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FTO Polymorphisms Are Associated with Obesity But Not with Diabetes in East Asian Populations:A Meta-analysis

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Biomedical and Environmental Sciences 2009年第6期22卷 449-457页

作者： Bo XI jie mi Graduate School Peking Union Medical College Beijing 100730 China Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China

Objective To clarify the contradictory findings in patients with obesity and type 2 diabetes by meta-analysis. Methods PubMed and Embase were searched for articles published up to March 2009. All studies on the association of FTO polymorphisms with obesity and type 2 diabetes were included. Pooled odds ratio was calculated using the model of fixed or random effects. Sensitivity analysis was performed to evaluate the stability of meta-analytic results. Results Meta-analysis suggested that rs9939609 A allele was more significantly associated with obesity risk than T allele （3 studies / 2 004 cases and 4 544 control subjects）： random effect odds ratio （OR）-1.28, 95%CI=1.05 and 1.55, P heterogeneity =0.05, I^2=66.6%. Similar results were observed in rs8050136 polymorphism （3 studies/2 404 cases and 5 713 control subjects）： fixed effect OR =1.25, 95%CI-1.13, 1.37, Pheterogeneity =0.12, 12=51.9%. However, no significant association was found between genetics and risk of type 2 diabetes after control of potential confounders （at least for Bmi） either for rs9939609 （fixed effect OR=1.05, 95% CI 0.97,1.13） or for rs8050136 polymorphism （fixed effect OR -1.07, 95%CI： 0.99, 1.16）. Furthermore, the sensitivity analysis strengthened our confidence in validity of the association. Conclusion FTO polymorphisms are associated with obesity but not with type 2 diabetes in East Asian populations. Further large-scale studies are required to conclusively establish the association.

关键词： FTO: Polymorphism Obesity Type 2 diabetes Meta-analysis

Genome-wide Association Studies of Common Obesity: Now and Future

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Biomedical and Environmental Sciences 2013年第10期26卷 787-791页

作者： XI Bo mi jie Department of Maternal and Child Health Care School of Public HealthShandong University Department of Epidemiology Capital Institute of Pediatrics

Obesity has become a major public health concern worldwide. Obesity is a complex disease influenced by both genetic and environmental factors. Epidemiological studies have indicated that environmental factors, such as excessive energy intake and lack of physical activity, might contribute to the development of obesity. Genetic factors also play an important role in the pathogenesis of obesity Indeed, approximately 40%-70% of the variation in body mass index （Bmi） can be attributed to genetic factors.

关键词： FTO gene Now and Future Genome-wide Association Studies of Common Obesity

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肥胖全基因组关联研究的现状与展望

中华流行病学杂志 2010年第12期31卷 1425-1428页

作者：席波米杰首都儿科研究所流行病学研究室北京100020

常见复杂性疾病,又称多基因疾病,是由多对微效基因与环境因素共同作用所致,具有明显的遗传异质性、表型复杂性及种族差异性等特征.常见复杂性疾病和单基因疾病的一个最显著的区别是,它不依照经典的孟德尔模式遗传.伴随着生活环境的改变... 详细信息

常见复杂性疾病,又称多基因疾病,是由多对微效基因与环境因素共同作用所致,具有明显的遗传异质性、表型复杂性及种族差异性等特征.常见复杂性疾病和单基因疾病的一个最显著的区别是,它不依照经典的孟德尔模式遗传.伴随着生活环境的改变,发展中国家正经历着流行病由过去严重传染性疾病向常见慢性疾病的转移[1].以肥胖为例,1980-2002年期间,美国20岁以上成年人的肥胖率增加了1倍 6～19岁儿童青少年的超重率增加了2倍[2].2006年世界卫生组织（WHO）数据显示,世界肥胖人群已逾4亿[3].

关键词：肥胖全基因组关联研究体脂和肥胖相关基因

Impacts of Types and Degree of Obesity on Non-Alcoholic Fatty Liver Disease and Related Dyslipidemia in Chinese School-Age Children?

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Biomedical and Environmental Sciences 2011年第1期24卷 22-30页

作者： MENG LingHui LUO Na mi jie Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China Graduate SchoolPeking Union Medical College Beijing 100730 China Primary and middle School Students Health CareCenter affiliated to the Education Committee of Haidian District Beijing 100081 China

Objective To explore the impacts of types and degree of obesity on non‐alcoholic fatty liver disease （NAFLD） and related lipids disturbance in Chinese school‐age children. Methods A total of 1 452 school‐age Children of 7 to 17 years were recruited in Beijing with representative cluster sampling method. Data of anthropometric measurements including weight, height and waist circumference were collected from March to May of 2007. Body mass index（Bmi）was calculated. Blood samples were obtained and lipid profiles including triglyceride （TG）, total cholesterol （TC）, high‐density lipoprotein cholesterol （HDL‐C） and low‐density lipoprotein cholesterol （LDL‐C） were measured, while glutamate‐pyruvate transaminase （ALT） and glutamic‐oxalacetic transaminase （AST） were determined to evaluate liver function. The liver was also scanned by sonography, and abnormal hepatic sonograms were documented. NAFLD was diagnosed according to the criteria recommended by the Fatty Liver and Alcoholic Liver Disease Study Group under the Chinese Liver Disease Association. Analysis of covariance （ANOVA）, Chi‐square test for trend and binary logistic regression analysis were performed. Results The dyslipidemia and ultrasonographic fatty liver deteriorated with the degree of obesity defined either by Bmi or waist circumference. Compared with Bmi, waist circumference contributed more to the development of dyslipidemia, fatty liver and NAFLD. The highest levels of TG, TC, LDL‐C, and lowest level of HDL‐C were seen in the mixed obese group followed by abdominal obese, peripheral obese and non‐obese ones. Adjusted for gender and age, the odds ratios （ORs） and their 95% confidence intervals of peripheral obesity, abdominal obesity and mixed obesity were 0, 10.93 （0.98‐121.96） and 79.16 （10.95‐572.44） for predicting NAFLD; 12.61 （1.24‐127.78）, 19.39 （5.23‐71.85）, and 93.21 （29.56‐293.90） for predicting ultrasonographic fatty liver; 1.78 （0.59‐5.44）, 3.01 （1.91‐4.77）, and 4.64 （3.52‐6.12） for predicting d

关键词： Obesity type Degree of obesity Dyslipidemia NAFLD School‐age Children

Reduced Arterial Compliance Associated with Metabolic Syndrome in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2010年第2期23卷 102-107页

作者： BO XI LI ZHANG jie mi Department of Epidemiology Capital Institute of Paediatrics Beijing 100020 China Graduate School Peking Union Medical College Beijing 100730 China

Objective To explore the metabolic syndrome and its association with arterial compliance in Chinese children and adolescents. Methods 337 participants aged 6 to 18 years with males accounted for 55.8% were grouped according to their traits of metablic syndrome. Anthropometry, blood pressure, fasting plasma glucose, insulin and serum lipid profile were measured. Homeostasis model was assessed and insulin resistance （HOMA-IR） index was measured and calculated for estimating individual insulin resistance. Arterial compliance was also measured using digital pulse wave analyzing method （micro medical, London）, and stiffness index was calculated. Results The stiffness index in participants with metablic syndrome was significant higher than that in participants with no riskof metablic syndrome [（7.69±1.63） vs （6.25±0.86） m/s, P〈0.01] and stiffness index and HOMA-IR were progressively increased with the increase of traits of metablic syndrom （P for linear trend 〈0.001）. After gender, age, and pubertal development were adjusted, both traits of metablic syndrome and HOMA-IR were correlated positively with stiffness index （both P〈0.05）. Conclusion The clustering of metablic syndrome was closely associated with risk at increased arterial stiffness in Chinese children and adolescents. It was suggested that arterial compliance assessment of children and adolescents might be an important measure for prevention of cardiovascular diseases.

关键词： Metabolic syndrome Arterial compliance Children and adolescents

Continuous-Discrete Adaptive Observers For a Class of Nonlinear Systems With Sampled Output 36

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Continuous-Discrete Adaptive Observers For a Class of Nonlin...

Timing and secular trend of pubertal development in Beijing girls

第36届中国控制会议

作者： Guanglei Zhao jie mi Institute of Electrical Engineering Yanshan University Department of Human Resource Yanshan University

ISBN: (纸本)9781538629185

This paper considers the continuous-discrete time adaptive observer design for a class of nonlinear systems with unknown constant parameters and sampled output measurements. The proposed observer is in impulsive dynamics form with an inter-sample output predictor, where the observer state flows continuously when the output is not available, and a corrective term corresponding to measured samples is used to update the observer state. By assuming appropriate persistent excitation conditions and following a technical lemma, an upper bound of the sampling intervals is derived, with which, the convergence of the observer state and unknown parameters can be ensured. Finally, the proposed observer is used in an example of single-link flexible-joint robot manipulator to show the effectiveness.

关键词： nonlinear systems continuous-discrete adaptive observer sampled output measurements persistent excitation unknown parameter

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World Journal of Pediatrics 2014年第1期10卷 74-79页

作者： Fang-Fang Chen You-Fa Wang jie mi Department of Epidemiology Capital Institute of PediatricsBeijingChina Johns Hopkins Global Center for Childhood ObesityDepartment of International HealthCenter for Human NutritionBloomberg School of Public HealthJohns Hopkins UniversityBaltimoreUSA

Background:Historical research is limited in changes in pubertal development in Chinese *** aimed to identify the timing of pubertal characteristics and the secular trend of menarche age among Beijing girls from the 1980s through the ***:Six data sets were analyzed,including the Beijing Child and Adolescent Metabolic Syndrome study in 2004,where 9778 Bejing girls aged 6–18 years were *** Fetal Origins of Adult Disease study provided retrospective menarche age from 1940 through *** four studies were conducted in Beijing to obtain supplementary information to assess secular trend in menarche *** regression method was used to analyze the ***:Among Beijing girls in 2004,the median age at menarche was 12.1 years,which was 0.6 years earlier in urban than in rural *** median age at Breast Tanner Stage 2 was 9.5±1.2 years,representing 9.4±1.1 years and 9.6±1.2 years for urban and rural girls,*** contrast,the median age at Pubic Hair Tanner Stage 2 was 11.1±1.1 years,representing 10.8±1.1 and 11.4±1.1 years for urban and rural girls,*** menarche age of urban girls decreased by 4.2 months per decade,and that of rural girls by 9.6 months per decade from 1980 to ***:Urban girls mature earlier than rural girls in Beijing.A secular trend towards earlier menarche was observed between the 1980s and the 2000s.

关键词： breast menarche puberty pubic hair

Application of convolutional neural network-based endoscopic imaging in esophageal cancer or high-grade dysplasia: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1998-2016页

作者： Jun-Qi Zhang Jun-jie mi Rong Wang The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012Shanxi ProvinceChina

BACKGROUND Esophageal cancer is the seventh-most common cancer type worldwide,accounting for 5%of death from *** of novel diagnostic techniques has facilitated screening,early detection,and improved *** neural network(CNN)-based image analysis promises great potential for diagnosing and determining the prognosis of esophageal cancer,enabling even early detection of *** PubMed,EMBASE,Web of Science and Cochrane Library databases were searched for articles published up to November 30,*** evaluated the diagnostic accuracy of using the CNN model with still image-based analysis and with video-based analysis for esophageal cancer or HGD,as well as for the invasion depth of esophageal *** pooled sensitivity,pooled specificity,positive likelihood ratio(PLR),negative likelihood ratio(NLR),diagnostic odds ratio(DOR)and area under the curve(AUC)were estimated,together with the 95%confidence intervals(CI).A bivariate method and hierarchical summary receiver operating characteristic method were used to calculate the diagnostic test accuracy of the CNN ***-regression and subgroup analyses were used to identify sources of *** A total of 28 studies were included in this systematic review and *** still image-based analysis for the diagnosis of esophageal cancer or HGD provided a pooled sensitivity of 0.95(95%CI:0.92-0.97),pooled specificity of 0.92(0.89-0.94),PLR of 11.5(8.3-16.0),NLR of 0.06(0.04-0.09),DOR of 205(115-365),and AUC of 0.98(0.96-0.99).When video-based analysis was used,a pooled sensitivity of 0.85(0.77-0.91),pooled specificity of 0.73(0.59-0.83),PLR of 3.1(1.9-5.0),NLR of 0.20(0.12-0.34),DOR of 15(6-38)and AUC of 0.87(0.84-0.90)were *** of invasion depth resulted in a pooled sensitivity of 0.90(0.87-0.92),pooled specificity of 0.83(95%CI:0.76-0.88),PLR of 7.8(1.9-32.0),NLR of 0.10(0.41-0.25),DOR of 118(11-1305),and AUC of 0.95(0.92-0.96).CONCLUSION CN

关键词： Esophageal cancer High-grade dysplasia Convolutional neural network Deep learning Systematic review Meta-analysis

Association of metabolic syndrome with arterial compliance in children and adolescents

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Frontiers of Medicine 2007年第1期1卷 68-73页

作者： ZHANG Li mi jie LI ming JIANG Benyu Department of Epidemiology Capital Institute of PediatricsBeijing 100020China Department of Endocrinology Chinese Academy of Medical SciencePeking Union Medical College HospitalBeijing 100730China Clinical Pharmacology St Thomas’HospitalLambeth Palace RdLondon SEI 7EHUK

The association of metabolic syndrome(MS)with arterial compliance in children and adolescents was explored.337 subjects(188 men and 149 women)aged 6–18(10.95±3.01)years,out of“Beijing Child Metabolic Syndrome Study”,were divided into three case groups(one component,two components,three&more components of MS)and one control group based on the Cook’s MS definition in children and *** including anthropometry,blood pressure,fasting plasma glucose and insulin,serum lipid profile were *** model assessment for insulin resistance(HOMA-IR)index was calculated for estimating individual insulin *** compliance was measured using digital pulse wave analyzing method from the pulse trace machine(micro medical,London),and then the stiffness index(SI)was *** mean value of SI in MS group was significant higher than that in control group[(7.69±1.63)vs(6.25±0.86)m/s,P<0.01].With the increase of the clustering of MS components,SI and HOMA-IR were gradually *** taking account of gender,age and pubertal development,the partial correlation analysis showed that the amount of components of MS and HOMA-IR were positively correlated with SI(both P values were less than 0.05).The arterial compliance of MS group was significantly lowered in children and adolescents,and with the increase of the clustering of MS components,arterial compliance was gradually *** was suggested that arterial compliance assessment in children and adolescents was important for early prevention of cardiovascular diseases.

关键词： metabolic syndrome arterial compliance children and adolescents