carbonate stage. Zoned magnetite was formed by fluid replacement， overgrowth， and fluid infilling. Our study highlights the importance of mineral inclusion assemblages， and textural and chemical zonation of magnetite in constraining fluid evolution.

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Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

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Food Science and Human Wellness 2024年第5期13卷 2642-2652页

作者： Rong yuan Qiqi Xin Weili Shi yu miao Zhengchuan Zhu Yahui yuan Ying Chen Xiaoning Chen Sean Xiao Leng Keji Chen Weihong Cong Cardiovascular Diseases Laboratory Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China School of Health Economics and Management Nanjing University of Chinese MedicineNanjing 210023China Department of Otolaryngology Jiangsu Province Hospital of Chinese MedicineNanjing 210029China Division of Geriatric Medicine and Gerontology Department of MedicineJohns Hopkins University School of MedicineBaltimore 21224United States

Atherosclerosis remains a great threat to human health *** studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in ***,whether TMP-PF improves atherosclerosis in vivo needs further *** present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE^(-/-)mice and explore the related molecule *** showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE^(-/-)***,TMP-PF exhibited a better modulation effect than TMP or PF ***,NR4A1 agonist abolished the anti-atherosclerotic effects of *** conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

关键词： Atherosclerosis Hyperlipemia Angiogenesis Plaque stability Chinese medicine Tetramethylpyrazine Paeoniflorin

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Prediction of Th17/Treg cell balance on length of stay in intensive care units of patients with sepsis

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Journal of Intensive Medicine 2024年第2期4卷 240-246页

作者： yu Wu Guosheng Wu Minyu Li Yongqing Chang miao yu Yan Meng Xiaojian Wan Department of Intensive Care Medicine Changhai HospitalNaval Medical UniversityShanghaiChina Department of Anesthesiology Bethune International Peace HospitalShijiazhuangHebeiChina Department of Burns Changhai HospitalNaval Medical UniversityShanghaiChina Department of Special Needs Clinic Changhai HospitalNaval Medical UniversityShanghaiChina

Background Prolonged length of stay(LOS)of sepsis can drain a hospital's material and human *** study investigated the correlations between T helper type 17(Th17)and regulatory T(Treg)balance with LOS in *** A prospective clinical observational study was designed in Changhai Hospital affiliated to Naval Medical University in Shanghai,China,from January to October *** patients diagnosed with sepsis and who met the inclusion and exclusion criteria were recruited and whether the levels of cytokines,procalcitonin,subtypes,and biomarkers of T cells in the peripheral blood were *** analyzed the correlation between these and *** Sixty septic patients were classified into two groups according to whether their intensive care unit(ICU)stay exceeded 14 *** patients with LOS≥14 days were older([72.6±7.5]years vs.[63.3±10.4]years,P=0.015)and had higher Sequential Organ Failure Assessment(SOFA)(median[interquartile range]:6.5[5.0–11.0]vs.4.0[3.0–6.0],P=0.001)and higher Acute Physiology and Chronic Health Evaluation(APACHE)II scores(16.0[13.0–21.0]vs.8.5[7.0–14.0],P=0.001).There was no difference in other demographic characteristics and cytokines,interleukin-6,tumor necrosis factor-α,and interleukin-10 between the two *** Th17/Treg ratio of sepsis with LOS<14 days was considerably lower(0.48[0.38–0.56]vs.0.69[0.51–0.98],P=0.001).For patients with LOS≥14 days,the area under the receiver operating characteristic curve for the Th17/Treg ratio was *** improved to 0.840 and 0.850 when combined with the SOFA and APACHE II scores,*** The Th17/Treg ratio was proportional to septic severity and can be used as a potential predictor of ICU stay in sepsis,presenting a new option for ICU practitioners to better care for patients with sepsis.

关键词： Sepsis Th17/Treg Length of stay Intensive care units

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Salivary metabolites are promising noninvasive biomarkers of druginduced liver injury

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World Journal of Gastroenterology 2024年第18期30卷 2454-2466页

作者： Si-miao yu Hao-Cheng Zheng Si-Ci Wang Wen-Ya Rong Ping Li Jing Jing Ting-Ting He Jia-Hui Li Xia Ding Rui-Lin Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology of Traditional Chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Drug-induced liver injury(DILI)is one of the most common adverse events of medication use,and its incidence is ***,early detection of DILI is a crucial challenge due to a lack of biomarkers and noninvasive *** To identify salivary metabolic biomarkers of DILI for the future development of noninvasive diagnostic *** Saliva samples from 31 DILI patients and 35 healthy controls(HCs)were subjected to untargeted metabolomics using ultrahigh-pressure liquid chromatography coupled with tandem mass *** analyses,including partial least squares-discriminant analysis modeling,t tests and weighted metabolite coexpression network analysis(WMCNA),were conducted to identify key differentially expressed metabolites(DEMs)and metabolite *** we utilized least absolute shrinkage and selection operato and random fores analyses for biomarker *** use of each metabolite and metabolite set to detect DILI was evaluated with area under the receiver operating characteristic *** We found 247 differentially expressed salivary metabolites between the DILI group and the HC *** WMCNA,we identified a set of 8 DEMs closely related to liver injury for further prediction ***,the distinct separation of DILI patients and HCs was achieved with five metabolites,namely,12-hydroxydodecanoic acid,3-hydroxydecanoic acid,tetradecanedioic acid,hypoxanthine,and inosine(area under the curve:0.733-1).CONCLUSION Salivary metabolomics revealed previously unreported metabolic alterations and diagnostic biomarkers in the saliva of DILI *** study may provide a potentially feasible and noninvasive diagnostic method for DILI,but further validation is needed.

关键词： Drug-Induced liver injury Salivary Metabolomics Biomarker Weighted metabolite Coexpression network analysis Machine learning Noninvasive Diagnostic method Metabolites

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Computed tomography-based radiomic model for the prediction of neoadjuvant immunochemotherapy response in patients with advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4115-4128页

作者： Jun Zhang Qi Wang Tian-Hui Guo Wen Gao Yi-miao yu Rui-Feng Wang Hua-Long yu Jing-Jing Chen Ling-Ling Sun Bi-yuan Zhang Hai-Ji Wang Department of Radiation Oncology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Neoadjuvant immunochemotherapy(nICT)has emerged as a popular treatment approach for advanced gastric cancer(AGC)in clinical practice ***,the response of AGC patients to nICT displays significant heterogeneity,and no existing radiomic model utilizes baseline computed tomography to predict treatment *** To establish a radiomic model to predict the response of AGC patients to *** Patients with AGC who received nICT(n=60)were randomly assigned to a training cohort(n=42)or a test cohort(n=18).Various machine learning models were developed using selected radiomic features and clinical risk factors to predict the response of AGC patients to *** individual radiomic nomogram was established based on the chosen radiomic signature and clinical *** performance of all the models was assessed through receiver operating characteristic curve analysis,decision curve analysis(DCA)and the Hosmer Lemeshow goodness-of-fit *** The radiomic nomogram could accurately predict the response of AGC patients to *** the test cohort,the area under curve was 0.893,with a 95%confidence interval of *** indicated that the clinical application of the radiomic nomogram yielded greater net benefit than alternative *** A nomogram combining a radiomic signature and a clinical signature was designed to predict the efficacy of nICT in patients with *** tool can assist clinicians in treatment-related decision-making.

关键词： Gastric cancer Radiomics Computed tomography Neoadjuvant immunochemotherapy Machine learning Immunology

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理解中国经济高质量发展

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中山大学学报（社会科学版） 2024年第1期64卷 1-12页

作者：余淼杰辽宁大学中国经济研究院沈阳110036

习近平新时代中国特色社会主义经济思想的核心内容体现为“三新一高”,即新发展阶段、新发展理念、新发展格局和高质量发展。十八大以来,中国经济积极应对国际环境挑战,已进入以高质量发展为表征的新发展阶段,并取得显著成效。新发展阶... 详细信息

习近平新时代中国特色社会主义经济思想的核心内容体现为“三新一高”,即新发展阶段、新发展理念、新发展格局和高质量发展。十八大以来,中国经济积极应对国际环境挑战,已进入以高质量发展为表征的新发展阶段,并取得显著成效。新发展阶段必须坚持创新为第一动力、协调为内生特征、绿色为普遍形态、开放为必由之路、共享为最终目标。坚持目标导向与问题导向相结合的指导方针,秉持新发展理念促进高质量发展。同时,要深度挖掘内驱潜力,构建全国统一大市场,发挥超大规模市场优势,在国内国际“双循环”的新发展格局中实现更高水平的对外开放,最终实现中华民族伟大复兴。

关键词：新发展阶段新发展理念新发展格局高质量发展

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