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Grain boundary restructuring and La/Ce/Y application in Nd–Fe–B magnets

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Chinese Physics B 2019年第7期28卷 25-53页

作者： mi Yan Jiaying jin Tianyu Ma School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsKey Laboratory of Novel Materials for Information Technology of Zhejiang Province Zhejiang University

Since the 1980 s, Nd–Fe–B with largest energy product(BH)max approaching the theoretical limit has become the landmark of permanent magnetic *** application spectrum for Nd–Fe–B continues to expand over time both in the industrial and commercial sectors, which leads to growing research interests for solving the long-standing drawbacks of Nd–Fe–B, i.e., poor corrosion resistance, low coercivity, high Dy/Tb and low La/Ce/Y *** the above obstacles, we aim to present the novel grain boundary restructuring(GBR) approach, from GB design, processing, to structure evolution and property evaluation with a focus on the corrosion and coercivity mechanism of the restructured 2:14:1-typed *** with an introduction to the fundamental of GBR, two representative examples,high-electrode-potential(Pr, Nd)32.5Fe62.0Cu5.5 and low-melting-point Dy71.5Fe28.5, are given with detailed descriptions of the advantages of GBR to enhance the intrinsic anti-corrosion stability and to strengthen the coercivity at low Dy ***–property correlations are established to understand the critical importance of regulating the restructured GB phase to maximize the all-round performance of the 2:14:1-typed permanent *** at sustainable and balanced development of rare earth(RE) industry, the proceeding section proposes new prototypes of La–Ce and Y–Ce co-substitutions with dual benefits of stabilizing the 2:14:1 tetragonal phase and strengthening the intrinsic hard *** findings of additional REFe2 intergranular phase delight that the GBR approach also opens up a new horizon of research and application to develop high-performance La/Ce/Y-rich permanent magnets with deliberately tailored GB phase.

关键词： grain boundary restructuring coercivity corrosion resistance Dy/Tb La/Ce/Y

Pharmacokinetics of H002, a novel S1PR_1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry

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Acta Pharmaceutica Sinica B 2016年第6期6卷 576-583页

作者： Jiaqi mi Manman Zhao Shu Yang Shuang Yang jing jin xiaojian Wang Qiong xiao jinping Hu Yan Li Department of Drug Metabolism Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD StudyKey Laboratory of Active Substances Discovery and Drug Ability Evaluation State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

A rapid and sensitive liquid chromatography–tandem mass spectrometry(LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the internal *** samples were prepared by simple protein precipitation. The analytes and internal standard were separated on a Zorbax SB-C18 column with a gradient mobile phase consisting of methanol and water containing 0.1% formic acid at a flow rate of 0.2 mL /min with an operating temperature of 20 1C. The detection was performed on a triple quadrupole tandem mass spectrometer with positive electrospray ionization in multiple-reaction monitoring *** detection responses were obtained from 0.2–100 ng/mL for H002 and H002-M, while 0.5–100 ng/mL for H002-P. The intra- and inter-day precision(RSD%) was within 11.76%, with the accuracy(RE%) ranging from –9.84% to 9.12%. The analytes were shown to be stable during sample storage, preparation and analytic *** method was applied to determine the pharmacokinetics of H002 in rats, and a preliminary study showed that the pharmacokinetics of H002 correlated with its biological effect on peripheral blood lymphocytes.

关键词： S1P receptor S1PR1 modulator Sphingosine-1-phosphate S1P analogue Metabolite LC–MS/MS Pharmacokinetics Periphery blood lymphocyte

An efficient method for identification of risk factors

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Science China(Technological Sciences) 2009年第12期52卷 3626-3631页

作者： CHENG jin xiao RuCheng Department of Bridge Engineering Tongji UniversityShanghai 200092China

This paper presents a method to identify risk factors during bridge *** method integrates the concepts of analytical hierarchy process and fuzzy consistent matrix *** advantage of the method is that instead of using 9-point scale of relative importance of the conventional analytical hierarchy process,it uses a 3-point scale to describe the scale of importance,thus greatly simplifying the identification problem of risk ***,the difficulties of making judgment and comparison caused by uncertainty that jeopardizes the accuracy of the results in the conventional analytical hierarchy process can also be *** advantage of the method is that it does not involve consistency checking,thus saving a large amount of CPU *** has been demonstrated with a numerical example that the proposed fuzzy analytical hierarchy process based on 3-point scale can offer significant computational savings over the conventional analytical hierarchy process.

关键词： analytical hierarchy process risk fuzzy consistent matrix identification

nfluence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages

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Asian Journal of Andrology 2012年第2期14卷 330-334页

作者： mi mi Oh jin Wook Kim Myeong Heon jin Je Jong Kim Du Geon Moon Department of Urology Korea University Medical Center Seou1435-766 Korea Department of Urology Korea University Medical Center and Korea University Institute of Regenerative Medicine Seou1435-766 Korea

This study was performed to assess serum testosterone alterations induced by paradoxical sleep deprivation （PSD） and to verify their attenuation during sleep recovery （SR） based on different durations and ages. Wistar male rats aged 12 weeks for the younger group and 20 weeks for the elder group were randomly distributed into one of the following groups： a control group （cage and platform）, 3-day SD, 5-day SD, 7-day SD, 1-day SR, 3-day SR and 5-day SR groups. For PSD, the modified multiple platform method was used to specifically limit rapid eye movement （REM） sleep. Differences in the testosterone and luteinizing hormone levels between the younger group and the elder group according to duration of PSD and SR recovery were analysed. Testosterone continued to fall during the sleep deprivation period in a time-dependent manner in both the younger （P=-0.001, correlation coefficient r=-0.651） and elder groups （P=0.001, correlation coefficient r=-0.840）. The elder group showed a significantly lower level of testosterone compared with the younger group after PSD. Upon SR after 3 days of PSD, the testosterone level continued to rise for 5 days after sleep recovery in the younger group （P=0.013）, whereas testosterone concentrations failed to recover until day 5 in the elder group. PSD caused a more detrimental effect on serum testosterone in the elder group compared to the younger group with respect to decreases in luteinizing hormone （LH） levels. The replenishment of serum testosterone level was prohibited in the elder group suggesting that the effects of SD/SR may be age-dependent. The mechanism by which SD affects serum testosterone and how age may modify the process are still unclear.

关键词： luteinizing hormone paradoxical sleep deprivation recovery testosterone

Ultrafiltration with in-line coagulation for the removal of natural humic acid and membrane fouling mechanism

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Journal of Environmental Sciences 2006年第5期18卷 880-884页

作者： WANG jin WANG xiao-chang Department of Municipal and Environmental Engineering Beijing Jiaotong University Beijing 100044 China School of Environmental and Municipal Engineering Xi＇an University of Architecture and Technology Xi＇an 710055 China

Experimental and theoretical analysis were made on the natural humic acid removal and the membrane fouling of ultrafiltration （UF） with in-line coagulation. The results showed dissolved organic carbon （DOC） and UV254 removals by the UF with in-line coagulation at pH 7 were increased from 28% to 53% and 40% to 78% in comparison with direct UF treatment respectively. At the same time, the analysis of high performance liquid chromatography showed that UF with coagulation had significant improvement of removal of humic acid with molecular weights less than 6000 Da in particular. Compared to direct UF, the in-line coagulation UF also kept more constant permeate flux and very slight increase oftransmembrane pressure during a filtration circle. Two typical membrane fouling models were used by inducing two coefficients Kc and Kp corresponding to cake filtration model and pore narrowing model respectively. It was found that membrane fouling by pore-narrowing effect was effectively alleviated and that by cake-filtration was much decreased by in-line coagulation. Under the condition of coagulation prior to ultrafiltration at pH 7, the cake layer formed on the membrane surface became thicker, but the membrane filtration resistance was lower than that at pH 5 with the extension of operation time.

关键词： natural humic acid ultrafiltration (UF) in-line coagulation high performance liquid chromatography (HPLC) membrane fouling

A review on liquid sloshing hydrodynamics

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Journal of Hydrodynamics 2021年第6期33卷 1089-1104页

作者： jin-hai Zheng mi-An Xue Peng Dou Yu-meng He Key Laboratory of Coastal Disaster and Protection of ministry of Education Hohai UniversityNanjing 210024China College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210024China

Liquid sloshing in tanks is a very complex nonlinear free surface fluid flow problem,which must be considered in most of the marine engineering problems such as naval architecture,offshore engineering and so *** liquid sloshing in large containers can damage the tank structure due to the direct liquid impacting *** also affects the capsizing process of the liquid cargo *** works on mitigating sloshing by using all kinds of the baffles were thus followed with *** layers with thinner thickness were shown to reduce the sloshing load of water in *** sloshing characteristics in tanks with different sizes were different,therefore,scaling effect of sloshing should also be *** in a tank can also be used as tuned liquid dampers(TLDs)to dampen wind,wave and flow-induced motions of floating or fixed marine *** paper present an overview on recent advances of liquid sloshing hydrodynamics including sloshing mitigation by using anti-sloshing baffle,layered fluids sloshing,scaling effect of sloshing and TLDs.

关键词： Sloshing mitigation layered fluids sloshing scaling effect of sloshing tuned liquid damper

A TRANSFER FORECASTING MODEL FOR CONTAINER THROUGHPUT GUIDED BY DISCRETE PSO

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Journal of Systems Science & Complexity 2014年第1期27卷 181-192页

作者： xiao jin xiao Yi FU Julei LAI Kin Keung Business School Sichuan University Chengdu 610064 China. School of Information Management Central China Normal University Wuhan 430079 China Academy ofMathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China. Information System & Management National University of Defense Technology Changsha 410073 China. Department of Management Sciences City University of Hong Kong Hong Kong China.

Abstract Accurate forecast of future container throughput of a port is very important for its con struction, upgrading, and operation management. This study proposes a transfer forecasting model guided by discrete particle swarm optimization algorithm （TF-DPSO）. It firstly transfers some related time series in source domain to assist in modeling the target time series by transfer learning technique, and then constructs the forecasting model by a pattern matching method called analog complexing. Finally, the discrete particle swarm optimization algorithm is introduced to find the optimal match between the two important parameters in TF-DPSO. The container throughput time series of two im portant ports in China, Shanghai Port and Ningbo Port are used for empirical analysis, and the results show the effectiveness of the proposed model.

关键词： Analog complexing container throughput forecasting discrete particle swarm optimiza-tion transfer forecasting model.

Comprehensive molecular characterization and identification of prognostic signature in stomach adenocarcinoma on the basis of energy-metabolism-related genes

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 478-497页

作者： jin-Jia Chang xiao-Yu Wang Wei Zhang Cong Tan Wei-Qi Sheng mi-Die Xu Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Laboratory of Immunology and Virology Experiment Center for Science and TechnologyShanghai University of Traditional Chinese MedicineShanghai201203China Department of Gynecologic Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

BACKGROUND Stomach adenocarcinoma(STAD)is a leading cause of cancer deaths,but its molecular and prognostic characteristics has never been fully *** To describe a molecular evaluation of primary STAD and develop new therapies and identify promising prognostic *** We describe a comprehensive molecular evaluation of primary STAD based on comprehensive analysis of energy-metabolism-related gene(EMRG)expression *** On the basis of 86 EMRGs that were significantly associated to patients’progression-free survival(PFS),we propose a molecular classification dividing gastric cancer into two subtypes:Cluster 1,most of which are young patients and display more immune and stromal cell components in tumor microenvironment and lower tumor priority;and Cluster 2,which show early stages and better ***,we construct a 6-gene signature that can classify the prognostic risk of patients after a three-phase training test and validation *** with patients with low-risk score,patients with high-risk score had shorter overall ***,calibration and DCA analysis plots indicate the excellent predictive performance of the 6-gene signature,and which present higher robustness and clinical usability compared with three previous reported prognostic gene *** to gene set enrichment analysis,gene sets related to the high-risk group were participated in the ECM receptor interaction and hedgehog signaling *** Identification of the EMRG-based molecular subtypes and prognostic gene model provides a roadmap for patient stratification and trials of targeted therapies.

关键词： Gastric cancer Molecular subtype Energy-metabolism-related genes Prognosis factor Roadmap

Simulation of dual transponder carrier ranging measurements

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1395-1403页

作者： Xiang-yu ZHA xiao-jun jin Zhong-he jin Department of lnformation Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

The most dominant error source for microwave ranging is the frequency instability of the oscillator that generates the carrier phase signal. The oscillator noise is very difficult to filter due to its extremely low frequency. A dual transponder carrier ranging method can effectively minimize the oscillator noise by combing the reference phase and the to-and-fro measurement phase from the same single oscillator. This method does not require an accurate time tagging system, since it extracts phases on the same satellite. This paper analyzes the dual transponder carrier ranging system by simulation of the phase measurements with comprehensive error models. Both frequency domain and time domain noise transfer characteristics were simulated to compare them with dual one-way ranging. The simulation results in the two domains conformed to each other and demonstrated that a high level of accuracy can also be achieved by use of the dual transponder carder ranging system, with relatively simple instruments.

关键词： Dual transponder carrier ranging Dual one-way ranging Oscillator noise Transfer characteristic