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Poisson-Boltzmann Theory of Bionanosystems

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Communications in Computational Physics 2008年第5期3卷 1100-1116页

作者： A.Sayyed-Ahmad Y.miao P.Ortoleva Center for Cell and Virus Theory Department of ChemistryIndiana UniversityBloomington IN 47405USA.

The structure and function of BNS(bionanosystems)such as macromolecules,viruses and ribosomes are strongly affected by electrostatic *** their supra-million atom size makes them difficult to simulate via a straightforward PoissonBoltzmann(PB)*** we explore a multiscale approach that results in a coarse-grained PB equation that follows rigorously from the all-atom PB *** derivation of the coarse-grained equation follows from an ansatz on the dependence of the electrical potential in two distinct ways,*** reflecting atomic-scale variations and the other capturing nanometer-scale *** this ansatz and a series expansion of the potential in a length-scale ratio,the coarse-grained PB equation is *** multiscale methodology and an efficient computational methodology provide a way to efficiently simulate BNS electrostatics with atomic-scale resolution for the first time,avoiding the need for excessive supercomputer *** coarse-grained PB equation contains a tensorial dielectric constant that mediates the channeling of the electric field along macromolecules in an aqueous *** multiscale approach and novel salinity connections to the PB equation presented here should enhance the accuracy and wider applicability of PB modeling。

关键词： Poisson-Boltzmann equation multiscale analysis bionanostructures viruses ribosomes macromolecules.

以大型单中心医院登记为基础的6737例接受手术切除的胃癌患者的生存报告

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中国癌症杂志 2024年第3期34卷 268-277页

作者：沈洁王江立王泽洲莫淼周昌明袁晶徐大志郑莹复旦大学附属肿瘤医院肿瘤预防部复旦大学上海医学院肿瘤学系上海200032 复旦大学附属肿瘤医院胃外1科复旦大学上海医学院肿瘤学系上海200032 上海肿瘤疾病人工智能工程技术研究中心上海200032

背景与目的:收集以医院登记为基础的6737例接受手术切除的胃癌患者的随访资料,分析其1、3和5年观察总生存(overall survival,OS)率和无病生存(disease-free survival,DFS)率,为中国的胃癌防控和政策制定提供真实世界研究证据。方法:纳入... 详细信息

背景与目的:收集以医院登记为基础的6737例接受手术切除的胃癌患者的随访资料,分析其1、3和5年观察总生存(overall survival,OS)率和无病生存(disease-free survival,DFS)率,为中国的胃癌防控和政策制定提供真实世界研究证据。方法:纳入2015年1月1日—2020年12月31日在复旦大学附属肿瘤医院接受手术治疗的胃癌患者共6737例,通过查阅患者病史了解患者的临床信息,并通过复诊病史、电话随访和死因数据链接等方式收集患者的生存随访资料,随访统计时间截至2023年11月30日。采用Kaplan-Meier法估计患者1、3和5年OS率和DFS率,并在不同年龄组、性别、治疗时期、肿瘤分期及病理学特征等亚组中分别描述。结果:接受手术切除的胃癌患者经中位50.99个月随访后,5年OS率和Ⅰ~Ⅲ期患者5年DFS率分别为70.37%和69.46%。Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期胃癌患者的5年OS率分别为94.32%、82.56%、51.01%和23.97%。不同年龄、部位、大体分型、Borrmann分型和Lauren分型的患者生存有显著差异。结论:肿瘤分期是影响胃癌患者生存的重要因素,应加强人群(尤其是高危人群)胃癌的筛查和早诊早治,进一步改善患者的生存。

关键词：胃癌总生存率无病生存率医院登记

Influence of developmental cervical stenosis on dural sac space

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Chinese Medical Journal 2014年第22期127卷 3857-3861页

作者： Tang Yanchao Yu miao Liu Zhongjun Sun Yu Liu Xiaoguang Department of Orthopaedics Peking University Third HospitalBeijing 100191 China

Background This retrospective study aimed to investigate the difference of the intra-dural reserving space for spinal cord in magnetic resonance imaging （MRI） between patients with and without developmental cervical stenosis and its clinical *** A total of 264 patients with cervical spondylotic myelopathy who had decompression surgeries were *** average follow-up was 29 *** on their lateral radiographs,they were divided into stenosis group and non-stenosis *** the magnetic resonance images,the ratio of the sagittal diameter of the dural sac to that of the vertebral body was measured and calculated as MRI Pavlov ratio at the mid-vertebral level on T2-weighted sagittal images from C3 to *** ratio of the transverse area of the spinal cord to that of the dural sac was measured and calculated as occupation ratio on T2-weighted axial images at the same *** MRI Pavlov ratio and occupation ratio were compared between the two *** stenosis group was further divided into space-reserving and non-space-reserving subgroups based on the occupation ratios; then clinical parameters were compared between the two subgroups to determine the clinical significance of the reserving *** The MRI Pavlov ratio of the stenosis group was significantly smaller than that of the non-stenosis group at C3-C7 （P ＜0.01）,while the occupation ratio was significantly larger only at C7 （P ＜0.05）.For the space-reserving subgroup,the postoperative recovery rate was lower （P ＜0.05）.The postoperative recovery rate was （23±6）％ in anterior approach,larger than （-23±15）％ in posterior approach （P ＜0.05）.Conclusions Developmental cervical stenosis is associated with a smaller sagittal diameter of the dural sac,but does not lead to a significant decrease in intra-dural space available for the *** patients with normal intra-dural space,the recovery after anterior decompression surgery was better than posterior approach.

关键词： cervical spondylosis developmental cervical stenosis reserving space for spinal cord cervical decompression surgery

Optimization of the S-band side-coupled cavities for proton acceleration

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Nuclear Science and Techniques 2020年第3期31卷 1-9页

作者： Hao-Yun Li Xin-miao Wan Wei Chen Chen-Hui Shi Zhi-Hui Li The Key Laboratory of Radiation Physics and Technology of Ministry of Education Institute of Nuclear Science and Technology Sichuan University

The proton beam with energy around 100 MeV has seen wide applications in modern scientific research and in various ***,proton sources in China fall short for meeting experimental needs owing to the vast size and expensive traditional proton *** Institute of Nuclear Science and Technology of Sichuan University proposed to build a 3 GHz side-coupled cavity linac(SCL)for re-accelerating a 26 MeV proton beam extracted from a CS-30 cyclotron to 120 *** carried out investigations into several vital factors of S-band SCL for proton acceleration,such as optimization of SCL cavity geometry,end cell tuning,and bridge coupler *** demonstrated that the effective shunt impedance per unit length ranged from 22.5 to 59.8 MX/m throughout the acceleration process,and the acceleration gradient changed from 11.5 to 15.7 MV/m when the maximum surface electric field was equivalent to Kilpatrick electric *** obtained equivalent circuit parameters of the biperiodic structures and applied them to the end cell tuning;results of the theoretical analysis agreed well with the 3D *** designed and optimized a bridge coupler based on the previously obtained biperiodic structure parameters,and the field distribution un-uniformness was\1.5%for a two-tank *** radio frequency power distribution system of the linac was obtained based on the preliminary beam dynamics design.

关键词： Proton beam Side-coupled cavity linac Accelerating cavity Biperiodic structure Bridge coupler

Molecular dynamics study on mechanical behaviors of Ti/Ni nanolaminate with a pre-existing void

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Nano Materials Science 2022年第2期4卷 113-125页

作者： Mengjia Su Qiong Deng Lanting Liu Lianyang Chen He He Yinggang miao Joint International Research Laboratory of Impact Dynamics and Its Engineering Applications School of AeronauticsNorthwestern Polytechnical UniversityXi'anShaanxi 710072China

Metallic nanolaminated materials possess excellent mechanical properties due to their unique modulation structures and interfacial ***,how microdefects affect their mechanical properties is still *** evaluate the influences of void location(in the crystalline layer and the Ti/Ni interface),void diameter(d)and thickness of the intermediate layer(h)on overall tensile behaviors,various types of defective Ti/Ni nanolaminates with pre-existing void are established by the molecular dynamics method in this *** results indicate that the strength and plastic deformation mechanisms are strongly dependent on those *** stresses of Ti/Ni nanolaminates decrease distinctly with increasing void diameter,while peak stresses with a void in the crystalline layer decrease with increasing d/*** void locations lead eventually to disparate initial plastic deformation carriers around the void,and various evolutions in the microstructure of the defective Ti/Ni *** Ti/Ni interface plays a significant role in the tensile *** semi-coherent interface impedes new grains and lattice dislocations from passing across the interface,while the incoherent interface facilitates dislocations generating and sliding along the interface,and absorbs the dislocations moving to the *** results also indicate that the strain rate significantly affects the evolution of the microstructure and the tensile properties of defective Ti/Ni nanolaminates.

关键词： Defective Ti/Ni nanolaminate Pre-existing void Interface Tensile behaviors Molecular dynamics

Intervention effect of neuromuscular electrical stimulation on ICU acquired weakness: A meta-analysis

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International Journal of Nursing Sciences 2020年第2期7卷 228-237页

作者： miao Liu Jian Luo Jun Zhou Xiaomin Zhu School of Nursing Yangtze UniversityHubeiChina Affiliated Union Hospital of Tongji Medical College Huazhong University of Science and TechnologyHubeiChina

Objective:The early use of neuromuscular electrical stimulation(NMES)to prevent intensive care unit-acquired weakness(ICU-AW)in critical patients is still a controversial *** conducted a systematic review to clarify the effectiveness of NMES in preventing ***:The Cochrane Library,PubMed,EMBASE,MEDUNE,Web of Science,Ovid,CNKI,Wanfang,VIP,China Biology Medicine disc(CBMdisc)and other databases were searched for randomized controlled trials on the influence of NMES on *** studies were selected according to the inclusion and exclusion *** data and quality were evaluated,a meta-analysis was performed by RevMan 5.3 ***:A total of 11 randomized controlled trials with 576 patients were *** meta-analysis results showed that NMES can improve muscle strength[MD=1.78,95%CI(0.44,3.12,P=0.009);shorten the mechanical ventilation(MV)time[SMD=-0.65,95%CI(-1.03,-0.27,P=0.001],ICU length of stay[MD=-3.41,95%CI(-4.58,-4.24),P0.05).Conclusion:Early implementation of the NMES intervention in ICU patients can prevent ICU-AW and improve their quality of life by enhancing their muscle strength and shortening the MV duration,length of stay in the ICU and total length of stay in the hospital.

关键词： Activities of daily living Electrical stimulation Intensive care unit Length of stay Mechanical ventilation Muscle strengths Quality of life Weakness

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基于注意力残差卷积自编码器的轴承故障诊断

机械制造 2024年第5期62卷 85-90,96页

作者：罗强傅顺军苗梦奇余建波上海船舶设备研究所上海200031 同济大学机械与能源工程学院上海201804

以卷积神经网络为代表的有监督深度神经网络凭借优异的提取能力,在轴承故障诊断领域得到广泛应用,不足是需要大量标签数据。在残差跳跃中嵌入注意力机制,构建注意力残差模块,并将注意力残差模块与卷积自编码器结合,得到注意力残差卷积... 详细信息

以卷积神经网络为代表的有监督深度神经网络凭借优异的提取能力,在轴承故障诊断领域得到广泛应用,不足是需要大量标签数据。在残差跳跃中嵌入注意力机制,构建注意力残差模块,并将注意力残差模块与卷积自编码器结合,得到注意力残差卷积自编码器。采用注意力残差卷积自编码器,在无监督学习下进行轴承振动信号的特征提取,显著提高轴承故障诊断能力。试验结果表明,注意力残差卷积自编码器具有优异的特征提取和选择能力,特征学习能力和故障诊断效果明显好于现有典型深度神经网络。

关键词：注意力残差卷积自编码器轴承故障诊断

The dimension and morphology of alveolar bone at maxillaryanterior teeth in periodontitis: a retrospective analysis usingCBCT

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International Journal of Oral Science 2020年第1期12卷 50-58页

作者： Xue Zhang Yuchao Li Ziming Ge Haijiao Zhao Lei miao Yaping Pan Department of Periodontics School of StomatologyChina Medical UniversityShenyangChina

The morphology of the alveolar bone at the maxillary anterior teeth in periodontitis patients was evaluated by cone-beam computed tomography(CBCT) to investigate the distribution of alveolar defects and provide guidance for clinical practice. Ninety periodontitis patients and 30 periodontally healthy individuals were selected to determine the morphology of the alveolar bone at the maxillary anterior teeth according to the degree of bone loss, tooth type, sex and age. The differences in the dimensions between periodontitis patients and healthy individuals were compared, and the distribution of alveolar bone defects was analyzed.A classification system was established regarding the sagittal positions and angulations of the teeth. The buccal residual bone was thicker and the lingual bone was thinner in the periodontitis patients than in the periodontally healthy individuals, and there were differences between the different tooth types, sexes and age subgroups. The buccal undercut was close to the alveolar ridge, while fenestration was reduced and the apical bone height was higher in periodontitis patients than in periodontally healthy *** apical bone height increased with the aggravation of bone loss and age. The proportions of different sagittal positions changed with the aggravation of bone loss. Moreover, the teeth moved more buccally regarding the positions of the maxillary anterior *** morphology of the alveolar bone at the maxillary anterior teeth differed between periodontitis patients and healthy individuals,and the differences were related to the degree of bone loss, tooth type, sex and age.

关键词： alveolar CBCT positions

Molten Salts Strategy for the Synthesis of CoP Nanoparticles Entrapped,N,P co-Doped Mesoporous Carbons as Electrocatalysts for Hydrogen Evolution

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Chemical Research in Chinese Universities 2022年第1期38卷 237-242页

作者： XU Jing miao Sijia TANG Duihai ZHANG Wenting ZHAO Zhen QIAO Zhen-An Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034P.R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012P.R.China

Amolten salt process was developed to prepare CoP nanoparticles(NPs) embedded, N,P co-doped carbons with the combination of hand milling and high temperature carbonization. The characterization results implied that the as-prepared samples possessed mesoporous structures. Moreover, the mass ratios of the precursors affected the crystalline structures and the porosities of the final electrocatalysts. The as-prepared catalysts exhibited excellent electrocatalytic performances towards hydrogen evolution reaction(HER) under acidic and alkaline conditions. The as-prepared samples were designed as GxMyCoz, where x, y and z meant the amounts of glucose, melamine and CoCl2, respectively. The optimum sample of G6.0M2.0Co5.0 showed the best HER property with a low onset overpotential and a small Tafel slope, as well as excellent electrocatalytic stability.

关键词： CoP nanoparticle Mesopore N P co-doped carbon Hydrogen evolution reaction Molten salt