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Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第10期30卷 1393-1404页

作者： ming-Hui Zeng Qi-Yu Shi liang Xu Yu-Qiang mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic *** date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of *** patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very *** To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle *** The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently *** and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 *** efficacy of the EDAS was evaluated in the initial ***,the efficacy of the EDAS was internally verified in a validation *** The EDAS consisted of 33 items in six dimensions,with a total of 165 *** EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise *** The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

Carbon felt electrode coated with WS2 enables a high-performance polysulfide/ferricyanide flow battery

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Rare Metals 2024年第10期43卷 5039-5047页

作者： liang-Yu Li Su Yan Ying-Jia Huang fang-fang Zhong Jin-Chao Cao Mei Ding Chuan-Kun Jia College of Materials Science and Engineering Changsha University of Science and Technology Institute of Energy Storage Technology College of Energy and Power EngineeringChangsha University of Science and Technology Binzhou Institute of Technology Weiqiao-UCAS Science and Technology Park

Polysulfide/ferricyanide flow batteries （S/Fe RFBs）,with the advantages of abundant earth reservation low cost,high safety,and environmental friendliness,have attracted significant interest and demonstrated noteworthy potential for practical ***,the battery performance,including the energy efficiency （EE）,voltage efficiency （VE）,and power density of the S/Fe RFBs remains low owing to the slow redox kinetics of polysulfide *** address these concerns,WS2was selected as the booster and deposited on a commercial carbon felt electrode （WS2–CF） to stimulate the redox reactions of polysulfide *** better hydrophilicity and smaller charge-transfer resistance,WS2–CF exhibits enhanced electrochemical activity toward polysulfide redox ***,the battery performance of S/Fe RFB with WS2–CF as the anode has been improved,with EE of 84%,VE of 84%,and a peak power density of 175.7 mW·cm-2,which are all higher than the cell only with the bare carbon felt （CF） as electrodes (76%,77% and 155.8 mW·cm-2,respectively).Furthermore,the cycling life of the S/Fe RFB with WS2–CF has been prolonged to 2200 cycles with a capacity retention of 96% a 40 mA·cm-2because of the good stability of WS2–CF as the ***,under the same conditions,the S/Fe RFB without WS2–CF terminated after 1500 cycles with a fast capacity *** successful utilization of WS2as a booster on an electrode provides an efficient strategy for obtaining advanced S/Fe RFBs for practical applications.

关键词： Carbon felt Energy storage Polysulfide/ferricyanide flow battery Tungsten disulfide

Reconceptualization of immune checkpoint inhibitor-associated gastritis

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World Journal of Gastroenterology 2024年第36期30卷 4031-4035页

作者： Ying-fang Deng Xian-Shu Cui liang Wang Department of Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

In recent years,with the extensive application of immunotherapy in clinical practice,it has achieved encouraging therapeutic *** enhancing clinical efficacy,however,it can also cause autoimmune damage,triggering immunerelated adverse events(irAEs).Reports of immunotherapy-induced gastritis have been increasing annually,but due to its atypical clinical symptoms,early diagnosis poses a certain ***,it can lead to severe complications such as gastric bleeding,elevating the risk of adverse outcomes for solid tumor patients if immunotherapy is ***,gaining a thorough understanding of the pathogenesis,clinical manifestations,diagnostic criteria,and treatment of immune-related gastritis is of utmost importance for early identification,diagnosis,and ***,the treatment of immune-related gastritis should be personalized according to the specific condition of each *** patients with grade 2-3 irAEs,restarting immune checkpoint inhibitors(ICIs)therapy may be considered when symptoms subside to grade *** restarting ICIs therapy,it is often recommended to use different types of *** grade 4 irAEs,permanent discontinuation of the medication is necessary.

关键词： Programmed cell death receptor-1 Programmed cell death-ligand 1 Cytotoxic T lymphocyte-associated antigen 4 Immune-related adverse events Immune-related gastritis

Influence of mixture Gas Conditions on the Laminar Combustion Characteristics of Natural Gas

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Journal of Thermal Science 2024年第3期33卷 1231-1241页

作者： LOU Diming ZHU Kan ZHANG Yunhua REN Yedi TAN Piqiang fang liang FAN Lanlan School of Automotive Studies Tongji UniversityShanghai201804China Ji’nan Power Co.Ltd Sinotruk GroupJi’nan250200China

Natural gas is a promising alternative fuel for the internal combustion engine,and natural gas engine has become an efficient and feasible measure to deal with the energy shortage and climate *** the laminar flame characteristics are the foundation of the turbulent flame,the laminar flame characteristics of natural gas have a significant impact on the combustion status and efficiency of the engine.A visual constant volume bomb was used to study the influence of the gas components,different excess air coefficient(λ),and initial conditions on the laminar combustion characteristics of natural *** experimental results showed that when the initial pressure and temperature were 0.1 MPa and 300 K respectively,compared to propane,ethane had a remarkable influence on the equivalent-combustion laminar-combustion-speed,with an average increase of approximately 5.1%for every 2.5%increase in the ethane *** laminar combustion velocity of the natural gas under different excess air coefficients had a maximum value at aboutλ=1.0,and the Markstein length of the flame decreased with the increase of theλ.The increase in the initial pressure of the mixture resulted in a decrease in the equivalent-combustion laminar-combustion-speed of the flame,a significant decrease in the Markstein *** increase of the initial temperature of the mixture led to a rapid increase of the equivalent-combustion laminar-combustion-speed,but the effect on the flame Markstein length was not dominant.

关键词： constant volume bomb natural gas engine combustion characteristics laminar combustion velocity Markstein length

Large eddy simulation of flow over a three-dimensional hill with different slope angles

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Frontiers of Earth Science 2024年第1期18卷 98-111页

作者： liang LI Deqian ZHENG Guixiang CHEN Pingzhi fang Wenyong MA Shengming TANG School of Civil Engineering Henan University of TechnologyZhengzhou 450001China Henan International Joint Laboratory of Modern Green Ecological Storage System Zhengzhou 450001China Henan Key Laboratory of Grain Storage Facility and Safety Zhengzhou 450001China Shanghai Typhoon Institute of China Meteorological Administration Shanghai 200030China Wind Engineering Research Center Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Slope variation will significantly affect the characteristics of the wind field around a *** paper conducts a large-eddy simulation(LES)on an ideal 3D hill to study the impact of slope on wind field *** slopes ranging from 10°to 45°at 5°intervals are considered,which covers most conventional hill *** inflow turbulence for the LES is generated by adopting a modified generation method that combines the equilibrium boundary conditions with the Fluent inherent vortex method to improve the simulation *** time-averaged flow field and the instantaneous vortex structure under the eight slopes are comparatively *** accuracy of the present method is verified by comparison with experimental *** slope can affect both the mean and fluctuating wind flow fields around the 3D hill,especially on the hilltop and the leeward side,where a critical slope of 25°can be *** fluctuating wind speeds at the tops of steep hills(with slope angles beyond 25°)decrease with increasing slope,while the opposite phenomenon occurs on gentle *** increasing slope,the energy of the high-speed descending airflow is enhanced and pushes the separated flow closer to the hill surface,resulting in increased wind speed near the wall boundary on the leeward side and inhibiting the development of *** vortex shedding trajectory in the wake region becomes wider and longer,suppressing the growth of the mean wind near the wall boundary and enhancing the turbulence intensity.

关键词： large eddy simulation inflow turbulence topographic wind field critical slope flow mechanism

Progressive meristem and single-cell transcriptomes reveal the regulatory mechanisms underlying maize inflorescence development and sex differentiation

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Molecular Plant 2024年第7期17卷 1019-1037页

作者： Yonghao Sun liang Dong Lu Kang Wanshun Zhong David Jackson fang Yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA School of Agriculture Sun Yat-Sen UniversityShenzhen 518107China

Maize develops separate ear and tassel inflorescences with initially similar morphology but ultimately different architecture and *** detailed regulatory mechanisms underlying these changes still remain largely *** this study,through analyzing the time-course meristem transcriptomes and floret single-cell transcriptomes of ear and tassel,we revealed the regulatory dynamics and pathways underlying inflorescence development and sex *** identified 16 diverse gene clusters with differential spatiotemporal expression patterns and revealed biased regulation of redox,programmed cell death,and hormone signals during meristem differentiation between ear and ***,based on their dynamic expression patterns,we revealed the roles of two RNA-binding proteins in regulating inflorescence meristem activity and axillary meristem ***,using the transcriptional profiles of 53910 single cells,we uncovered the cellular heterogeneity between ear and tassel *** found that multiple signals associatedwith either enhancedcell death or reduced growth are responsiblefortassel pistil suppression,while part of the gibberellic acid signal may act non-cell-autonomously to regulate ear stamen arrest during sex *** further showed that the pistil-protection gene SILKLESS 1(SK1)functions antagonistically to the known pistil-suppression genes through regulating common molecular pathways,and constructed a regulatory network for pistil-fate ***,our study provides a deep understanding of the regulatory mechanisms underlying inflorescence development and sex differentiation in maize,laying the foundation for identifying new regulators and pathways for maize hybrid breeding and improvement.

关键词： maize inflorescence floral organ sex differentiation single-cell RNA sequencing RNA-binding protein

A Novel Fracturing Fluid with High-Temperature Resistance for Ultra-Deep Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 975-987页

作者： Lian Liu liang Li Kebo Jiao Junwei fang Yun Luo Northwest Oilfield Branch China Petroleum&Chemical CorporationUrumqi830011China Sinopec Key Laboratory for Enhanced Recovery in Fractured and Cavernous Reservoir Urumqi830011China

Ultra-deep reservoirs play an important role at present in fossil energy *** to the related high temperature,high pressure,and high formation fracture pressure,however,methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are *** response to the above problem,a fracturing fluid with a density of 1.2~1.4 g/cm^(3)was developed by using Potassium formatted,hydroxypropyl guanidine gum and zirconium crosslinking *** fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min was verified under a shear rate of 1701/s and at a temperature of 175℃.This fluid has good sand-carrying performances,a low viscosity after breaking the rubber,and the residue content is less than 200 mg/*** with ordinary reconstruction fluid,it can increase the density by 30%~40%and reduce the wellhead pressure of 8000 m level reconstruction ***,the new fracturing fluid can significantly mitigate safety risks.

关键词： Ultra-deep reservoir high-temperature resistance weighted fracturing fluid guanidine gum potassium formatted

Effects of plug tray cell size on the growth of Atractylodes Chinensis (DC) Koidz seedlings

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 45-52页

作者： Kaixuan Shi Juwen liang fang Ji Dongxian He Key Laboratory of Agricultural Engineering in Structure and Environment of MARA College of Water Resources&Civil EngineeringChina Agricultural UniversityBeijing 100083China

Atractylodes Chinensis(DC)Koidz is a perennial herb often used as a prescription medicine for influenza,to invigorate the spleen and remove *** quality of the herb is determined by the quality of the *** traditional *** seedling production technique has nonuniform seedlings and low *** plug seedling technique was used to produce *** *** study was conducted to determine the growth characteristics of *** seedlings according to the cell size of plug trays and number of days after *** height,stem diameter,rhizome diameter,number of leaves,leaf area,and shoot dry and fresh weight of *** seedlings were significantly higher in the P32-D treatment than in the P72,P50,and P32 treatments,but not significantly different from the P28-D treatment 60 d after *** P28-D treatment resulted in a considerable drop in rhizome fresh weight and healthy seedling index,both of which are key indicators for assessing seedling *** the differences in Pn among treatments were not significantly different,Tr was considerably greater in *** seedlings treated with P32-D and P28-D than in the other three *** P32-D and P28-D treatments had considerably greater potential maximum photochemical efficiency of PSII,quantum yield of photosystem II,photochemical quenching and electron transport rate than the other three *** vitality of *** seedlings was significantly stronger in the P32-D treatment than in the other four treatments,and it was 1.9 times higher than in the P28-D *** soluble protein,soluble sugar,and starch contents of *** seedlings were highest in the P32-D treatment,but the differences among treatments were not ***,EUE,PY and EY were significantly higher in the P32-D treatment than in the other four treatments,being 1.3,1.3,1.4 and 1.4 times higher than in P28-D,*** the other hand,as for the change in the gro

关键词： Atractylodes Chinensis(DC)Koidz plug seedling plug tray cell size

Evaluation of Multi-Temporal-Spatial Scale Adjustment Capability and Cluster Optimization Operation Method for Distribution Networks with Distributed Photovoltaics

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Energy Engineering 2024年第9期121卷 2655-2680页

作者： Jiaxin Qiao Yuchen Hao Yingqi Liao fang liang Jing Bian Northeast Electric Power University Key Laboratory of Modern Power System Simulation and Control&Renewable Energy TechnologyMinistry of EducationJilin132011China State Grid Jiangsu Electric Power Co. Ltd.Power Dispatch Control CenterNanjing210017China State Grid Jiangsu Electric Power Co. Ltd.Nanjing Power Supply BranchPower Dispatch Control CenterNanjing210019China

Themassive integration of high-proportioned distributed photovoltaics into distribution networks poses significant challenges to the flexible regulation capabilities of distribution *** accurately assess the flexible regulation capabilities of distribution stations,amulti-temporal and spatial scale regulation capability assessment technique is proposed for distribution station areas with distributed photovoltaics,considering different geographical locations,coverage areas,and response ***,the multi-temporal scale regulation characteristics and response capabilities of different regulation resources in distribution station areas are analyzed,and a resource regulation capability model is established to quantify the adjustable range of different regulation *** this basis,considering the limitations of line transmission capacity,a regulation capability assessment index for distribution stations is proposed to evaluate their regulation ***,considering different geographical locations and coverage areas,a comprehensive performance index based on electrical distance modularity and active power balance is established,and a cluster division method based on genetic algorithms is proposed to fully leverage the coordination and complementarity among nodes and improve the active power matching degree within ***,an economic optimization model with the objective of minimizing the economic cost of the distribution station is established,comprehensively considering the safety constraints of the distribution network and the regulation constraints of *** model can provide scientific guidance for the economic dispatch of the distribution station ***,case studies demonstrate that the proposed assessment and optimization methods effectively evaluate the regulation capabilities of distribution stations,facilitate the consumption of distributed photovoltaics,and enhance the economic efficiency of th

关键词： Distributed photovoltaic distribution station area assessment of adjustment capacity line transmission capacity economic optimization