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Fibroblast growth factor 23 and bone mineralisation

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International Journal of Oral Science 2015年第1期7卷 8-13页

作者： Yu-Chen guo quan Yuan State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Fibroblast growth factor 23 （FGF23） is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models. Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease （CKD） and may play a critical role in mineral ion disorders and bone metabolism in these patients. Our recent publications have also shown that FGF23 and its cofactor, Klotho, may play an independent role in directly regulating bone mineralisation instead of producing a systematic effect. In this review, we will discuss the new role of FGF23 in bone mineralisation and the pathophysiology of CKD-related bone disorders.

关键词： bone mineralisation chronic kidney disease fibroblast growth factor 23

Constraining Ω with the fluctuation of the local Hubble flow

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Chinese Journal of Astronomy and Astrophysics 2009年第2期9卷 151-156页

作者： quan guo Huan-Yuan Shan National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

We present an analysis of the fluctuation of the local Hubble flow using 350 galaxies in the Local Volume （D 〈 5 Mpc, hereafter LV） with accurate measurements of distances, positions and radial velocities, and compare the results with the theoretical prediction of the local Hubble flow induced by density perturbations. This allows us to set a useful constraint on the local Ω parameters： ΩM - 0.6 and ΩA - 0.7, which may serve as compelling evidence for the existence of dark energy in the local Universe.

关键词： cosmology dark matter -- cosmology large-scale structure of universe --galaxies peculiar -- techniques radial velocities

Production and Characterization of Monoclonal Antibody Against Recombinant Human Erythropoietin

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Biomedical and Environmental Sciences 2007年第3期20卷 184-188页

作者： JIE-BO mi JIN YAN XIAO-JIE DING ZHEN-quan guo MEI-PING ZHAO WEN-BAO CHANG Beijing National Laboratory for Molecular Sciences（BNLMS） College of Chemistry and Molecular Engineering College of Life Sciences Peking University Beijing 100871 China

Objective To produce specific monoclonal antibody （mAb） against recombinant human erythropoietin （rHuEPO） for development of highly efficient methods for erythropoietin detection in biological fluids. Methods rHuEPO was covalently coupled with bovine serum albumin （BSA） and the conjugate was used to immunize mice to produce specific mAb against rHuEPO based on hybridoma technology. The obtained F3-mAb was characterized by enzyme-linked irmnunosorbent assay （ELISA）, SDS-PAGE and Western blot. Results The isotype of F3-mAb was found to be IgM with an affinity constant of 2.1x10s L/mol. The competitive ELISA using the obtained IgM showed a broader linear range and lower detection limit compared with previous work. Conclusions The modification of rHuEPO was proved to be successful in generating required specific mAb with high avidity to rHuEPO.

关键词： Recombinant human erythropoietin Monoclonal antibody IgM ELISA

瓜蒌- 薤白调节肠道菌群治疗冠心病模型大鼠的作用及机制

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中国组织工程研究 2025年第5期29卷 917-927页

作者：孙广瀚谢珍聪孙咪徐洋郭栋山东中医药大学第一临床医学院山东省济南市250014 山东中医药大学教师发展中心山东省济南市250355 山东中医药大学药物研究院山东省济南市250355

背景:基于网络药理学方法发现瓜蒌-薤白药对中主要生物活性化合物对冠心病有多功能作用;然而其治疗冠心病的机制尚未得到充分阐释。目的:探讨瓜蒌-薤白通过调节肠道微生物的组成改善冠心病的作用及机制。方法:40只SD大鼠按随机数字表法... 详细信息

背景:基于网络药理学方法发现瓜蒌-薤白药对中主要生物活性化合物对冠心病有多功能作用;然而其治疗冠心病的机制尚未得到充分阐释。目的:探讨瓜蒌-薤白通过调节肠道微生物的组成改善冠心病的作用及机制。方法:40只SD大鼠按随机数字表法分为空白组、模型组、阳性药组、药对组,除空白组外,其余大鼠连续灌胃脂肪乳剂和注射垂体后叶素制备冠心病大鼠模型。造模后模型组大鼠灌胃蒸馏水(10 mL/kg)进行对照,阳性药组大鼠每日灌胃辛伐他汀4 mg/kg,药对组每日灌胃瓜蒌-薤白7.56 g/kg,各组大鼠给药均为14 d。观察大鼠心电图、心肌病理及血脂变化,并通过16S rDNA测序技术研究大鼠经干预后肠道微生物结构。结果与结论:①心电图结果显示模型组ST抬高;阳性药组与药对组心电图无明显问题。②与空白组相比,模型组总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均显著增高(P0.05),Simpson指数降低(Pmicutes、Muribaculaceae_norank等相对丰度降低;与阳性药相比,药对组Desulfobacterota、Bacteroides等相对丰度升高,Firmicutes、[Eubacterium]_coprostanoligenes_group_norank等相对丰度降低;LEfSe结果发现差异显著的种群富集于药对组最多,其次是空白组、阳性药组,模型组最少。⑥结论:瓜蒌-薤白可以通过调节肠道菌群改善冠心病的发生发展,为进一步研发瓜蒌-薤白提供新的启示。

关键词： “瓜蒌-薤白”药对 16S rDNA 冠心病肠道菌群大鼠

Grain size distribution and topology in 3D grain growth simulation with large-scale Monte Carlo method

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International Journal of minerals,Metallurgy and Materials 2009年第1期16卷 37-42页

作者： Hao Wang guo-quan Liu Xiang-ge Qin School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering Jiamusi University Jiamusi 154007 China

Three-dimensional normal grain growth was appropriately simulated using a Potts model Monte Carlo algorithm. The quasi-stationary grain size distribution obtained from simulation agreed well with the experimental result of pure iron. The Weibull function with a parameter β=2.77 and the Yu-Liu function with a parameter v =2.71 fit the quasi-stationary grain size distribution well. The grain volume distribution is a function that decreased exponentially with increasing grain volume. The distribution of boundary area of grains has a peak at S/〈S〉=0.5, where S is the boundary area of a grain and 〈S〉 is the mean boundary area of all grains in the system. The lognormal function fits the face number distribution well and the peak of the face number distribution is f=10. The mean radius off-faced grains is not proportional to the face number, but appears to be related by a curve convex upward. In the 2D cross-section, both the perimeter law and the Aboav-Weaire law are observed to hold.

关键词： three-dimensional grain growth Monte Carlo simulation grain size distribution topology

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茄子新品种‘博杂1号-巨圆茄’

园艺学报 2008年第4期35卷 622-622页

作者：王晋华赵肖斌丁俊杰米国全程志芳河南省农业科学院园艺研究所郑州450002 河南省优质农产品开发服务中心郑州450003

‘博杂1号-巨圆茄’是以北京‘九叶茄’自交系S53为母本,‘紫罐茄’变异株自交系S64为父本配制的中晚熟一代杂种。植株生长势强,果实黑紫,圆形,果肉白色细嫩,味甜,口感好,不易老,不褐变,种子较少,商品性佳。平均单果质量750g,最大2300g... 详细信息

‘博杂1号-巨圆茄’是以北京‘九叶茄’自交系S53为母本,‘紫罐茄’变异株自交系S64为父本配制的中晚熟一代杂种。植株生长势强,果实黑紫,圆形,果肉白色细嫩,味甜,口感好,不易老,不褐变,种子较少,商品性佳。平均单果质量750g,最大2300g,产量82.5t·hm-2。高抗病毒病,抗褐纹病和绵疫病。适合河南、河北、山东、山西、陕西露地栽培和春提早、秋延后设施栽培。

关键词：茄子一代杂种品种

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高番茄红素樱桃番茄新品种‘樱红1号’

园艺学报 2009年第2期36卷 307-307页

作者：王晋华赵肖斌丁俊杰米国全程志芳河南省农业科学院园艺研究所郑州450002 河南省优质农产品开发服务中心郑州450003

‘樱红1号’樱桃番茄是从荷兰‘樱桃红’和日本‘ペペ’杂交后代中系统选育出的新品种。该品种植株为无限生长型,生长势较强,第8～9节着生第1花序,单穗结果30～50个。果实圆形,单果质量15～20g,果色鲜红亮丽,番茄红素含量***-1,酸甜可口... 详细信息

‘樱红1号’樱桃番茄是从荷兰‘樱桃红’和日本‘ペペ’杂交后代中系统选育出的新品种。该品种植株为无限生长型,生长势较强,第8～9节着生第1花序,单穗结果30～50个。果实圆形,单果质量15～20g,果色鲜红亮丽,番茄红素含量***-1,酸甜可口,耐贮藏,产量达45.0～***-2。高抗病毒病和枯萎病,抗根结线虫病,耐青枯病。适于我国华北地区露地和设施栽培。

关键词：番茄番茄红素品种

Tensile properties and fractographs of Ti–2.5Al–1.5Mn foils at different temperatures

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Rare Metals 2017年第4期36卷 247-255页

作者： Zhen-Wu Ma guo-quan Tong Feng Chen College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016China

The tensile properties and fractographs of Ti- 2.5Al-1.5Mn foils at different temperatures were investi- gated. It is observed that material properties closely cor- relate with the thickness （T） to grain size （d） ratio and deformation temperature. Tensile analysis shows that local deformation is the main deformation feature in foils forming at room temperature, which may lead to premature fracture. The causes of inhomogeneous deformation behavior are the limited number of deformable grains contained in deformation zone and the weak transferability of hardening among different grains. Fracture analysis reveals that the size of dimples can represent the ductility of foils at room temperature. With the further increase of deformation temperature, the main plastic deformation mode of foils is transformed from intragranular disloca- tions and twin crystal to grain-boundary gliding and roll- ing. In conclusion, foil forming at elevated temperature can increase the hardening transferability and the number of deformable grains in deformation zone, which is an effective method to improve the formability and reduce the scatter of material properties.

关键词： Size effects Titanium foils Tensile properties Homogeneous deformation Elevated temperature

INTRINSIC FEATURES OF TURBULENT FLOW IN STRONGLY 3-D SKEW BLADE PASSAGE OF A FRANCIS TURBINE

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Journal of Hydrodynamics 2007年第1期19卷 92-99页

作者： ZHANG Li-xiang WANG Wen-quan guo Yakun Department of Engineering Mechanics Kunming University of Science and Technology Kunming 650051 China guo Yakun Department of Engineering University of Aberdeen Aberdeen AB24 3UE UK.

The turbulent flow, with the Reynolds number of 5.9×10^5, in the strongly 3-D skew blade passage of a true Francis hydro turbine was simulated by the Large Eddy Simulation （LES） approach to investigate the spatial and temporal distributions of the fully developed turbulence in the passage with strongly 3-D complex geometry. The simulations show that the strong three-dimensionality of the passage has a great amplification effect on the turbulence in the passage, and the distributions of the turbulence are diversely nonuniform, for instance, the rise of turbulent kinetic energy in the lower 1/3 region of the passage is more than 45%, whereas its rise in the upper 1/3 region is less than 1%. With the LES approach, the details of the flow structures at the near-wall surfaces of the blades could be obtained. Several turbulent spots were captured.

关键词： turbulent flow Large Eddy Simulation (LES),hydro turbine