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Mitochondrial Characteristics of the Powdery Mildew Genus Erysiphe Revealed an Extraordinary Evolution in Protein-coding Genes

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Mitochondrial Characteristics of the Powdery Mildew Genus Er...

Optical scanning endoscope via a single multimode optical fiber

中国植物病理学会2024年学术年会

作者： JI Xiaobei TIAN Ye LIU Wenbo LIN Chunhua HE fei YANG Jun miao Weiguo LI Zhigang School of Plant Protection Hainan University/Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests (Hainan University)Ministry of Education State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests Department of Plant BiosecurityCollege of Plant ProtectionChina Agricultural University

The genusErysiphe was an obligate parasite causing powdery mildew disease on a wide range of higher ***,the knowledge of their mitogenome architecture for lifestyle adaptability was ***,we assembled the first complete mitogenome(190 559 bp in size) for rubber tree powdery mildew pathogen Erysiphe *** analysis of the Erysiphe mitogenomes exhibited conserved gene content,genome organization and codon usage bias,but extensive dynamic intron gain/loss events were presented between Erysiphe *** phylogeny of the Ascomycota species constructed in the phylogenetic analysis showed genetic divergences of the Erysiphe *** with other distant saprophytic and plant pathogenic fungi,Erysiphe had a flat distribution of evolutionary pressures on fungal standard protein-coding genes(PCGs).The Erysiphe PCGs had the highest mean selection *** particular,Erysiphe's coxl,uadl,cob and rps3 genes had the most elevated selection pressures among corresponding PCGs across fungal ***,the investigations provided a novel insight into the potential evolutionary pattern of the genus Erysiphe to adapt obligate biotrophic lifestyle and promoted the understanding of the high plasticity and population evolution of fungal mitogenomes.

关键词： Erysiphe mitochondria powdery mildew fungi E. quercicola rubber tree

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Opto-Electronic Science 2024年第3期3卷 1-32页

作者： Guangxing Wu Runze Zhu Yanqing Lu Minghui Hong fei Xu Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117576Singapore College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210023China pen.Tung Sah Institute of Micro-Nano Science and Technology Xiamen University33 Qunxian RoadXiamen 361005China

Optical endoscopy has become an essential diagnostic and therapeutic approach in modern biomedicine for directly observing organs and tissues deep inside the human body,enabling non-invasive,rapid diagnosis and *** fiber endoscopy is highly competitive among various endoscopic imaging techniques due to its high flexibility,compact structure,excellent resolution,and resistance to electromagnetic *** the past decade,endoscopes based on a single multimode optical fiber(MMF)have attracted widespread research interest due to their potential to significantly reduce the footprint of optical fiber endoscopes and enhance imaging *** comparison with other imaging principles of MMF endoscopes,the scanning imaging method based on the wavefront shaping technique is highly developed and provides benefits including excellent imaging contrast,broad applicability to complex imaging scenarios,and good compatibility with various well-established scanning imaging *** this review,various technical routes to achieve light focusing through MMF and procedures to conduct the scanning imaging of MMF endoscopes are *** advancements in imaging performance enhancements,integrations of various imaging modalities with MMF scanning endoscopes,and applications are *** specific to this endoscopic imaging technology are analyzed,and potential remedies and avenues for future developments are discussed.

关键词： multimode optical fiber endoscope scanning imaging focusing wavefront shaping

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教考分离模式与方法

湖北开放职业学院学报 2024年第14期37卷 174-176页

作者：苗翡大连理工大学城市学院辽宁大连116600

作为以培养人才为主要目标的高校,被国家、社会、家庭和个人寄予厚望。教考分离教学管理模式较好诠释并完成各高校的首要任务:提升教学质量,调动学习积极性,提高学习效果。本文通过教学调研,运用比较的方法对教考合一与教考分离、试卷... 详细信息

作为以培养人才为主要目标的高校,被国家、社会、家庭和个人寄予厚望。教考分离教学管理模式较好诠释并完成各高校的首要任务:提升教学质量,调动学习积极性,提高学习效果。本文通过教学调研,运用比较的方法对教考合一与教考分离、试卷库与试题库进行对比分析,在此基础上总结出一套与教考分离模式相匹配的操作方法。通过研究发现:教考分离教学管理模式有效规避了传统教考合一教学管理模式存在的不足;试题库与试卷库在组卷过程中各有优势,需要各校进行相机抉择;为了教考分离的顺利开展,需要三方主体从教到考两个环节全程推进,确保实现人才培养这一核心目标。

关键词：教考合一教考分离试卷库模式试题库模式

Experimental models for preclinical research in kidney disease

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动物学研究 2024年第5期 1161页

作者： Jin miao Huanhuan Zhu Junni Wang Jianghua Chen fei Han Weiqiang Lin Kidney Disease Center First Affiliated Hospital Zhejiang University School of Medicine Institute of Nephrology Zhejiang University Key Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang Province Zhejiang Clinical Research Center of Kidney and Urinary System Disease Department of Nephrology Center for Regeneration and Aging Medicine Fourth Affiliated Hospital of School of Medicine and International School of Medicine International Institutes of Medicine Zhejiang University

Acute kidney injury(AKI) and chronic kidney disease(CKD) are significant public health issues associated with a long-term increase in mortality risk, resulting from various etiologies including renal ischemia, sepsis, drug toxicity, and diabetes mellitus. Numerous preclinical models have been developed to deepen.our understanding of the pathophysiological mechanisms and therapeutic approaches for kidney diseases. Among these, rodent models have proven to be powerful tools in the discovery of novel therapeutics, while the development of kidney organoids has emerged as a promising advancement in the field. This review provides a comprehensive analysis of the construction methodologies, underlying biological mechanisms, and recent therapeutic developments across different AKI and CKD models. Additionally, this review summarizes the advantages, limitations, and challenges inherent in these preclinical models, thereby contributing robust evidence to support the development of effective therapeutic strategies.

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Dietary saccharin sodium supplementation improves the production performance of dairy goats without residue in milk in summer

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ANIMAL NUTRITION 2024年第3期18卷 166-176页

作者： Zhang, Xiongfei Lv, Jirong Hui, Jingtao Wu, Ao Zhao, Lichao Feng, Linyu Deng, Lu Yu, miao Liu, Feng Yao, Junhu Lei, Xinjian Northwest A&F Univ Coll Anim Sci & Technol Yangling 712100 Shaanxi Peoples R China Northwest A&F Univ Key Lab Livestock Biol Yangling 712100 Shaanxi Peoples R China DadHank Biotechnol Corp Sichuan Prov Anim Feeding Regulat Ctr Chengdu 611130 Sichuan Peoples R China

The purpose of this study was to investigate the effects of dietary saccharin sodium supplementation on production performance, serum biochemical indicators, and rumen fermentation of dairy goats in summer. Twelve Guanzhong dairy goats with similar body weight, days in milk, and milk yield were randomly divided into two dietary treatments: (1) CON: basal diet; (2) SS: basal diet + 150 mg/kg saccharin sodium on the basis of dry matter. The experiment lasted 35 d, including 7 d for adaptation and 28 d for dietary treatments, sampling and data collection. Each dairy goat was housed individually in a clean separate pen.with ad libitum access to diet and water. The goats fed SS diet had increased dry matter intake (DMI; P = 0.037), 4% fat corrected milk yield (P = 0.049), energy corrected milk yield (P = 0.037), milk protein yield (P = 0.031), and total solids yield (P = 0.036). Serum activity of aspartate aminotransferase (P = 0.047) and concentrations of 70-kDa heat shock protein (P = 0.090), malondialdehyde (P = 0.092), and total protein (P = 0.057) were lower in goats fed SS diet than those fed CON diet. Supplementation of saccharin sodium tended to increase activity of glutathione peroxidase in serum (P = 0.079). The concentrations of rumen total volatile fatty acid (P = 0.042) and butyrate (P = 0.038) were increased by saccharin sodium supplementation. Dietary supplementation of saccharin sodium increased the relative abundance of Lachnobacterium (P = 0.022), Pseudoramibacter (P = 0.022), Shuttleworthia (P = 0.025), and Syntrophococcus (P = 0.037), but reduced the relative abundance of Prevotella_1 (P = 0.037) and Lachnospiraceae_UCG_008 (P = 0.037) in rumen. Saccharin sodium was observed in feces and urine of goats fed diet supplemented with saccharin sodium, but saccharin sodium was undetectable in the milk of goats receiving SS diet. In conclusion, administration of saccharin sodium was effective in increasing fat and energy corrected milk yield by increasing DM

关键词： Dairy goat Heat stress Production performance Rumen fermentation Rumen microorganisms Saccharin sodium HEAT-STRESS PHYSIOLOGICAL-RESPONSES RUMINAL FERMENTATION GROWTH-PERFORMANCE RUMEN FERMENTATION FEEDING-BEHAVIOR OXIDATIVE STATUS CLIMATE-CHANGE CALVES ADAPTATION

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横向载荷与预紧力对螺栓断裂寿命的影响

东北大学学报（自然科学版） 2024年第1期45卷 68-75页

作者：苗兴琳黄贤振丁鹏飞郑智群东北大学机械工程与自动化学院辽宁沈阳110819

螺栓连接依靠自身简单可靠的特点被广泛应用于各个行业,然而螺栓的疲劳断裂却是一个非常突出的问题.因此,为准确预测螺栓断裂失效寿命,进行了螺栓材料的疲劳裂纹扩展实验,求得了螺栓材料的断裂参数,从而建立了Paris裂纹扩展模型.然后运... 详细信息

螺栓连接依靠自身简单可靠的特点被广泛应用于各个行业,然而螺栓的疲劳断裂却是一个非常突出的问题.因此,为准确预测螺栓断裂失效寿命,进行了螺栓材料的疲劳裂纹扩展实验,求得了螺栓材料的断裂参数,从而建立了Paris裂纹扩展模型.然后运用有限元方法与疲劳裂纹扩展实验进行对标,并取得较好的效果,为螺栓断裂失效寿命的计算奠定了基础.最后,考虑到螺栓预紧力与横向载荷对螺栓断裂的影响,建立了带裂纹的螺栓有限元模型,并采用有限元方法进行螺栓失效寿命计算的定量分析.结果表明:横向载荷与螺栓预紧力对应力强度因子和螺栓使用寿命具有较大的影响.

关键词：螺栓断裂失效寿命有限元计算横向载荷定量分析

Study on the mechanism of SND in the treatment of anxiety disorders based on network pharmacology, molecular docking and experiment validation

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Pharmacology Discovery 2024年第2期4卷 10-23页

作者： fei-Yan Wang Ping Yuan Mei-Ling Zheng Xiao-Di Guo Long Li Jin Wang Shan miao Ya-Jun Shi Shan-Bo Ma Xiao-pen. Shi College of pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalAir Force Medical UniversityXi’an 710032China Outpatient Department of University Hospital Northwestern Polytechnical University HospitalXi’an 710072China The College of Life Sciences Northwest UniversityXi’an 710127China

Background:Sini decoction(SND)is a classic traditional Chinese medicine(TCM)formulation that can be used to treat anxiety-related disorders,but the active substance and underlying molecular mechanism of its anxiolytic effects are *** this study,network pharmacology,molecular docking research and experimental verification methods were used to preliminarily explore the bioactive compounds and potential target mechanisms of SND ***:The active components and corresponding targets of SND were collected by ***,OMIM,PharmGkb,TTD and Drugbank were used to search for the targets of anxiety *** core target of SND in the treatment of anxiety was screened by PPI.R language was used to analyze the intersection targets of SND in the treatment of anxiety disorders by GO and KEGG enrichment *** Vina was used for molecular docking,and Discovery Studio was used for visual conformation analysis after *** anti-anxiety effect and molecular mechanism of SND were studied by in vivo ***:Based on network pharmacological analysis,we obtained 112 active ingredients and 350 effective targets related to anxiety from *** PPI analysis,26 targets such as STAT3,MAPK3,MAPK1,MAPK14,SRC,HSP90AA1,TP53 and PIK3CA were identified as core *** and KEGG analysis showed that the anxiolytic mechanism of SND may be related to the neuroactive ligand-receptor interaction pathway and inflammatory *** docking showed that quercetin,naringenin,licochalcone A had high affinity with JAK2,MAPK14 and *** experiments have shown that SND reverses the upregulation of GluN2B(NMDAR)and GluA1(AMPAR)proteins,and SND improves anxiety disorders by regulating glutamate transmitter levels,which may be related to neuroactive ligand-receptor interaction pathways,particularly glutamate ***:This study shows that SND can improve FS-induced behavioral changes in mice and can modulate hippocampal synapse-asso

关键词： SND anxiety disorders network pharmacology molecular docking pharmacological mechanisms

富血小板血浆辅助自体脂肪面部移植的临床效果观察

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中国医疗美容 2024年第6期14卷 11-15页

作者：张淼韩飞牡丹江市第二人民医院整形外科黑龙江牡丹江157000

目的探究富血小板血浆(Platelet-Rich Plasma,PRP)辅助自体脂肪面部移植的临床效果。方法采用随机数字表法将我院2022年1月-2023年6月收治的需行面部年轻化治疗的患者60例分为两组,各30例。对照组采用自体脂肪颗粒填充,研究组采用PRP注... 详细信息

目的探究富血小板血浆(Platelet-Rich Plasma,PRP)辅助自体脂肪面部移植的临床效果。方法采用随机数字表法将我院2022年1月-2023年6月收治的需行面部年轻化治疗的患者60例分为两组,各30例。对照组采用自体脂肪颗粒填充,研究组采用PRP注射联合自体脂肪颗粒填充,术后行3个月随访。对比两组皮肤老化症状改善情况、面部改善效果、并发症。结果治疗前,两组颞部及额部皮下脂肪厚度比较,差异无统计学意义(P>0.05);治疗后,研究组颞部及额部皮下脂肪厚度均大于对照组,差异有统计学意义(P<0.05)。研究组面部改善优良率高于对照组,差异有统计学意义(P<0.05);研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论PRP辅助自体脂肪面部移植能够有效改善行面部年轻化治疗患者皮肤老化症状,利于提升脂肪存活率,且术后并发症发生率较低,安全可靠,值得推广应用。

关键词：面部年轻化富血小板血浆自体脂肪颗粒填充面部改善效果

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宋锦纹样在现代女装中的活化应用研究

西部皮革 2024年第13期46卷 139-141页

作者：何霏苗勇河南科技学院服装学院

作为中国传统的手工艺品，宋锦以艳丽的色泽、精致的图案和独特的制造工艺著称。在宋代美学的影响下，宋锦形成了与汉唐蜀锦截然不同的风格。文章从宋锦的产生与发展入手，探讨了宋锦纹样的发展及其影响因素。并通过现实案例，分析了宋... 详细信息

作为中国传统的手工艺品，宋锦以艳丽的色泽、精致的图案和独特的制造工艺著称。在宋代美学的影响下，宋锦形成了与汉唐蜀锦截然不同的风格。文章从宋锦的产生与发展入手，探讨了宋锦纹样的发展及其影响因素。并通过现实案例，分析了宋锦纹样在现代服饰设计中的应用，以实现传统文化的活态传承。

关键词：宋锦文化意蕴纹样现代女装