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Asian Microgravity Pre-Symposium 9th China-Japan-Korea Workshop on Microgravity Sciences

作者： ZQ Niu XJ Qu C Liu mf Feng State Key Lab of Biomembrane and Membrane Biotechnology Institute of ZoologyChinese Academy of Sciences

＜正＞Hematopoietic stem cells（HSCs） are the source of a variety of blood cells and immune *** maintain the stable of stem cell pool in vivo through self renewal and *** addition,HSCs have a strong plasticity to form different tissue cells through *** they become more and more important in clinics for re-construction hematopoiesis and diseases *** the serious deficiency of donors in the world,HSCs from umbilical cord blood（UCB） has emerged as a promising source of stem cells due to its ***,the low yield of HSCs in UCB limits its *** vivo expansion may overcome this *** interrelationship of cells in vivo are three dimension（3-D）,and simulating microgravity will provide an environment similar to the 3-D

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Structure and bonding of donor-acceptor complexes XBeY（X=CO, OC, Ng;Y=O, CO3）

Structure and bonding of donor-acceptor complexes XBeY（X=CO...

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中国化学会第29届学术年会

作者： Qingnan Zhang MH Chen mf Zhou G Frenking Department of Chemistry Fudan University Fachbereich Chemie Philipps-Universit?t

Reactions of laser-evaporated beryllium atoms with CO2 molecules formed OCBeO and OCBeCO3 complexes in solid neon,which rearranged to COBeO and COBeCO3 isomers under UV light *** C-O stretching frequency of OCBeCO3 was observed at 2263.1 cm-1,which is significantly higher than that of OCBeO at *** chemical calculations reveal that the binding energy of OCBeO is larger than that of *** observed unusually high frequency of OCBeCO3 is due to strong electrostatic but weakπback-donation interaction between CO and *** NgBeCO3（Ng=Ar,Kr,Xe）complexes were also prepared by reactions of beryllium atoms with CO and O2 mixtures in solid neon matrix doped by heavier noble gas *** calculations suggest that these complexes involve strong noble gas bonding which is dominated by polarization and charge transfer interactions.

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Proptosis in orbital myeloid sarcoma: A precursor to acute leukaemia

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Journal of Acute Disease 2017年第3期6卷 134-136页

作者： Fhun LC Tai ELM Wan-Hazabbah WH Liza-Sharmini AT Chong mf Department of Ophthalmology Hospital Raja Permaisuri BainunJalan Hospital30450IpohPerak Department of Ophthalmology School of Medical SciencesHealth Campus Universiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Myeloid sarcoma is a rare, aggressive presentation of acute myeloid leukemia which tends to affect bones and soft tissue. It is usually seen in children, and has a poor prognosis. We report a case of orbital myeloid sarcoma presenting with unilateral proptosis in a young adult who subsequently developed acute myeloid leukaemia. An 18-year-old male presented with sudden, progressively increasing right eye swelling over two weeks. Examination revealed right eye proptosis, with a positive relative afferent papillary defect and a right eye visual acuity of 6/60, pinhole 6/18. The right fundus showed optic disc hyperemia, tortuous veins and choroidal folds. The left eye was normal. On initial examination, computed tomography (CT) of the brain and orbit showed an enhancing mass at the lateral aspect of the right orbit measuring 3.8 x 2.1 cm, with optic nerve displacement. Right lateral orbitotomy and excisional biopsy yielded a tissue diagnosis of myeloid sarcoma. The peripheral blood smear was normal at this time. The patient defaulted treatment but presented again three months later with right eye massive proptosis and loss of vision. A repeated CT scan showed a large lobulated mass measuring 104.5mm x 87.21mmm x 77.25mm occupying the right orbit, with destruction of the bony orbital walls and intracranial extension. A repeat full blood picture and bone marrow aspiration showed 30% blast cells, consistent with the diagnosis of acute myeloid leukemia. Patient was started on chemotherapy and radiotherapy. The tumour regressed after five cycles, but unfortunately, patient passed away due to brain metastases.

关键词： Proptosis Leukemia Orbital myeloid sarcoma

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Graphene Oxide/Multilayer-Graphene Synthesized from Electrochemically Exfoliated Graphite and Its Influence on Mechanical Behavior of Polyurethane Composites

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Materials Sciences and Applications 2018年第7期9卷 565-575页

作者： L. M. Flores-Vélez O. Domínguez Faculty of Chemistry UASLP San Luis Potosí México Institute of Metallurgy UASLP San Luis Potosí México

Graphene Oxide/Multilayer-Graphene (GO-MG) flakes were obtained using an electrochemically exfoliated graphite (GR) electrode from secondary steel-making industry performed in a two-electrode system using tungsten as the counter electrode and GR as the working electrode. The exfoliated GO-MG flakes were processed and incorporated in an elastomeric polyurethane (PU) matrix. The mechanical properties of the PU/GO-MG composites were evaluated and compared with equivalent composites made of PU/GR powder. From experimental data analysis it was concluded that GO-MG flakes were approximately composed of 67 wt% GO and 33 wt% MG. The number of layers in the graphene flakes was estimated to be between 2 and 5 sheets. PU showed a breaking stress of 570 kPa, while the PU/20wt% GR attained a maximum stress of 750 kPa as compared to PU/10wt% GO-mf composite exhibiting a breaking stress of 1060 kPa.

关键词： Electrochemical Exfoliation Graphene Oxide Nanocomposites Polyurethane

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Ultrafast laser-scanning time-stretch imaging at visible wavelengths

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Light(Science & Applications) 2016年第1期5卷 303-312页

作者： Jiang-Lai Wu Yi-Qing Xu Jing-Jiang Xu Xiao-Ming Wei Antony CS Chan Anson HL Tang Andy KS Lau Bob mf Chung Ho Cheung Shum Edmund Y Lam Kenneth KY Wong Kevin K Tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong Kong 999077China Department of Bioengineering University of WashingtonSeattleWashington 98195USA Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong Kong 999077China

Optical time-stretch imaging enables the continuous capture of non-repetitive events in real time at a line-scan rate of tens of MHz—a distinct advantage for the ultrafast dynamics monitoring and high-throughput screening that are widely needed in biological ***,its potential is limited by the technical challenge of achieving significant pulse stretching(that is,high temporal dispersion)and low optical loss,which are the critical factors influencing imaging quality,in the visible spectrum demanded in many of these *** present a new pulse-stretching technique,termed free-space angular-chirpenhanced delay(FACED),with three distinguishing features absent in the prevailing dispersive-fiber-based implementations:(1)it generates substantial,reconfigurable temporal dispersion in free space(41 ns nm^(−1))with low intrinsic loss(o6 dB)at visible wavelengths;(2)its wavelength-invariant pulse-stretching operation introduces a new paradigm in time-stretch imaging,which can now be implemented both with and without spectral encoding;and(3)pulse stretching in FACED inherently provides an ultrafast all-optical laser-beam scanning mechanism at a line-scan rate of tens of *** FACED,we demonstrate not only ultrafast laser-scanning time-stretch imaging with superior bright-field image quality compared with previous work but also,for the first time,MHz fluorescence and colorized time-stretch *** results show that this technique could enable a wider scope of applications in high-speed and high-throughput biological microscopy that were once out of reach.

关键词： optical time-stretch imaging pulse stretching ultrafast laser scanning

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Bioactive Steroid from the Root Bark of Psorospermum corymbiferum

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中国天然药物 2011年第4期9卷 264-266页

作者： Zubair mf Oladosu IA Olawore NO Usman LA Fakunle CO Hamid AA Ali MS Department of Chemistry University of llorinNigeria Department of Chemistry University of IbadanNigeria Department of Chemistry Ladoke Akintola University of TechnologyOgbomoso Department of Chemistry Bowen UniversityIwoNigeria International Centre for Chemical and Biological Studies(ICCBS) Pakistan

AIM:To isolate,characterize and investigate the antifungal activity of the root bark of Psorospermum corymbiferum(Clusiaceae).METHODS:The finely ground root bark of Psorospermum corymbiferum was cold-extracted by percolation with 98% ethanol(5.0 L) for two *** ethanol extract was macerated with n-hexane,chloroform,ethylacetate and methanol successively to give the respective solvent *** of the extract was done using column chromatography on silica gel with cyclohexene:ethylacetate(1:1) as eluents,and the subfractions were purified by TLC using cyclohexane:ethylacetate(7:3).The structures were elucidated based on spectral analysis(IR,1H NMR and 13C NMR) in comparison with the data with those reported in the *** minimum inhibitory concentration(MIC) was determined on Candida alblican and Candida ***:Three known compounds,acetylvismione F,prenylated bianthrone and 1,8-dihydroxyanthraquinone and a steroid were isolated from the *** determined on Candida alblican and *** were 20 and 15 μ***-1,*** steroidal compound(diosgenin) was characterized for the first time from Psorospermum corymbiferum(Clusiaceae).CONCLUSION:The results suggested that the isolation has anticandidal properties,supporting the use of this plant in folk *** current drug of choice for disseminated Candidiasis is amphotericin B with MIC of 0.39 μ***-1,which could be a promising lead for a new antifungal drug especially if subjected to SAR in antifungal drug design.

关键词：生物活性化合物胆汁酸化学分析

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Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies

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World Journal of Clinical Oncology 2011年第11期2卷 367-376页

作者： Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António mf Araújo Department of Medical Oncology Portuguese Oncology InstitutePorto 4200-072Portugal 2nd Department of Medicine Discipline of Clinical SemioticsFaculty of MedicineUniversity of PortoPorto 4200-319Portugal Molecular Oncology Unit CI IPOPFGPorto 4200-072Portugal 2nd Departament of Molecular Immunology and Pathology Instituto de Ciências Biomédicas Abel Salazar(ICBAS)University of PortoPorto 4099-003Portugal Head of Lung Clinic of the Department of Medical Oncology Portuguese Oncology InstitutePorto 4200-072Portugal

Lung cancer is currently the leading cause of cancer death in Western ***-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological *** the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful *** studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these *** article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior.