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Effect of moxibustion on autophagy and the inflammatory response of synovial cells in rheumatoid arthritis model rats

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Journal of Traditional Chinese Medicine 2022年第1期42卷 73-82页

作者： HAO Feng WANG Qiang LIU Lei WU Libin CAI Ronglin SANG Jiajia HU Jun WANG Jie YU Qing HE Lu SHEN Yingchao miao yiming HU Ling WU Zijian College of Acupuncture-moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China Translational Medicine Research Center of Nanjing University of Chinese Medicine Nanjing 210023China Changshu Hospital Affiliated to Nanjing University of Chinese Medicine Changshu 215500China College of Acupuncture-moxibustion and Tuina Anhui University of Chinese MedicineHefei 230012China Institute of Acupuncture and Meridian Anhui Academy of Chinese MedicineHefei 230038China Affiliate Hospital of Nanjing University of Chinese Medicine/Jiangsu Province of Chinese Medicine Nanjing 210029China the first clinical medical college of Nanjing University of Chinese Medicine Nanjing 210029China

OBJECTIVE:To investigate the effect of moxibustion on synovitis and the autophagy of synoviocytes in rheumatoid arthritis(RA).METHODS:Forty Sprague-Dawley rats were randomly divided into a normal group,model group,moxibustion group,cigarette moxibustion group,and medicine group,with eight rats included in each group.The RA model was established by subcutaneous injection of complete Freund's adjuvant into the left posterior toe.Rats in the model group were not interfered with.In the moxibustion group,rats were treated by moxibustion,where a 1-cm diameter moxa stick was applied at the left Zusanli(ST 36)point.The distance of the moxa stick to the skin was 2 cm and moxibustion was completed for 20 min daily for 15 d total.In the cigarette moxibustion group,the moxa stick was replaced by a common cigarette.In the medicine group,rats were treated with a tripterygium glycoside suspension(8 mg/kg)once a day for 15 d total.In each group,the left hind limb toe volume was measured with a toe volume meter;the synovial cells were observed by hematoxylin and eosin staining;the interleukin(IL)-4,IL-6,IL-10,IL-1β,IL-23,IL-17,and tumor necrosis factor(TNF)-αlevels in serum were measured by enzyme-linked immunosorbent assay;the erythrocyte sedimentation rate(ESR)were detected by Westergren sedimentation rate testing;the C-reactive protein(CRP)and rheumatoid factor(RF)levels in serum were detected by rate nephelometry;the expression levels of ULK1,autophagy-associated protein(Atg)3,Atg5,and Atg12 messenger RNA(m RNA)in synovium were detected by real time-quantitative polymerase chain reaction(RT-q PCR);and the protein expression levels of phosphatidylinositol-3-kinase(PI3K),protein kinase B(Akt),mammalian target of rapamycin(mTOR),LC3-Ⅱ,beclin-1,phosphorylated-PI3K(p-PI3K),p-Akt,p-mTOR in synovium were detected by Western blotting.RESULTS:Among the RA model rats,joint swelling,an inflammatory reaction,and the proliferation of synovial tissue were obvious and the signal of the PI3K/Akt/mTOR pathway was active,while autophagy was in

关键词： moxibustion arthritis rheumatoid synovitis autophagy

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miR-34a-5p/PLCD3轴调控骨关节炎进展的机制

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中国组织工程研究 2024年第33期28卷 5320-5325页

作者：应璞许岳路通薛燚缪逸鸣南京中医药大学常熟附属医院江苏省常熟市215500

背景:目前已有针对miRNA/mRNA轴调节骨关节炎疾病进程的分子机制研究。先前生物信息学研究发现具有临床预测价值的mRNA(磷脂酶Cδ3:phospholipase C delta 3,PLCD3)及其靶向miRNA(miR-34a-5p),尚缺实验验证其调控骨关节炎的具体作用及... 详细信息

背景:目前已有针对miRNA/mRNA轴调节骨关节炎疾病进程的分子机制研究。先前生物信息学研究发现具有临床预测价值的mRNA(磷脂酶Cδ3:phospholipase C delta 3,PLCD3)及其靶向miRNA(miR-34a-5p),尚缺实验验证其调控骨关节炎的具体作用及机制。目的:探讨miR-34a-5p/PLCD3轴对骨关节炎进展的调控作用及机制。方法:选择15例膝骨关节炎患者的滑膜为骨关节炎组,同时选择同期因创伤致髌骨骨折行内固定术的15例年轻患者的健康滑膜为对照组,Real-time PCR法检测滑膜中PLCD3及miR-34a-5p的表达。通过细胞转染的方法,将人滑膜关节炎成纤维细胞(human fibroblast like synovial cells-osteoarthritis,HFLS-OA)进行处理,并分为miR-34a-5p模拟物组、pCDH-PLCD3组、miR-34a-5p模拟物+pCDH-PLCD3组、miR-34a-5p抑制剂组、si-PLCD3组、miR-34a-5p抑制剂+si-PLCD3组,通过Real-time PCR法检测PLCD3和miR-34a-5p表达的关系;通过CCK-8法、细胞划痕实验检测各组HFLS-OA细胞活力及细胞迁移的影响;使用Western Blot法检测凋亡标记蛋白表达水平;使用ELISA法检测炎症因子的表达。结果与结论:①PLCD3是miR-34a-5p的直接靶标,同时PLCD3和miR-34a-5p表达水平呈负相关。②PLCD3上调会促进HFLS-OA细胞的增殖并抑制细胞迁移,而miR-34a-5p上调会显著抑制HFLS-OA细胞的活性并增强细胞迁移;miR-34a-5p过表达使HFLS-OA细胞Casp3和Casp9蛋白水平显著升高,而PLCD3过表达则表现出相反趋势。③PLCD3过表达显著增加了HFLS-OA细胞白细胞介素6和肿瘤坏死因子α的表达,而miR-34a-5p模拟物则表现出保护活性。④结果说明,miR-34a-5p/PLCD3轴可能通过调节滑膜细胞的炎症过程或凋亡来影响骨关节炎的进展。

关键词：骨关节炎滑膜 miR-34a-5p 磷脂酶Cδ3 PLCD3 白细胞介素6 肿瘤坏死因子α

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骨关节炎滑膜中PLCD3 mRNA的表达情况及其与免疫细胞浸润的关系

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国际检验医学杂志 2024年第2期45卷 208-212页

作者：应璞郑治许岳周烨戈昱凡薛燚缪逸鸣南京中医药大学常熟附属医院骨科江苏常熟215500

目的探究骨关节炎(OA)滑膜中磷脂酶Cδ3(PLCD3)mRNA的表达情况及其与免疫细胞浸润的关系。方法基于前期发现的OA差异表达基因,通过收集临床OA组和对照组的滑膜组织,检测相关差异表达基因PLCD3 mRNA的表达差异,并采用CIBERSORT算法分析... 详细信息

目的探究骨关节炎(OA)滑膜中磷脂酶Cδ3(PLCD3)mRNA的表达情况及其与免疫细胞浸润的关系。方法基于前期发现的OA差异表达基因,通过收集临床OA组和对照组的滑膜组织,检测相关差异表达基因PLCD3 mRNA的表达差异,并采用CIBERSORT算法分析免疫细胞在OA组及对照组中的浸润模式,并进一步对PLCD3与浸润性免疫细胞的相关性进行分析。结果相较于对照组,PLCD3 mRNA相对表达水平在OA组滑膜组织中明显升高(P<0.05),OA滑膜组织中幼稚B细胞、活化NK细胞、M2巨噬细胞和活化肥大细胞的比例相对较高(P<0.05),PLCD3与这4种免疫细胞比例呈正相关(P<0.05)。结论PLCD3可能是诊断OA的关键生物标志物,其可能通过与浸润性免疫细胞的相互作用参与了OA的发病过程。

关键词：骨关节炎磷脂酶Cδ3 免疫细胞浸润

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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng yiming Deng Xingquan Zhao Liping Liu Ning Ma Feng Gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for sICAS.Design Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with sICAS.Patients eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial artery.The eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 ratio.Both groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style modification.All participants will be followed up for 3years.Study outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary outcome.Discussion BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating sICAS.Trial registration number NCT03703635;https://www.***.gov.

关键词： balloon prospective centre

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Plastic deformation behavior of a Cu-10Ta alloy under strong impact loading

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Defence Technology（防务技术） 2024年第2期32卷 368-382页

作者： Ping Song Jianghai Liu Wenbin Li yiming Li Research Institute of Chemical Defense Academy of Military ScienceBeijing102205China Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjing210094China

In this work,a Cu-10Ta alloy with a copper to tantalum mass ratio of 9:1 is prepared using powder metallurgy technology.Physical properties of the alloy,including density,microstructure,melting point,and constant-volume specific heat,are tested.Via the split Hopkinson pressure bar(SHPB)and flyerplate impact experiments,the relationship between equivalent stress and equivalent plastic strain of the material is studied at temperatures of 298-823 K and under strain rates of 1×10^(-3)-5.2×10^(3)s^(-1),and the Hugoniot relationship at impact pressures of 1.46-17.25 GPa and impact velocities of 108-942 m/s is obtained.Evolution of the Cu-10Ta microstructure that occurs during high-strain-rate impact is analyzed.Results indicate that the Cu-10Ta alloy possesses good thermal stability,and at ambient temperatures of up to 50%its melting point,stress softening of less than 15%of the initial strength is observed.A modified J-C constitutive model is employed to accurately predict the variation of yield strength with strain rate.Under strong impact,the copper phase is identified as the primary source of plastic deformation in the Cu-10Ta alloy,while significant deformation of the high-strength tantalum particles is less pronounced.Furthermore,the longitudinal wave speed D is found to correlate linearly with the particle velocity u upon strong impact.Analysis reveals that the sound speed and spallation strength of the alloy increase with increasing impact pressure.

关键词： Cu-10Ta SHPB Plastic deformation Flyer impact Hugoniot relationship

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Fast spreading of surface ozone in both temporal and spatial scale in Pearl River Delta

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Journal of Environmental Sciences 2024年第3期137卷 540-552页

作者： Tianhui Cao Haichao Wang Lei Li Xiao Lu yiming Liu Shaojia Fan School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Guangdong Provincial Observation and Research Station for Climate Environment and Air Quality Change in the Pearl River Estuary Key Laboratory of Tropical Atmosphere-Ocean SystemMinistry of EducationZhuhai 519082China

Surface ozone(O_(3))is a major air pollutant and draw increasing attention in the Pearl River Delta(PRD),China.Here,we characterize the spatial-temporal variability of ozone based on a dataset obtained from 57 national monitoring sites during 2013-2019.Our results show that:(1)the seasonal difference of ozone distribution in the inland and coastal areas was significant,which was largely affected by the wind pattern reversals related to the East Asian monsoon,and local ozone production and destruction;(2)the daily maximum 8hr average(MDA8 O_(3))showed an overall upward trend by 1.11 ppbv/year.While the trends in the nine cities varied differently by ranging from-0.12 to 2.51 ppbv/year.The hot spots of ozone were spreading to southwestern areas from the central areas since 2016.And ozone is becoming a year-round air pollution problem with the pollution season extending to winter and spring in PRD region.(3)at the central and southwestern PRD cities,the percentage of exceedance days from the continuous type(defined as≥3 days)was increasing.Furthermore,the ozone concentration of continuous type was much higher than that of scattered exceedance type(<3 days).In addition,although the occurrence of continuous type starts to decline since2017,the total number of exceedance days during the continuous type is increasing.These results indicate that it is more difficult to eliminate the continuous exceedance than the scatter pollution days and highlight the great challenge in mitigation of O_(3)pollution in these cities.

关键词： Surface ozone pollution Ozone trend Spatial and temporal variability Pearl River Delta Pollution mitigation

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Maximizing conditional independence for unsupervised domain adaptation

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Science China(Information Sciences) 2024年第5期67卷 136-149页

作者： yiming ZHAI Chuanxian REN Youwei LUO Daoqing DAI School of Mathematics Sun Yat-Sen University

Unsupervised domain adaptation(UDA) studies how to transfer a learner from a labeled source domain to an unlabeled target domain with different distributions. Existing methods mainly focus on matching marginal distributions of the source and target domains, which probably leads to a misalignment of samples from the same class but different domains. In this paper, we tackle this misalignment issue by achieving the class-conditioned transferring from a new perspective. Specifically, we propose a method named maximizing conditional independence(MCI) for UDA, which maximizes the conditional independence of feature and domain given class in the reproducing kernel Hilbert spaces. The optimization of conditional independence can be viewed as a surrogate for minimizing class-wise mutual information between feature and domain. An interpretable empirical estimation of the conditional dependence measure is deduced and connected with the unconditional case. Besides, we provide an upper bound on the target error by taking the class-conditional distribution into account, which provides a new theoretical insight for class-conditioned transferring. Extensive experiments on six benchmark datasets and various ablation studies validate the effectiveness of the proposed model in dealing with UDA.

关键词： conditional independence kernel method domain adaptation class-conditioned transferring

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Upper and Lower Bounds of the α-Universal Triple I Method for Unified Interval Implications

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Computers, Materials & Continua 2024年第4期79卷 1063-1088页

作者： yiming Tang Jianwei Gao Yifan Huang School of Computer and Information Hefei University of TechnologyHefei230601China Department of Electrical and Computer Engineering University of AlbertaEdmontonAB T6R 2V4Canada

Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.

关键词： Fuzzy reasoning the CRI method the triple I method fuzzy implication interval robustness

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Byzantine Robust Federated Learning Scheme Based on Backdoor Triggers

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Computers, Materials & Continua 2024年第5期79卷 2813-2831页

作者： Zheng Yang Ke Gu yiming Zuo School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China

Federated learning is widely used to solve the problem of data decentralization and can provide privacy protectionfor data owners. However, since multiple participants are required in federated learning, this allows attackers tocompromise. Byzantine attacks pose great threats to federated learning. Byzantine attackers upload maliciouslycreated local models to the server to affect the prediction performance and training speed of the global model. Todefend against Byzantine attacks, we propose a Byzantine robust federated learning scheme based on backdoortriggers. In our scheme, backdoor triggers are embedded into benign data samples, and then malicious localmodels can be identified by the server according to its validation dataset. Furthermore, we calculate the adjustmentfactors of local models according to the parameters of their final layers, which are used to defend against datapoisoning-based Byzantine attacks. To further enhance the robustness of our scheme, each localmodel is weightedand aggregated according to the number of times it is identified as malicious. Relevant experimental data showthat our scheme is effective against Byzantine attacks in both independent identically distributed (IID) and nonindependentidentically distributed (non-IID) scenarios.

关键词： Federated learning Byzantine attacks backdoor triggers

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Impact of carbon disclosure on debt financing costs

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 98-108页

作者： yiming Hu Yunfeng Liang School of Management and Economics Beijing Institute of TechnologyBeijing 100081China China Center for International Economic Exchanges Beijing 100050China

Creditors,such as banks,often use disclosed environmental information to assess a company’s environmental risk and ensure the safety of debt funds.Consequently,carbon disclosures have become an important consideration for creditors when making investments.This study explores the relationship between carbon disclosure and debt financing costs using data on listed companies from 2008 to 2019.The results show that carbon disclosure can reduce the debt financing costs of enterprises,and that this influence is more significant for private companies than for state-owned enterprises.Instrumental variables and Propensity Score Matching(PSM)were used to evaluate the robustness of negative relationships.Furthermore,carbon disclosure has a more significant impact on debt costs with less environmental supervision pressure,weak residents’environmental awareness,and weak product market competition.These findings provide guidance for companies’carbon information disclosure and support the establishment of official carbon disclosure standards.

关键词： Carbon disclosure Debt financing cost State-owned enterprise Private enterprise

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