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Biomedical and Environmental Sciences 2022年第5期35卷 448-452页

作者： FAN Ya Hui LI Xin Ling LIU Xiao Hua GUO Zhi Feng YAN Meng Qing DUAN Xiao Ran miao wen bin WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052HenanChina Director of Efficacy and Safety Evaluation Laboratory Pony Testing Group Shanghai Co.Ltd.Shanghai 201600China

Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low ***,the health hazards caused by long-term,low-dose exposure to OPs are easily *** is a large class of OPs that is widely used in *** inhibition of the cholinesterase(ChE)activity is the main toxicity mechanism of OPs,and such an activity is used as a biomarker of exposure to OPs.

关键词： pesticides China. residue

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG bin TANG DAN XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen Zhao bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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应对技术范式转变挑战:知识管理动态模型

科学学研究 2006年第5期24卷 727-733页

作者：吴晓波苗文斌郭雯浙江大学管理学院浙江杭州310027 中国科学院科技政策与管理科学研究所北京100080

在当前知识管理研究的基础上,从技术范式转变对知识管理研究提出的挑战入手,对技术范式转变时期知识管理的理论和现实意义进行探讨。通过对组件知识、架构知识的变化特征及两者对企业吸收能力的影响,企业惯例在变革中所发挥的作用的分析... 详细信息

在当前知识管理研究的基础上,从技术范式转变对知识管理研究提出的挑战入手,对技术范式转变时期知识管理的理论和现实意义进行探讨。通过对组件知识、架构知识的变化特征及两者对企业吸收能力的影响,企业惯例在变革中所发挥的作用的分析,构建技术范式转变时期知识管理的动态模型,尝试性地对已有知识管理理论做出拓展,为技术范式转变期企业的知识管理实践提供理论依据和现实指导。

关键词：管理工程知识管理理论研究技术范式

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氯乙烯致癌机制研究进展

中国职业医学 2007年第5期34卷 420-422页

作者：缪文彬王威夏昭林复旦大学公共卫生学院劳动卫生教研室与公共卫生安全教育部重点实验室上海200032

氯乙烯单体(vinyl chloride monomer,VCM)是目前聚氯乙烯生产工业的主要原料,上世纪70年代首次报道VCM对实验大鼠的致癌作用[1],1974年首次报道职业性接触VCM引起人肝血管肉瘤(ASL)后[2],其毒性日益受到关注.

关键词：氯乙烯代谢产物加合物基因突变

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医院后勤工作社会化的意义与实践

中国医药导报 2005年第14期2卷 29-30,86页

作者：苗文彬兰州大学第一医院 730000

我国的医院目前仍沿革全民制、拨款制和公益性的公有制体制,医院的后勤工作仍在“医后一体”的管理体制下运行。当前的医疗卫生事业已经产业化,把医院推向了市场经济的竞争行列,后勤部门因其提供服务的项目和方式最具有市场经济运作功能... 详细信息

我国的医院目前仍沿革全民制、拨款制和公益性的公有制体制,医院的后勤工作仍在“医后一体”的管理体制下运行。当前的医疗卫生事业已经产业化,把医院推向了市场经济的竞争行列,后勤部门因其提供服务的项目和方式最具有市场经济运作功能,最有必要进行企业化和社会化的改革。探索现代医院的发展,建立后勤社会化的新体制,医院后勤制度的改革就成为整个医疗卫生体制改革的重要环节。本文拟就医院后勤工作社会化的意义与实践作初步探讨。

关键词：后勤社会化意义实践

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期68卷 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi bin Hong Xiaoying Bian wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

关键词： cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation

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永磁同步电机改进型滑模观测器无传感器控制

电气传动 2013年第7期43卷 19-22,30页

作者：苗文彬赵烨戴鹏董苏中国矿业大学信息与电气工程学院江苏徐州221008

传统滑模观测器存在抖振和高次谐波的问题,难以满足系统高性能调速要求。为改善这一问题,设计并实现了一种将反电势估算值反馈引入到定子电流观测计算中,并采用扩展卡尔曼滤波器和饱和函数的改进型滑模观测器转子位置估算方法。通过实... 详细信息

传统滑模观测器存在抖振和高次谐波的问题,难以满足系统高性能调速要求。为改善这一问题,设计并实现了一种将反电势估算值反馈引入到定子电流观测计算中,并采用扩展卡尔曼滤波器和饱和函数的改进型滑模观测器转子位置估算方法。通过实验结果表明,该改进型滑模观测器能在很大程度上削弱抖振和高次谐波带来的负面影响,并具有良好的鲁棒性及动态跟踪性能。Matlab仿真及DSP实验验证了该改进型滑模观测器的有效性与实用性。

关键词：永磁同步电动机无传感器控制滑模观测器卡尔曼滤波饱和函数

逆变器寄生电容对永磁同步电机无传感器控制的影响

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电气传动 2014年第6期44卷 3-7页

作者：戴鹏赵烨苗文彬董苏中国矿业大学信息与电气工程学院江苏徐州221116

逆变器非线性特性会对基于高频注入法的永磁同步电机转子位置和速度观测产生影响,不利于电机的精确控制。在分析逆变器非线性特性中寄生电容效应及其对高频载波电流响应影响的基础上,提出了一种旨在减小此非线性影响的新颖补偿方法。此... 详细信息

逆变器非线性特性会对基于高频注入法的永磁同步电机转子位置和速度观测产生影响,不利于电机的精确控制。在分析逆变器非线性特性中寄生电容效应及其对高频载波电流响应影响的基础上,提出了一种旨在减小此非线性影响的新颖补偿方法。此方法直接利用高频电流响应中的正序电流分量对包含转子位置信息的负序电流分量进行补偿,使作为位置观测器输入的误差信号更为精确。仿真和实验结果证明了此补偿方法的正确性,有效提高了转子位置检测精度,且具有良好的动稳态性能。

关键词：永磁同步电机逆变器非线性寄生电容高频注入补偿

中国人群GSTM1基因多态与原发性肝癌关系的Meta分析

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环境与职业医学 2008年第4期25卷 333-336页

作者：缪文彬王威冀芳夏昭林复旦大学公共卫生学院劳动卫生教研室教育部公共卫生安全重点实验室上海200032 上海出入境检验检疫局上海200135

[目的]探讨谷胱甘肽-S-转移酶M1(GSTM1)基因多态性与原发性肝癌发病风险的关系。[方法]采用Meta分析方法对各研究进行合并效应值估计,进行敏感性分析、发表偏倚评估和累积Meta分析。[结果]共有国内外符合条件的13篇文献纳入分析,累计病... 详细信息

[目的]探讨谷胱甘肽-S-转移酶M1(GSTM1)基因多态性与原发性肝癌发病风险的关系。[方法]采用Meta分析方法对各研究进行合并效应值估计,进行敏感性分析、发表偏倚评估和累积Meta分析。[结果]共有国内外符合条件的13篇文献纳入分析,累计病例和对照数分别为1216和1685例。GSTM1空白基因型个体的原发性肝癌发病风险为非空白基因型个体的1.710倍(95%CI:1.307～2.236,P<0.05)。发表偏倚评估未发现明显的发表偏倚,敏感性分析显示Meta分析结果可信,累积Meta分析显示合并OR值随着时间推移和样本含量的增大而逐渐稳定。[结论]中国人群中GSTM1基因空白型的个体是原发性肝癌的易感人群。

关键词：谷胱甘肽-S-转移酶M1 基因多态性原发性肝癌 Meta分析